ISMARA results: HSF4

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Illumina Body Map 2: averaged replicates

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Results for HSF4

Z-value: 1.80

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Transcription factors associated with HSF4

Gene Symbol	Gene ID	Gene Info
HSF4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000102878.11	heat shock transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HSF4	hg19_v2_chr16_+_67198683_67198715	0.39	2.8e-02	Click!

Activity profile of HSF4 motif

Sorted Z-values of HSF4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chrX_-_73072534 Show fit	3.43	ENST00000429829.1	XIST Ensembl NCBI GeneCards UniProt NextProt Show fit	X inactive specific transcript (non-protein coding)
chr13_-_31736027 Show fit	2.51	ENST00000380406.5 ENST00000320027.5 ENST00000380405.4	HSPH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	heat shock 105kDa/110kDa protein 1
chr13_-_31736132 Show fit	2.49	ENST00000429785.2	HSPH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	heat shock 105kDa/110kDa protein 1
chr13_-_31736478 Show fit	2.48	ENST00000445273.2	HSPH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	heat shock 105kDa/110kDa protein 1
chr14_+_63671105 Show fit	2.25	ENST00000316754.3	RHOJ Ensembl NCBI GeneCards UniProt NextProt Show fit	ras homolog family member J
chr19_-_14629224 Show fit	2.19	ENST00000254322.2	DNAJB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	DnaJ (Hsp40) homolog, subfamily B, member 1
chr1_+_161494036 Show fit	2.17	ENST00000309758.4	HSPA6 Ensembl NCBI GeneCards UniProt NextProt Show fit	heat shock 70kDa protein 6 (HSP70B')
chr4_+_76932326 Show fit	2.16	ENST00000513353.1 ENST00000341029.5	ART3 Ensembl NCBI GeneCards UniProt NextProt Show fit	ADP-ribosyltransferase 3
chr1_-_173638976 Show fit	2.15	ENST00000333279.2	ANKRD45 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin repeat domain 45
chr10_-_115423792 Show fit	2.13	ENST00000369360.3 ENST00000360478.3 ENST00000359988.3 ENST00000369358.4	NRAP Ensembl NCBI GeneCards UniProt NextProt Show fit	nebulin-related anchoring protein

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	9.7	GO:0007021	tubulin complex assembly(GO:0007021)
0.9	7.5	GO:1903750	regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.3	5.0	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1	3.7	GO:0006471	protein ADP-ribosylation(GO:0006471)
0.0	3.6	GO:0002088	lens development in camera-type eye(GO:0002088)
0.3	2.9	GO:0035799	ureter maturation(GO:0035799)
0.1	2.3	GO:0061299	retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.3	2.2	GO:0070370	heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.6	1.9	GO:0007412	axon target recognition(GO:0007412)
0.2	1.9	GO:0003433	chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)

Showing 1 to 10 of 78 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	9.9	GO:0071682	endocytic vesicle lumen(GO:0071682)
0.5	9.7	GO:0097512	cardiac myofibril(GO:0097512)
0.0	4.6	GO:0031225	anchored component of membrane(GO:0031225)
0.0	2.7	GO:1904115	axon cytoplasm(GO:1904115)
0.0	2.2	GO:0008180	COP9 signalosome(GO:0008180)
0.4	2.1	GO:0005927	muscle tendon junction(GO:0005927)
0.3	2.1	GO:0034751	aryl hydrocarbon receptor complex(GO:0034751)
0.2	1.5	GO:0098575	lumenal side of lysosomal membrane(GO:0098575)
0.0	1.4	GO:0044295	axonal growth cone(GO:0044295)
0.2	1.2	GO:0032280	symmetric synapse(GO:0032280)

Showing 1 to 10 of 29 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	10.8	GO:0005212	structural constituent of eye lens(GO:0005212)
0.5	7.5	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.1	5.4	GO:0001671	ATPase activator activity(GO:0001671)
0.1	4.7	GO:0051879	Hsp90 protein binding(GO:0051879)
0.4	3.7	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.2	2.9	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	2.9	GO:0031072	heat shock protein binding(GO:0031072)
0.0	2.3	GO:0030544	Hsp70 protein binding(GO:0030544)
0.1	2.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	2.1	GO:0005518	collagen binding(GO:0005518)

Showing 1 to 10 of 59 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
2.3	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
1.9	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
1.8	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
1.5	PID HNF3A PATHWAY	FOXA1 transcription factor network
1.4	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
1.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
1.0	PID LKB1 PATHWAY	LKB1 signaling events
1.0	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.9	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.7	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network

Showing 1 to 10 of 15 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.4	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	2.4	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions
0.0	2.0	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.0	1.5	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	1.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	1.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	1.0	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	1.0	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	0.9	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	0.9	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)

Showing 1 to 10 of 14 entries

Results for HSF4

Z-value: 1.80

Motif logo

Transcription factors associated with HSF4

Activity-expression correlation:

Activity profile of HSF4 motif

Sorted Z-values of HSF4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: