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Illumina Body Map 2: averaged replicates
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Results for IRX3
Z-value: 2.20
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Transcription factors associated with IRX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRX3 | hg19_v2_chr16_-_54320675_54320715 | 0.14 | 4.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_54320078 Show fit | 8.13 |
ENST00000231009.2
|
granzyme K (granzyme 3; tryptase II) |
|
| chr15_-_22473353 Show fit | 5.97 |
ENST00000557788.2
|
immunoglobulin heavy variable 4/OR15-8 (non-functional) |
|
| chr14_-_106453155 Show fit | 5.53 |
ENST00000390594.2
|
immunoglobulin heavy variable 1-2 |
|
| chr14_+_22386325 Show fit | 5.12 |
ENST00000390439.2
|
T cell receptor alpha variable 13-2 |
|
| chr1_+_26644441 Show fit | 5.11 |
ENST00000374213.2
|
CD52 molecule |
|
| chr22_+_23154239 Show fit | 5.08 |
ENST00000390315.2
|
immunoglobulin lambda variable 3-10 |
|
| chr13_-_46716969 Show fit | 4.92 |
ENST00000435666.2
|
lymphocyte cytosolic protein 1 (L-plastin) |
|
| chr14_-_107179265 Show fit | 4.81 |
ENST00000390634.2
|
immunoglobulin heavy variable 2-70 |
|
| chr1_+_158259558 Show fit | 4.78 |
ENST00000368170.3
|
CD1c molecule |
|
| chr2_-_89545079 Show fit | 4.77 |
ENST00000468494.1
|
immunoglobulin kappa variable 2-30 |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 72.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 18.9 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.5 | 7.7 | GO:0045059 | positive thymic T cell selection(GO:0045059) |
| 0.3 | 6.2 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 0.1 | 6.0 | GO:0042267 | natural killer cell mediated cytotoxicity(GO:0042267) |
| 0.2 | 5.6 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.2 | 5.4 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.1 | 5.1 | GO:0045730 | respiratory burst(GO:0045730) |
| 1.2 | 4.9 | GO:0019442 | tryptophan catabolic process to acetyl-CoA(GO:0019442) |
| 0.3 | 4.9 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.6 | 29.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 18.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 7.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.6 | 7.7 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.2 | 6.3 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 4.8 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 3.9 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.2 | 3.5 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 3.1 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 59.5 | GO:0003823 | antigen binding(GO:0003823) |
| 0.5 | 29.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 8.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 7.7 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 7.3 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.0 | 6.2 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.7 | 6.0 | GO:0070891 | lipoteichoic acid binding(GO:0070891) |
| 0.1 | 5.0 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.5 | 4.8 | GO:0030884 | lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884) |
| 0.8 | 4.0 | GO:0033695 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 9.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 6.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.4 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 3.4 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 2.6 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 2.4 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 2.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 2.2 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.9 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.3 | 7.7 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.1 | 6.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 6.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 6.4 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.2 | 4.9 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 4.6 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.2 | 4.0 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 3.5 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 3.2 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |