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Illumina Body Map 2: averaged replicates
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Results for HOXB8
Z-value: 1.68
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Transcription factors associated with HOXB8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB8 | hg19_v2_chr17_-_46691990_46692066 | 0.22 | 2.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_108145499 Show fit | 4.09 |
ENST00000369020.3
ENST00000369022.2 |
sex comb on midleg-like 4 (Drosophila) |
|
| chr4_+_156824840 Show fit | 4.03 |
ENST00000536354.2
|
tryptophan 2,3-dioxygenase |
|
| chr7_-_27142290 Show fit | 3.67 |
ENST00000222718.5
|
homeobox A2 |
|
| chr5_+_54398463 Show fit | 3.44 |
ENST00000274306.6
|
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
|
| chr4_-_71532207 Show fit | 3.32 |
ENST00000543780.1
ENST00000391614.3 |
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides |
|
| chr4_-_71532668 Show fit | 3.10 |
ENST00000510437.1
|
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides |
|
| chr19_-_10697895 Show fit | 3.08 |
ENST00000591240.1
ENST00000589684.1 ENST00000591676.1 ENST00000250244.6 ENST00000590923.1 |
adaptor-related protein complex 1, mu 2 subunit |
|
| chr14_+_22337014 Show fit | 2.94 |
ENST00000390436.2
|
T cell receptor alpha variable 13-1 |
|
| chr14_-_106453155 Show fit | 2.92 |
ENST00000390594.2
|
immunoglobulin heavy variable 1-2 |
|
| chr4_-_71532339 Show fit | 2.83 |
ENST00000254801.4
|
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 32.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 18.1 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.0 | 4.6 | GO:0016266 | O-glycan processing(GO:0016266) |
| 1.0 | 4.0 | GO:0019442 | tryptophan catabolic process to acetyl-CoA(GO:0019442) |
| 0.1 | 4.0 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 1.2 | 3.7 | GO:0035283 | rhombomere 3 development(GO:0021569) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 0.2 | 3.4 | GO:0032071 | regulation of endodeoxyribonuclease activity(GO:0032071) |
| 0.6 | 3.0 | GO:2000473 | regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473) |
| 0.6 | 3.0 | GO:0070980 | biphenyl catabolic process(GO:0070980) |
| 0.4 | 2.9 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 37.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 13.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 13.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 12.5 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 7.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 4.1 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 3.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 3.0 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 3.0 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 3.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 34.1 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 13.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 12.6 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 10.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 6.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 4.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.6 | 3.7 | GO:0004833 | tryptophan 2,3-dioxygenase activity(GO:0004833) |
| 0.3 | 3.6 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 0.1 | 3.0 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.6 | 2.9 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 5.1 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 4.1 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 3.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 2.8 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 2.6 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 2.4 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 2.1 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 1.9 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 1.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 11.0 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 6.1 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.2 | 5.3 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 4.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 4.3 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 4.2 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.2 | 4.1 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 3.9 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 3.2 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 3.0 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |