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Illumina Body Map 2: averaged replicates

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Results for IRF6_IRF4_IRF5

Z-value: 1.64

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Transcription factors associated with IRF6_IRF4_IRF5

Gene Symbol Gene ID Gene Info
IRF6
ENSG00000117595.6 interferon regulatory factor 6
IRF4
ENSG00000137265.10 interferon regulatory factor 4
IRF5
ENSG00000128604.14 interferon regulatory factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF4hg19_v2_chr6_+_391739_3917590.431.3e-02Click!
IRF5hg19_v2_chr7_+_128577972_1285780470.431.5e-02Click!
IRF6hg19_v2_chr1_-_209979465_209979494-0.222.2e-01Click!

Activity profile of IRF6_IRF4_IRF5 motif

Sorted Z-values of IRF6_IRF4_IRF5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_169680745 6.77 ENST00000236147.4
SELL
selectin L
chr8_+_8559406 5.11 ENST00000519106.1
CLDN23
claudin 23
chr12_+_113344582 4.63 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr19_+_16254488 4.34 ENST00000588246.1
ENST00000593031.1
HSH2D
hematopoietic SH2 domain containing
chr14_+_22931924 4.07 ENST00000390477.2
TRDC
T cell receptor delta constant
chr17_+_18380051 4.02 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
LGALS9C
lectin, galactoside-binding, soluble, 9C
chr11_-_104817919 3.84 ENST00000533252.1
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr12_+_113344755 3.22 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr17_+_25958174 3.12 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9
lectin, galactoside-binding, soluble, 9
chr12_+_113344811 3.07 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr17_-_20370847 3.01 ENST00000423676.3
ENST00000324290.5
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr9_-_100881466 2.81 ENST00000341469.2
ENST00000342043.3
ENST00000375098.3
TRIM14
tripartite motif containing 14
chr13_-_46961580 2.73 ENST00000378787.3
ENST00000378797.2
ENST00000429979.1
ENST00000378781.3
KIAA0226L
KIAA0226-like
chr11_+_128563652 2.72 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr16_+_29127282 2.64 ENST00000562902.1
RP11-426C22.5
RP11-426C22.5
chr11_-_615942 2.53 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr3_+_154797877 2.43 ENST00000462745.1
ENST00000493237.1
MME
membrane metallo-endopeptidase
chr14_+_22992573 2.42 ENST00000390516.1
TRAJ21
T cell receptor alpha joining 21
chr3_-_146262352 2.41 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr3_-_146262637 2.34 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr19_+_17638041 2.28 ENST00000601861.1
FAM129C
family with sequence similarity 129, member C
chr7_-_38339890 2.23 ENST00000390341.2
TRGV10
T cell receptor gamma variable 10 (non-functional)
chr1_+_179262905 2.21 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
SOAT1
sterol O-acyltransferase 1
chr2_+_219125714 2.18 ENST00000522678.1
ENST00000519574.1
ENST00000521462.1
GPBAR1
G protein-coupled bile acid receptor 1
chr3_-_146262365 2.18 ENST00000448787.2
PLSCR1
phospholipid scramblase 1
chr12_+_46123448 2.12 ENST00000334344.6
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr2_-_89417335 2.05 ENST00000490686.1
IGKV1-17
immunoglobulin kappa variable 1-17
chr11_-_65548265 2.02 ENST00000532090.2
AP5B1
adaptor-related protein complex 5, beta 1 subunit
chr3_-_146262488 1.99 ENST00000487389.1
PLSCR1
phospholipid scramblase 1
chr1_+_179263308 1.99 ENST00000426956.1
SOAT1
sterol O-acyltransferase 1
chr12_+_46123682 1.94 ENST00000422737.1
ARID2
AT rich interactive domain 2 (ARID, RFX-like)
chr3_-_146262293 1.92 ENST00000448205.1
PLSCR1
phospholipid scramblase 1
chr4_+_69917078 1.92 ENST00000502942.1
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr16_-_74734672 1.91 ENST00000306247.7
ENST00000575686.1
MLKL
mixed lineage kinase domain-like
chr22_+_23247030 1.89 ENST00000390324.2
IGLJ3
immunoglobulin lambda joining 3
chr11_-_118134997 1.87 ENST00000278937.2
MPZL2
myelin protein zero-like 2
chr6_-_82462425 1.86 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
FAM46A
family with sequence similarity 46, member A
chr14_+_22993296 1.80 ENST00000390517.1
TRAJ20
T cell receptor alpha joining 20
chr11_-_321340 1.75 ENST00000526811.1
IFITM3
interferon induced transmembrane protein 3
chr7_-_138794394 1.72 ENST00000242351.5
ENST00000471652.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr12_+_6881678 1.72 ENST00000441671.2
ENST00000203629.2
LAG3
lymphocyte-activation gene 3
chr7_-_138794081 1.72 ENST00000464606.1
ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr11_+_5711010 1.72 ENST00000454828.1
TRIM22
tripartite motif containing 22
chr3_+_114012819 1.71 ENST00000383671.3
TIGIT
T cell immunoreceptor with Ig and ITIM domains
chr3_-_146262428 1.68 ENST00000486631.1
PLSCR1
phospholipid scramblase 1
chr19_+_17638059 1.66 ENST00000599164.1
ENST00000449408.2
ENST00000600871.1
ENST00000599124.1
FAM129C
family with sequence similarity 129, member C
chr21_+_42733870 1.66 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr17_+_41363854 1.65 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
TMEM106A
transmembrane protein 106A
chr11_-_321050 1.60 ENST00000399808.4
IFITM3
interferon induced transmembrane protein 3
chr9_+_95820966 1.60 ENST00000375472.3
ENST00000465709.1
SUSD3
sushi domain containing 3
chr12_+_113376157 1.59 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr1_+_241695670 1.51 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr16_-_28518153 1.50 ENST00000356897.1
IL27
interleukin 27
chr5_+_156569944 1.50 ENST00000521769.1
ITK
IL2-inducible T-cell kinase
chr11_+_32851487 1.48 ENST00000257836.3
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr19_+_52264104 1.46 ENST00000340023.6
FPR2
formyl peptide receptor 2
chr3_+_154797781 1.46 ENST00000382989.3
MME
membrane metallo-endopeptidase
chr1_+_207669495 1.44 ENST00000367052.1
ENST00000367051.1
ENST00000367053.1
CR1
complement component (3b/4b) receptor 1 (Knops blood group)
chr16_+_12058961 1.43 ENST00000053243.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr7_-_142176790 1.42 ENST00000390369.2
TRBV7-4
T cell receptor beta variable 7-4 (gene/pseudogene)
chr18_+_19750894 1.35 ENST00000581694.1
GATA6
GATA binding protein 6
chr10_+_134210672 1.35 ENST00000305233.5
ENST00000368609.4
PWWP2B
PWWP domain containing 2B
chr16_-_67970990 1.35 ENST00000358514.4
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr16_+_12059050 1.34 ENST00000396495.3
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr6_+_89791507 1.33 ENST00000354922.3
PNRC1
proline-rich nuclear receptor coactivator 1
chr3_+_122283175 1.32 ENST00000383661.3
DTX3L
deltex 3-like (Drosophila)
chr3_+_187086120 1.31 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr11_-_57335280 1.30 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr17_-_7164410 1.29 ENST00000574070.1
CLDN7
claudin 7
chr20_-_62203808 1.28 ENST00000467148.1
HELZ2
helicase with zinc finger 2, transcriptional coactivator
chr1_+_221051699 1.27 ENST00000366903.6
HLX
H2.0-like homeobox
chr6_+_106546808 1.27 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr3_+_154798162 1.24 ENST00000360490.2
MME
membrane metallo-endopeptidase
chr19_+_42300548 1.23 ENST00000344550.4
CEACAM3
carcinoembryonic antigen-related cell adhesion molecule 3
chr11_-_118135160 1.23 ENST00000438295.2
MPZL2
myelin protein zero-like 2
chr19_+_52264449 1.21 ENST00000599326.1
ENST00000598953.1
FPR2
formyl peptide receptor 2
chr19_+_42300369 1.21 ENST00000357396.3
ENST00000221999.4
CEACAM3
carcinoembryonic antigen-related cell adhesion molecule 3
chr15_+_41136734 1.16 ENST00000568580.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr3_+_122283064 1.14 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr17_-_29645836 1.13 ENST00000578584.1
CTD-2370N5.3
CTD-2370N5.3
chr17_-_36981556 1.11 ENST00000536127.1
ENST00000225428.5
CWC25
CWC25 spliceosome-associated protein homolog (S. cerevisiae)
chr11_-_615570 1.10 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr11_+_130029457 1.06 ENST00000278742.5
ST14
suppression of tumorigenicity 14 (colon carcinoma)
chr14_+_22972735 1.05 ENST00000390500.1
TRAJ37
T cell receptor alpha joining 37
chrX_+_49028265 1.04 ENST00000376322.3
ENST00000376327.5
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr7_-_77045617 1.04 ENST00000257626.7
GSAP
gamma-secretase activating protein
chr12_+_62654119 1.02 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15
ubiquitin specific peptidase 15
chr21_+_42797958 1.02 ENST00000419044.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr22_+_40297105 1.01 ENST00000540310.1
GRAP2
GRB2-related adaptor protein 2
chr12_-_51664058 1.00 ENST00000605627.1
SMAGP
small cell adhesion glycoprotein
chr8_+_23386557 1.00 ENST00000523930.1
SLC25A37
solute carrier family 25 (mitochondrial iron transporter), member 37
chr12_-_31477072 0.99 ENST00000454658.2
FAM60A
family with sequence similarity 60, member A
chr11_+_5710919 0.99 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr17_-_54991369 0.97 ENST00000537230.1
TRIM25
tripartite motif containing 25
chr18_-_67624160 0.96 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule
chr14_+_105267250 0.95 ENST00000342537.7
ZBTB42
zinc finger and BTB domain containing 42
chr5_+_118668846 0.94 ENST00000513374.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr16_+_3062457 0.94 ENST00000445369.2
CLDN9
claudin 9
chr12_+_75874984 0.94 ENST00000550491.1
GLIPR1
GLI pathogenesis-related 1
chr22_+_36044411 0.93 ENST00000409652.4
APOL6
apolipoprotein L, 6
chrM_+_9207 0.92 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr12_+_69004619 0.92 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
RAP1B
RAP1B, member of RAS oncogene family
chr16_+_66638003 0.92 ENST00000562357.1
ENST00000360086.4
ENST00000562707.1
ENST00000361909.4
ENST00000460097.1
ENST00000565666.1
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr12_+_75874580 0.92 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr3_-_122283079 0.91 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr14_+_39736299 0.90 ENST00000341502.5
ENST00000396158.2
ENST00000280083.3
CTAGE5
CTAGE family, member 5
chr21_+_42798158 0.89 ENST00000441677.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr21_+_42798094 0.89 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr2_+_68961934 0.89 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr12_+_75874460 0.89 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr4_-_164534657 0.88 ENST00000339875.5
MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr19_+_58898627 0.86 ENST00000598098.1
ENST00000598495.1
ENST00000196551.3
ENST00000596046.1
RPS5
ribosomal protein S5
chr10_-_91174215 0.86 ENST00000371837.1
LIPA
lipase A, lysosomal acid, cholesterol esterase
chr14_+_39736582 0.85 ENST00000556148.1
ENST00000348007.3
CTAGE5
CTAGE family, member 5
chr1_-_53018654 0.84 ENST00000257177.4
ENST00000355809.4
ENST00000528642.1
ENST00000470626.1
ENST00000371544.3
ZCCHC11
zinc finger, CCHC domain containing 11
chr12_-_51663959 0.84 ENST00000604188.1
ENST00000398453.3
SMAGP
small cell adhesion glycoprotein
chr1_-_160990886 0.83 ENST00000537746.1
F11R
F11 receptor
chr2_+_68961905 0.83 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr14_+_23000889 0.83 ENST00000390525.1
TRAJ12
T cell receptor alpha joining 12
chr1_+_241695424 0.82 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr3_-_122283100 0.81 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr16_+_66637777 0.81 ENST00000563672.1
ENST00000424011.2
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr15_+_83478370 0.81 ENST00000286760.4
WHAMM
WAS protein homolog associated with actin, golgi membranes and microtubules
chr5_-_156569850 0.80 ENST00000524219.1
HAVCR2
hepatitis A virus cellular receptor 2
chr15_+_41136586 0.78 ENST00000431806.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr12_-_51663682 0.77 ENST00000603838.1
SMAGP
small cell adhesion glycoprotein
chr6_-_128222103 0.77 ENST00000434358.1
ENST00000543064.1
ENST00000368248.2
THEMIS
thymocyte selection associated
chr10_+_71561649 0.77 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
COL13A1
collagen, type XIII, alpha 1
chr2_+_68962014 0.76 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr8_-_22926526 0.76 ENST00000347739.3
ENST00000542226.1
TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr7_+_30323923 0.75 ENST00000323037.4
ZNRF2
zinc and ring finger 2
chr10_+_114710516 0.75 ENST00000542695.1
ENST00000346198.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr4_-_39529180 0.75 ENST00000515021.1
ENST00000510490.1
ENST00000316423.6
UGDH
UDP-glucose 6-dehydrogenase
chrX_+_23801280 0.75 ENST00000379251.3
ENST00000379253.3
ENST00000379254.1
ENST00000379270.4
SAT1
spermidine/spermine N1-acetyltransferase 1
chr1_-_153514241 0.74 ENST00000368718.1
ENST00000359215.1
S100A5
S100 calcium binding protein A5
chr18_-_67623906 0.74 ENST00000583955.1
CD226
CD226 molecule
chr11_-_67141090 0.73 ENST00000312438.7
CLCF1
cardiotrophin-like cytokine factor 1
chr21_+_42798124 0.73 ENST00000417963.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr3_-_122283424 0.73 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr14_-_20881579 0.72 ENST00000556935.1
ENST00000262715.5
ENST00000556549.1
TEP1
telomerase-associated protein 1
chr1_-_207119738 0.72 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chr11_-_57334732 0.72 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr17_-_54991395 0.71 ENST00000316881.4
TRIM25
tripartite motif containing 25
chrX_+_9433289 0.70 ENST00000422314.1
TBL1X
transducin (beta)-like 1X-linked
chr14_+_105266933 0.69 ENST00000555360.1
ZBTB42
zinc finger and BTB domain containing 42
chr17_+_78234625 0.69 ENST00000508628.2
ENST00000582970.1
ENST00000456466.1
ENST00000319921.4
RNF213
ring finger protein 213
chr2_-_231989808 0.68 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr7_+_142985308 0.67 ENST00000310447.5
CASP2
caspase 2, apoptosis-related cysteine peptidase
chr12_-_51663728 0.66 ENST00000603864.1
ENST00000605426.1
SMAGP
small cell adhesion glycoprotein
chr6_+_32605134 0.66 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr8_-_22926623 0.65 ENST00000276431.4
TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr5_+_133707252 0.65 ENST00000506787.1
ENST00000507277.1
UBE2B
ubiquitin-conjugating enzyme E2B
chr2_+_87808725 0.64 ENST00000413202.1
LINC00152
long intergenic non-protein coding RNA 152
chr7_-_150779995 0.64 ENST00000462940.1
ENST00000492838.1
ENST00000392818.3
ENST00000488752.1
ENST00000476627.1
TMUB1
transmembrane and ubiquitin-like domain containing 1
chr13_-_43566301 0.63 ENST00000398762.3
ENST00000313640.7
ENST00000313624.7
EPSTI1
epithelial stromal interaction 1 (breast)
chr7_+_18330035 0.62 ENST00000413509.2
HDAC9
histone deacetylase 9
chr2_-_191878681 0.62 ENST00000409465.1
STAT1
signal transducer and activator of transcription 1, 91kDa
chr11_+_126173647 0.61 ENST00000263579.4
DCPS
decapping enzyme, scavenger
chr16_+_68119324 0.61 ENST00000349223.5
NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr1_+_221054411 0.60 ENST00000427693.1
HLX
H2.0-like homeobox
chr16_-_88851618 0.60 ENST00000301015.9
PIEZO1
piezo-type mechanosensitive ion channel component 1
chr2_+_7017796 0.60 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr13_-_76056250 0.59 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1D4
TBC1 domain family, member 4
chr13_+_51483814 0.59 ENST00000336617.3
ENST00000422660.1
RNASEH2B
ribonuclease H2, subunit B
chr12_+_121131970 0.58 ENST00000535656.1
MLEC
malectin
chr7_+_106809406 0.58 ENST00000468410.1
ENST00000478930.1
ENST00000464009.1
ENST00000222574.4
HBP1
HMG-box transcription factor 1
chr4_-_88141755 0.58 ENST00000273963.5
KLHL8
kelch-like family member 8
chr19_+_10196781 0.57 ENST00000253110.11
C19orf66
chromosome 19 open reading frame 66
chr18_-_67624412 0.57 ENST00000580335.1
CD226
CD226 molecule
chr14_-_102552659 0.56 ENST00000441629.2
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr14_-_67955426 0.56 ENST00000554480.1
TMEM229B
transmembrane protein 229B
chr6_+_32605195 0.56 ENST00000374949.2
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr11_+_809961 0.56 ENST00000530797.1
RPLP2
ribosomal protein, large, P2
chr1_+_179051160 0.55 ENST00000367625.4
ENST00000352445.6
TOR3A
torsin family 3, member A
chr15_-_75748115 0.55 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr18_+_3262954 0.55 ENST00000584539.1
MYL12B
myosin, light chain 12B, regulatory
chr1_-_247615308 0.55 ENST00000318749.6
OR2B11
olfactory receptor, family 2, subfamily B, member 11
chr7_+_142985467 0.55 ENST00000392925.2
CASP2
caspase 2, apoptosis-related cysteine peptidase
chr3_-_39196049 0.55 ENST00000514182.1
CSRNP1
cysteine-serine-rich nuclear protein 1
chr17_-_76778339 0.55 ENST00000591455.1
ENST00000446868.3
ENST00000361101.4
ENST00000589296.1
CYTH1
cytohesin 1
chr1_+_46016465 0.55 ENST00000434299.1
AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr10_+_71561630 0.53 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
COL13A1
collagen, type XIII, alpha 1
chr15_-_26108355 0.53 ENST00000356865.6
ATP10A
ATPase, class V, type 10A
chrX_-_63425561 0.53 ENST00000374869.3
ENST00000330258.3
AMER1
APC membrane recruitment protein 1
chr4_+_109541772 0.52 ENST00000506397.1
ENST00000394668.2
RPL34
ribosomal protein L34
chr2_-_191878874 0.52 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
STAT1
signal transducer and activator of transcription 1, 91kDa
chr9_+_112542572 0.52 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr9_-_32526184 0.52 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr2_+_217277137 0.52 ENST00000430374.1
ENST00000357276.4
ENST00000444508.1
SMARCAL1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
chr2_-_7005785 0.51 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr11_+_809647 0.51 ENST00000321153.4
RPLP2
ribosomal protein, large, P2
chr1_-_8000872 0.50 ENST00000377507.3
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr17_-_38083843 0.50 ENST00000304046.2
ENST00000579695.1
ORMDL3
ORM1-like 3 (S. cerevisiae)
chr22_-_31688431 0.50 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr1_+_78769549 0.50 ENST00000370758.1
PTGFR
prostaglandin F receptor (FP)
chr10_+_71561704 0.50 ENST00000520267.1
COL13A1
collagen, type XIII, alpha 1
chr1_+_46016703 0.49 ENST00000481885.1
ENST00000351829.4
ENST00000471651.1
AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr5_+_133706865 0.49 ENST00000265339.2
UBE2B
ubiquitin-conjugating enzyme E2B
chr16_+_68119247 0.48 ENST00000575270.1
NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr4_-_18023350 0.47 ENST00000539056.1
ENST00000382226.5
ENST00000326877.4
LCORL
ligand dependent nuclear receptor corepressor-like

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF6_IRF4_IRF5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0002519 natural killer cell tolerance induction(GO:0002519)
1.3 12.5 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.7 4.2 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.6 3.6 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
0.5 5.9 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.5 1.4 GO:0045957 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.5 5.1 GO:0071492 cellular response to UV-A(GO:0071492)
0.5 1.4 GO:0007493 endodermal cell fate determination(GO:0007493)
0.4 1.3 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.4 4.3 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.4 2.3 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.3 3.8 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.3 1.0 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.3 2.3 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.3 2.2 GO:0038183 bile acid signaling pathway(GO:0038183)
0.3 1.7 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.3 1.1 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.3 1.1 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.3 4.4 GO:0060982 coronary artery morphogenesis(GO:0060982)
0.3 1.1 GO:0009447 putrescine catabolic process(GO:0009447)
0.3 1.0 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
0.3 2.3 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.3 5.6 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.3 1.0 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.2 1.0 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.2 0.6 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.2 0.6 GO:1904585 response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586) hepatocyte dedifferentiation(GO:1990828)
0.2 1.0 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 6.8 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2 0.3 GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294)
0.2 16.4 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.2 2.7 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.2 1.8 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 1.1 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.1 1.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 1.3 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.4 GO:0033320 UDP-D-xylose metabolic process(GO:0033319) UDP-D-xylose biosynthetic process(GO:0033320)
0.1 0.7 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.1 0.7 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 0.7 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.7 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 1.2 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.1 0.5 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.1 1.5 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 6.8 GO:0033198 response to ATP(GO:0033198)
0.1 0.9 GO:0030450 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.1 0.6 GO:0043335 protein unfolding(GO:0043335)
0.1 1.5 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 1.9 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 0.5 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.1 0.5 GO:0090156 cellular sphingolipid homeostasis(GO:0090156)
0.1 2.8 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.1 0.7 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1 0.4 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.1 1.7 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1 0.2 GO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation(GO:2001186)
0.1 2.7 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.7 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.1 1.7 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.1 1.9 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.7 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.1 1.7 GO:0032695 negative regulation of interleukin-12 production(GO:0032695)
0.1 1.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 0.2 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.1 0.3 GO:0030573 bile acid catabolic process(GO:0030573)
0.1 0.2 GO:0001172 transcription, RNA-templated(GO:0001172)
0.1 1.0 GO:0000733 DNA strand renaturation(GO:0000733)
0.1 0.4 GO:1901355 cellular response to rapamycin(GO:0072752) response to rapamycin(GO:1901355)
0.1 0.2 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.4 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 1.5 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.1 0.5 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.1 0.6 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.1 0.2 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.1 2.6 GO:0010390 histone monoubiquitination(GO:0010390)
0.1 4.1 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.5 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.2 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.0 1.0 GO:0090527 actin filament reorganization(GO:0090527)
0.0 1.3 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.3 GO:0032916 transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910) positive regulation of transforming growth factor beta3 production(GO:0032916) chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.0 0.6 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 1.1 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0 0.8 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.0 0.7 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 3.3 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 0.2 GO:0019542 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.0 0.8 GO:0043383 negative T cell selection(GO:0043383)
0.0 0.4 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.1 GO:0006429 leucyl-tRNA aminoacylation(GO:0006429)
0.0 0.9 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 1.2 GO:0039702 viral budding via host ESCRT complex(GO:0039702)
0.0 2.5 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 2.8 GO:0070206 protein trimerization(GO:0070206)
0.0 0.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 2.8 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 0.4 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.4 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0051808 translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.0 0.2 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.6 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.4 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.3 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.4 GO:0010225 response to UV-C(GO:0010225)
0.0 0.8 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.3 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.5 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.5 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.0 0.5 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.3 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.2 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.9 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 2.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:0006787 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 1.7 GO:0051205 protein insertion into membrane(GO:0051205)
0.0 0.8 GO:0050892 intestinal absorption(GO:0050892)
0.0 0.5 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.1 GO:0006382 adenosine to inosine editing(GO:0006382) IDP metabolic process(GO:0046707) IDP catabolic process(GO:0046709) negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.3 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.7 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 1.8 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.2 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.2 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.5 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.3 GO:0006885 regulation of pH(GO:0006885) regulation of cellular pH(GO:0030641)
0.0 0.1 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 1.8 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.4 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 1.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.2 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 0.3 GO:0032268 regulation of cellular protein metabolic process(GO:0032268)
0.0 0.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.3 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 1.4 GO:0030193 regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.0 0.4 GO:0030851 granulocyte differentiation(GO:0030851)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.4 3.8 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.2 0.6 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 6.0 GO:0043296 apical junction complex(GO:0043296)
0.1 1.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.1 0.3 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 1.1 GO:0033503 HULC complex(GO:0033503)
0.1 0.4 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 0.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.8 GO:0005787 signal peptidase complex(GO:0005787)
0.1 0.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.5 GO:0035339 SPOTS complex(GO:0035339)
0.1 4.1 GO:0090544 BAF-type complex(GO:0090544)
0.1 4.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 1.4 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.8 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.4 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.1 1.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 1.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.2 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.4 GO:0031415 NatA complex(GO:0031415)
0.0 0.4 GO:0097452 GAIT complex(GO:0097452)
0.0 5.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.9 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 4.1 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 0.3 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.4 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.2 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.0 12.7 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 14.8 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 2.0 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.4 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.7 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.2 GO:0030891 VCB complex(GO:0030891)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 0.8 GO:0001772 immunological synapse(GO:0001772)
0.0 0.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.9 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 1.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.6 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.4 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 1.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.2 GO:0015030 Cajal body(GO:0015030)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 2.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.8 GO:0008180 COP9 signalosome(GO:0008180)
0.0 3.5 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 5.4 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.0 GO:0005811 lipid particle(GO:0005811)
0.0 0.5 GO:0099738 cell cortex region(GO:0099738)
0.0 1.6 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.7 GO:0005643 nuclear pore(GO:0005643)
0.0 0.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0035631 CD40 receptor complex(GO:0035631)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0004772 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
1.1 12.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.8 6.8 GO:0043208 glycosphingolipid binding(GO:0043208)
0.8 3.1 GO:0048030 disaccharide binding(GO:0048030)
0.5 12.5 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.5 1.4 GO:0004877 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.3 2.7 GO:0005124 N-formyl peptide receptor activity(GO:0004982) scavenger receptor binding(GO:0005124)
0.3 1.0 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.3 2.2 GO:0038181 bile acid receptor activity(GO:0038181)
0.2 0.7 GO:0004145 diamine N-acetyltransferase activity(GO:0004145) polyamine binding(GO:0019808)
0.2 1.4 GO:0045569 TRAIL binding(GO:0045569)
0.2 1.7 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 6.3 GO:0070403 NAD+ binding(GO:0070403)
0.2 1.3 GO:0031849 olfactory receptor binding(GO:0031849)
0.2 0.5 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.2 0.5 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.2 1.6 GO:0042296 ISG15 transferase activity(GO:0042296)
0.2 3.8 GO:0050700 CARD domain binding(GO:0050700)
0.1 2.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 1.0 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.8 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.1 0.5 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 0.9 GO:0004771 sterol esterase activity(GO:0004771)
0.1 0.4 GO:0004644 phosphoribosylamine-glycine ligase activity(GO:0004637) phosphoribosylformylglycinamidine cyclo-ligase activity(GO:0004641) phosphoribosylglycinamide formyltransferase activity(GO:0004644)
0.1 0.7 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.1 0.4 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.1 1.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 0.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.7 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.1 1.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 1.7 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.6 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.3 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.1 0.2 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.1 1.0 GO:0036310 annealing helicase activity(GO:0036310)
0.1 0.3 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.1 4.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.6 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.2 GO:0070984 SET domain binding(GO:0070984)
0.1 0.8 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.3 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.7 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 0.2 GO:0015616 DNA translocase activity(GO:0015616)
0.1 0.7 GO:0051378 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 0.2 GO:0004074 biliverdin reductase activity(GO:0004074)
0.1 0.6 GO:0030911 TPR domain binding(GO:0030911)
0.1 0.4 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.3 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 0.1 GO:0070717 poly-purine tract binding(GO:0070717)
0.0 0.1 GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity(GO:0008124)
0.0 0.4 GO:0043515 kinetochore binding(GO:0043515)
0.0 1.0 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 1.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.4 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 1.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 1.3 GO:0031078 NAD-dependent histone deacetylase activity(GO:0017136) histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) NAD-dependent protein deacetylase activity(GO:0034979)
0.0 0.1 GO:0004823 leucine-tRNA ligase activity(GO:0004823)
0.0 1.9 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.3 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 2.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 5.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.6 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 1.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 1.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 3.6 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.6 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.9 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 1.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 2.7 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.5 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.7 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.8 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.9 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 7.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.2 GO:0031852 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 1.4 GO:0019003 GDP binding(GO:0019003)
0.0 1.2 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 5.7 GO:0003924 GTPase activity(GO:0003924)
0.0 2.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.4 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 2.2 GO:0003823 antigen binding(GO:0003823)
0.0 0.5 GO:0019956 chemokine binding(GO:0019956)
0.0 4.3 GO:0042277 peptide binding(GO:0042277)
0.0 0.9 GO:0019843 rRNA binding(GO:0019843)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 2.3 GO:0005178 integrin binding(GO:0005178)
0.0 3.1 GO:0005125 cytokine activity(GO:0005125)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.2 ST JAK STAT PATHWAY Jak-STAT Pathway
0.2 6.8 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.1 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.4 PID IL27 PATHWAY IL27-mediated signaling events
0.0 5.3 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.3 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 2.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 7.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.6 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 2.2 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 2.3 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.7 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 4.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.3 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 1.3 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.9 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.8 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 0.5 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.8 PID ATR PATHWAY ATR signaling pathway
0.0 0.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.7 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.6 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.2 22.2 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 2.0 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 5.1 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 9.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 2.3 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.2 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 2.5 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 2.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 0.6 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 1.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.6 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.7 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.5 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 2.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.3 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.8 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.6 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.6 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.5 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 1.9 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 4.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.3 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 2.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0 0.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 3.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.4 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.4 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.3 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 0.3 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII