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Illumina Body Map 2: averaged replicates

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Results for IRF3

Z-value: 2.08

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Transcription factors associated with IRF3

Gene Symbol Gene ID Gene Info
IRF3
ENSG00000126456.11 interferon regulatory factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF3hg19_v2_chr19_-_50168861_501688730.105.9e-01Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_74847800 8.56 ENST00000296029.3
PF4
platelet factor 4
chr6_+_31540056 6.06 ENST00000418386.2
LTA
lymphotoxin alpha
chr2_+_219125714 5.96 ENST00000522678.1
ENST00000519574.1
ENST00000521462.1
GPBAR1
G protein-coupled bile acid receptor 1
chr19_+_18284477 5.88 ENST00000407280.3
IFI30
interferon, gamma-inducible protein 30
chr12_+_113416340 5.84 ENST00000552756.1
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr1_+_167599532 4.75 ENST00000537350.1
RCSD1
RCSD domain containing 1
chr12_+_113416191 4.68 ENST00000342315.4
ENST00000392583.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr7_-_92747269 4.59 ENST00000446617.1
ENST00000379958.2
SAMD9
sterile alpha motif domain containing 9
chr3_-_27764190 4.59 ENST00000537516.1
EOMES
eomesodermin
chr2_+_163175394 4.56 ENST00000446271.1
ENST00000429691.2
GCA
grancalcin, EF-hand calcium binding protein
chr3_+_186649133 4.45 ENST00000417392.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr2_-_73869508 3.88 ENST00000272425.3
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr5_-_95158375 3.67 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr5_-_95158644 3.53 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr12_+_113416265 3.44 ENST00000449768.2
OAS2
2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr1_+_151129103 3.42 ENST00000368910.3
TNFAIP8L2
tumor necrosis factor, alpha-induced protein 8-like 2
chr12_+_113376157 3.38 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr4_-_169401628 3.33 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr16_+_89006197 3.26 ENST00000378347.2
RP11-830F9.6
Uncharacterized protein; cDNA FLJ26728 fis, clone PNC06635
chr19_+_49977466 3.21 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr16_-_28518153 3.19 ENST00000356897.1
IL27
interleukin 27
chr3_-_172241250 3.18 ENST00000420541.2
ENST00000241261.2
TNFSF10
tumor necrosis factor (ligand) superfamily, member 10
chr6_-_32821599 3.17 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_-_159046617 3.14 ENST00000368130.4
AIM2
absent in melanoma 2
chr20_-_56195449 2.94 ENST00000541799.1
ZBP1
Z-DNA binding protein 1
chr19_-_47735918 2.93 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BBC3
BCL2 binding component 3
chr6_-_2876744 2.88 ENST00000420981.2
RP11-420G6.4
RP11-420G6.4
chr16_-_67970990 2.87 ENST00000358514.4
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr12_-_32040123 2.84 ENST00000535163.1
RP11-428G5.5
RP11-428G5.5
chr6_+_26440700 2.80 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr7_-_139756791 2.74 ENST00000489809.1
PARP12
poly (ADP-ribose) polymerase family, member 12
chr12_-_10022735 2.74 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr7_-_92777606 2.73 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L
sterile alpha motif domain containing 9-like
chr14_+_24605361 2.73 ENST00000206451.6
ENST00000559123.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr20_-_56195525 2.68 ENST00000371173.3
ENST00000395822.3
ENST00000340462.4
ENST00000343535.4
ZBP1
Z-DNA binding protein 1
chr6_+_32821924 2.64 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr17_-_63052929 2.64 ENST00000439174.2
GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr11_-_57334732 2.56 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr1_-_161039753 2.55 ENST00000368015.1
ARHGAP30
Rho GTPase activating protein 30
chr14_+_86401039 2.55 ENST00000557195.1
CTD-2341M24.1
CTD-2341M24.1
chr3_+_63897605 2.55 ENST00000487717.1
ATXN7
ataxin 7
chr22_+_36044411 2.54 ENST00000409652.4
APOL6
apolipoprotein L, 6
chr5_-_96143602 2.52 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
ERAP1
endoplasmic reticulum aminopeptidase 1
chr3_+_122283175 2.49 ENST00000383661.3
DTX3L
deltex 3-like (Drosophila)
chr11_-_4414880 2.48 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr8_-_67525473 2.47 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr2_-_231084659 2.45 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110
SP110 nuclear body protein
chr6_+_26365443 2.44 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr15_+_45003675 2.40 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
B2M
beta-2-microglobulin
chr2_-_231084617 2.37 ENST00000409815.2
SP110
SP110 nuclear body protein
chr1_-_89664595 2.37 ENST00000355754.6
GBP4
guanylate binding protein 4
chr3_+_42190714 2.34 ENST00000449246.1
TRAK1
trafficking protein, kinesin binding 1
chr10_+_91087651 2.31 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr2_+_218933972 2.30 ENST00000374155.3
RUFY4
RUN and FYVE domain containing 4
chr14_+_73525265 2.29 ENST00000525161.1
RBM25
RNA binding motif protein 25
chr15_-_62352570 2.28 ENST00000261517.5
ENST00000395896.4
ENST00000395898.3
VPS13C
vacuolar protein sorting 13 homolog C (S. cerevisiae)
chr6_+_26402517 2.26 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr6_+_26402465 2.24 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr1_+_221054411 2.23 ENST00000427693.1
HLX
H2.0-like homeobox
chr1_+_25599018 2.20 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
RHD
Rh blood group, D antigen
chr6_+_26365387 2.19 ENST00000532865.1
ENST00000530653.1
ENST00000527417.1
BTN3A2
butyrophilin, subfamily 3, member A2
chr6_-_32806483 2.12 ENST00000374899.4
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_-_615570 2.09 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr19_+_49977818 2.09 ENST00000594009.1
ENST00000595510.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr8_+_27238147 2.06 ENST00000412793.1
PTK2B
protein tyrosine kinase 2 beta
chr3_+_122399697 2.05 ENST00000494811.1
PARP14
poly (ADP-ribose) polymerase family, member 14
chr16_-_29875057 2.05 ENST00000219789.6
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr12_-_8218926 2.05 ENST00000546241.1
C3AR1
complement component 3a receptor 1
chr14_+_24605389 2.04 ENST00000382708.3
ENST00000561435.1
PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr2_-_231084820 2.03 ENST00000258382.5
ENST00000338556.3
SP110
SP110 nuclear body protein
chr7_-_138794081 2.01 ENST00000464606.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr10_+_91061712 2.01 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr1_-_161039647 2.01 ENST00000368013.3
ARHGAP30
Rho GTPase activating protein 30
chr17_+_25958174 2.00 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr14_-_20881579 1.98 ENST00000556935.1
ENST00000262715.5
ENST00000556549.1
TEP1
telomerase-associated protein 1
chr6_-_32806506 1.97 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr1_+_948803 1.92 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr5_-_96143796 1.88 ENST00000296754.3
ERAP1
endoplasmic reticulum aminopeptidase 1
chr3_+_63898275 1.86 ENST00000538065.1
ATXN7
ataxin 7
chr12_-_127256858 1.84 ENST00000542248.1
ENST00000540684.1
LINC00944
long intergenic non-protein coding RNA 944
chr9_+_5450503 1.84 ENST00000381573.4
ENST00000381577.3
CD274
CD274 molecule
chr12_-_8218997 1.83 ENST00000307637.4
C3AR1
complement component 3a receptor 1
chr20_-_47894569 1.83 ENST00000371744.1
ENST00000371752.1
ENST00000396105.1
ZNFX1
zinc finger, NFX1-type containing 1
chr3_+_122283064 1.80 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr12_-_322821 1.79 ENST00000359674.4
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr16_-_11350036 1.78 ENST00000332029.2
SOCS1
suppressor of cytokine signaling 1
chr3_+_187086120 1.76 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr19_+_39786962 1.75 ENST00000333625.2
IFNL1
interferon, lambda 1
chr22_+_39436862 1.73 ENST00000381565.2
ENST00000452957.2
APOBEC3F
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr16_-_71323271 1.72 ENST00000565850.1
ENST00000568910.1
ENST00000434935.2
ENST00000338099.5
CMTR2
cap methyltransferase 2
chr1_+_25598989 1.71 ENST00000454452.2
RHD
Rh blood group, D antigen
chr5_-_60139347 1.71 ENST00000511799.1
ELOVL7
ELOVL fatty acid elongase 7
chr12_-_99288536 1.69 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr16_+_29127282 1.68 ENST00000562902.1
RP11-426C22.5
RP11-426C22.5
chrX_+_119384607 1.68 ENST00000326624.2
ENST00000557385.1
ZBTB33
zinc finger and BTB domain containing 33
chr17_+_36861735 1.66 ENST00000378137.5
ENST00000325718.7
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr1_+_221054584 1.64 ENST00000549319.1
HLX
H2.0-like homeobox
chr7_-_944631 1.64 ENST00000453175.2
ADAP1
ArfGAP with dual PH domains 1
chr6_-_36355486 1.58 ENST00000538992.1
ETV7
ets variant 7
chr11_-_60720002 1.58 ENST00000538739.1
SLC15A3
solute carrier family 15 (oligopeptide transporter), member 3
chr11_+_66008698 1.58 ENST00000531597.1
PACS1
phosphofurin acidic cluster sorting protein 1
chr3_+_122399444 1.57 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr8_+_145438870 1.56 ENST00000527931.1
FAM203B
family with sequence similarity 203, member B
chr19_+_10196781 1.56 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr4_-_169239921 1.56 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr3_-_122283079 1.53 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr11_-_67418120 1.52 ENST00000255082.3
ACY3
aspartoacylase (aminocyclase) 3
chr6_-_36355513 1.52 ENST00000340181.4
ENST00000373737.4
ETV7
ets variant 7
chrX_+_10031499 1.51 ENST00000454666.1
WWC3
WWC family member 3
chr16_-_29874462 1.48 ENST00000566113.1
ENST00000569956.1
ENST00000570016.1
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr1_+_79115503 1.47 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr7_-_138794394 1.47 ENST00000242351.5
ENST00000471652.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr14_-_91976874 1.47 ENST00000557018.1
SMEK1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr22_+_31892261 1.46 ENST00000432498.1
ENST00000540643.1
ENST00000443326.1
ENST00000414585.1
SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chrX_+_57313113 1.45 ENST00000374900.4
FAAH2
fatty acid amide hydrolase 2
chr3_-_71114066 1.42 ENST00000485326.2
FOXP1
forkhead box P1
chr15_-_55611306 1.40 ENST00000563262.1
RAB27A
RAB27A, member RAS oncogene family
chr11_-_615942 1.38 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr20_-_25038804 1.38 ENST00000323482.4
ACSS1
acyl-CoA synthetase short-chain family member 1
chr1_+_145292806 1.35 ENST00000448873.2
NBPF10
neuroblastoma breakpoint family, member 10
chr3_-_122283100 1.34 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr20_+_61436146 1.32 ENST00000290291.6
OGFR
opioid growth factor receptor
chr14_-_24615523 1.27 ENST00000559056.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr12_+_113376249 1.26 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr3_-_53079281 1.25 ENST00000394750.1
SFMBT1
Scm-like with four mbt domains 1
chr11_+_93861993 1.24 ENST00000227638.3
ENST00000436171.2
PANX1
pannexin 1
chr20_-_33872518 1.22 ENST00000374436.3
EIF6
eukaryotic translation initiation factor 6
chr7_+_134832808 1.22 ENST00000275767.3
TMEM140
transmembrane protein 140
chr11_+_125461607 1.21 ENST00000527606.1
STT3A
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr14_-_91976794 1.21 ENST00000555462.1
SMEK1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr11_-_57335280 1.21 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr2_+_127413481 1.19 ENST00000259254.4
GYPC
glycophorin C (Gerbich blood group)
chr10_-_102046417 1.18 ENST00000370372.2
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr6_-_110964453 1.16 ENST00000413605.2
CDK19
cyclin-dependent kinase 19
chr11_+_5646213 1.15 ENST00000429814.2
TRIM34
tripartite motif containing 34
chr19_+_17516494 1.15 ENST00000534306.1
CTD-2521M24.9
CTD-2521M24.9
chr20_-_33872548 1.14 ENST00000374443.3
EIF6
eukaryotic translation initiation factor 6
chr21_+_42792442 1.10 ENST00000398600.2
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_-_323248 1.09 ENST00000535347.1
ENST00000536824.1
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr2_-_145275828 1.09 ENST00000392861.2
ENST00000409211.1
ZEB2
zinc finger E-box binding homeobox 2
chr22_-_36556821 1.08 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3
apolipoprotein L, 3
chr14_-_100841794 1.08 ENST00000556295.1
ENST00000554820.1
WARS
tryptophanyl-tRNA synthetase
chr10_-_102046098 1.07 ENST00000441611.1
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr2_-_145275228 1.06 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
ZEB2
zinc finger E-box binding homeobox 2
chr16_-_29874211 1.04 ENST00000563415.1
CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr20_+_44509857 1.04 ENST00000372523.1
ENST00000372520.1
ZSWIM1
zinc finger, SWIM-type containing 1
chr7_+_142353445 1.03 ENST00000390396.1
TRBV23-1
T cell receptor beta variable 23-1 (non-functional)
chr1_-_161014731 1.03 ENST00000368020.1
USF1
upstream transcription factor 1
chr8_+_22446763 1.02 ENST00000450780.2
ENST00000430850.2
ENST00000447849.1
AC037459.4
Uncharacterized protein
chr4_+_130017268 1.01 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
C4orf33
chromosome 4 open reading frame 33
chr12_-_127256772 1.01 ENST00000536517.1
LINC00944
long intergenic non-protein coding RNA 944
chr9_-_100954910 1.00 ENST00000375077.4
CORO2A
coronin, actin binding protein, 2A
chr3_-_122283424 1.00 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr22_+_31892373 0.98 ENST00000443011.1
ENST00000400289.1
ENST00000444859.1
ENST00000400288.2
SFI1
Sfi1 homolog, spindle assembly associated (yeast)
chr20_+_46988646 0.98 ENST00000416742.1
ENST00000425021.1
LINC00494
long intergenic non-protein coding RNA 494
chr1_-_154580616 0.97 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr14_-_100841670 0.97 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS
tryptophanyl-tRNA synthetase
chr14_-_100841930 0.97 ENST00000555031.1
ENST00000553395.1
ENST00000553545.1
ENST00000344102.5
ENST00000556338.1
ENST00000392882.2
ENST00000553934.1
WARS
tryptophanyl-tRNA synthetase
chr4_+_118955635 0.96 ENST00000433996.2
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr4_-_85771168 0.96 ENST00000514071.1
WDFY3
WD repeat and FYVE domain containing 3
chr20_+_388935 0.96 ENST00000382181.2
ENST00000400247.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr14_-_24615805 0.96 ENST00000560410.1
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr2_+_99771418 0.94 ENST00000393473.2
ENST00000393477.3
ENST00000393474.3
ENST00000340066.1
ENST00000393471.2
ENST00000449211.1
ENST00000434566.1
ENST00000410042.1
LIPT1
MRPL30
lipoyltransferase 1
39S ribosomal protein L30, mitochondrial
chrX_-_109561294 0.93 ENST00000372059.2
ENST00000262844.5
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr9_-_95087604 0.89 ENST00000542613.1
ENST00000542053.1
ENST00000358855.4
ENST00000545558.1
ENST00000432670.2
ENST00000433029.2
ENST00000411621.2
NOL8
nucleolar protein 8
chr15_+_55611128 0.88 ENST00000164305.5
ENST00000539642.1
PIGB
phosphatidylinositol glycan anchor biosynthesis, class B
chr22_-_36635563 0.86 ENST00000451256.2
APOL2
apolipoprotein L, 2
chr17_-_40264321 0.85 ENST00000430773.1
ENST00000413196.2
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr6_-_711395 0.85 ENST00000606285.1
RP11-532F6.3
RP11-532F6.3
chr6_-_41039567 0.84 ENST00000468811.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr20_+_388679 0.83 ENST00000356286.5
ENST00000475269.1
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr17_+_8316442 0.82 ENST00000582812.1
NDEL1
nudE neurodevelopment protein 1-like 1
chr12_+_6561190 0.80 ENST00000544021.1
ENST00000266556.7
TAPBPL
TAP binding protein-like
chr4_+_87928140 0.80 ENST00000307808.6
AFF1
AF4/FMR2 family, member 1
chr19_+_50887585 0.80 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr1_-_25747283 0.80 ENST00000346452.4
ENST00000340849.4
ENST00000349438.4
ENST00000294413.7
ENST00000413854.1
ENST00000455194.1
ENST00000243186.6
ENST00000425135.1
RHCE
Rh blood group, CcEe antigens
chr22_-_36635598 0.79 ENST00000454728.1
APOL2
apolipoprotein L, 2
chr9_+_125026882 0.78 ENST00000297908.3
ENST00000373730.3
ENST00000546115.1
ENST00000344641.3
MRRF
mitochondrial ribosome recycling factor
chr2_+_127413677 0.78 ENST00000356887.7
GYPC
glycophorin C (Gerbich blood group)
chr2_-_214017151 0.78 ENST00000452786.1
IKZF2
IKAROS family zinc finger 2 (Helios)
chr9_-_32526184 0.76 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr17_-_40264692 0.76 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr6_+_42018614 0.75 ENST00000465926.1
ENST00000482432.1
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr14_+_73525144 0.73 ENST00000261973.7
ENST00000540173.1
RBM25
RNA binding motif protein 25
chr20_-_47894936 0.72 ENST00000371754.4
ZNFX1
zinc finger, NFX1-type containing 1
chr8_+_26150628 0.72 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr4_+_118955500 0.72 ENST00000296499.5
NDST3
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr9_-_95087838 0.71 ENST00000442668.2
ENST00000421075.2
ENST00000536624.1
NOL8
nucleolar protein 8
chr16_-_28223229 0.71 ENST00000566073.1
XPO6
exportin 6
chrX_+_77154935 0.70 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr7_-_32931623 0.70 ENST00000452926.1
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr1_-_182558374 0.69 ENST00000367559.3
ENST00000539397.1
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr7_-_32931387 0.69 ENST00000304056.4
KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr14_+_73525229 0.69 ENST00000527432.1
ENST00000531500.1
ENST00000525321.1
ENST00000526754.1
RBM25
RNA binding motif protein 25
chr10_-_22292675 0.67 ENST00000376946.1
DNAJC1
DnaJ (Hsp40) homolog, subfamily C, member 1
chr2_+_127413704 0.66 ENST00000409836.3
GYPC
glycophorin C (Gerbich blood group)
chr4_+_87856129 0.66 ENST00000395146.4
ENST00000507468.1
AFF1
AF4/FMR2 family, member 1
chr20_+_388791 0.65 ENST00000441733.1
ENST00000353660.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr17_-_61517572 0.65 ENST00000582997.1
CYB561
cytochrome b561
chr2_-_152118276 0.63 ENST00000409092.1
RBM43
RNA binding motif protein 43

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 6.1 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
1.8 7.3 GO:0046967 cytosol to ER transport(GO:0046967)
1.5 4.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.4 8.6 GO:0045918 negative regulation of cytolysis(GO:0045918)
1.3 5.3 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
1.3 14.0 GO:0018377 protein myristoylation(GO:0018377)
1.2 2.4 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
1.0 2.0 GO:0032831 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831)
0.9 1.8 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.9 6.0 GO:0038183 bile acid signaling pathway(GO:0038183)
0.8 0.8 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
0.8 2.3 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.6 2.5 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.6 7.4 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.6 3.5 GO:2000110 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
0.6 1.7 GO:0036451 cap mRNA methylation(GO:0036451)
0.5 3.2 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.5 3.0 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.5 2.4 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.5 4.1 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.4 6.5 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.4 3.9 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.4 4.9 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.4 4.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.4 4.6 GO:0060700 regulation of ribonuclease activity(GO:0060700)
0.3 3.1 GO:0070269 pyroptosis(GO:0070269)
0.3 9.1 GO:0072643 interferon-gamma secretion(GO:0072643)
0.3 1.0 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.3 4.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.3 1.2 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.3 2.1 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.3 1.7 GO:0043380 regulation of memory T cell differentiation(GO:0043380)
0.3 1.8 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
0.2 7.2 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.2 3.2 GO:0045625 positive regulation of interferon-gamma biosynthetic process(GO:0045078) regulation of T-helper 1 cell differentiation(GO:0045625)
0.2 2.4 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.2 1.2 GO:0043686 co-translational protein modification(GO:0043686)
0.2 1.7 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.2 2.2 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.2 1.4 GO:0072619 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.2 1.4 GO:0019542 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.2 1.7 GO:0070383 DNA cytosine deamination(GO:0070383)
0.2 4.7 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.2 3.9 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.2 1.4 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.2 1.4 GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.2 2.6 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.2 4.6 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.2 4.4 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.2 2.3 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.1 19.0 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 1.6 GO:1902570 protein localization to nucleolus(GO:1902570)
0.1 1.7 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 5.2 GO:0015695 organic cation transport(GO:0015695)
0.1 0.8 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 2.2 GO:0060155 platelet dense granule organization(GO:0060155)
0.1 2.9 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.1 3.5 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.1 2.0 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 1.5 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 1.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 1.2 GO:0009249 protein lipoylation(GO:0009249)
0.1 1.7 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 4.3 GO:0010390 histone monoubiquitination(GO:0010390)
0.1 1.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.1 1.0 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 1.0 GO:0035973 aggrephagy(GO:0035973)
0.1 1.1 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.1 2.9 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 0.8 GO:0032790 ribosome disassembly(GO:0032790)
0.1 3.9 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 1.6 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 1.3 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 5.2 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.0 0.6 GO:0007144 female meiosis I(GO:0007144)
0.0 0.3 GO:1903772 virus maturation(GO:0019075) regulation of viral budding via host ESCRT complex(GO:1903772)
0.0 0.7 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.3 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.7 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 2.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.5 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.6 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.2 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.0 1.8 GO:0006953 acute-phase response(GO:0006953)
0.0 0.7 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0 1.8 GO:0051205 protein insertion into membrane(GO:0051205)
0.0 1.8 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 0.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 3.4 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 2.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.5 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.4 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 1.2 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 3.9 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.0 1.2 GO:0070206 protein trimerization(GO:0070206)
0.0 0.3 GO:0021891 olfactory bulb interneuron development(GO:0021891)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.6 GO:0097679 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) other organism cytoplasm(GO:0097679)
1.2 7.0 GO:0008537 proteasome activator complex(GO:0008537)
1.0 7.3 GO:0042825 TAP complex(GO:0042825)
0.6 5.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.6 1.7 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.6 1.7 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.5 2.4 GO:0031905 early endosome lumen(GO:0031905)
0.4 2.4 GO:0071797 LUBAC complex(GO:0071797)
0.3 3.1 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.3 0.6 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.2 1.0 GO:0097635 extrinsic component of autophagosome membrane(GO:0097635)
0.2 0.8 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.2 1.0 GO:0044530 supraspliceosomal complex(GO:0044530)
0.2 5.3 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 0.6 GO:0005712 chiasma(GO:0005712)
0.1 0.8 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 1.0 GO:0016589 NURF complex(GO:0016589)
0.1 2.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 2.4 GO:0071011 precatalytic spliceosome(GO:0071011)
0.1 2.2 GO:0031083 BLOC-1 complex(GO:0031083)
0.1 1.2 GO:0032059 bleb(GO:0032059)
0.1 1.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 2.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 1.3 GO:0097342 ripoptosome(GO:0097342)
0.1 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 1.6 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 2.3 GO:1904115 axon cytoplasm(GO:1904115)
0.0 3.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 2.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 4.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 4.6 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.7 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 3.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 2.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.5 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 5.1 GO:0016363 nuclear matrix(GO:0016363)
0.0 4.7 GO:0005884 actin filament(GO:0005884)
0.0 1.2 GO:0016592 mediator complex(GO:0016592)
0.0 3.3 GO:0043202 lysosomal lumen(GO:0043202)
0.0 4.3 GO:0005681 spliceosomal complex(GO:0005681)
0.0 1.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.5 GO:0005811 lipid particle(GO:0005811)
0.0 0.9 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 2.3 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.4 GO:0034385 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 6.6 GO:0005769 early endosome(GO:0005769)
0.0 0.9 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 32.3 GO:0005739 mitochondrion(GO:0005739)
0.0 0.6 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.6 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.5 18.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
1.5 4.6 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
1.3 6.6 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
1.1 4.4 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
0.9 6.0 GO:0038181 bile acid receptor activity(GO:0038181)
0.8 4.1 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.8 3.2 GO:0015440 peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977) TAP1 binding(GO:0046978)
0.8 7.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.6 1.7 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.5 7.2 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.5 3.0 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.5 2.0 GO:0048030 disaccharide binding(GO:0048030)
0.5 3.9 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.4 4.4 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.4 2.9 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.3 1.7 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.3 2.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.3 2.9 GO:0042296 ISG15 transferase activity(GO:0042296)
0.3 2.6 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.3 3.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.3 1.6 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.3 13.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 1.8 GO:0031849 olfactory receptor binding(GO:0031849)
0.2 1.2 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.2 3.9 GO:0004875 complement receptor activity(GO:0004875)
0.2 1.2 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.2 0.8 GO:0070012 oligopeptidase activity(GO:0070012)
0.2 1.3 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.2 1.4 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.2 5.5 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 9.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.2 1.7 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 0.6 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.2 2.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 1.5 GO:0004046 aminoacylase activity(GO:0004046)
0.1 1.6 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1 1.9 GO:0031386 protein tag(GO:0031386)
0.1 1.7 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 2.0 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 5.2 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 4.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.3 GO:0004985 opioid receptor activity(GO:0004985)
0.1 0.8 GO:0019213 deacetylase activity(GO:0019213)
0.1 5.9 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.1 1.8 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.1 2.3 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.2 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 1.0 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 0.6 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.6 GO:0003696 satellite DNA binding(GO:0003696)
0.1 4.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.8 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 5.3 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 1.8 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 2.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 1.4 GO:0031489 myosin V binding(GO:0031489)
0.0 1.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 2.2 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.3 GO:0005123 death receptor binding(GO:0005123)
0.0 1.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.7 GO:0048156 tau protein binding(GO:0048156)
0.0 0.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.4 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.7 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.9 GO:0008270 zinc ion binding(GO:0008270)
0.0 2.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 5.9 GO:0004386 helicase activity(GO:0004386)
0.0 0.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 3.6 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 2.9 GO:0051117 ATPase binding(GO:0051117)
0.0 0.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 1.4 GO:0050681 androgen receptor binding(GO:0050681)
0.0 2.7 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.1 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 3.6 GO:0005125 cytokine activity(GO:0005125)
0.0 0.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.5 GO:0032947 protein complex scaffold(GO:0032947)
0.0 1.6 GO:0044325 ion channel binding(GO:0044325)
0.0 1.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.2 PID IL27 PATHWAY IL27-mediated signaling events
0.1 8.6 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 2.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 13.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 4.5 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 9.8 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 2.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 2.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.6 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 1.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 3.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 4.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 4.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 8.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.4 14.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 31.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 1.7 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 12.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2 7.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 5.9 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 4.4 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 4.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 4.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 2.9 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.4 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 2.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.6 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.1 1.8 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.1 4.1 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.1 2.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.7 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 2.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 1.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 9.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.6 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 1.7 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 6.0 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 4.6 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 1.6 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 3.9 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 1.2 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 1.1 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME G1 PHASE Genes involved in G1 Phase