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Illumina Body Map 2: averaged replicates
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Results for IRF9
Z-value: 1.68
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Transcription factors associated with IRF9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF9 | hg19_v2_chr14_+_24630465_24630531 | 0.33 | 6.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_161600990 Show fit | 5.93 |
ENST00000531221.1
|
Fc fragment of IgG, low affinity IIIb, receptor (CD16b) |
|
| chr1_-_161600942 Show fit | 5.72 |
ENST00000421702.2
|
Fc fragment of IgG, low affinity IIIb, receptor (CD16b) |
|
| chr6_+_6588902 Show fit | 5.08 |
ENST00000230568.4
|
lymphocyte antigen 86 |
|
| chr3_-_27764190 Show fit | 5.01 |
ENST00000537516.1
|
eomesodermin |
|
| chr1_-_161600822 Show fit | 4.86 |
ENST00000534776.1
ENST00000540048.1 |
Fc fragment of IgG, low affinity IIIb, receptor (CD16b) Fc fragment of IgG, low affinity IIIa, receptor (CD16a) |
|
| chr22_+_40297105 Show fit | 4.80 |
ENST00000540310.1
|
GRB2-related adaptor protein 2 |
|
| chr21_+_42733870 Show fit | 4.62 |
ENST00000330714.3
ENST00000436410.1 ENST00000435611.1 |
myxovirus (influenza virus) resistance 2 (mouse) |
|
| chr22_+_40297079 Show fit | 4.47 |
ENST00000344138.4
ENST00000543252.1 |
GRB2-related adaptor protein 2 |
|
| chr1_-_150738261 Show fit | 4.45 |
ENST00000448301.2
ENST00000368985.3 |
cathepsin S |
|
| chr12_+_113344755 Show fit | 3.88 |
ENST00000550883.1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 28.9 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.7 | 16.5 | GO:0003373 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.1 | 16.5 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.1 | 9.3 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 1.4 | 8.5 | GO:0002729 | positive regulation of natural killer cell cytokine production(GO:0002729) |
| 2.1 | 6.2 | GO:0050823 | peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823) |
| 1.1 | 5.3 | GO:1904845 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.2 | 5.3 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.5 | 5.1 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 1.7 | 5.0 | GO:0002302 | CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.9 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 16.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 10.1 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 9.3 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 1.3 | 8.8 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 6.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.2 | 5.3 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 4.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 4.6 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 4.5 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 23.4 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.9 | 16.5 | GO:0019864 | IgG binding(GO:0019864) |
| 0.0 | 16.5 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 12.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.3 | 9.7 | GO:0050664 | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664) |
| 1.8 | 8.8 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) |
| 0.0 | 6.1 | GO:0005178 | integrin binding(GO:0005178) |
| 1.0 | 5.0 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.0 | 4.5 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.1 | 4.4 | GO:0001968 | fibronectin binding(GO:0001968) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 6.9 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 5.6 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 5.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 4.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.4 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 3.0 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.0 | 2.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.3 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 1.8 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 47.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 13.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 10.5 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.9 | 8.5 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 5.3 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 5.1 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.2 | 3.7 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 3.5 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.2 | 3.4 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 3.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |