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Illumina Body Map 2: averaged replicates

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Results for IRF9

Z-value: 1.68

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Transcription factors associated with IRF9

Gene Symbol Gene ID Gene Info
IRF9
ENSG00000213928.4 interferon regulatory factor 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF9hg19_v2_chr14_+_24630465_246305310.336.3e-02Click!

Activity profile of IRF9 motif

Sorted Z-values of IRF9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_161600990 5.93 ENST00000531221.1
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr1_-_161600942 5.72 ENST00000421702.2
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr6_+_6588902 5.08 ENST00000230568.4
LY86
lymphocyte antigen 86
chr3_-_27764190 5.01 ENST00000537516.1
EOMES
eomesodermin
chr1_-_161600822 4.86 ENST00000534776.1
ENST00000540048.1
FCGR3B
FCGR3A
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr22_+_40297105 4.80 ENST00000540310.1
GRAP2
GRB2-related adaptor protein 2
chr21_+_42733870 4.62 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2
myxovirus (influenza virus) resistance 2 (mouse)
chr22_+_40297079 4.47 ENST00000344138.4
ENST00000543252.1
GRAP2
GRB2-related adaptor protein 2
chr1_-_150738261 4.45 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr12_+_113344755 3.88 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr12_-_121477039 3.58 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr19_+_16254488 3.51 ENST00000588246.1
ENST00000593031.1
HSH2D
hematopoietic SH2 domain containing
chr12_-_121476959 3.38 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr12_+_113344582 3.37 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr4_-_76944621 3.37 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr21_+_42797958 3.33 ENST00000419044.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_-_121476750 3.31 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr18_-_67624160 3.24 ENST00000581982.1
ENST00000280200.4
CD226
CD226 molecule
chr6_-_24936170 3.20 ENST00000538035.1
FAM65B
family with sequence similarity 65, member B
chr21_+_42798158 3.19 ENST00000441677.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chrX_+_37639302 2.95 ENST00000545017.1
ENST00000536160.1
CYBB
cytochrome b-245, beta polypeptide
chr2_-_7005785 2.83 ENST00000256722.5
ENST00000404168.1
ENST00000458098.1
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr6_+_106546808 2.78 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr2_+_7005959 2.73 ENST00000442639.1
RSAD2
radical S-adenosyl methionine domain containing 2
chr21_+_42798124 2.71 ENST00000417963.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr18_-_67623906 2.68 ENST00000583955.1
CD226
CD226 molecule
chr12_+_113344811 2.64 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr21_+_42798094 2.63 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr18_-_67624412 2.59 ENST00000580335.1
CD226
CD226 molecule
chr12_+_113376157 2.35 ENST00000228928.7
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr14_-_67981916 2.31 ENST00000357461.2
TMEM229B
transmembrane protein 229B
chrX_+_37639264 2.31 ENST00000378588.4
CYBB
cytochrome b-245, beta polypeptide
chr1_+_66820058 2.29 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr8_+_27238147 2.26 ENST00000412793.1
PTK2B
protein tyrosine kinase 2 beta
chr1_+_241695670 2.23 ENST00000366557.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr6_-_31324943 2.22 ENST00000412585.2
ENST00000434333.1
HLA-B
major histocompatibility complex, class I, B
chr1_+_241695424 2.20 ENST00000366558.3
ENST00000366559.4
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr6_-_33281979 2.17 ENST00000426633.2
ENST00000467025.1
TAPBP
TAP binding protein (tapasin)
chr17_-_54991369 2.13 ENST00000537230.1
TRIM25
tripartite motif containing 25
chr20_-_56195449 2.12 ENST00000541799.1
ZBP1
Z-DNA binding protein 1
chr20_-_56195525 2.09 ENST00000371173.3
ENST00000395822.3
ENST00000340462.4
ENST00000343535.4
ZBP1
Z-DNA binding protein 1
chr13_-_46961580 2.07 ENST00000378787.3
ENST00000378797.2
ENST00000429979.1
ENST00000378781.3
KIAA0226L
KIAA0226-like
chr4_-_169401628 2.03 ENST00000514748.1
ENST00000512371.1
ENST00000260184.7
ENST00000505890.1
ENST00000511577.1
DDX60L
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like
chr3_+_122283175 2.02 ENST00000383661.3
DTX3L
deltex 3-like (Drosophila)
chr6_-_33282163 2.01 ENST00000434618.2
ENST00000456592.2
TAPBP
TAP binding protein (tapasin)
chr6_-_33282024 2.00 ENST00000475304.1
ENST00000489157.1
TAPBP
TAP binding protein (tapasin)
chr1_+_79086088 1.99 ENST00000370751.5
ENST00000342282.3
IFI44L
interferon-induced protein 44-like
chr14_-_67981870 1.94 ENST00000555994.1
TMEM229B
transmembrane protein 229B
chr16_-_74734672 1.89 ENST00000306247.7
ENST00000575686.1
MLKL
mixed lineage kinase domain-like
chr17_+_6659153 1.89 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr15_+_45003675 1.88 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
B2M
beta-2-microglobulin
chr2_+_163175394 1.83 ENST00000446271.1
ENST00000429691.2
GCA
grancalcin, EF-hand calcium binding protein
chr7_+_18535893 1.80 ENST00000432645.2
ENST00000441542.2
HDAC9
histone deacetylase 9
chr2_+_7017796 1.65 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr17_+_78234625 1.60 ENST00000508628.2
ENST00000582970.1
ENST00000456466.1
ENST00000319921.4
RNF213
ring finger protein 213
chr11_-_615570 1.57 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
IRF7
interferon regulatory factor 7
chr17_+_6658878 1.57 ENST00000574394.1
XAF1
XIAP associated factor 1
chr2_-_152146385 1.57 ENST00000414946.1
ENST00000243346.5
NMI
N-myc (and STAT) interactor
chr11_-_57334732 1.51 ENST00000526659.1
ENST00000527022.1
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr6_-_32806483 1.50 ENST00000374899.4
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
chr3_-_142166796 1.50 ENST00000392981.2
XRN1
5'-3' exoribonuclease 1
chr3_+_122399697 1.48 ENST00000494811.1
PARP14
poly (ADP-ribose) polymerase family, member 14
chr7_+_134832808 1.42 ENST00000275767.3
TMEM140
transmembrane protein 140
chr8_-_27941359 1.41 ENST00000418860.1
NUGGC
nuclear GTPase, germinal center associated
chr13_-_43566301 1.40 ENST00000398762.3
ENST00000313640.7
ENST00000313624.7
EPSTI1
epithelial stromal interaction 1 (breast)
chr12_+_6881678 1.37 ENST00000441671.2
ENST00000203629.2
LAG3
lymphocyte-activation gene 3
chr4_-_147442817 1.33 ENST00000507030.1
SLC10A7
solute carrier family 10, member 7
chr18_+_13382553 1.33 ENST00000586222.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr22_+_42148515 1.30 ENST00000540880.1
MEI1
meiosis inhibitor 1
chr3_+_187086120 1.28 ENST00000259030.2
RTP4
receptor (chemosensory) transporter protein 4
chr15_-_26108355 1.24 ENST00000356865.6
ATP10A
ATPase, class V, type 10A
chr1_+_79115503 1.24 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr17_+_41363854 1.23 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
TMEM106A
transmembrane protein 106A
chr14_+_100531738 1.23 ENST00000555706.1
EVL
Enah/Vasp-like
chr10_-_91174215 1.22 ENST00000371837.1
LIPA
lipase A, lysosomal acid, cholesterol esterase
chr1_+_948803 1.21 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr16_-_28518153 1.21 ENST00000356897.1
IL27
interleukin 27
chr3_-_130745403 1.20 ENST00000504725.1
ENST00000509060.1
ASTE1
asteroid homolog 1 (Drosophila)
chr3_+_122283064 1.18 ENST00000296161.4
DTX3L
deltex 3-like (Drosophila)
chr3_-_142166904 1.18 ENST00000264951.4
XRN1
5'-3' exoribonuclease 1
chr11_-_4414880 1.15 ENST00000254436.7
ENST00000543625.1
TRIM21
tripartite motif containing 21
chr3_-_121379739 1.14 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr9_-_32526184 1.14 ENST00000545044.1
ENST00000379868.1
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr10_+_91061712 1.11 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr6_-_32806506 1.11 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr17_-_54991395 1.11 ENST00000316881.4
TRIM25
tripartite motif containing 25
chr3_-_122283079 1.10 ENST00000471785.1
ENST00000466126.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr3_+_151986709 1.06 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
MBNL1
muscleblind-like splicing regulator 1
chr11_-_60720002 1.04 ENST00000538739.1
SLC15A3
solute carrier family 15 (oligopeptide transporter), member 3
chr3_-_122283100 1.03 ENST00000492382.1
ENST00000462315.1
PARP9
poly (ADP-ribose) polymerase family, member 9
chr11_-_67141090 1.03 ENST00000312438.7
CLCF1
cardiotrophin-like cytokine factor 1
chr2_+_33701707 1.02 ENST00000425210.1
ENST00000444784.1
ENST00000423159.1
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chrX_-_39956656 0.99 ENST00000397354.3
ENST00000378444.4
BCOR
BCL6 corepressor
chr19_+_17516494 0.97 ENST00000534306.1
CTD-2521M24.9
CTD-2521M24.9
chr11_-_615942 0.96 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr11_-_57335280 0.96 ENST00000287156.4
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr12_-_56753858 0.96 ENST00000314128.4
ENST00000557235.1
ENST00000418572.2
STAT2
signal transducer and activator of transcription 2, 113kDa
chr1_+_158979792 0.94 ENST00000359709.3
ENST00000430894.2
IFI16
interferon, gamma-inducible protein 16
chr17_-_74489215 0.92 ENST00000585701.1
ENST00000591192.1
ENST00000589526.1
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr11_+_5646213 0.90 ENST00000429814.2
TRIM34
tripartite motif containing 34
chr10_+_91174486 0.89 ENST00000416601.1
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr3_-_146262352 0.88 ENST00000462666.1
PLSCR1
phospholipid scramblase 1
chr12_+_113376249 0.86 ENST00000551007.1
ENST00000548514.1
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr17_+_7211656 0.84 ENST00000416016.2
EIF5A
eukaryotic translation initiation factor 5A
chr3_-_146262365 0.84 ENST00000448787.2
PLSCR1
phospholipid scramblase 1
chr1_-_154580616 0.83 ENST00000368474.4
ADAR
adenosine deaminase, RNA-specific
chr3_+_122399444 0.82 ENST00000474629.2
PARP14
poly (ADP-ribose) polymerase family, member 14
chr6_-_82462425 0.81 ENST00000369754.3
ENST00000320172.6
ENST00000369756.3
FAM46A
family with sequence similarity 46, member A
chr14_+_24630465 0.80 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
IRF9
interferon regulatory factor 9
chr4_-_147442982 0.78 ENST00000511374.1
ENST00000264986.3
SLC10A7
solute carrier family 10, member 7
chr1_+_158979680 0.74 ENST00000368131.4
ENST00000340979.6
IFI16
interferon, gamma-inducible protein 16
chr18_+_3262954 0.72 ENST00000584539.1
MYL12B
myosin, light chain 12B, regulatory
chr1_+_154377669 0.71 ENST00000368485.3
ENST00000344086.4
IL6R
interleukin 6 receptor
chr10_-_95242044 0.71 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chr3_-_146262637 0.70 ENST00000472349.1
ENST00000342435.4
PLSCR1
phospholipid scramblase 1
chr3_-_142166846 0.69 ENST00000463916.1
ENST00000544157.1
XRN1
5'-3' exoribonuclease 1
chr1_+_158979686 0.69 ENST00000368132.3
ENST00000295809.7
IFI16
interferon, gamma-inducible protein 16
chr16_-_15736881 0.69 ENST00000540441.2
KIAA0430
KIAA0430
chr3_-_179169181 0.68 ENST00000497513.1
GNB4
guanine nucleotide binding protein (G protein), beta polypeptide 4
chr3_-_122283424 0.67 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr10_-_95241951 0.64 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr3_-_28389922 0.60 ENST00000415852.1
AZI2
5-azacytidine induced 2
chr10_+_91174314 0.58 ENST00000371795.4
IFIT5
interferon-induced protein with tetratricopeptide repeats 5
chr19_+_10196981 0.58 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr7_-_105332084 0.56 ENST00000472195.1
ATXN7L1
ataxin 7-like 1
chr3_-_146262488 0.56 ENST00000487389.1
PLSCR1
phospholipid scramblase 1
chr15_+_58702742 0.54 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr2_+_7073174 0.54 ENST00000416587.1
RNF144A
ring finger protein 144A
chr3_-_146262428 0.52 ENST00000486631.1
PLSCR1
phospholipid scramblase 1
chr16_+_53412368 0.51 ENST00000565189.1
RP11-44F14.2
RP11-44F14.2
chr5_-_142783694 0.51 ENST00000394466.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr3_-_146262293 0.48 ENST00000448205.1
PLSCR1
phospholipid scramblase 1
chr5_-_142784003 0.43 ENST00000416954.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr4_+_37892682 0.43 ENST00000508802.1
ENST00000261439.4
ENST00000402522.1
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr20_+_61436146 0.42 ENST00000290291.6
OGFR
opioid growth factor receptor
chr19_+_17516624 0.38 ENST00000596322.1
ENST00000600008.1
ENST00000601885.1
CTD-2521M24.9
CTD-2521M24.9
chr13_+_50070077 0.37 ENST00000378319.3
ENST00000426879.1
PHF11
PHD finger protein 11
chr14_-_57277163 0.34 ENST00000555006.1
OTX2
orthodenticle homeobox 2
chr5_-_95297678 0.33 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr2_+_33701684 0.32 ENST00000442390.1
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr12_-_27167233 0.32 ENST00000535819.1
ENST00000543803.1
ENST00000535423.1
ENST00000539741.1
ENST00000343028.4
ENST00000545600.1
ENST00000543088.1
TM7SF3
transmembrane 7 superfamily member 3
chr20_+_11898507 0.31 ENST00000378226.2
BTBD3
BTB (POZ) domain containing 3
chr13_+_50070491 0.30 ENST00000496612.1
ENST00000357596.3
ENST00000485919.1
ENST00000442195.1
PHF11
PHD finger protein 11
chr2_-_106810742 0.29 ENST00000409501.3
ENST00000428048.2
ENST00000441952.1
ENST00000457835.1
ENST00000540130.1
UXS1
UDP-glucuronate decarboxylase 1
chrX_+_22056165 0.26 ENST00000535894.1
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr2_-_106810783 0.25 ENST00000283148.7
UXS1
UDP-glucuronate decarboxylase 1
chr6_+_37400974 0.22 ENST00000455891.1
ENST00000373451.4
CMTR1
cap methyltransferase 1
chr4_-_169239921 0.22 ENST00000514995.1
ENST00000393743.3
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr19_+_10222189 0.21 ENST00000321826.4
P2RY11
purinergic receptor P2Y, G-protein coupled, 11
chr1_-_182558374 0.21 ENST00000367559.3
ENST00000539397.1
RNASEL
ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
chr17_+_38296576 0.18 ENST00000264645.7
CASC3
cancer susceptibility candidate 3
chr2_-_152118276 0.18 ENST00000409092.1
RBM43
RNA binding motif protein 43
chr17_-_4167142 0.17 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr6_+_126240442 0.12 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
NCOA7
nuclear receptor coactivator 7
chr9_+_102668915 0.11 ENST00000259400.6
ENST00000531035.1
ENST00000525640.1
ENST00000534052.1
ENST00000526607.1
STX17
syntaxin 17
chr3_-_46037299 0.11 ENST00000296137.2
FYCO1
FYVE and coiled-coil domain containing 1
chrX_-_63005405 0.09 ENST00000374878.1
ENST00000437457.2
ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr3_-_141747459 0.08 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr17_-_40264692 0.04 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr5_-_137911049 0.03 ENST00000297185.3
HSPA9
heat shock 70kDa protein 9 (mortalin)
chr5_-_95297534 0.02 ENST00000513343.1
ENST00000431061.2
ELL2
elongation factor, RNA polymerase II, 2
chr2_-_55920952 0.01 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr14_+_100531615 0.01 ENST00000392920.3
EVL
Enah/Vasp-like
chr1_+_236687881 0.01 ENST00000526634.1
LGALS8
lectin, galactoside-binding, soluble, 8

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0050823 peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
1.7 5.0 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.4 8.5 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
1.1 4.5 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
1.1 5.3 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.9 2.8 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.7 16.5 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.7 4.4 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.7 2.8 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.7 3.4 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.6 4.4 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.5 5.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.4 2.5 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
0.4 4.0 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659) regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.4 2.8 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.3 2.3 GO:2000537 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.3 1.6 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.3 3.5 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.3 1.2 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.3 28.9 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.3 2.2 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.3 3.4 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950) negative regulation of myoblast fusion(GO:1901740)
0.2 1.0 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.2 1.4 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.2 1.6 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.2 5.3 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 0.5 GO:0033320 UDP-D-xylose metabolic process(GO:0033319) UDP-D-xylose biosynthetic process(GO:0033320)
0.2 2.0 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.2 0.7 GO:0002384 hepatic immune response(GO:0002384)
0.1 2.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 16.5 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 3.2 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.1 1.0 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.1 1.2 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 2.5 GO:0035456 response to interferon-beta(GO:0035456)
0.1 1.4 GO:0001778 plasma membrane repair(GO:0001778)
0.1 1.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 1.8 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 1.3 GO:0010990 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.2 GO:0036451 cap mRNA methylation(GO:0036451)
0.1 1.1 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.1 9.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 3.2 GO:0010390 histone monoubiquitination(GO:0010390)
0.1 1.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 1.3 GO:0045141 meiotic telomere clustering(GO:0045141)
0.0 1.9 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.3 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 0.3 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 1.2 GO:0045332 phospholipid translocation(GO:0045332)
0.0 3.9 GO:0032481 positive regulation of type I interferon production(GO:0032481)
0.0 0.5 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.4 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.2 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.0 1.2 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 0.1 GO:0016240 autophagosome docking(GO:0016240)
0.0 0.9 GO:0070206 protein trimerization(GO:0070206)
0.0 1.0 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 0.3 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:2000543 positive regulation of gastrulation(GO:2000543)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 8.8 GO:0042825 TAP complex(GO:0042825)
0.6 4.4 GO:0036021 endolysosome lumen(GO:0036021)
0.4 1.9 GO:0031905 early endosome lumen(GO:0031905)
0.2 5.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.2 2.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 1.0 GO:0097058 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.2 0.7 GO:0070110 ciliary neurotrophic factor receptor complex(GO:0070110)
0.1 0.8 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 2.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 2.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 16.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.8 GO:0005642 annulate lamellae(GO:0005642)
0.0 1.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 9.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 4.4 GO:0005811 lipid particle(GO:0005811)
0.0 4.6 GO:0005643 nuclear pore(GO:0005643)
0.0 6.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 4.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 10.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.0 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 4.4 GO:0031968 mitochondrial outer membrane(GO:0005741) organelle outer membrane(GO:0031968)
0.0 1.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 1.8 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 0.1 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.7 GO:0016460 myosin II complex(GO:0016460)
0.0 4.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 16.9 GO:0005730 nucleolus(GO:0005730)
0.0 0.5 GO:0034364 high-density lipoprotein particle(GO:0034364)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 23.4 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
1.8 8.8 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
1.0 5.0 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.9 16.5 GO:0019864 IgG binding(GO:0019864)
0.7 2.8 GO:0009041 uridylate kinase activity(GO:0009041)
0.7 3.4 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.4 3.4 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.4 2.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.3 9.7 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.3 1.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.2 0.7 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.2 2.0 GO:0042296 ISG15 transferase activity(GO:0042296)
0.2 1.3 GO:0031849 olfactory receptor binding(GO:0031849)
0.2 0.5 GO:0048040 UDP-glucuronate decarboxylase activity(GO:0048040)
0.2 1.0 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.2 1.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 4.0 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.2 1.2 GO:0004771 sterol esterase activity(GO:0004771)
0.1 3.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 1.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 2.8 GO:0070403 NAD+ binding(GO:0070403)
0.1 4.4 GO:0001968 fibronectin binding(GO:0001968)
0.1 1.1 GO:0031386 protein tag(GO:0031386)
0.1 12.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.2 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.1 4.4 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 2.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.2 GO:0042605 peptide antigen binding(GO:0042605)
0.1 1.2 GO:0005522 profilin binding(GO:0005522)
0.1 1.8 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) NAD-dependent protein deacetylase activity(GO:0034979)
0.0 2.3 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 2.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.8 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 1.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 1.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 1.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.7 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 16.5 GO:0008017 microtubule binding(GO:0008017)
0.0 0.4 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.3 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 2.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 6.1 GO:0005178 integrin binding(GO:0005178)
0.0 1.3 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 4.5 GO:0001047 core promoter binding(GO:0001047)
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 3.2 GO:0042393 histone binding(GO:0042393)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 5.6 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.8 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 6.9 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 2.3 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 5.3 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.0 PID IL27 PATHWAY IL27-mediated signaling events
0.0 3.4 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 3.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.3 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.7 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 1.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.4 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 2.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.1 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 4.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 8.5 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.5 47.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 2.9 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.2 10.5 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.2 3.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2 3.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 13.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 5.3 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 3.5 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 2.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 2.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 0.7 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 3.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 5.1 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 2.1 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.7 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.8 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 1.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 2.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.0 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters