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Illumina Body Map 2: averaged replicates
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Results for HOXD9
Z-value: 1.61
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Transcription factors associated with HOXD9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD9 | hg19_v2_chr2_+_176987088_176987088 | 0.00 | 1.0e+00 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXD9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.4 | 5.1 | GO:0043950 | positive regulation of cAMP-mediated signaling(GO:0043950) |
| 0.7 | 3.7 | GO:2000471 | regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473) |
| 0.0 | 3.5 | GO:0038095 | Fc-epsilon receptor signaling pathway(GO:0038095) |
| 0.0 | 2.9 | GO:0001895 | retina homeostasis(GO:0001895) |
| 0.7 | 2.8 | GO:0019442 | tryptophan catabolic process to acetyl-CoA(GO:0019442) |
| 0.7 | 2.8 | GO:0050717 | positive regulation of interleukin-1 alpha secretion(GO:0050717) |
| 0.5 | 2.8 | GO:0015722 | canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823) |
| 0.1 | 2.8 | GO:1901685 | glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687) |
| 0.1 | 2.6 | GO:0015671 | oxygen transport(GO:0015671) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 5.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.4 | 2.8 | GO:0072558 | NLRP1 inflammasome complex(GO:0072558) protease inhibitor complex(GO:0097179) |
| 0.2 | 2.6 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 1.5 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 1.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 1.4 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 1.3 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 1.3 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.0 | 1.3 | GO:0005637 | nuclear inner membrane(GO:0005637) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.1 | GO:0003823 | antigen binding(GO:0003823) |
| 1.0 | 5.1 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.1 | 3.7 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 3.5 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.6 | 2.8 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.5 | 2.8 | GO:0016822 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
| 0.0 | 2.8 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 2.6 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.2 | 2.4 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 0.0 | 1.8 | GO:0003785 | actin monomer binding(GO:0003785) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 3.6 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 2.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 2.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 2.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 2.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.5 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 1.3 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 1.2 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 3.7 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.2 | 3.4 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 3.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 3.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.8 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 2.8 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 2.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 2.4 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 1.5 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |