Motif ID: IRX3

Z-value: 2.202


Transcription factors associated with IRX3:

Gene SymbolEntrez IDGene Name
IRX3 ENSG00000177508.11 IRX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRX3hg19_v2_chr16_-_54320675_543207150.144.5e-01Click!


Activity profile for motif IRX3.

activity profile for motif IRX3


Sorted Z-values histogram for motif IRX3

Sorted Z-values for motif IRX3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRX3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_54320078 8.127 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr15_-_22473353 5.971 ENST00000557788.2
IGHV4OR15-8
immunoglobulin heavy variable 4/OR15-8 (non-functional)
chr14_-_106453155 5.530 ENST00000390594.2
IGHV1-2
immunoglobulin heavy variable 1-2
chr14_+_22386325 5.117 ENST00000390439.2
TRAV13-2
T cell receptor alpha variable 13-2
chr1_+_26644441 5.111 ENST00000374213.2
CD52
CD52 molecule
chr22_+_23154239 5.077 ENST00000390315.2
IGLV3-10
immunoglobulin lambda variable 3-10
chr13_-_46716969 4.920 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr14_-_107179265 4.810 ENST00000390634.2
IGHV2-70
immunoglobulin heavy variable 2-70
chr1_+_158259558 4.776 ENST00000368170.3
CD1C
CD1c molecule
chr2_-_89545079 4.766 ENST00000468494.1
IGKV2-30
immunoglobulin kappa variable 2-30
chr4_+_71091786 4.385 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr14_-_106781017 4.083 ENST00000390612.2
IGHV4-28
immunoglobulin heavy variable 4-28
chr22_+_23161491 3.867 ENST00000390316.2
IGLV3-9
immunoglobulin lambda variable 3-9 (gene/pseudogene)
chr3_+_151451707 3.810 ENST00000356517.3
AADACL2
arylacetamide deacetylase-like 2
chr2_+_89975669 3.728 ENST00000474213.1
IGKV2D-30
immunoglobulin kappa variable 2D-30
chr11_+_60223225 3.623 ENST00000524807.1
ENST00000345732.4
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr6_-_108145499 3.540 ENST00000369020.3
ENST00000369022.2
SCML4

sex comb on midleg-like 4 (Drosophila)

chr2_+_7865923 3.474 ENST00000417930.1
AC092580.4
AC092580.4
chr4_+_156824840 3.356 ENST00000536354.2
TDO2
tryptophan 2,3-dioxygenase
chr14_+_22204418 3.346 ENST00000390426.2
TRAV4
T cell receptor alpha variable 4
chr14_-_106494587 3.203 ENST00000390597.2
IGHV2-5
immunoglobulin heavy variable 2-5
chr1_+_117297007 3.123 ENST00000369478.3
ENST00000369477.1
CD2

CD2 molecule

chr2_+_90139056 2.997 ENST00000492446.1
IGKV1D-16
immunoglobulin kappa variable 1D-16
chr11_-_118213455 2.904 ENST00000300692.4
CD3D
CD3d molecule, delta (CD3-TCR complex)
chr14_-_106725723 2.862 ENST00000390609.2
IGHV3-23
immunoglobulin heavy variable 3-23
chr14_-_106758101 2.834 ENST00000390611.2
IGHV2-26
immunoglobulin heavy variable 2-26
chr14_-_106845789 2.821 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr14_-_106478603 2.793 ENST00000390596.2
IGHV4-4
immunoglobulin heavy variable 4-4
chr5_+_35856951 2.755 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R



interleukin 7 receptor



chr2_+_90121477 2.733 ENST00000483379.1
IGKV1D-17
immunoglobulin kappa variable 1D-17
chr11_-_118213360 2.701 ENST00000529594.1
CD3D
CD3d molecule, delta (CD3-TCR complex)
chr2_-_136875712 2.700 ENST00000241393.3
CXCR4
chemokine (C-X-C motif) receptor 4
chr7_-_38289173 2.663 ENST00000436911.2
TRGC2
T cell receptor gamma constant 2
chr14_-_106967788 2.626 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr14_-_106830057 2.621 ENST00000390616.2
IGHV4-34
immunoglobulin heavy variable 4-34
chr12_+_5541267 2.618 ENST00000423158.3
NTF3
neurotrophin 3
chr14_+_22433675 2.617 ENST00000390442.3
TRAV12-3
T cell receptor alpha variable 12-3
chr14_-_106805716 2.585 ENST00000438142.2
IGHV4-31
immunoglobulin heavy variable 4-31
chr10_-_96829246 2.490 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
CYP2C8


cytochrome P450, family 2, subfamily C, polypeptide 8


chr6_-_49834209 2.449 ENST00000507853.1
CRISP1
cysteine-rich secretory protein 1
chr14_-_107131560 2.373 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr11_+_60739115 2.331 ENST00000344028.5
ENST00000346437.4
CD6

CD6 molecule

chr2_-_89417335 2.293 ENST00000490686.1
IGKV1-17
immunoglobulin kappa variable 1-17
chr22_+_23063100 2.272 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19
chr5_-_156390230 2.248 ENST00000407087.3
ENST00000274532.2
TIMD4

T-cell immunoglobulin and mucin domain containing 4

chr11_-_74408739 2.245 ENST00000529912.1
CHRDL2
chordin-like 2
chr22_+_40297079 2.233 ENST00000344138.4
ENST00000543252.1
GRAP2

GRB2-related adaptor protein 2

chr14_-_106692191 2.232 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr1_+_196788887 2.224 ENST00000367421.3
ENST00000320493.5
ENST00000367424.4
CFHR2
CFHR1

complement factor H-related 2
complement factor H-related 1

chr6_-_49834240 2.222 ENST00000335847.4
CRISP1
cysteine-rich secretory protein 1
chr18_-_56985776 2.221 ENST00000587244.1
CPLX4
complexin 4
chr14_-_106926724 2.186 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr6_-_24799117 2.126 ENST00000565469.1
RP3-369A17.5
chromosome 6 open reading frame 229
chr14_-_106963409 2.108 ENST00000390621.2
IGHV1-45
immunoglobulin heavy variable 1-45
chr1_-_7913089 2.090 ENST00000361696.5
UTS2
urotensin 2
chr12_-_10251603 2.065 ENST00000457018.2
CLEC1A
C-type lectin domain family 1, member A
chr11_-_118213331 2.050 ENST00000392884.2
CD3D
CD3d molecule, delta (CD3-TCR complex)
chr5_-_156362666 2.041 ENST00000406964.1
TIMD4
T-cell immunoglobulin and mucin domain containing 4
chr6_+_71104588 2.024 ENST00000418403.1
RP11-462G2.1
RP11-462G2.1
chr14_-_106610852 2.016 ENST00000390603.2
IGHV3-15
immunoglobulin heavy variable 3-15
chr1_+_160709029 2.006 ENST00000444090.2
ENST00000441662.2
SLAMF7

SLAM family member 7

chr11_+_60739249 1.981 ENST00000542157.1
ENST00000433107.2
ENST00000452451.2
ENST00000352009.5
CD6



CD6 molecule



chr2_+_90259593 1.981 ENST00000471857.1
IGKV1D-8
immunoglobulin kappa variable 1D-8
chr2_-_89459813 1.980 ENST00000390256.2
IGKV6-21
immunoglobulin kappa variable 6-21 (non-functional)
chr2_-_89521942 1.979 ENST00000482769.1
IGKV2-28
immunoglobulin kappa variable 2-28
chr4_+_69681710 1.970 ENST00000265403.7
ENST00000458688.2
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr1_+_160709055 1.969 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7



SLAM family member 7



chr12_-_10542617 1.952 ENST00000240618.6
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr2_-_158300556 1.952 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr2_+_119699864 1.952 ENST00000541757.1
ENST00000412481.1
MARCO

macrophage receptor with collagenous structure

chr2_+_114163945 1.920 ENST00000453673.3
IGKV1OR2-108
immunoglobulin kappa variable 1/OR2-108 (non-functional)
chr14_-_106791536 1.895 ENST00000390613.2
IGHV3-30
immunoglobulin heavy variable 3-30
chr19_-_54974894 1.895 ENST00000333834.4
LENG9
leukocyte receptor cluster (LRC) member 9
chr14_-_106471723 1.890 ENST00000390595.2
IGHV1-3
immunoglobulin heavy variable 1-3
chr1_-_169733789 1.886 ENST00000609271.1
ENST00000454271.1
SELE
RP1-117P20.3
selectin E
RP1-117P20.3
chr4_+_40195262 1.869 ENST00000503941.1
RHOH
ras homolog family member H
chr12_+_101869096 1.861 ENST00000551346.1
SPIC
Spi-C transcription factor (Spi-1/PU.1 related)
chr1_+_81001398 1.847 ENST00000418041.1
ENST00000443104.1
RP5-887A10.1

RP5-887A10.1

chrX_+_78426469 1.837 ENST00000276077.1
GPR174
G protein-coupled receptor 174
chr1_+_81106951 1.812 ENST00000443565.1
RP5-887A10.1
RP5-887A10.1
chr15_-_81616446 1.807 ENST00000302824.6
STARD5
StAR-related lipid transfer (START) domain containing 5
chr4_-_38784592 1.795 ENST00000502321.1
TLR10
toll-like receptor 10
chr15_+_81225699 1.790 ENST00000560027.1
KIAA1199
KIAA1199
chr16_+_32063311 1.784 ENST00000426099.1
AC142381.1
AC142381.1
chr12_-_9885888 1.749 ENST00000327839.3
CLECL1
C-type lectin-like 1
chr1_+_160709076 1.747 ENST00000359331.4
ENST00000495334.1
SLAMF7

SLAM family member 7

chr1_-_157522180 1.745 ENST00000356953.4
ENST00000368188.2
ENST00000368190.3
ENST00000368189.3
FCRL5



Fc receptor-like 5



chr3_+_100354442 1.737 ENST00000475887.1
GPR128
G protein-coupled receptor 128
chr14_-_106586656 1.694 ENST00000390602.2
IGHV3-13
immunoglobulin heavy variable 3-13
chr11_+_60739140 1.682 ENST00000313421.7
CD6
CD6 molecule
chr4_-_69434245 1.633 ENST00000317746.2
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr17_+_34639793 1.625 ENST00000394465.2
ENST00000394463.2
ENST00000378342.4
CCL4L2


chemokine (C-C motif) ligand 4-like 2


chr17_+_34430980 1.616 ENST00000250151.4
CCL4
chemokine (C-C motif) ligand 4
chr1_+_196912902 1.615 ENST00000476712.2
ENST00000367415.5
CFHR2

complement factor H-related 2

chr2_+_85921414 1.591 ENST00000263863.4
ENST00000524600.1
GNLY

granulysin

chr11_+_57365150 1.586 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
SERPING1




serpin peptidase inhibitor, clade G (C1 inhibitor), member 1




chr17_+_38673270 1.577 ENST00000578280.1
RP5-1028K7.2
RP5-1028K7.2
chr14_+_95047725 1.559 ENST00000554760.1
ENST00000554866.1
ENST00000329597.7
ENST00000556775.1
SERPINA5



serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5



chr1_-_114414316 1.541 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22





protein tyrosine phosphatase, non-receptor type 22 (lymphoid)





chr17_-_46657473 1.529 ENST00000332503.5
HOXB4
homeobox B4
chr1_+_57320437 1.517 ENST00000361249.3
C8A
complement component 8, alpha polypeptide
chr10_+_96698406 1.515 ENST00000260682.6
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr2_-_88427568 1.514 ENST00000393750.3
ENST00000295834.3
FABP1

fatty acid binding protein 1, liver

chrX_-_55291163 1.512 ENST00000519203.1
ENST00000374951.1
PAGE3

P antigen family, member 3 (prostate associated)

chr9_-_4679419 1.509 ENST00000609131.1
ENST00000607997.1
RP11-6J24.6

RP11-6J24.6

chr7_-_41742697 1.509 ENST00000242208.4
INHBA
inhibin, beta A
chr16_+_33605231 1.508 ENST00000570121.2
IGHV3OR16-12
immunoglobulin heavy variable 3/OR16-12 (non-functional)
chr2_+_89923550 1.508 ENST00000509129.1
IGKV1D-37
immunoglobulin kappa variable 1D-37 (non-functional)
chr16_-_33647696 1.507 ENST00000558425.1
ENST00000569103.2
RP11-812E19.9

Uncharacterized protein

chr2_+_143635222 1.502 ENST00000375773.2
ENST00000409512.1
ENST00000410015.2
KYNU


kynureninase


chr12_-_9268707 1.482 ENST00000318602.7
A2M
alpha-2-macroglobulin
chr2_-_88125471 1.477 ENST00000398146.3
RGPD2
RANBP2-like and GRIP domain containing 2
chr2_+_217735493 1.472 ENST00000456163.1
AC007557.1
HCG1816075; Uncharacterized protein
chr3_+_177159695 1.472 ENST00000442937.1
LINC00578
long intergenic non-protein coding RNA 578
chr8_-_86253888 1.468 ENST00000522389.1
ENST00000432364.2
ENST00000517618.1
CA1


carbonic anhydrase I


chr2_+_113885138 1.465 ENST00000409930.3
IL1RN
interleukin 1 receptor antagonist
chr12_+_9980113 1.458 ENST00000537723.1
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr21_-_34185944 1.450 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr22_+_22516550 1.449 ENST00000390284.2
IGLV4-60
immunoglobulin lambda variable 4-60
chr14_+_95047744 1.442 ENST00000553511.1
ENST00000554633.1
ENST00000555681.1
ENST00000554276.1
SERPINA5



serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5



chr11_-_118083600 1.437 ENST00000524477.1
AMICA1
adhesion molecule, interacts with CXADR antigen 1
chr1_+_171060018 1.428 ENST00000367755.4
ENST00000392085.2
ENST00000542847.1
ENST00000538429.1
ENST00000479749.1
FMO3




flavin containing monooxygenase 3




chr17_+_18380051 1.423 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
LGALS9C





lectin, galactoside-binding, soluble, 9C





chr2_+_85921522 1.421 ENST00000409696.3
GNLY
granulysin
chr12_+_47473369 1.415 ENST00000546455.1
PCED1B
PC-esterase domain containing 1B
chr12_-_91398796 1.404 ENST00000261172.3
ENST00000551767.1
EPYC

epiphycan

chr11_+_114166536 1.393 ENST00000299964.3
NNMT
nicotinamide N-methyltransferase
chr22_+_40297105 1.387 ENST00000540310.1
GRAP2
GRB2-related adaptor protein 2
chr5_+_159848807 1.378 ENST00000352433.5
PTTG1
pituitary tumor-transforming 1
chr12_+_29542557 1.366 ENST00000550906.1
OVCH1-AS1
OVCH1 antisense RNA 1
chr22_-_50970919 1.363 ENST00000329363.4
ENST00000437588.1
ODF3B

outer dense fiber of sperm tails 3B

chr1_+_207070775 1.362 ENST00000391929.3
ENST00000294984.2
ENST00000367093.3
IL24


interleukin 24


chr11_-_5255861 1.361 ENST00000380299.3
HBD
hemoglobin, delta
chr12_-_68553512 1.358 ENST00000229135.3
IFNG
interferon, gamma
chr17_-_29641104 1.356 ENST00000577894.1
ENST00000330927.4
EVI2B

ecotropic viral integration site 2B

chr10_-_101841588 1.332 ENST00000370418.3
CPN1
carboxypeptidase N, polypeptide 1
chr1_+_196857144 1.322 ENST00000367416.2
ENST00000251424.4
ENST00000367418.2
CFHR4


complement factor H-related 4


chr16_+_30484054 1.316 ENST00000564118.1
ENST00000454514.2
ENST00000433423.2
ITGAL


integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)


chr3_+_122044084 1.314 ENST00000264474.3
ENST00000479204.1
CSTA

cystatin A (stefin A)

chr7_+_23210760 1.294 ENST00000366347.4
AC005082.1
Uncharacterized protein
chr10_-_90712520 1.271 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_+_242011485 1.269 ENST00000423131.1
ENST00000523590.1
EXO1

exonuclease 1

chr4_-_70725856 1.256 ENST00000226444.3
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chrX_+_12809463 1.187 ENST00000380663.3
ENST00000380668.5
ENST00000398491.2
ENST00000489404.1
PRPS2



phosphoribosyl pyrophosphate synthetase 2



chr1_-_89488510 1.185 ENST00000564665.1
ENST00000370481.4
GBP3

guanylate binding protein 3

chr22_+_37309662 1.176 ENST00000403662.3
ENST00000262825.5
CSF2RB

colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)

chr5_-_13944652 1.174 ENST00000265104.4
DNAH5
dynein, axonemal, heavy chain 5
chr5_-_64858944 1.173 ENST00000508421.1
ENST00000510693.1
ENST00000514814.1
ENST00000515497.1
ENST00000396679.1
CENPK




centromere protein K




chr14_+_22236722 1.173 ENST00000390428.3
TRAV6
T cell receptor alpha variable 6
chr7_+_139529040 1.168 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1


thromboxane A synthase 1 (platelet)


chr2_+_231090471 1.168 ENST00000373645.3
SP140
SP140 nuclear body protein
chr3_+_111630451 1.161 ENST00000495180.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr13_+_113030625 1.154 ENST00000283550.3
SPACA7
sperm acrosome associated 7
chr2_+_189839046 1.154 ENST00000304636.3
ENST00000317840.5
COL3A1

collagen, type III, alpha 1

chr17_+_34431212 1.149 ENST00000394495.1
CCL4
chemokine (C-C motif) ligand 4
chr4_-_84035905 1.146 ENST00000311507.4
PLAC8
placenta-specific 8
chr12_-_21757774 1.141 ENST00000261195.2
GYS2
glycogen synthase 2 (liver)
chr5_+_110559603 1.136 ENST00000512453.1
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr2_+_231090433 1.125 ENST00000486687.2
ENST00000350136.5
ENST00000392045.3
ENST00000417495.3
ENST00000343805.6
ENST00000420434.3
SP140





SP140 nuclear body protein





chr1_+_22964073 1.124 ENST00000402322.1
C1QA
complement component 1, q subcomponent, A chain
chr8_-_101724989 1.124 ENST00000517403.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr21_-_34186006 1.119 ENST00000490358.1
C21orf62
chromosome 21 open reading frame 62
chr7_+_139528952 1.111 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1



thromboxane A synthase 1 (platelet)



chr17_-_29641084 1.108 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr14_+_22554680 1.076 ENST00000390451.2
TRAV23DV6
T cell receptor alpha variable 23/delta variable 6
chr14_-_105487381 1.074 ENST00000392590.3
ENST00000336219.3
CDCA4

cell division cycle associated 4

chr3_-_191000172 1.064 ENST00000427544.2
UTS2B
urotensin 2B
chr21_-_47613673 1.062 ENST00000594486.1
AP001468.1
Protein LOC101060037
chr12_+_69742121 1.058 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
LYZ


lysozyme


chr7_+_139529085 1.058 ENST00000539806.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr3_+_177159744 1.044 ENST00000439009.1
LINC00578
long intergenic non-protein coding RNA 578
chr16_+_31539183 1.044 ENST00000302312.4
AHSP
alpha hemoglobin stabilizing protein
chr2_-_231989808 1.042 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr17_-_54893250 1.038 ENST00000397862.2
C17orf67
chromosome 17 open reading frame 67
chr4_+_69962185 1.029 ENST00000305231.7
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr14_+_100485712 1.028 ENST00000544450.2
EVL
Enah/Vasp-like
chr6_+_130742231 1.026 ENST00000545622.1
TMEM200A
transmembrane protein 200A
chr1_+_196743912 1.019 ENST00000367425.4
CFHR3
complement factor H-related 3
chr3_+_186383741 1.015 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr3_+_46395219 1.013 ENST00000445132.2
ENST00000292301.4
CCR2

chemokine (C-C motif) receptor 2

chr5_+_118668846 1.012 ENST00000513374.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr5_+_162887556 1.011 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
HMMR


hyaluronan-mediated motility receptor (RHAMM)


chr15_+_38226827 1.006 ENST00000559502.1
ENST00000558148.1
ENST00000558158.1
TMCO5A


transmembrane and coiled-coil domains 5A


chr6_+_116782527 1.005 ENST00000368606.3
ENST00000368605.1
FAM26F

family with sequence similarity 26, member F

chr12_+_20963632 0.990 ENST00000540853.1
ENST00000261196.2
SLCO1B3

solute carrier organic anion transporter family, member 1B3

chr6_-_32784687 0.976 ENST00000447394.1
ENST00000438763.2
HLA-DOB

major histocompatibility complex, class II, DO beta

chr2_-_69180012 0.973 ENST00000481498.1
GKN2
gastrokine 2
chr11_-_104905840 0.965 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
CASP1










caspase 1, apoptosis-related cysteine peptidase










chr12_-_10605929 0.965 ENST00000347831.5
ENST00000359151.3
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr15_-_31521567 0.959 ENST00000560812.1
ENST00000559853.1
ENST00000558109.1
RP11-16E12.2


RP11-16E12.2


chr16_+_56995854 0.950 ENST00000566128.1
CETP
cholesteryl ester transfer protein, plasma
chr4_-_42154895 0.943 ENST00000502486.1
ENST00000504360.1
BEND4

BEN domain containing 4

chr16_-_54882145 0.939 ENST00000561591.1
RP11-1136G4.1
RP11-1136G4.1
chr11_+_827248 0.935 ENST00000527089.1
ENST00000530183.1
EFCAB4A

EF-hand calcium binding domain 4A

chrX_+_12924732 0.932 ENST00000218032.6
ENST00000311912.5
TLR8

toll-like receptor 8

chr4_+_70146217 0.928 ENST00000335568.5
ENST00000511240.1
UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chr14_-_92247032 0.926 ENST00000556661.1
ENST00000553676.1
ENST00000554560.1
CATSPERB


catsper channel auxiliary subunit beta


chr1_+_109256067 0.926 ENST00000271311.2
FNDC7
fibronectin type III domain containing 7
chr3_+_186330712 0.922 ENST00000411641.2
ENST00000273784.5
AHSG

alpha-2-HS-glycoprotein

chr6_-_26216872 0.918 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.9 7.7 GO:0045059 positive thymic T cell selection(GO:0045059)
0.8 0.8 GO:0014857 skeletal muscle cell proliferation(GO:0014856) regulation of skeletal muscle cell proliferation(GO:0014857)
0.8 3.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.7 2.0 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.6 1.7 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.6 2.8 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.5 1.6 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.5 2.6 GO:0007403 glial cell fate determination(GO:0007403)
0.5 1.5 GO:0060279 progesterone secretion(GO:0042701) regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.4 3.4 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.4 1.5 GO:0048539 bone marrow development(GO:0048539)
0.4 1.9 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.4 1.5 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.4 4.0 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.3 7.7 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.3 1.0 GO:0014831 intestine smooth muscle contraction(GO:0014827) gastro-intestinal system smooth muscle contraction(GO:0014831)
0.3 7.2 GO:0032814 regulation of natural killer cell activation(GO:0032814)
0.3 1.0 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) positive regulation of cellular extravasation(GO:0002693) monocyte extravasation(GO:0035696) eosinophil activation(GO:0043307) eosinophil degranulation(GO:0043308) T cell extravasation(GO:0072683)
0.3 1.3 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.3 0.9 GO:0016554 cytidine to uridine editing(GO:0016554)
0.3 0.3 GO:0030072 peptide secretion(GO:0002790) peptide hormone secretion(GO:0030072)
0.3 3.3 GO:0030644 cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064)
0.3 0.9 GO:0010535 regulation of activation of JAK2 kinase activity(GO:0010534) positive regulation of activation of JAK2 kinase activity(GO:0010535)
0.3 1.1 GO:0006789 bilirubin conjugation(GO:0006789) biphenyl metabolic process(GO:0018879) biphenyl catabolic process(GO:0070980)
0.3 0.8 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.3 0.8 GO:0045726 regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726) flavin adenine dinucleotide metabolic process(GO:0072387)
0.3 0.8 GO:0009698 phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804)
0.3 1.0 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.2 0.9 GO:0045356 positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.2 0.9 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.2 9.9 GO:0002286 T cell activation involved in immune response(GO:0002286)
0.2 0.6 GO:0015888 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.2 1.0 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 5.1 GO:0045730 respiratory burst(GO:0045730)
0.2 0.8 GO:0070995 NADPH oxidation(GO:0070995)
0.2 0.6 GO:0051661 regulation of asymmetric cell division(GO:0009786) maintenance of centrosome location(GO:0051661)
0.2 0.9 GO:0002115 store-operated calcium entry(GO:0002115)
0.2 0.7 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.2 0.3 GO:0032641 lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109)
0.2 0.6 GO:0032604 granulocyte macrophage colony-stimulating factor production(GO:0032604) regulation of granulocyte macrophage colony-stimulating factor production(GO:0032645) positive regulation of granulocyte macrophage colony-stimulating factor production(GO:0032725)
0.2 0.9 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 1.7 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.1 0.8 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.5 GO:0071361 cellular response to ethanol(GO:0071361)
0.1 1.4 GO:0043206 extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.1 0.5 GO:0014742 positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742)
0.1 0.4 GO:0032416 negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883) negative regulation of sodium ion transmembrane transport(GO:1902306) negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.1 0.5 GO:0017014 innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385) protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119) positive regulation of killing of cells of other organism(GO:0051712)
0.1 0.2 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.1 2.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 2.7 GO:0019059 obsolete initiation of viral infection(GO:0019059)
0.1 0.5 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.8 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.5 GO:0007100 mitotic centrosome separation(GO:0007100)
0.1 2.2 GO:0050832 defense response to fungus(GO:0050832)
0.1 1.4 GO:0017144 drug metabolic process(GO:0017144)
0.1 0.2 GO:0051552 flavone metabolic process(GO:0051552)
0.1 0.8 GO:0042640 anagen(GO:0042640)
0.1 0.7 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.3 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 0.3 GO:0010966 regulation of phosphate transport(GO:0010966)
0.1 1.1 GO:0055075 potassium ion homeostasis(GO:0055075)
0.1 1.5 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.1 1.2 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1 0.6 GO:0043368 positive T cell selection(GO:0043368)
0.1 1.1 GO:1901797 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.1 2.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 1.3 GO:0002566 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 0.9 GO:0055091 phospholipid homeostasis(GO:0055091)
0.1 0.7 GO:0008218 bioluminescence(GO:0008218)
0.1 0.8 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.1 1.6 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.1 1.8 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.1 0.4 GO:2000109 positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393) macrophage apoptotic process(GO:0071888) regulation of macrophage apoptotic process(GO:2000109) positive regulation of macrophage apoptotic process(GO:2000111)
0.1 0.7 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.1 1.5 GO:0001960 negative regulation of cytokine-mediated signaling pathway(GO:0001960)
0.1 0.2 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1 1.8 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 0.4 GO:0060414 aorta development(GO:0035904) aorta morphogenesis(GO:0035909) aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.1 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.4 GO:0045007 depurination(GO:0045007)
0.0 0.6 GO:0090399 replicative senescence(GO:0090399)
0.0 3.2 GO:0006956 complement activation(GO:0006956)
0.0 0.6 GO:0050702 interleukin-1 beta secretion(GO:0050702)
0.0 1.1 GO:0019835 cytolysis(GO:0019835)
0.0 0.2 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.0 2.4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.2 GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway(GO:0031635) opioid receptor signaling pathway(GO:0038003)
0.0 0.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.5 GO:0015695 organic cation transport(GO:0015695)
0.0 0.7 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0 0.6 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.2 GO:0010107 potassium ion import(GO:0010107)
0.0 0.3 GO:0097479 synaptic vesicle exocytosis(GO:0016079) synaptic vesicle transport(GO:0048489) synaptic vesicle localization(GO:0097479) establishment of synaptic vesicle localization(GO:0097480) synaptic vesicle cycle(GO:0099504)
0.0 0.6 GO:0042447 hormone catabolic process(GO:0042447)
0.0 2.4 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 1.0 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.9 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.4 GO:0001945 lymph vessel development(GO:0001945)
0.0 2.2 GO:0019079 viral genome replication(GO:0019079)
0.0 0.2 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 1.0 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 1.1 GO:0030199 collagen fibril organization(GO:0030199)
0.0 1.3 GO:0043631 RNA polyadenylation(GO:0043631)
0.0 3.6 GO:0042113 B cell activation(GO:0042113)
0.0 1.2 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 0.2 GO:0019985 translesion synthesis(GO:0019985)
0.0 1.0 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.4 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 0.8 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539)
0.0 0.7 GO:0051281 positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.0 0.1 GO:0071801 regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803)
0.0 0.6 GO:0006069 ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0 1.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 1.2 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.9 GO:0001824 blastocyst development(GO:0001824)
0.0 0.7 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209) regulation of sequestering of calcium ion(GO:0051282) negative regulation of sequestering of calcium ion(GO:0051283) calcium ion transmembrane import into cytosol(GO:0097553) calcium ion import into cytosol(GO:1902656)
0.0 0.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.2 GO:0070170 regulation of tooth mineralization(GO:0070170)
0.0 0.4 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.0 0.2 GO:0060046 regulation of acrosome reaction(GO:0060046)
0.0 0.4 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.3 GO:0045351 type I interferon biosynthetic process(GO:0045351)
0.0 1.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.2 GO:0071436 sodium ion export(GO:0071436)
0.0 0.7 GO:0006693 prostaglandin metabolic process(GO:0006693)
0.0 0.7 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 1.0 GO:0034724 DNA replication-independent nucleosome assembly(GO:0006336) CENP-A containing nucleosome assembly(GO:0034080) DNA replication-independent nucleosome organization(GO:0034724) CENP-A containing chromatin organization(GO:0061641)
0.0 0.4 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.3 GO:0007603 phototransduction, visible light(GO:0007603)
0.0 0.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.6 GO:0007398 ectoderm development(GO:0007398)
0.0 0.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.2 GO:0009593 detection of chemical stimulus(GO:0009593)
0.0 0.1 GO:0048311 mitochondrion distribution(GO:0048311)
0.0 0.3 GO:0097061 dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061)
0.0 0.5 GO:0051412 response to corticosterone(GO:0051412)
0.0 0.6 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.3 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.7 GO:0048678 response to axon injury(GO:0048678)
0.0 0.3 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.9 GO:0042098 T cell proliferation(GO:0042098)
0.0 0.4 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107) peptidyl-threonine modification(GO:0018210)
0.0 0.6 GO:0051925 obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)
0.0 0.2 GO:0007281 germ cell development(GO:0007281)
0.0 0.7 GO:0050954 sensory perception of sound(GO:0007605) sensory perception of mechanical stimulus(GO:0050954)
0.0 0.5 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.4 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 1.5 GO:0042742 defense response to bacterium(GO:0042742)
0.0 4.7 GO:0002764 immune response-regulating signaling pathway(GO:0002764)
0.0 0.5 GO:0051928 positive regulation of calcium ion transport(GO:0051928)
0.0 0.7 GO:0051349 positive regulation of lyase activity(GO:0051349)
0.0 0.1 GO:0002674 negative regulation of acute inflammatory response(GO:0002674)
0.0 2.3 GO:0031018 endocrine pancreas development(GO:0031018)
0.0 0.0 GO:0019236 response to pheromone(GO:0019236)
0.0 0.2 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of wound healing(GO:0061045) negative regulation of hemostasis(GO:1900047)
0.0 0.1 GO:1903513 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.0 0.1 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.7 GO:0042593 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.0 1.8 GO:0051216 cartilage development(GO:0051216)
0.0 0.9 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.5 GO:0000186 activation of MAPKK activity(GO:0000186)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.7 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.5 1.5 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.5 1.4 GO:0033150 cytoskeletal calyx(GO:0033150)
0.4 1.2 GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex(GO:0030526)
0.3 0.9 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.3 4.9 GO:0001891 phagocytic cup(GO:0001891)
0.3 1.1 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.2 1.1 GO:0005602 complement component C1 complex(GO:0005602)
0.2 1.3 GO:0045179 apical cortex(GO:0045179)
0.2 3.5 GO:0005833 hemoglobin complex(GO:0005833)
0.2 0.6 GO:0005588 collagen type V trimer(GO:0005588)
0.2 0.5 GO:0043196 varicosity(GO:0043196)
0.2 1.0 GO:0001520 outer dense fiber(GO:0001520) sperm flagellum(GO:0036126)
0.2 1.5 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.8 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.8 GO:0045177 apical plasma membrane(GO:0016324) apical part of cell(GO:0045177)
0.1 0.8 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 3.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.2 GO:0000806 Y chromosome(GO:0000806)
0.1 0.3 GO:0098827 terminal cisterna(GO:0014802) endoplasmic reticulum subcompartment(GO:0098827)
0.1 1.0 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.3 GO:0032449 CBM complex(GO:0032449)
0.1 0.4 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 1.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.8 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.1 GO:0005595 collagen type XII trimer(GO:0005595)
0.0 0.7 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.3 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.7 GO:0005858 axonemal dynein complex(GO:0005858)
0.0 0.7 GO:0005606 laminin-1 complex(GO:0005606)
0.0 16.6 GO:0005792 obsolete microsome(GO:0005792)
0.0 0.5 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.8 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 3.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.7 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 8.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.6 GO:0005871 kinesin complex(GO:0005871)
0.0 0.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.5 GO:0005884 actin filament(GO:0005884)
0.0 0.9 GO:0019861 obsolete flagellum(GO:0019861)
0.0 0.6 GO:0042581 specific granule(GO:0042581)
0.0 0.5 GO:0045120 pronucleus(GO:0045120)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.2 GO:0043204 perikaryon(GO:0043204)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 1.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 1.9 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.3 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 1.2 GO:0030027 lamellipodium(GO:0030027)
0.0 0.7 GO:0032420 stereocilium(GO:0032420)
0.0 1.2 GO:0000786 nucleosome(GO:0000786)
0.0 0.8 GO:0005902 microvillus(GO:0005902)
0.0 0.2 GO:0030315 T-tubule(GO:0030315)
0.0 0.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.6 GO:0031513 nonmotile primary cilium(GO:0031513)
0.0 0.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 5.1 GO:0009986 cell surface(GO:0009986)
0.0 42.8 GO:0005576 extracellular region(GO:0005576)
0.0 0.7 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)
0.0 0.4 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 1.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0000776 kinetochore(GO:0000776)
0.0 1.2 GO:0000922 spindle pole(GO:0000922)
0.0 3.1 GO:0010008 endosome membrane(GO:0010008) endosomal part(GO:0044440)
0.0 0.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.5 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0071723 lipopeptide binding(GO:0071723)
0.8 3.3 GO:0004796 thromboxane-A synthase activity(GO:0004796)
0.8 4.0 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.7 2.8 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.7 2.7 GO:0032027 myosin light chain binding(GO:0032027)
0.6 3.4 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.5 1.5 GO:0048184 obsolete follistatin binding(GO:0048184)
0.5 1.5 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.5 3.2 GO:0032190 acrosin binding(GO:0032190)
0.4 1.3 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0045145) double-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0051908)
0.4 1.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.4 1.5 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.4 1.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 1.4 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.3 2.6 GO:0048406 nerve growth factor binding(GO:0048406)
0.3 1.0 GO:0045735 nutrient reservoir activity(GO:0045735)
0.3 1.5 GO:0019966 interleukin-1 binding(GO:0019966)
0.3 1.1 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.3 0.8 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.3 1.9 GO:0070492 oligosaccharide binding(GO:0070492)
0.3 0.3 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.3 0.8 GO:0004370 glycerol kinase activity(GO:0004370)
0.2 0.7 GO:0004947 bradykinin receptor activity(GO:0004947)
0.2 2.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 0.9 GO:0017129 triglyceride binding(GO:0017129)
0.2 1.2 GO:0004914 interleukin-3 receptor activity(GO:0004912) interleukin-5 receptor activity(GO:0004914)
0.2 0.9 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.2 0.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 1.0 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.2 0.6 GO:0019767 IgE receptor activity(GO:0019767)
0.2 0.6 GO:0015403 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403) uptake transmembrane transporter activity(GO:0015563)
0.2 1.7 GO:0030492 hemoglobin binding(GO:0030492)
0.2 1.3 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.2 0.7 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.2 6.0 GO:0001972 retinoic acid binding(GO:0001972)
0.2 0.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.9 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 0.7 GO:0005534 galactose binding(GO:0005534)
0.1 0.8 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.4 GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
0.1 1.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 2.0 GO:0032393 MHC class I receptor activity(GO:0032393)
0.1 1.4 GO:0003796 lysozyme activity(GO:0003796)
0.1 3.1 GO:0043499 obsolete eukaryotic cell surface binding(GO:0043499)
0.1 2.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 1.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 8.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.5 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 0.5 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.1 0.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.4 GO:0047718 indanol dehydrogenase activity(GO:0047718)
0.1 1.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 1.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 2.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 0.4 GO:0005224 ATP-binding and phosphorylation-dependent chloride channel activity(GO:0005224) channel-conductance-controlling ATPase activity(GO:0005260)
0.1 2.1 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 0.3 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.4 GO:0070052 collagen V binding(GO:0070052)
0.1 0.8 GO:1990782 receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.1 0.5 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 1.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 1.9 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.6 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 0.3 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 0.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 5.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 2.0 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 2.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.7 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.4 GO:0055105 ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.1 0.6 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 1.0 GO:0051636 obsolete Gram-negative bacterial cell surface binding(GO:0051636)
0.1 2.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 1.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.3 GO:0004905 type I interferon receptor activity(GO:0004905)
0.1 0.9 GO:0008494 translation activator activity(GO:0008494)
0.0 1.0 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.4 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.2 GO:0016944 obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0 0.6 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.2 GO:0004988 obsolete mu-opioid receptor activity(GO:0004988)
0.0 0.5 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.3 GO:0004532 exoribonuclease activity(GO:0004532)
0.0 0.5 GO:0033612 receptor serine/threonine kinase binding(GO:0033612)
0.0 0.6 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 0.2 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.3 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 4.8 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 2.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 7.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 1.0 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.2 GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060)
0.0 0.4 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.4 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.2 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 1.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.2 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0019862 IgA binding(GO:0019862)
0.0 0.3 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 3.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.0 7.9 GO:0030246 carbohydrate binding(GO:0030246)
0.0 1.2 GO:0019825 oxygen binding(GO:0019825)
0.0 0.9 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.3 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.2 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.3 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.5 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.7 GO:0008009 chemokine activity(GO:0008009)
0.0 0.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.0 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 1.7 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.1 GO:0070330 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) aromatase activity(GO:0070330)
0.0 0.6 GO:0046332 SMAD binding(GO:0046332)
0.0 0.4 GO:0001637 G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950)
0.0 0.1 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.4 GO:0000049 tRNA binding(GO:0000049)
0.0 0.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.4 GO:0051213 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) dioxygenase activity(GO:0051213)
0.0 0.5 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 0.0 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 10.5 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 0.3 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.1 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.7 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway