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Illumina Body Map 2: averaged replicates
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Results for ID4_TCF4_SNAI2
Z-value: 4.76
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Transcription factors associated with ID4_TCF4_SNAI2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000172201.6 | inhibitor of DNA binding 4, HLH protein | |
| ENSG00000196628.9 | transcription factor 4 | |
| ENSG00000019549.4 | snail family transcriptional repressor 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF4 | hg19_v2_chr18_-_53253112_53253199 | -0.56 | 7.9e-04 | Click! |
| SNAI2 | hg19_v2_chr8_-_49833978_49833996 | -0.07 | 6.9e-01 | Click! |
| ID4 | hg19_v2_chr6_+_19837592_19837621 | 0.01 | 9.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_120220561 Show fit | 13.89 |
ENST00000276681.6
|
mal, T-cell differentiation protein 2 (gene/pseudogene) |
|
| chr1_+_60280458 Show fit | 13.52 |
ENST00000455990.1
ENST00000371208.3 |
hook microtubule-tethering protein 1 |
|
| chr19_+_7660716 Show fit | 9.35 |
ENST00000160298.4
ENST00000446248.2 |
calmodulin regulated spectrin-associated protein family, member 3 |
|
| chr11_+_27062860 Show fit | 7.42 |
ENST00000528583.1
|
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 |
|
| chr18_+_47088401 Show fit | 7.41 |
ENST00000261292.4
ENST00000427224.2 ENST00000580036.1 |
lipase, endothelial |
|
| chr11_+_27062272 Show fit | 7.12 |
ENST00000529202.1
ENST00000533566.1 |
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 |
|
| chr11_+_27062502 Show fit | 6.94 |
ENST00000263182.3
|
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 |
|
| chr17_-_46035187 Show fit | 6.44 |
ENST00000300557.2
|
proline rich 15-like |
|
| chr16_+_68771128 Show fit | 6.15 |
ENST00000261769.5
ENST00000422392.2 |
cadherin 1, type 1, E-cadherin (epithelial) |
|
| chr4_-_77819002 Show fit | 6.15 |
ENST00000334306.2
|
sosondowah ankyrin repeat domain family member B |
Network of associatons between targets according to the STRING database.
First level regulatory network of ID4_TCF4_SNAI2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 28.6 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.5 | 23.1 | GO:0010107 | potassium ion import(GO:0010107) |
| 1.8 | 23.0 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.2 | 21.7 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.7 | 19.9 | GO:0006590 | thyroid hormone generation(GO:0006590) |
| 2.6 | 18.4 | GO:0060671 | epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672) |
| 0.7 | 17.5 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 1.1 | 16.3 | GO:0015705 | iodide transport(GO:0015705) |
| 0.8 | 16.0 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.9 | 15.4 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 105.1 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 53.3 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.8 | 33.0 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 32.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 26.3 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 22.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.2 | 21.9 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.0 | 21.9 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 17.5 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.2 | 16.9 | GO:0034707 | chloride channel complex(GO:0034707) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 29.1 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.2 | 28.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 5.4 | 21.5 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.4 | 20.0 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 19.1 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.9 | 16.9 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.9 | 15.4 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.8 | 15.2 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.8 | 15.2 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.5 | 13.2 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.2 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.2 | 20.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 15.1 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.2 | 12.7 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 8.5 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.2 | 8.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 7.3 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 6.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 6.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 6.1 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 54.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 1.0 | 46.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 33.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 22.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.3 | 19.6 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.2 | 18.4 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.6 | 18.1 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.3 | 15.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 13.8 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.4 | 12.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |