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Illumina Body Map 2: averaged replicates

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Results for IRX3

Z-value: 2.20

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Transcription factors associated with IRX3

Gene Symbol Gene ID Gene Info
IRX3
ENSG00000177508.11 iroquois homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX3hg19_v2_chr16_-_54320675_543207150.144.5e-01Click!

Activity profile of IRX3 motif

Sorted Z-values of IRX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_54320078 8.13 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr15_-_22473353 5.97 ENST00000557788.2
IGHV4OR15-8
immunoglobulin heavy variable 4/OR15-8 (non-functional)
chr14_-_106453155 5.53 ENST00000390594.2
IGHV1-2
immunoglobulin heavy variable 1-2
chr14_+_22386325 5.12 ENST00000390439.2
TRAV13-2
T cell receptor alpha variable 13-2
chr1_+_26644441 5.11 ENST00000374213.2
CD52
CD52 molecule
chr22_+_23154239 5.08 ENST00000390315.2
IGLV3-10
immunoglobulin lambda variable 3-10
chr13_-_46716969 4.92 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr14_-_107179265 4.81 ENST00000390634.2
IGHV2-70
immunoglobulin heavy variable 2-70
chr1_+_158259558 4.78 ENST00000368170.3
CD1C
CD1c molecule
chr2_-_89545079 4.77 ENST00000468494.1
IGKV2-30
immunoglobulin kappa variable 2-30
chr4_+_71091786 4.39 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr14_-_106781017 4.08 ENST00000390612.2
IGHV4-28
immunoglobulin heavy variable 4-28
chr22_+_23161491 3.87 ENST00000390316.2
IGLV3-9
immunoglobulin lambda variable 3-9 (gene/pseudogene)
chr3_+_151451707 3.81 ENST00000356517.3
AADACL2
arylacetamide deacetylase-like 2
chr2_+_89975669 3.73 ENST00000474213.1
IGKV2D-30
immunoglobulin kappa variable 2D-30
chr11_+_60223225 3.62 ENST00000524807.1
ENST00000345732.4
MS4A1
membrane-spanning 4-domains, subfamily A, member 1
chr6_-_108145499 3.54 ENST00000369020.3
ENST00000369022.2
SCML4
sex comb on midleg-like 4 (Drosophila)
chr2_+_7865923 3.47 ENST00000417930.1
AC092580.4
AC092580.4
chr4_+_156824840 3.36 ENST00000536354.2
TDO2
tryptophan 2,3-dioxygenase
chr14_+_22204418 3.35 ENST00000390426.2
TRAV4
T cell receptor alpha variable 4
chr14_-_106494587 3.20 ENST00000390597.2
IGHV2-5
immunoglobulin heavy variable 2-5
chr1_+_117297007 3.12 ENST00000369478.3
ENST00000369477.1
CD2
CD2 molecule
chr2_+_90139056 3.00 ENST00000492446.1
IGKV1D-16
immunoglobulin kappa variable 1D-16
chr11_-_118213455 2.90 ENST00000300692.4
CD3D
CD3d molecule, delta (CD3-TCR complex)
chr14_-_106725723 2.86 ENST00000390609.2
IGHV3-23
immunoglobulin heavy variable 3-23
chr14_-_106758101 2.83 ENST00000390611.2
IGHV2-26
immunoglobulin heavy variable 2-26
chr14_-_106845789 2.82 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr14_-_106478603 2.79 ENST00000390596.2
IGHV4-4
immunoglobulin heavy variable 4-4
chr5_+_35856951 2.75 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R
interleukin 7 receptor
chr2_+_90121477 2.73 ENST00000483379.1
IGKV1D-17
immunoglobulin kappa variable 1D-17
chr11_-_118213360 2.70 ENST00000529594.1
CD3D
CD3d molecule, delta (CD3-TCR complex)
chr2_-_136875712 2.70 ENST00000241393.3
CXCR4
chemokine (C-X-C motif) receptor 4
chr7_-_38289173 2.66 ENST00000436911.2
TRGC2
T cell receptor gamma constant 2
chr14_-_106967788 2.63 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr14_-_106830057 2.62 ENST00000390616.2
IGHV4-34
immunoglobulin heavy variable 4-34
chr12_+_5541267 2.62 ENST00000423158.3
NTF3
neurotrophin 3
chr14_+_22433675 2.62 ENST00000390442.3
TRAV12-3
T cell receptor alpha variable 12-3
chr14_-_106805716 2.58 ENST00000438142.2
IGHV4-31
immunoglobulin heavy variable 4-31
chr10_-_96829246 2.49 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
CYP2C8
cytochrome P450, family 2, subfamily C, polypeptide 8
chr6_-_49834209 2.45 ENST00000507853.1
CRISP1
cysteine-rich secretory protein 1
chr14_-_107131560 2.37 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr11_+_60739115 2.33 ENST00000344028.5
ENST00000346437.4
CD6
CD6 molecule
chr2_-_89417335 2.29 ENST00000490686.1
IGKV1-17
immunoglobulin kappa variable 1-17
chr22_+_23063100 2.27 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19
chr5_-_156390230 2.25 ENST00000407087.3
ENST00000274532.2
TIMD4
T-cell immunoglobulin and mucin domain containing 4
chr11_-_74408739 2.25 ENST00000529912.1
CHRDL2
chordin-like 2
chr22_+_40297079 2.23 ENST00000344138.4
ENST00000543252.1
GRAP2
GRB2-related adaptor protein 2
chr14_-_106692191 2.23 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr1_+_196788887 2.22 ENST00000320493.5
ENST00000367424.4
ENST00000367421.3
CFHR1
CFHR2
complement factor H-related 1
complement factor H-related 2
chr6_-_49834240 2.22 ENST00000335847.4
CRISP1
cysteine-rich secretory protein 1
chr18_-_56985776 2.22 ENST00000587244.1
CPLX4
complexin 4
chr14_-_106926724 2.19 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr6_-_24799117 2.13 ENST00000565469.1
RP3-369A17.5
chromosome 6 open reading frame 229
chr14_-_106963409 2.11 ENST00000390621.2
IGHV1-45
immunoglobulin heavy variable 1-45
chr1_-_7913089 2.09 ENST00000361696.5
UTS2
urotensin 2
chr12_-_10251603 2.07 ENST00000457018.2
CLEC1A
C-type lectin domain family 1, member A
chr11_-_118213331 2.05 ENST00000392884.2
CD3D
CD3d molecule, delta (CD3-TCR complex)
chr5_-_156362666 2.04 ENST00000406964.1
TIMD4
T-cell immunoglobulin and mucin domain containing 4
chr6_+_71104588 2.02 ENST00000418403.1
RP11-462G2.1
RP11-462G2.1
chr14_-_106610852 2.02 ENST00000390603.2
IGHV3-15
immunoglobulin heavy variable 3-15
chr1_+_160709029 2.01 ENST00000444090.2
ENST00000441662.2
SLAMF7
SLAM family member 7
chr11_+_60739249 1.98 ENST00000542157.1
ENST00000433107.2
ENST00000452451.2
ENST00000352009.5
CD6
CD6 molecule
chr2_+_90259593 1.98 ENST00000471857.1
IGKV1D-8
immunoglobulin kappa variable 1D-8
chr2_-_89459813 1.98 ENST00000390256.2
IGKV6-21
immunoglobulin kappa variable 6-21 (non-functional)
chr2_-_89521942 1.98 ENST00000482769.1
IGKV2-28
immunoglobulin kappa variable 2-28
chr4_+_69681710 1.97 ENST00000265403.7
ENST00000458688.2
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B10
chr1_+_160709055 1.97 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7
SLAM family member 7
chr12_-_10542617 1.95 ENST00000240618.6
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr2_-_158300556 1.95 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr2_+_119699864 1.95 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr2_+_114163945 1.92 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr14_-_106791536 1.89 ENST00000390613.2
IGHV3-30
immunoglobulin heavy variable 3-30
chr19_-_54974894 1.89 ENST00000333834.4
LENG9
leukocyte receptor cluster (LRC) member 9
chr14_-_106471723 1.89 ENST00000390595.2
IGHV1-3
immunoglobulin heavy variable 1-3
chr1_-_169733789 1.89 ENST00000454271.1
ENST00000609271.1
RP1-117P20.3
SELE
RP1-117P20.3
selectin E
chr4_+_40195262 1.87 ENST00000503941.1
RHOH
ras homolog family member H
chr12_+_101869096 1.86 ENST00000551346.1
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr1_+_81001398 1.85 ENST00000418041.1
ENST00000443104.1
RP5-887A10.1
RP5-887A10.1
chrX_+_78426469 1.84 ENST00000276077.1
GPR174
G protein-coupled receptor 174
chr1_+_81106951 1.81 ENST00000443565.1
RP5-887A10.1
RP5-887A10.1
chr15_-_81616446 1.81 ENST00000302824.6
STARD5
StAR-related lipid transfer (START) domain containing 5
chr4_-_38784592 1.80 ENST00000502321.1
TLR10
toll-like receptor 10
chr15_+_81225699 1.79 ENST00000560027.1
KIAA1199
KIAA1199
chr16_+_32063311 1.78 ENST00000426099.1
AC142381.1
AC142381.1
chr12_-_9885888 1.75 ENST00000327839.3
CLECL1
C-type lectin-like 1
chr1_+_160709076 1.75 ENST00000359331.4
ENST00000495334.1
SLAMF7
SLAM family member 7
chr1_-_157522180 1.75 ENST00000356953.4
ENST00000368188.2
ENST00000368190.3
ENST00000368189.3
FCRL5
Fc receptor-like 5
chr3_+_100354442 1.74 ENST00000475887.1
GPR128
G protein-coupled receptor 128
chr14_-_106586656 1.69 ENST00000390602.2
IGHV3-13
immunoglobulin heavy variable 3-13
chr11_+_60739140 1.68 ENST00000313421.7
CD6
CD6 molecule
chr4_-_69434245 1.63 ENST00000317746.2
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr17_+_34639793 1.62 ENST00000394465.2
ENST00000394463.2
ENST00000378342.4
CCL4L2
chemokine (C-C motif) ligand 4-like 2
chr17_+_34430980 1.62 ENST00000250151.4
CCL4
chemokine (C-C motif) ligand 4
chr1_+_196912902 1.62 ENST00000476712.2
ENST00000367415.5
CFHR2
complement factor H-related 2
chr2_+_85921414 1.59 ENST00000263863.4
ENST00000524600.1
GNLY
granulysin
chr11_+_57365150 1.59 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr17_+_38673270 1.58 ENST00000578280.1
RP5-1028K7.2
RP5-1028K7.2
chr14_+_95047725 1.56 ENST00000554760.1
ENST00000554866.1
ENST00000329597.7
ENST00000556775.1
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr1_-_114414316 1.54 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr17_-_46657473 1.53 ENST00000332503.5
HOXB4
homeobox B4
chr1_+_57320437 1.52 ENST00000361249.3
C8A
complement component 8, alpha polypeptide
chr10_+_96698406 1.52 ENST00000260682.6
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr2_-_88427568 1.51 ENST00000393750.3
ENST00000295834.3
FABP1
fatty acid binding protein 1, liver
chrX_-_55291163 1.51 ENST00000519203.1
ENST00000374951.1
PAGE3
P antigen family, member 3 (prostate associated)
chr9_-_4679419 1.51 ENST00000609131.1
ENST00000607997.1
RP11-6J24.6
RP11-6J24.6
chr7_-_41742697 1.51 ENST00000242208.4
INHBA
inhibin, beta A
chr16_+_33605231 1.51 ENST00000570121.2
IGHV3OR16-12
immunoglobulin heavy variable 3/OR16-12 (non-functional)
chr2_+_89923550 1.51 ENST00000509129.1
IGKV1D-37
immunoglobulin kappa variable 1D-37 (non-functional)
chr16_-_33647696 1.51 ENST00000558425.1
ENST00000569103.2
RP11-812E19.9
Uncharacterized protein
chr2_+_143635222 1.50 ENST00000375773.2
ENST00000409512.1
ENST00000410015.2
KYNU
kynureninase
chr12_-_9268707 1.48 ENST00000318602.7
A2M
alpha-2-macroglobulin
chr2_-_88125471 1.48 ENST00000398146.3
RGPD2
RANBP2-like and GRIP domain containing 2
chr2_+_217735493 1.47 ENST00000456163.1
AC007557.1
HCG1816075; Uncharacterized protein
chr3_+_177159695 1.47 ENST00000442937.1
LINC00578
long intergenic non-protein coding RNA 578
chr8_-_86253888 1.47 ENST00000522389.1
ENST00000432364.2
ENST00000517618.1
CA1
carbonic anhydrase I
chr2_+_113885138 1.47 ENST00000409930.3
IL1RN
interleukin 1 receptor antagonist
chr12_+_9980113 1.46 ENST00000537723.1
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr21_-_34185944 1.45 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr22_+_22516550 1.45 ENST00000390284.2
IGLV4-60
immunoglobulin lambda variable 4-60
chr14_+_95047744 1.44 ENST00000553511.1
ENST00000554633.1
ENST00000555681.1
ENST00000554276.1
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr11_-_118083600 1.44 ENST00000524477.1
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr1_+_171060018 1.43 ENST00000367755.4
ENST00000392085.2
ENST00000542847.1
ENST00000538429.1
ENST00000479749.1
FMO3
flavin containing monooxygenase 3
chr17_+_18380051 1.42 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
LGALS9C
lectin, galactoside-binding, soluble, 9C
chr2_+_85921522 1.42 ENST00000409696.3
GNLY
granulysin
chr12_+_47473369 1.42 ENST00000546455.1
PCED1B
PC-esterase domain containing 1B
chr12_-_91398796 1.40 ENST00000261172.3
ENST00000551767.1
EPYC
epiphycan
chr11_+_114166536 1.39 ENST00000299964.3
NNMT
nicotinamide N-methyltransferase
chr22_+_40297105 1.39 ENST00000540310.1
GRAP2
GRB2-related adaptor protein 2
chr5_+_159848807 1.38 ENST00000352433.5
PTTG1
pituitary tumor-transforming 1
chr12_+_29542557 1.37 ENST00000550906.1
OVCH1-AS1
OVCH1 antisense RNA 1
chr22_-_50970919 1.36 ENST00000329363.4
ENST00000437588.1
ODF3B
outer dense fiber of sperm tails 3B
chr1_+_207070775 1.36 ENST00000391929.3
ENST00000294984.2
ENST00000367093.3
IL24
interleukin 24
chr11_-_5255861 1.36 ENST00000380299.3
HBD
hemoglobin, delta
chr12_-_68553512 1.36 ENST00000229135.3
IFNG
interferon, gamma
chr17_-_29641104 1.36 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chr10_-_101841588 1.33 ENST00000370418.3
CPN1
carboxypeptidase N, polypeptide 1
chr1_+_196857144 1.32 ENST00000367416.2
ENST00000251424.4
ENST00000367418.2
CFHR4
complement factor H-related 4
chr16_+_30484054 1.32 ENST00000564118.1
ENST00000454514.2
ENST00000433423.2
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr3_+_122044084 1.31 ENST00000264474.3
ENST00000479204.1
CSTA
cystatin A (stefin A)
chr7_+_23210760 1.29 ENST00000366347.4
AC005082.1
Uncharacterized protein
chr10_-_90712520 1.27 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_+_242011485 1.27 ENST00000423131.1
ENST00000523590.1
EXO1
exonuclease 1
chr4_-_70725856 1.26 ENST00000226444.3
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chrX_+_12809463 1.19 ENST00000380663.3
ENST00000380668.5
ENST00000398491.2
ENST00000489404.1
PRPS2
phosphoribosyl pyrophosphate synthetase 2
chr1_-_89488510 1.19 ENST00000564665.1
ENST00000370481.4
GBP3
guanylate binding protein 3
chr22_+_37309662 1.18 ENST00000403662.3
ENST00000262825.5
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr5_-_13944652 1.17 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr5_-_64858944 1.17 ENST00000508421.1
ENST00000510693.1
ENST00000514814.1
ENST00000515497.1
ENST00000396679.1
CENPK
centromere protein K
chr14_+_22236722 1.17 ENST00000390428.3
TRAV6
T cell receptor alpha variable 6
chr7_+_139529040 1.17 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr2_+_231090471 1.17 ENST00000373645.3
SP140
SP140 nuclear body protein
chr3_+_111630451 1.16 ENST00000495180.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr13_+_113030625 1.15 ENST00000283550.3
SPACA7
sperm acrosome associated 7
chr2_+_189839046 1.15 ENST00000304636.3
ENST00000317840.5
COL3A1
collagen, type III, alpha 1
chr17_+_34431212 1.15 ENST00000394495.1
CCL4
chemokine (C-C motif) ligand 4
chr4_-_84035905 1.15 ENST00000311507.4
PLAC8
placenta-specific 8
chr12_-_21757774 1.14 ENST00000261195.2
GYS2
glycogen synthase 2 (liver)
chr5_+_110559603 1.14 ENST00000512453.1
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr2_+_231090433 1.13 ENST00000486687.2
ENST00000350136.5
ENST00000392045.3
ENST00000417495.3
ENST00000343805.6
ENST00000420434.3
SP140
SP140 nuclear body protein
chr1_+_22964073 1.12 ENST00000402322.1
C1QA
complement component 1, q subcomponent, A chain
chr8_-_101724989 1.12 ENST00000517403.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr21_-_34186006 1.12 ENST00000490358.1
C21orf62
chromosome 21 open reading frame 62
chr7_+_139528952 1.11 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr17_-_29641084 1.11 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr14_+_22554680 1.08 ENST00000390451.2
TRAV23DV6
T cell receptor alpha variable 23/delta variable 6
chr14_-_105487381 1.07 ENST00000392590.3
ENST00000336219.3
CDCA4
cell division cycle associated 4
chr3_-_191000172 1.06 ENST00000427544.2
UTS2B
urotensin 2B
chr21_-_47613673 1.06 ENST00000594486.1
AP001468.1
Protein LOC101060037
chr12_+_69742121 1.06 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
LYZ
lysozyme
chr7_+_139529085 1.06 ENST00000539806.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr3_+_177159744 1.04 ENST00000439009.1
LINC00578
long intergenic non-protein coding RNA 578
chr16_+_31539183 1.04 ENST00000302312.4
AHSP
alpha hemoglobin stabilizing protein
chr2_-_231989808 1.04 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr17_-_54893250 1.04 ENST00000397862.2
C17orf67
chromosome 17 open reading frame 67
chr4_+_69962185 1.03 ENST00000305231.7
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr14_+_100485712 1.03 ENST00000544450.2
EVL
Enah/Vasp-like
chr6_+_130742231 1.03 ENST00000545622.1
TMEM200A
transmembrane protein 200A
chr1_+_196743912 1.02 ENST00000367425.4
CFHR3
complement factor H-related 3
chr3_+_186383741 1.02 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr3_+_46395219 1.01 ENST00000445132.2
ENST00000292301.4
CCR2
chemokine (C-C motif) receptor 2
chr5_+_118668846 1.01 ENST00000513374.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr5_+_162887556 1.01 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
HMMR
hyaluronan-mediated motility receptor (RHAMM)
chr15_+_38226827 1.01 ENST00000559502.1
ENST00000558148.1
ENST00000558158.1
TMCO5A
transmembrane and coiled-coil domains 5A
chr6_+_116782527 1.01 ENST00000368606.3
ENST00000368605.1
FAM26F
family with sequence similarity 26, member F
chr12_+_20963632 0.99 ENST00000540853.1
ENST00000261196.2
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr6_-_32784687 0.98 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta
chr2_-_69180012 0.97 ENST00000481498.1
GKN2
gastrokine 2
chr11_-_104905840 0.97 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
CASP1
caspase 1, apoptosis-related cysteine peptidase
chr12_-_10605929 0.96 ENST00000347831.5
ENST00000359151.3
KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr15_-_31521567 0.96 ENST00000560812.1
ENST00000559853.1
ENST00000558109.1
RP11-16E12.2
RP11-16E12.2
chr16_+_56995854 0.95 ENST00000566128.1
CETP
cholesteryl ester transfer protein, plasma
chr4_-_42154895 0.94 ENST00000502486.1
ENST00000504360.1
BEND4
BEN domain containing 4
chr16_-_54882145 0.94 ENST00000561591.1
RP11-1136G4.1
RP11-1136G4.1
chr11_+_827248 0.93 ENST00000527089.1
ENST00000530183.1
EFCAB4A
EF-hand calcium binding domain 4A
chrX_+_12924732 0.93 ENST00000218032.6
ENST00000311912.5
TLR8
toll-like receptor 8
chr4_+_70146217 0.93 ENST00000335568.5
ENST00000511240.1
UGT2B28
UDP glucuronosyltransferase 2 family, polypeptide B28
chr14_-_92247032 0.93 ENST00000556661.1
ENST00000553676.1
ENST00000554560.1
CATSPERB
catsper channel auxiliary subunit beta
chr1_+_109256067 0.93 ENST00000271311.2
FNDC7
fibronectin type III domain containing 7
chr3_+_186330712 0.92 ENST00000411641.2
ENST00000273784.5
AHSG
alpha-2-HS-glycoprotein
chr6_-_26216872 0.92 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
1.0 3.1 GO:0001868 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
1.0 3.0 GO:0002818 intracellular defense response(GO:0002818)
0.7 2.1 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.7 2.1 GO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831)
0.7 2.0 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.6 1.9 GO:0006711 estrogen catabolic process(GO:0006711)
0.5 3.6 GO:2000501 regulation of natural killer cell chemotaxis(GO:2000501) positive regulation of natural killer cell chemotaxis(GO:2000503)
0.5 1.5 GO:0060279 positive regulation of ovulation(GO:0060279)
0.5 3.0 GO:0061107 seminal vesicle development(GO:0061107)
0.5 7.7 GO:0045059 positive thymic T cell selection(GO:0045059)
0.5 0.9 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.4 1.7 GO:0000912 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.4 4.7 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.4 72.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.4 4.8 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.4 1.1 GO:0002372 myeloid dendritic cell cytokine production(GO:0002372)
0.4 4.5 GO:0097267 omega-hydroxylase P450 pathway(GO:0097267)
0.3 1.4 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.3 4.9 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.3 1.0 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.3 1.0 GO:2000451 astrocyte chemotaxis(GO:0035700) positive regulation of immune complex clearance by monocytes and macrophages(GO:0090265) positive regulation of T cell extravasation(GO:2000409) positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451) regulation of astrocyte chemotaxis(GO:2000458)
0.3 1.0 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.3 2.7 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.3 6.2 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.3 2.5 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.3 0.8 GO:0043105 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.3 1.3 GO:0030070 insulin processing(GO:0030070)
0.3 0.8 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
0.3 4.7 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.3 0.8 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.3 1.5 GO:0048539 bone marrow development(GO:0048539)
0.3 2.8 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.2 0.2 GO:0046136 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.2 0.7 GO:0050787 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787)
0.2 1.2 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.2 1.2 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043) interleukin-3-mediated signaling pathway(GO:0038156)
0.2 5.4 GO:0052695 cellular glucuronidation(GO:0052695)
0.2 5.6 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.2 1.3 GO:0090131 mesenchyme migration(GO:0090131)
0.2 0.6 GO:0001810 regulation of type I hypersensitivity(GO:0001810) positive regulation of type I hypersensitivity(GO:0001812) type I hypersensitivity(GO:0016068)
0.2 1.0 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.2 0.8 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.2 3.0 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.2 0.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.2 0.8 GO:0002740 negative regulation of cytokine secretion involved in immune response(GO:0002740)
0.2 0.6 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.2 0.6 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.2 4.0 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 1.6 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 1.1 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 0.3 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
0.2 0.9 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 0.6 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.4 GO:1903414 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.1 0.7 GO:0039516 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.1 1.0 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 5.1 GO:0045730 respiratory burst(GO:0045730)
0.1 0.3 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 0.8 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.4 GO:1901291 negative regulation of double-strand break repair via single-strand annealing(GO:1901291)
0.1 0.5 GO:0035425 autocrine signaling(GO:0035425)
0.1 0.5 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.1 0.3 GO:0021503 neural fold bending(GO:0021503)
0.1 0.7 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.1 0.5 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 2.6 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 0.5 GO:0036509 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.1 1.8 GO:0002455 humoral immune response mediated by circulating immunoglobulin(GO:0002455)
0.1 1.8 GO:0006662 glycerol ether metabolic process(GO:0006662)
0.1 1.0 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 0.4 GO:0050883 negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883)
0.1 0.4 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.1 1.3 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.1 1.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 18.9 GO:0002377 immunoglobulin production(GO:0002377)
0.1 0.8 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 1.5 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.1 0.3 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 2.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 1.6 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.1 1.9 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.1 0.6 GO:0035690 cellular response to drug(GO:0035690)
0.1 1.7 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.1 0.8 GO:0070995 NADPH oxidation(GO:0070995)
0.1 1.9 GO:0070508 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.1 0.6 GO:1903232 melanosome assembly(GO:1903232)
0.1 0.7 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 0.4 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.1 0.1 GO:0032886 regulation of microtubule-based process(GO:0032886)
0.1 0.4 GO:0080154 regulation of fertilization(GO:0080154)
0.1 0.1 GO:0031346 positive regulation of cell projection organization(GO:0031346)
0.1 0.7 GO:0006939 smooth muscle contraction(GO:0006939)
0.1 0.9 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.5 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.1 6.0 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 0.6 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 0.5 GO:0048241 epinephrine transport(GO:0048241)
0.1 1.0 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 0.3 GO:0016062 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.6 GO:0070269 pyroptosis(GO:0070269)
0.1 0.9 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.1 0.5 GO:0051712 positive regulation of killing of cells of other organism(GO:0051712)
0.1 0.2 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.1 0.7 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.2 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.1 0.5 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.1 0.5 GO:0043631 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.1 0.3 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.1 0.7 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 1.1 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 0.2 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.1 0.3 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.7 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.0 0.9 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.2 GO:0060467 egg activation(GO:0007343) negative regulation of fertilization(GO:0060467)
0.0 0.4 GO:0003383 apical constriction(GO:0003383)
0.0 0.6 GO:0042723 thiamine-containing compound metabolic process(GO:0042723)
0.0 0.2 GO:0061358 negative regulation of Wnt protein secretion(GO:0061358)
0.0 2.2 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.7 GO:0015747 urate transport(GO:0015747)
0.0 0.6 GO:0043383 negative T cell selection(GO:0043383)
0.0 0.2 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 1.0 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 1.0 GO:0045724 nonmotile primary cilium assembly(GO:0035058) positive regulation of cilium assembly(GO:0045724) regulation of nonmotile primary cilium assembly(GO:1902855) positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.3 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.0 0.6 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.5 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 2.0 GO:0030155 regulation of cell adhesion(GO:0030155)
0.0 1.1 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0 0.6 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.4 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.0 0.8 GO:0070129 regulation of mitochondrial translation(GO:0070129)
0.0 1.3 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.7 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.0 GO:0002921 negative regulation of humoral immune response(GO:0002921)
0.0 0.5 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.1 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 1.6 GO:0043029 T cell homeostasis(GO:0043029)
0.0 1.3 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 1.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.4 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.0 0.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.2 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.6 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 0.3 GO:0070887 cellular response to chemical stimulus(GO:0070887)
0.0 0.2 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.0 0.5 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.5 GO:0015684 ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874)
0.0 1.3 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.9 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.2 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.4 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 1.4 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 2.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.9 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 2.4 GO:0045576 mast cell activation(GO:0045576)
0.0 0.3 GO:0060174 limb bud formation(GO:0060174)
0.0 0.6 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.7 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.3 GO:0009117 nucleoside phosphate metabolic process(GO:0006753) nucleotide metabolic process(GO:0009117)
0.0 1.5 GO:0002755 MyD88-dependent toll-like receptor signaling pathway(GO:0002755)
0.0 1.2 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.8 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.3 GO:0071169 establishment of protein localization to chromatin(GO:0071169)
0.0 0.5 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 0.3 GO:0045351 type I interferon biosynthetic process(GO:0045351)
0.0 0.3 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 1.8 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.0 0.4 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.0 0.4 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.2 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.2 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.5 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.0 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.5 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.9 GO:0006907 pinocytosis(GO:0006907)
0.0 0.4 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.7 GO:0014850 response to muscle activity(GO:0014850)
0.0 0.3 GO:0022417 protein maturation by protein folding(GO:0022417)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 1.2 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.6 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.4 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 2.4 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 3.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.9 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 1.9 GO:0001824 blastocyst development(GO:0001824)
0.0 0.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.5 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.3 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.5 GO:0097186 amelogenesis(GO:0097186)
0.0 0.2 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.7 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.0 0.8 GO:0032402 melanosome transport(GO:0032402)
0.0 0.1 GO:0048749 compound eye development(GO:0048749)
0.0 0.2 GO:1904251 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0 0.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.5 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.6 GO:0007398 ectoderm development(GO:0007398)
0.0 0.1 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.0 0.3 GO:0035640 exploration behavior(GO:0035640)
0.0 0.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 1.0 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.2 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.0 0.2 GO:0034505 tooth mineralization(GO:0034505)
0.0 0.5 GO:1903214 regulation of protein targeting to mitochondrion(GO:1903214) positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.9 GO:2000816 negative regulation of mitotic sister chromatid separation(GO:2000816)
0.0 0.3 GO:0051601 exocyst localization(GO:0051601)
0.0 0.1 GO:0060694 negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336) regulation of cholesterol transporter activity(GO:0060694) cellular response to vitamin E(GO:0071306) pancreatic stellate cell proliferation(GO:0072343) response to metformin(GO:1901558) regulation of pancreatic stellate cell proliferation(GO:2000229) negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.2 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 1.1 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.4 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
0.0 0.2 GO:0070307 lens fiber cell development(GO:0070307)
0.0 1.5 GO:0002250 adaptive immune response(GO:0002250)
0.0 0.3 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.0 0.2 GO:0008217 regulation of blood pressure(GO:0008217)
0.0 0.6 GO:0001701 in utero embryonic development(GO:0001701)
0.0 0.1 GO:1902075 cellular response to salt(GO:1902075) response to sodium arsenite(GO:1903935) cellular response to sodium arsenite(GO:1903936)
0.0 0.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.6 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.5 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.4 GO:0042113 B cell activation(GO:0042113)
0.0 0.1 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.1 GO:2000078 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560) positive regulation of type B pancreatic cell development(GO:2000078)
0.0 0.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.1 GO:0033504 floor plate development(GO:0033504)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.0 GO:0036026 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.6 7.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.6 29.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.5 1.5 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.5 1.4 GO:0097179 protease inhibitor complex(GO:0097179)
0.5 1.4 GO:0033150 cytoskeletal calyx(GO:0033150)
0.4 3.0 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.4 1.2 GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex(GO:0030526)
0.3 0.9 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.3 1.2 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.3 1.7 GO:0097149 centralspindlin complex(GO:0097149)
0.3 1.1 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.2 6.3 GO:0042101 T cell receptor complex(GO:0042101)
0.2 1.1 GO:0005602 complement component C1 complex(GO:0005602)
0.2 3.5 GO:0005833 hemoglobin complex(GO:0005833)
0.2 1.3 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.2 0.5 GO:0097679 other organism cytoplasm(GO:0097679)
0.2 1.5 GO:0005579 membrane attack complex(GO:0005579)
0.1 1.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 4.8 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.5 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.3 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
0.1 0.6 GO:0031905 early endosome lumen(GO:0031905)
0.1 0.5 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.1 0.9 GO:0036128 CatSper complex(GO:0036128)
0.1 1.2 GO:0036157 outer dynein arm(GO:0036157)
0.1 18.4 GO:0072562 blood microparticle(GO:0072562)
0.1 1.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.3 GO:0045179 apical cortex(GO:0045179)
0.1 0.2 GO:0000806 Y chromosome(GO:0000806)
0.1 0.4 GO:0002081 outer acrosomal membrane(GO:0002081)
0.1 0.6 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.1 1.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 1.0 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.7 GO:0005610 laminin-5 complex(GO:0005610)
0.1 0.4 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 0.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.0 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.3 GO:1990425 ryanodine receptor complex(GO:1990425)
0.1 0.8 GO:0071438 invadopodium membrane(GO:0071438)
0.1 0.5 GO:0043196 varicosity(GO:0043196)
0.1 3.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 0.6 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.1 GO:0005595 collagen type XII trimer(GO:0005595)
0.0 1.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.8 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.8 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.5 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 1.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.9 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 2.0 GO:0001772 immunological synapse(GO:0001772)
0.0 0.8 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.2 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.7 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 1.0 GO:0031105 septin complex(GO:0031105)
0.0 0.1 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.0 1.5 GO:0005581 collagen trimer(GO:0005581)
0.0 7.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 3.0 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.3 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.3 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 3.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.0 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.6 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.3 GO:0060091 kinocilium(GO:0060091)
0.0 0.1 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 34.2 GO:0005615 extracellular space(GO:0005615)
0.0 0.9 GO:0097546 ciliary base(GO:0097546)
0.0 3.9 GO:0001650 fibrillar center(GO:0001650)
0.0 0.5 GO:0005884 actin filament(GO:0005884)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.9 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.5 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.8 GO:0032420 stereocilium(GO:0032420)
0.0 1.1 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0031201 SNARE complex(GO:0031201)
0.0 1.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.9 GO:0043235 receptor complex(GO:0043235)
0.0 0.8 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.2 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)
0.0 0.2 GO:0005771 multivesicular body(GO:0005771)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.8 4.0 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.7 2.8 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.7 6.0 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.6 3.4 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.5 3.6 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.5 1.5 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.5 4.8 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.5 29.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.4 1.3 GO:0051908 double-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0051908)
0.4 2.6 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.3 1.4 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.3 3.2 GO:0032190 acrosin binding(GO:0032190)
0.3 59.5 GO:0003823 antigen binding(GO:0003823)
0.3 1.7 GO:0030492 hemoglobin binding(GO:0030492)
0.3 1.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.3 0.8 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.3 0.8 GO:0004370 glycerol kinase activity(GO:0004370)
0.3 1.8 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.3 1.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 1.5 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.2 0.7 GO:0004947 bradykinin receptor activity(GO:0004947)
0.2 2.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 0.9 GO:0017129 triglyceride binding(GO:0017129)
0.2 1.2 GO:0004914 interleukin-3 receptor activity(GO:0004912) interleukin-5 receptor activity(GO:0004914)
0.2 1.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.2 1.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.2 1.0 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.2 1.5 GO:0004064 arylesterase activity(GO:0004064)
0.2 2.7 GO:0032027 myosin light chain binding(GO:0032027)
0.2 1.3 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.2 0.7 GO:0048030 disaccharide binding(GO:0048030)
0.2 0.7 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.2 3.0 GO:0003796 lysozyme activity(GO:0003796)
0.2 2.0 GO:0032393 MHC class I receptor activity(GO:0032393)
0.2 0.6 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.1 0.4 GO:0097689 iron channel activity(GO:0097689)
0.1 7.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.9 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 0.6 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.1 0.7 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.8 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.4 GO:0047017 geranylgeranyl reductase activity(GO:0045550) prostaglandin-F synthase activity(GO:0047017)
0.1 0.4 GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity(GO:0034039)
0.1 1.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 1.8 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 0.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.5 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.1 0.2 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.1 0.5 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.1 1.3 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.1 1.9 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.6 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.1 0.7 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 0.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 0.5 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.1 1.8 GO:0032052 bile acid binding(GO:0032052)
0.1 0.7 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.1 0.4 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.1 2.5 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.1 0.3 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.5 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.1 0.3 GO:0019961 interferon binding(GO:0019961)
0.1 0.5 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 1.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 1.0 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 0.2 GO:0070538 oleic acid binding(GO:0070538)
0.1 1.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 0.4 GO:0070052 collagen V binding(GO:0070052)
0.1 0.7 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 0.3 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 0.9 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.1 1.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 2.1 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 0.6 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 0.8 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 5.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.5 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 7.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 2.0 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 1.7 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.5 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.2 GO:0005042 netrin receptor activity(GO:0005042)
0.1 1.1 GO:0039706 co-receptor binding(GO:0039706)
0.1 0.6 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 1.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.2 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 1.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.3 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 0.5 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.2 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.1 0.5 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.1 0.5 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 2.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.6 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.8 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 1.0 GO:0005522 profilin binding(GO:0005522)
0.0 1.4 GO:0001848 complement binding(GO:0001848)
0.0 0.2 GO:0072545 tyrosine binding(GO:0072545)
0.0 0.6 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0019862 IgA binding(GO:0019862)
0.0 0.2 GO:0038047 beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047)
0.0 1.1 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.4 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 1.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.2 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.5 GO:0033612 receptor serine/threonine kinase binding(GO:0033612)
0.0 0.7 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.2 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.1 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.6 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.4 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 8.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 3.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.0 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.2 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.5 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 1.1 GO:0004950 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.2 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0070330 aromatase activity(GO:0070330)
0.0 0.1 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.0 2.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 1.2 GO:0019825 oxygen binding(GO:0019825)
0.0 0.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.5 GO:0015299 solute:proton antiporter activity(GO:0015299)
0.0 1.7 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 6.2 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.7 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.0 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 0.4 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 1.0 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 2.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.8 GO:0050840 extracellular matrix binding(GO:0050840)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 9.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 3.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 1.3 PID IL23 PATHWAY IL23-mediated signaling events
0.1 1.2 PID IL5 PATHWAY IL5-mediated signaling events
0.1 4.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 0.4 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.6 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.5 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.5 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 2.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 2.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.2 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 2.0 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 2.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.3 PID ALK1 PATHWAY ALK1 signaling events
0.0 10.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.4 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.2 PID IL27 PATHWAY IL27-mediated signaling events
0.0 1.8 PID AURORA B PATHWAY Aurora B signaling
0.0 0.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.1 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 6.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.8 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 1.0 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.9 PID BMP PATHWAY BMP receptor signaling
0.0 1.0 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.7 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.8 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.0 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.6 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.2 PID AURORA A PATHWAY Aurora A signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.3 7.7 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.3 7.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.2 4.0 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.2 4.9 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 4.6 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 3.1 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.9 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 2.7 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 1.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 1.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 6.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 3.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 1.0 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 6.4 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 0.9 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.7 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 1.0 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 1.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 0.9 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 6.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.5 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 1.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 2.2 REACTOME KINESINS Genes involved in Kinesins
0.0 0.7 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.8 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.9 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.6 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.6 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 3.5 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 1.3 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 2.6 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.6 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.8 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.8 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.5 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 2.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.7 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 2.5 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.0 1.0 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.7 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.4 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.3 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 1.8 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.0 0.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 1.2 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.4 REACTOME REGULATION OF MITOTIC CELL CYCLE Genes involved in Regulation of mitotic cell cycle
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.5 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events