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Illumina Body Map 2: averaged replicates
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Results for HOXD10
Z-value: 1.92
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Transcription factors associated with HOXD10
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD10 | hg19_v2_chr2_+_176981307_176981307 | -0.53 | 1.7e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_186435137 Show fit | 8.16 |
ENST00000447445.1
|
kininogen 1 |
|
| chr3_+_186435065 Show fit | 7.13 |
ENST00000287611.2
ENST00000265023.4 |
kininogen 1 |
|
| chr4_+_155484155 Show fit | 6.57 |
ENST00000509493.1
|
fibrinogen beta chain |
|
| chr12_+_20963632 Show fit | 5.58 |
ENST00000540853.1
ENST00000261196.2 |
solute carrier organic anion transporter family, member 1B3 |
|
| chr12_+_20963647 Show fit | 5.34 |
ENST00000381545.3
|
solute carrier organic anion transporter family, member 1B3 |
|
| chr16_-_20556492 Show fit | 4.55 |
ENST00000568098.1
|
acyl-CoA synthetase medium-chain family member 2B |
|
| chr4_-_72649763 Show fit | 4.14 |
ENST00000513476.1
|
group-specific component (vitamin D binding protein) |
|
| chr18_-_68004529 Show fit | 2.92 |
ENST00000578633.1
|
RP11-484N16.1 |
|
| chr12_-_10151773 Show fit | 2.76 |
ENST00000298527.6
ENST00000348658.4 |
C-type lectin domain family 1, member B |
|
| chr6_+_161123270 Show fit | 2.63 |
ENST00000366924.2
ENST00000308192.9 ENST00000418964.1 |
plasminogen |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXD10
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 15.7 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.2 | 13.9 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 1.4 | 7.1 | GO:0030573 | bile acid catabolic process(GO:0030573) |
| 0.5 | 6.6 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
| 0.0 | 5.7 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 5.3 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 0.0 | 5.1 | GO:0006805 | xenobiotic metabolic process(GO:0006805) |
| 0.1 | 4.5 | GO:0042359 | vitamin D metabolic process(GO:0042359) |
| 0.2 | 4.3 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.8 | 4.2 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 10.8 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 7.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 6.9 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.5 | 6.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 4.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 4.0 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 3.5 | GO:0044215 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.0 | 3.3 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 3.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.6 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.4 | 10.8 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.0 | 6.9 | GO:0051087 | chaperone binding(GO:0051087) |
| 1.0 | 4.8 | GO:0047787 | delta4-3-oxosteroid 5beta-reductase activity(GO:0047787) |
| 0.7 | 4.3 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 1.4 | 4.1 | GO:1902271 | D3 vitamins binding(GO:1902271) |
| 0.3 | 4.1 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
| 0.1 | 3.7 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 3.6 | GO:0050664 | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664) |
| 0.2 | 3.5 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 4.2 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 3.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 3.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 3.1 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 3.1 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.0 | 2.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 2.4 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 2.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 2.3 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 17.3 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.7 | 13.2 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.4 | 8.4 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 5.0 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.4 | 4.8 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.1 | 4.1 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 3.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 3.4 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.2 | 3.3 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 3.0 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |