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Illumina Body Map 2: averaged replicates
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Results for IRF2_STAT2_IRF8_IRF1
Z-value: 5.22
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Transcription factors associated with IRF2_STAT2_IRF8_IRF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000168310.6 | interferon regulatory factor 2 | |
| ENSG00000170581.9 | signal transducer and activator of transcription 2 | |
| ENSG00000140968.6 | interferon regulatory factor 8 | |
| ENSG00000125347.9 | interferon regulatory factor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF1 | hg19_v2_chr5_-_131826457_131826514 | 0.69 | 1.5e-05 | Click! |
| IRF2 | hg19_v2_chr4_-_185395672_185395734 | 0.68 | 2.2e-05 | Click! |
| IRF8 | hg19_v2_chr16_+_85942594_85942635 | 0.67 | 2.8e-05 | Click! |
| STAT2 | hg19_v2_chr12_-_56753858_56753930 | 0.44 | 1.2e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_113416191 Show fit | 18.09 |
ENST00000342315.4
ENST00000392583.2 |
2'-5'-oligoadenylate synthetase 2, 69/71kDa |
|
| chr7_+_74188309 Show fit | 17.79 |
ENST00000289473.4
ENST00000433458.1 |
neutrophil cytosolic factor 1 |
|
| chrX_+_37639302 Show fit | 16.11 |
ENST00000545017.1
ENST00000536160.1 |
cytochrome b-245, beta polypeptide |
|
| chr12_+_113416340 Show fit | 15.95 |
ENST00000552756.1
|
2'-5'-oligoadenylate synthetase 2, 69/71kDa |
|
| chr16_+_12058961 Show fit | 14.91 |
ENST00000053243.1
|
tumor necrosis factor receptor superfamily, member 17 |
|
| chr16_+_57023406 Show fit | 14.37 |
ENST00000262510.6
ENST00000308149.7 ENST00000436936.1 |
NLR family, CARD domain containing 5 |
|
| chr12_+_113416265 Show fit | 13.81 |
ENST00000449768.2
|
2'-5'-oligoadenylate synthetase 2, 69/71kDa |
|
| chr7_+_150382781 Show fit | 13.46 |
ENST00000223293.5
ENST00000474605.1 |
GTPase, IMAP family member 2 |
|
| chr17_-_4643114 Show fit | 13.21 |
ENST00000293778.6
|
chemokine (C-X-C motif) ligand 16 |
|
| chrX_+_37639264 Show fit | 13.12 |
ENST00000378588.4
|
cytochrome b-245, beta polypeptide |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF2_STAT2_IRF8_IRF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 56.6 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 4.7 | 52.0 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.5 | 51.4 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 4.3 | 47.8 | GO:0018377 | protein myristoylation(GO:0018377) |
| 1.2 | 35.8 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.4 | 32.5 | GO:0002260 | lymphocyte homeostasis(GO:0002260) |
| 2.6 | 30.9 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 2.8 | 30.3 | GO:0045345 | positive regulation of MHC class I biosynthetic process(GO:0045345) |
| 5.8 | 29.2 | GO:1904844 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.1 | 27.3 | GO:0042157 | lipoprotein metabolic process(GO:0042157) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 83.5 | GO:0005829 | cytosol(GO:0005829) |
| 0.2 | 65.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 48.8 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 2.1 | 46.4 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.2 | 42.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 5.9 | 41.6 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 40.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 4.2 | 37.8 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.3 | 33.7 | GO:0005811 | lipid particle(GO:0005811) |
| 1.3 | 32.0 | GO:0097342 | ripoptosome(GO:0097342) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.2 | 86.7 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 66.3 | GO:0005525 | GTP binding(GO:0005525) |
| 1.8 | 44.3 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.7 | 34.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 34.3 | GO:0004386 | helicase activity(GO:0004386) |
| 1.0 | 32.7 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 6.5 | 32.5 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) |
| 0.7 | 30.5 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.9 | 28.7 | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153) |
| 0.2 | 27.7 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 54.2 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.5 | 48.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 41.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.8 | 31.1 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.2 | 21.9 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 19.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 19.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.5 | 17.7 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.3 | 16.1 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 15.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 213.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.7 | 71.7 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.7 | 50.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.7 | 48.2 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 1.2 | 41.2 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.3 | 33.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.4 | 29.7 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.9 | 27.8 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 2.7 | 26.7 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.4 | 26.5 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |