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Illumina Body Map 2: averaged replicates
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Results for HOXD11_HOXA11
Z-value: 1.59
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Transcription factors associated with HOXD11_HOXA11
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA11 | hg19_v2_chr7_-_27224795_27224840 | 0.13 | 4.7e-01 | Click! |
| HOXD11 | hg19_v2_chr2_+_176972000_176972025 | -0.01 | 9.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXD11_HOXA11
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 2.2 | 6.5 | GO:0090675 | intermicrovillar adhesion(GO:0090675) |
| 0.6 | 6.2 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.3 | 6.0 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 0.5 | 5.9 | GO:0097267 | omega-hydroxylase P450 pathway(GO:0097267) |
| 0.4 | 5.3 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.3 | 4.8 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 0.0 | 3.7 | GO:0042246 | tissue regeneration(GO:0042246) |
| 0.3 | 3.4 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.5 | 3.3 | GO:0072658 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.3 | 6.5 | GO:0044214 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
| 0.2 | 5.8 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 5.8 | GO:0030016 | myofibril(GO:0030016) |
| 0.3 | 4.8 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 3.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.3 | 3.4 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.1 | 3.3 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.5 | 3.2 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 0.0 | 3.1 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 2.1 | 6.2 | GO:0019115 | benzaldehyde dehydrogenase activity(GO:0019115) |
| 1.1 | 5.5 | GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 0.7 | 4.8 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.0 | 4.6 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 1.1 | 4.5 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.1 | 4.5 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 3.9 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.1 | 3.7 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.1 | 3.4 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 2.2 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 2.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.7 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.6 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 1.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.0 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 1.0 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.0 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.9 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 7.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 6.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.3 | 6.0 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.3 | 5.9 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.1 | 5.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 5.8 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 5.7 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 3.9 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 3.6 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |