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Illumina Body Map 2: averaged replicates
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Results for HOXC9
Z-value: 1.89
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Transcription factors associated with HOXC9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXC9 | hg19_v2_chr12_+_54393880_54393962 | -0.41 | 2.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_72649763 Show fit | 4.86 |
ENST00000513476.1
|
group-specific component (vitamin D binding protein) |
|
| chr4_-_70626314 Show fit | 4.58 |
ENST00000510821.1
|
sulfotransferase family, cytosolic, 1B, member 1 |
|
| chr4_+_155484155 Show fit | 4.42 |
ENST00000509493.1
|
fibrinogen beta chain |
|
| chr4_+_155484103 Show fit | 4.27 |
ENST00000302068.4
|
fibrinogen beta chain |
|
| chr9_-_104198042 Show fit | 3.72 |
ENST00000374855.4
|
aldolase B, fructose-bisphosphate |
|
| chr10_-_96829246 Show fit | 3.53 |
ENST00000371270.3
ENST00000535898.1 ENST00000539050.1 |
cytochrome P450, family 2, subfamily C, polypeptide 8 |
|
| chr5_-_135290651 Show fit | 3.41 |
ENST00000522943.1
ENST00000514447.2 |
leukocyte cell-derived chemotaxin 2 |
|
| chr5_-_135290705 Show fit | 3.27 |
ENST00000274507.1
|
leukocyte cell-derived chemotaxin 2 |
|
| chr10_+_5238793 Show fit | 3.02 |
ENST00000263126.1
|
aldo-keto reductase family 1, member C4 |
|
| chr19_-_58864848 Show fit | 2.70 |
ENST00000263100.3
|
alpha-1-B glycoprotein |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXC9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 9.7 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.2 | 6.8 | GO:0009812 | flavonoid metabolic process(GO:0009812) |
| 0.9 | 6.2 | GO:0002933 | lipid hydroxylation(GO:0002933) |
| 0.3 | 5.5 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 0.2 | 4.9 | GO:0042359 | vitamin D metabolic process(GO:0042359) |
| 0.1 | 4.6 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.0 | 4.5 | GO:0016042 | lipid catabolic process(GO:0016042) |
| 0.0 | 4.2 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.3 | 4.0 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
| 0.0 | 4.0 | GO:0007050 | cell cycle arrest(GO:0007050) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 8.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 5.4 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 4.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 4.4 | GO:0005770 | late endosome(GO:0005770) |
| 0.1 | 4.1 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 3.7 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 3.7 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 3.5 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 2.8 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 2.5 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.0 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.1 | 6.5 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 1.8 | 5.5 | GO:0019115 | benzaldehyde dehydrogenase activity(GO:0019115) |
| 0.2 | 5.2 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.2 | 5.0 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 1.6 | 4.9 | GO:1902271 | D3 vitamins binding(GO:1902271) |
| 0.0 | 4.6 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 3.9 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 3.8 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.3 | 3.7 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 8.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 4.5 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 4.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 4.1 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 3.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 3.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 2.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.5 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.4 | 5.7 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.3 | 5.5 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 4.9 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.3 | 4.8 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.1 | 4.7 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 4.7 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 4.5 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 4.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 4.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |