ISMARA results: HOXB6

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Illumina Body Map 2: averaged replicates

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Results for HOXB6_PRRX2

Z-value: 4.61

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Transcription factors associated with HOXB6_PRRX2

Gene Symbol	Gene ID	Gene Info
HOXB6 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000108511.8	homeobox B6
PRRX2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000167157.9	paired related homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXB6	hg19_v2_chr17_-_46682321_46682362	-0.20	2.8e-01	Click!
PRRX2	hg19_v2_chr9_+_132427883_132427951	0.02	9.1e-01	Click!

Activity profile of HOXB6_PRRX2 motif

Sorted Z-values of HOXB6_PRRX2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_7382745 Show fit	31.40	ENST00000436368.2 ENST00000311745.5 ENST00000355637.4 ENST00000340209.4	RBFOX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding protein, fox-1 homolog (C. elegans) 1
chr12_-_16761007 Show fit	24.82	ENST00000354662.1 ENST00000441439.2	LMO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr2_-_50201327 Show fit	24.41	ENST00000412315.1	NRXN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	neurexin 1
chr7_+_107110488 Show fit	17.72	ENST00000304402.4	GPR22 Ensembl NCBI GeneCards UniProt NextProt Show fit	G protein-coupled receptor 22
chr12_-_16761117 Show fit	17.53	ENST00000538051.1	LMO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 3 (rhombotin-like 2)
chr3_-_181160240 Show fit	16.54	ENST00000460993.1	RP11-275H4.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-275H4.1
chr2_+_162272605 Show fit	14.60	ENST00000389554.3	TBR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	T-box, brain, 1
chr18_+_32290218 Show fit	13.99	ENST00000348997.5 ENST00000588949.1 ENST00000597599.1	DTNA Ensembl NCBI GeneCards UniProt NextProt Show fit	dystrobrevin, alpha
chr5_-_88120083 Show fit	13.73	ENST00000509373.1	MEF2C Ensembl NCBI GeneCards UniProt NextProt Show fit	myocyte enhancer factor 2C
chr1_-_217250231 Show fit	13.39	ENST00000493748.1 ENST00000463665.1	ESRRG Ensembl NCBI GeneCards UniProt NextProt Show fit	estrogen-related receptor gamma

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB6_PRRX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.1	112.9	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.3	63.1	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.2	54.2	GO:0097120	receptor localization to synapse(GO:0097120)
0.6	50.0	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
1.8	41.5	GO:0071420	cellular response to histamine(GO:0071420)
0.5	41.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.2	35.5	GO:0048813	dendrite morphogenesis(GO:0048813)
4.8	33.8	GO:0003138	primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.4	33.4	GO:0046426	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.5	30.1	GO:0007274	neuromuscular synaptic transmission(GO:0007274)

Showing 1 to 10 of 454 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	170.4	GO:0045211	postsynaptic membrane(GO:0045211)
0.2	69.8	GO:0098794	postsynapse(GO:0098794)
0.2	65.7	GO:0005802	trans-Golgi network(GO:0005802)
0.3	49.2	GO:0042383	sarcolemma(GO:0042383)
1.2	47.6	GO:1902711	GABA-A receptor complex(GO:1902711)
0.9	41.9	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.6	41.9	GO:0031430	M band(GO:0031430)
0.2	32.8	GO:0031674	I band(GO:0031674)
2.9	31.4	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.2	30.4	GO:0031225	anchored component of membrane(GO:0031225)

Showing 1 to 10 of 175 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	66.9	GO:0004860	protein kinase inhibitor activity(GO:0004860)
0.2	59.9	GO:0005516	calmodulin binding(GO:0005516)
0.3	59.8	GO:0044325	ion channel binding(GO:0044325)
0.1	52.8	GO:0005509	calcium ion binding(GO:0005509)
1.0	49.7	GO:0004385	guanylate kinase activity(GO:0004385)
0.1	47.7	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.2	47.3	GO:0051015	actin filament binding(GO:0051015)
1.4	47.1	GO:0002162	dystroglycan binding(GO:0002162)
0.3	41.1	GO:0030165	PDZ domain binding(GO:0030165)
4.7	37.9	GO:0050682	AF-2 domain binding(GO:0050682)

Showing 1 to 10 of 304 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	49.4	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.4	27.0	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.3	25.1	PID LKB1 PATHWAY	LKB1 signaling events
0.1	21.2	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	18.3	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	17.7	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	15.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.1	15.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	13.5	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	12.9	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events

Showing 1 to 10 of 71 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	68.0	REACTOME MYOGENESIS	Genes involved in Myogenesis
1.4	50.1	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.3	34.4	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.2	31.1	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.9	29.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.6	28.7	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
1.2	28.4	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.5	25.8	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.3	22.8	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.7	18.3	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Showing 1 to 10 of 90 entries

Results for HOXB6_PRRX2

Z-value: 4.61

Motif logo

Transcription factors associated with HOXB6_PRRX2

Activity-expression correlation:

Activity profile of HOXB6_PRRX2 motif

Sorted Z-values of HOXB6_PRRX2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB6_PRRX2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: