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Illumina Body Map 2: averaged replicates
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Results for HSF1
Z-value: 2.00
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Transcription factors associated with HSF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HSF1 | hg19_v2_chr8_+_145515263_145515299 | 0.38 | 3.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_161494036 Show fit | 4.23 |
ENST00000309758.4
|
heat shock 70kDa protein 6 (HSP70B') |
|
| chr19_-_7766991 Show fit | 4.10 |
ENST00000597921.1
ENST00000346664.5 |
Fc fragment of IgE, low affinity II, receptor for (CD23) |
|
| chr2_+_90043607 Show fit | 3.46 |
ENST00000462693.1
|
immunoglobulin kappa variable 2D-24 (non-functional) |
|
| chr2_-_89513402 Show fit | 3.28 |
ENST00000498435.1
|
immunoglobulin kappa variable 1-27 |
|
| chr1_-_183538319 Show fit | 3.22 |
ENST00000420553.1
ENST00000419402.1 |
neutrophil cytosolic factor 2 |
|
| chr20_-_44455976 Show fit | 3.21 |
ENST00000372555.3
|
troponin C type 2 (fast) |
|
| chr11_+_1892102 Show fit | 3.13 |
ENST00000417766.1
|
lymphocyte-specific protein 1 |
|
| chr20_+_43803517 Show fit | 2.99 |
ENST00000243924.3
|
peptidase inhibitor 3, skin-derived |
|
| chr19_+_1065922 Show fit | 2.97 |
ENST00000539243.2
|
histocompatibility (minor) HA-1 |
|
| chr12_+_10705960 Show fit | 2.94 |
ENST00000544591.1
|
RP11-291B21.2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of HSF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.7 | GO:0038095 | Fc-epsilon receptor signaling pathway(GO:0038095) |
| 0.1 | 10.1 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 8.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 8.7 | GO:0006968 | cellular defense response(GO:0006968) |
| 1.0 | 6.7 | GO:0070370 | heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370) |
| 0.2 | 5.2 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 1.3 | 5.0 | GO:0071613 | granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663) |
| 0.1 | 4.9 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.4 | 4.7 | GO:2000332 | blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.4 | 4.6 | GO:0051873 | killing by host of symbiont cells(GO:0051873) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 10.8 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.2 | 8.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 8.1 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 7.4 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 7.1 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 6.9 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.8 | 5.9 | GO:0097013 | phagocytic vesicle lumen(GO:0097013) |
| 0.0 | 5.7 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.3 | 5.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.7 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 11.5 | GO:0031072 | heat shock protein binding(GO:0031072) |
| 0.1 | 9.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 6.6 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.6 | 5.6 | GO:0019863 | IgE binding(GO:0019863) |
| 0.2 | 5.5 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.1 | 5.3 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.0 | 5.2 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.1 | 5.0 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.4 | 4.7 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 5.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 5.0 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 4.6 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 4.2 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.1 | 4.1 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 3.8 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 3.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 3.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.2 | 10.0 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.2 | 6.1 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 4.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.2 | 4.2 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 3.7 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 3.2 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 3.1 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 0.1 | 2.8 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 2.7 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |