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Illumina Body Map 2: averaged replicates
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Results for HOXC10_HOXD13
Z-value: 2.54
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Transcription factors associated with HOXC10_HOXD13
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD13 | hg19_v2_chr2_+_176957619_176957619 | 0.64 | 7.2e-05 | Click! |
| HOXC10 | hg19_v2_chr12_+_54378923_54378970 | 0.40 | 2.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_18243119 Show fit | 9.85 |
ENST00000538724.1
ENST00000229002.2 |
RERG/RAS-like |
|
| chr6_+_118869452 Show fit | 8.63 |
ENST00000357525.5
|
phospholamban |
|
| chr1_-_178838404 Show fit | 8.17 |
ENST00000444255.1
|
angiopoietin-like 1 |
|
| chrX_+_65382381 Show fit | 7.49 |
ENST00000519389.1
|
hephaestin |
|
| chr2_+_176994408 Show fit | 6.54 |
ENST00000429017.1
ENST00000313173.4 ENST00000544999.1 |
homeobox D8 |
|
| chrX_+_65382433 Show fit | 6.44 |
ENST00000374727.3
|
hephaestin |
|
| chr2_-_216300784 Show fit | 6.09 |
ENST00000421182.1
ENST00000432072.2 ENST00000323926.6 ENST00000336916.4 ENST00000357867.4 ENST00000359671.1 ENST00000346544.3 ENST00000345488.5 ENST00000357009.2 ENST00000446046.1 ENST00000356005.4 ENST00000443816.1 ENST00000426059.1 ENST00000354785.4 |
fibronectin 1 |
|
| chr12_-_18243075 Show fit | 5.97 |
ENST00000536890.1
|
RERG/RAS-like |
|
| chr12_-_15038779 Show fit | 5.45 |
ENST00000228938.5
ENST00000539261.1 |
matrix Gla protein |
|
| chr7_+_134551583 Show fit | 5.37 |
ENST00000435928.1
|
caldesmon 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXC10_HOXD13
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 22.1 | GO:0006825 | copper ion transport(GO:0006825) |
| 1.3 | 18.8 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.0 | 16.8 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.1 | 13.0 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 2.9 | 8.6 | GO:1901876 | regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081) |
| 0.3 | 8.6 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.5 | 7.2 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
| 0.5 | 6.6 | GO:1904321 | response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322) |
| 0.1 | 6.5 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.3 | 6.4 | GO:0008595 | tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 21.8 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 1.2 | 17.9 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 16.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 15.1 | GO:0030017 | sarcomere(GO:0030017) |
| 0.0 | 10.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 9.5 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 8.9 | GO:0002102 | podosome(GO:0002102) |
| 0.2 | 8.6 | GO:0090533 | cation-transporting ATPase complex(GO:0090533) |
| 0.7 | 7.8 | GO:0098651 | basement membrane collagen trimer(GO:0098651) |
| 0.0 | 6.8 | GO:0005796 | Golgi lumen(GO:0005796) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 23.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 1.9 | 22.8 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.6 | 20.5 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 18.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 14.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 12.9 | GO:0005525 | GTP binding(GO:0005525) |
| 0.3 | 11.1 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 10.8 | GO:0008201 | heparin binding(GO:0008201) |
| 1.2 | 8.6 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.1 | 7.9 | GO:0008307 | structural constituent of muscle(GO:0008307) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 24.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 12.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 11.6 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 11.3 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 10.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 6.6 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.2 | 6.1 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 5.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 5.6 | PID ENDOTHELIN PATHWAY | Endothelins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.7 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.3 | 22.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.6 | 18.8 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 11.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 6.8 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 0.2 | 6.6 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.1 | 6.0 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 5.2 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 4.2 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.1 | 3.4 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |