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Illumina Body Map 2: averaged replicates
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Results for IRF3
Z-value: 2.08
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Transcription factors associated with IRF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF3 | hg19_v2_chr19_-_50168861_50168873 | 0.10 | 5.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_74847800 Show fit | 8.56 |
ENST00000296029.3
|
platelet factor 4 |
|
| chr6_+_31540056 Show fit | 6.06 |
ENST00000418386.2
|
lymphotoxin alpha |
|
| chr2_+_219125714 Show fit | 5.96 |
ENST00000522678.1
ENST00000519574.1 ENST00000521462.1 |
G protein-coupled bile acid receptor 1 |
|
| chr19_+_18284477 Show fit | 5.88 |
ENST00000407280.3
|
interferon, gamma-inducible protein 30 |
|
| chr12_+_113416340 Show fit | 5.84 |
ENST00000552756.1
|
2'-5'-oligoadenylate synthetase 2, 69/71kDa |
|
| chr1_+_167599532 Show fit | 4.75 |
ENST00000537350.1
|
RCSD domain containing 1 |
|
| chr12_+_113416191 Show fit | 4.68 |
ENST00000342315.4
ENST00000392583.2 |
2'-5'-oligoadenylate synthetase 2, 69/71kDa |
|
| chr7_-_92747269 Show fit | 4.59 |
ENST00000446617.1
ENST00000379958.2 |
sterile alpha motif domain containing 9 |
|
| chr3_-_27764190 Show fit | 4.59 |
ENST00000537516.1
|
eomesodermin |
|
| chr2_+_163175394 Show fit | 4.56 |
ENST00000446271.1
ENST00000429691.2 |
grancalcin, EF-hand calcium binding protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.0 | GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590) |
| 1.3 | 14.0 | GO:0018377 | protein myristoylation(GO:0018377) |
| 0.3 | 9.1 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 1.4 | 8.6 | GO:0045918 | negative regulation of cytolysis(GO:0045918) |
| 0.6 | 7.4 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 1.8 | 7.3 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.2 | 7.2 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
| 0.4 | 6.5 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 2.0 | 6.1 | GO:0002874 | regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) |
| 0.9 | 6.0 | GO:0038183 | bile acid signaling pathway(GO:0038183) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 32.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 2.9 | 8.6 | GO:0097679 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) other organism cytoplasm(GO:0097679) |
| 1.0 | 7.3 | GO:0042825 | TAP complex(GO:0042825) |
| 1.2 | 7.0 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.0 | 6.6 | GO:0005769 | early endosome(GO:0005769) |
| 0.6 | 5.5 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.2 | 5.3 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 5.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 4.7 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 4.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 18.6 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.3 | 13.2 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.2 | 9.2 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 1.7 | 8.6 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.5 | 7.2 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.8 | 7.0 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 1.3 | 6.6 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.9 | 6.0 | GO:0038181 | bile acid receptor activity(GO:0038181) |
| 0.1 | 5.9 | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors(GO:0016667) |
| 0.0 | 5.9 | GO:0004386 | helicase activity(GO:0004386) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 9.8 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 8.6 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 4.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.5 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 3.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.3 | 3.2 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 2.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.6 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 31.9 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.4 | 14.6 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.2 | 12.5 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 9.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 8.6 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 7.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 6.0 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.2 | 5.9 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 4.6 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.1 | 4.4 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |