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Illumina Body Map 2: averaged replicates

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Results for IRX5

Z-value: 1.73

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Transcription factors associated with IRX5

Gene Symbol Gene ID Gene Info
IRX5
ENSG00000176842.10 iroquois homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX5hg19_v2_chr16_+_54964740_549647890.096.2e-01Click!

Activity profile of IRX5 motif

Sorted Z-values of IRX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_54901540 4.83 ENST00000539562.2
UNC13C
unc-13 homolog C (C. elegans)
chr3_+_35681728 4.07 ENST00000421492.1
ENST00000458225.1
ENST00000337271.5
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr14_+_39944025 3.99 ENST00000554328.1
ENST00000556620.1
ENST00000557197.1
RP11-111A21.1
RP11-111A21.1
chr7_+_123241908 3.88 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
ASB15
ankyrin repeat and SOCS box containing 15
chr4_+_76995855 3.71 ENST00000355810.4
ENST00000349321.3
ART3
ADP-ribosyltransferase 3
chr12_+_21679220 3.45 ENST00000256969.2
C12orf39
chromosome 12 open reading frame 39
chr14_-_23876801 3.27 ENST00000356287.3
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr14_-_23877474 2.94 ENST00000405093.3
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr4_+_141264597 2.77 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
SCOC
short coiled-coil protein
chr7_+_54398390 2.68 ENST00000458615.1
ENST00000426205.1
RP11-436F9.1
RP11-436F9.1
chr3_+_158787041 2.64 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr1_-_169733789 2.62 ENST00000454271.1
ENST00000609271.1
RP1-117P20.3
SELE
RP1-117P20.3
selectin E
chr9_+_105757590 2.59 ENST00000374798.3
ENST00000487798.1
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr1_+_248128535 2.55 ENST00000366480.3
OR2AK2
olfactory receptor, family 2, subfamily AK, member 2
chr19_+_50691437 2.55 ENST00000598205.1
MYH14
myosin, heavy chain 14, non-muscle
chr14_-_47601041 2.53 ENST00000554762.1
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr5_+_121187625 2.49 ENST00000321339.1
FTMT
ferritin mitochondrial
chr10_-_96829246 2.41 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
CYP2C8
cytochrome P450, family 2, subfamily C, polypeptide 8
chr1_+_196857144 2.39 ENST00000367416.2
ENST00000251424.4
ENST00000367418.2
CFHR4
complement factor H-related 4
chr20_+_10199566 2.20 ENST00000430336.1
SNAP25
synaptosomal-associated protein, 25kDa
chr12_+_126107042 2.20 ENST00000535886.1
TMEM132B
transmembrane protein 132B
chr3_+_156799587 2.17 ENST00000469196.1
RP11-6F2.5
RP11-6F2.5
chr11_+_59807748 2.12 ENST00000278855.2
ENST00000532905.1
PLAC1L
oocyte secreted protein 2
chr20_+_10199468 2.12 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr1_-_213020991 2.12 ENST00000332912.3
C1orf227
chromosome 1 open reading frame 227
chr3_-_20053741 2.11 ENST00000389050.4
PP2D1
protein phosphatase 2C-like domain containing 1
chr4_-_186392898 1.97 ENST00000510617.1
ENST00000307588.3
CCDC110
coiled-coil domain containing 110
chr1_-_112106556 1.90 ENST00000443498.1
ADORA3
adenosine A3 receptor
chr7_-_99573640 1.90 ENST00000411734.1
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr12_+_24376201 1.86 ENST00000540733.1
ENST00000539583.1
RP11-778H2.1
RP11-778H2.1
chr12_-_78934441 1.85 ENST00000546865.1
ENST00000547089.1
RP11-171L9.1
RP11-171L9.1
chr1_-_112106578 1.84 ENST00000369717.4
ADORA3
adenosine A3 receptor
chr22_+_18721427 1.81 ENST00000342888.3
AC008132.1
Uncharacterized protein
chr6_-_49834240 1.79 ENST00000335847.4
CRISP1
cysteine-rich secretory protein 1
chr19_-_50266580 1.78 ENST00000246801.3
TSKS
testis-specific serine kinase substrate
chr6_+_22569784 1.77 ENST00000510882.2
HDGFL1
hepatoma derived growth factor-like 1
chr12_-_88423164 1.76 ENST00000298699.2
ENST00000550553.1
C12orf50
chromosome 12 open reading frame 50
chrX_+_47863734 1.73 ENST00000304355.5
SPACA5
sperm acrosome associated 5
chr7_-_99573677 1.72 ENST00000292401.4
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr6_-_49834209 1.71 ENST00000507853.1
CRISP1
cysteine-rich secretory protein 1
chr4_+_114066764 1.67 ENST00000511380.1
ANK2
ankyrin 2, neuronal
chr3_+_186383741 1.65 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr17_-_10450866 1.63 ENST00000578017.1
MYH2
myosin, heavy chain 2, skeletal muscle, adult
chr6_-_52705641 1.62 ENST00000370989.2
GSTA5
glutathione S-transferase alpha 5
chr8_+_87878640 1.62 ENST00000518476.1
CNBD1
cyclic nucleotide binding domain containing 1
chr6_-_50016364 1.61 ENST00000322246.4
DEFB112
defensin, beta 112
chr8_-_17555164 1.60 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr5_+_36608280 1.56 ENST00000513646.1
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_-_127174806 1.52 ENST00000545853.1
ENST00000537478.1
RP11-407A16.3
RP11-407A16.3
chr6_+_22569678 1.49 ENST00000230012.3
HDGFL1
hepatoma derived growth factor-like 1
chr6_+_29429217 1.48 ENST00000396792.2
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr9_-_113100088 1.47 ENST00000374510.4
ENST00000423740.2
ENST00000374511.3
ENST00000374507.4
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr7_+_129847688 1.46 ENST00000297819.3
SSMEM1
serine-rich single-pass membrane protein 1
chrX_-_52258669 1.45 ENST00000441417.1
XAGE1A
X antigen family, member 1A
chr4_-_80329356 1.39 ENST00000358842.3
GK2
glycerol kinase 2
chr16_-_54882145 1.39 ENST00000561591.1
RP11-1136G4.1
RP11-1136G4.1
chr1_+_196912902 1.39 ENST00000476712.2
ENST00000367415.5
CFHR2
complement factor H-related 2
chrX_+_52513455 1.38 ENST00000446098.1
XAGE1C
X antigen family, member 1C
chr8_-_74495065 1.30 ENST00000523533.1
STAU2
staufen double-stranded RNA binding protein 2
chr3_+_108855558 1.30 ENST00000467240.1
ENST00000477643.1
ENST00000479039.1
ENST00000593799.1
RP11-59E19.1
RP11-59E19.1
chr1_-_85870177 1.29 ENST00000542148.1
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr11_+_34999328 1.29 ENST00000526309.1
PDHX
pyruvate dehydrogenase complex, component X
chr17_-_67264947 1.27 ENST00000586811.1
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chrX_-_15333736 1.25 ENST00000380470.3
ASB11
ankyrin repeat and SOCS box containing 11
chr18_-_70305745 1.23 ENST00000581073.1
CBLN2
cerebellin 2 precursor
chr19_-_48059113 1.23 ENST00000391901.3
ENST00000314121.4
ENST00000448976.1
ZNF541
zinc finger protein 541
chr4_+_185973026 1.22 ENST00000506338.1
ENST00000509017.1
RP11-386B13.3
RP11-386B13.3
chr4_+_113739244 1.22 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
ANK2
ankyrin 2, neuronal
chr12_+_10365404 1.18 ENST00000266458.5
ENST00000421801.2
ENST00000544284.1
ENST00000545047.1
ENST00000543602.1
ENST00000545887.1
GABARAPL1
GABA(A) receptor-associated protein like 1
chr3_+_186158134 1.17 ENST00000414102.1
RP11-78H24.1
RP11-78H24.1
chr1_+_63989004 1.17 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr4_+_41361616 1.15 ENST00000513024.1
LIMCH1
LIM and calponin homology domains 1
chr1_-_186365908 1.15 ENST00000598663.1
AL596220.1
Uncharacterized protein
chr20_+_44330651 1.15 ENST00000305479.2
WFDC13
WAP four-disulfide core domain 13
chrX_-_120066151 1.14 ENST00000419982.2
ENST00000416816.1
CT47A12
cancer/testis antigen family 47, member A12
chrX_-_138790348 1.14 ENST00000414978.1
ENST00000519895.1
MCF2
MCF.2 cell line derived transforming sequence
chr1_-_152086556 1.13 ENST00000368804.1
TCHH
trichohyalin
chr12_+_2912363 1.13 ENST00000544366.1
FKBP4
FK506 binding protein 4, 59kDa
chr5_+_169758393 1.12 ENST00000521471.1
ENST00000518357.1
ENST00000436248.3
CTB-114C7.3
CTB-114C7.3
chr20_+_38633006 1.11 ENST00000432633.1
ENST00000445606.1
RP11-101E14.2
RP11-101E14.2
chr4_+_159131596 1.11 ENST00000512481.1
TMEM144
transmembrane protein 144
chr11_-_35547572 1.10 ENST00000378880.2
PAMR1
peptidase domain containing associated with muscle regeneration 1
chr5_+_128300810 1.10 ENST00000262462.4
SLC27A6
solute carrier family 27 (fatty acid transporter), member 6
chr2_-_105372203 1.09 ENST00000424321.1
AC068057.2
long intergenic non-protein coding RNA 1114
chr2_-_88427568 1.08 ENST00000393750.3
ENST00000295834.3
FABP1
fatty acid binding protein 1, liver
chrX_+_47867194 1.07 ENST00000376940.3
SPACA5
sperm acrosome associated 5
chr4_+_144312659 1.07 ENST00000509992.1
GAB1
GRB2-associated binding protein 1
chr1_+_240408560 1.05 ENST00000441342.1
ENST00000545751.1
FMN2
formin 2
chr1_-_116383738 1.04 ENST00000320238.3
NHLH2
nescient helix loop helix 2
chrX_-_120071012 1.04 ENST00000457020.2
CT47A11
cancer/testis antigen family 47, member A11
chr5_-_36001108 1.03 ENST00000333811.4
UGT3A1
UDP glycosyltransferase 3 family, polypeptide A1
chr6_+_53948221 1.03 ENST00000460844.2
MLIP
muscular LMNA-interacting protein
chr11_+_63057412 1.02 ENST00000544661.1
SLC22A10
solute carrier family 22, member 10
chr12_-_120315074 1.02 ENST00000261833.7
ENST00000392521.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr2_+_210517895 1.01 ENST00000447185.1
MAP2
microtubule-associated protein 2
chr9_-_21166659 1.01 ENST00000380225.1
IFNA21
interferon, alpha 21
chr1_-_85156417 1.01 ENST00000422026.1
SSX2IP
synovial sarcoma, X breakpoint 2 interacting protein
chr11_-_89653576 1.01 ENST00000420869.1
TRIM49D1
tripartite motif containing 49D1
chr10_-_91403625 1.01 ENST00000322191.6
ENST00000342512.3
ENST00000371774.2
PANK1
pantothenate kinase 1
chr3_+_68053359 1.00 ENST00000478136.1
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chrY_+_23698778 1.00 ENST00000303902.5
RBMY1A1
RNA binding motif protein, Y-linked, family 1, member A1
chr6_-_117747015 1.00 ENST00000368508.3
ENST00000368507.3
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chrX_-_33229636 0.99 ENST00000357033.4
DMD
dystrophin
chr12_+_8309630 0.99 ENST00000396570.3
ZNF705A
zinc finger protein 705A
chr20_-_3762087 0.97 ENST00000379756.3
SPEF1
sperm flagellar 1
chr8_+_9009296 0.96 ENST00000521718.1
RP11-10A14.4
Uncharacterized protein
chr17_-_3301704 0.95 ENST00000322608.2
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr5_+_140566 0.95 ENST00000502646.1
PLEKHG4B
pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
chr14_-_23623577 0.93 ENST00000422941.2
ENST00000453702.1
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chrX_+_9935392 0.93 ENST00000445307.2
AC002365.1
Homo sapiens uncharacterized LOC100288814 (LOC100288814), mRNA.
chr5_+_175490540 0.92 ENST00000515817.1
FAM153B
family with sequence similarity 153, member B
chr14_+_56127960 0.92 ENST00000553624.1
KTN1
kinectin 1 (kinesin receptor)
chrX_+_52240504 0.92 ENST00000399805.2
XAGE1B
X antigen family, member 1B
chr12_+_58335360 0.91 ENST00000300145.3
XRCC6BP1
XRCC6 binding protein 1
chr2_+_228735763 0.91 ENST00000373666.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr2_+_5866581 0.90 ENST00000413960.1
AC010729.2
AC010729.2
chr15_+_66585555 0.90 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr12_-_58329819 0.90 ENST00000551421.1
RP11-620J15.3
RP11-620J15.3
chr10_-_97175444 0.90 ENST00000486141.2
SORBS1
sorbin and SH3 domain containing 1
chr9_+_96846740 0.89 ENST00000288976.3
PTPDC1
protein tyrosine phosphatase domain containing 1
chr10_+_96698406 0.89 ENST00000260682.6
CYP2C9
cytochrome P450, family 2, subfamily C, polypeptide 9
chr1_+_87012922 0.89 ENST00000263723.5
CLCA4
chloride channel accessory 4
chr17_+_22022437 0.89 ENST00000540040.1
MTRNR2L1
MT-RNR2-like 1
chr11_+_124134723 0.88 ENST00000524943.2
OR8G5
olfactory receptor, family 8, subfamily G, member 5
chr18_-_46784778 0.88 ENST00000582399.1
DYM
dymeclin
chr11_-_1619524 0.87 ENST00000412090.1
KRTAP5-2
keratin associated protein 5-2
chr15_-_80634126 0.87 ENST00000558244.1
LINC00927
long intergenic non-protein coding RNA 927
chr2_-_39456673 0.87 ENST00000378803.1
ENST00000395035.3
CDKL4
cyclin-dependent kinase-like 4
chrX_+_47990039 0.86 ENST00000304270.5
SPACA5B
sperm acrosome associated 5B
chr5_-_145895753 0.86 ENST00000311104.2
GPR151
G protein-coupled receptor 151
chr1_-_21377383 0.86 ENST00000374935.3
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr7_+_871559 0.85 ENST00000421580.1
SUN1
Sad1 and UNC84 domain containing 1
chr3_+_173116225 0.84 ENST00000457714.1
NLGN1
neuroligin 1
chr8_+_30496078 0.84 ENST00000517349.1
SMIM18
small integral membrane protein 18
chr15_-_80634104 0.83 ENST00000561432.1
ENST00000558913.1
ENST00000558578.1
LINC00927
long intergenic non-protein coding RNA 927
chr14_-_23624511 0.83 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr16_+_87636474 0.82 ENST00000284262.2
JPH3
junctophilin 3
chr2_+_78143006 0.82 ENST00000443419.1
AC073628.1
AC073628.1
chr10_-_23528745 0.82 ENST00000376501.5
C10orf115
chromosome 10 open reading frame 115
chr17_+_58641908 0.81 ENST00000592917.1
RP11-15E18.4
Uncharacterized protein
chr4_+_159131630 0.81 ENST00000504569.1
ENST00000509278.1
ENST00000514558.1
ENST00000503200.1
TMEM144
transmembrane protein 144
chr15_+_21145765 0.81 ENST00000553416.1
CT60
cancer/testis antigen 60 (non-protein coding)
chr2_+_35056422 0.81 ENST00000592523.1
ENST00000588944.1
ENST00000585391.1
ENST00000591221.1
ENST00000586769.1
ENST00000588650.1
AC012593.1
AC012593.1
chr8_+_12803146 0.80 ENST00000447063.2
KIAA1456
KIAA1456
chr11_+_55029628 0.79 ENST00000417545.2
TRIM48
tripartite motif containing 48
chr15_-_64665911 0.79 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1
Uncharacterized protein
chr5_+_66675200 0.78 ENST00000503106.1
RP11-434D9.1
RP11-434D9.1
chr17_+_58018269 0.78 ENST00000591035.1
RP11-178C3.1
Uncharacterized protein
chr3_+_81043000 0.78 ENST00000482617.1
RP11-6B4.1
RP11-6B4.1
chr13_+_76362974 0.77 ENST00000497947.2
LMO7
LIM domain 7
chr10_-_51958906 0.77 ENST00000489640.1
ASAH2
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
chr12_+_11187087 0.77 ENST00000601123.1
AC018630.1
Uncharacterized protein
chr3_+_155838337 0.76 ENST00000490337.1
ENST00000389636.5
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr1_-_89641680 0.76 ENST00000294671.2
GBP7
guanylate binding protein 7
chr1_+_10509971 0.76 ENST00000320498.4
CORT
cortistatin
chr1_-_179457805 0.76 ENST00000600581.1
AL160286.1
Uncharacterized protein
chrY_-_24038660 0.76 ENST00000382677.3
RBMY1D
RNA binding motif protein, Y-linked, family 1, member D
chr2_+_38177620 0.76 ENST00000402091.3
RMDN2
regulator of microtubule dynamics 2
chr2_-_183106641 0.74 ENST00000346717.4
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr8_+_120885949 0.74 ENST00000523492.1
ENST00000286234.5
DEPTOR
DEP domain containing MTOR-interacting protein
chr12_-_21556577 0.74 ENST00000450590.1
ENST00000453443.1
SLCO1A2
solute carrier organic anion transporter family, member 1A2
chr7_+_6121296 0.73 ENST00000428901.1
AC004895.4
AC004895.4
chr18_+_616672 0.73 ENST00000338387.7
CLUL1
clusterin-like 1 (retinal)
chrX_+_79675965 0.73 ENST00000308293.5
FAM46D
family with sequence similarity 46, member D
chr1_+_15668240 0.72 ENST00000444385.1
FHAD1
forkhead-associated (FHA) phosphopeptide binding domain 1
chr3_-_139199565 0.72 ENST00000511956.1
RBP2
retinol binding protein 2, cellular
chr1_-_241683001 0.72 ENST00000366560.3
FH
fumarate hydratase
chr4_+_122722466 0.71 ENST00000243498.5
ENST00000379663.3
ENST00000509800.1
EXOSC9
exosome component 9
chr4_+_69962185 0.69 ENST00000305231.7
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr9_+_117904097 0.69 ENST00000374016.1
DEC1
deleted in esophageal cancer 1
chr5_-_177207634 0.69 ENST00000513554.1
ENST00000440605.3
FAM153A
family with sequence similarity 153, member A
chr2_+_34935472 0.68 ENST00000604250.1
AC073218.2
AC073218.2
chr3_+_52245458 0.68 ENST00000459884.1
ALAS1
aminolevulinate, delta-, synthase 1
chr5_+_96079240 0.68 ENST00000515663.1
CAST
calpastatin
chr14_+_56127989 0.67 ENST00000555573.1
KTN1
kinectin 1 (kinesin receptor)
chr1_-_201438282 0.67 ENST00000367311.3
ENST00000367309.1
PHLDA3
pleckstrin homology-like domain, family A, member 3
chr15_+_66585879 0.66 ENST00000319212.4
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr13_-_34250861 0.65 ENST00000445227.1
ENST00000454681.2
RP11-141M1.3
RP11-141M1.3
chr13_-_41768654 0.64 ENST00000379483.3
KBTBD7
kelch repeat and BTB (POZ) domain containing 7
chr3_-_72897545 0.64 ENST00000325599.8
SHQ1
SHQ1, H/ACA ribonucleoprotein assembly factor
chr14_+_35747825 0.63 ENST00000540871.1
PSMA6
proteasome (prosome, macropain) subunit, alpha type, 6
chr3_+_180586536 0.63 ENST00000465551.1
FXR1
fragile X mental retardation, autosomal homolog 1
chr1_-_21377447 0.63 ENST00000374937.3
ENST00000264211.8
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr9_-_125330838 0.63 ENST00000304865.2
OR1L8
olfactory receptor, family 1, subfamily L, member 8
chr18_+_6729725 0.63 ENST00000400091.2
ENST00000583410.1
ENST00000584387.1
ARHGAP28
Rho GTPase activating protein 28
chr2_+_113299990 0.63 ENST00000537335.1
ENST00000417433.2
POLR1B
polymerase (RNA) I polypeptide B, 128kDa
chr16_+_21689835 0.62 ENST00000286149.4
ENST00000388958.3
OTOA
otoancorin
chr4_+_69962212 0.61 ENST00000508661.1
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr6_+_116850174 0.61 ENST00000416171.2
ENST00000368597.2
ENST00000452373.1
ENST00000405399.1
FAM26D
family with sequence similarity 26, member D
chr3_-_139199589 0.59 ENST00000506825.1
RBP2
retinol binding protein 2, cellular
chr3_-_146323019 0.59 ENST00000492200.1
ENST00000482567.1
PLSCR5
phospholipid scramblase family, member 5
chr5_+_169010638 0.59 ENST00000265295.4
ENST00000506574.1
ENST00000515224.1
ENST00000508247.1
ENST00000513941.1
SPDL1
spindle apparatus coiled-coil protein 1
chr8_+_9009202 0.59 ENST00000518496.1
RP11-10A14.4
Uncharacterized protein
chr12_+_71833550 0.59 ENST00000266674.5
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr10_-_15130767 0.58 ENST00000356189.5
ACBD7
acyl-CoA binding domain containing 7
chr18_-_69449517 0.57 ENST00000584810.1
RP11-723G8.2
Uncharacterized protein
chr12_+_10365082 0.57 ENST00000545859.1
GABARAPL1
GABA(A) receptor-associated protein like 1
chr4_-_22444733 0.57 ENST00000508133.1
GPR125
G protein-coupled receptor 125
chr1_-_62190793 0.56 ENST00000371177.2
ENST00000606498.1
TM2D1
TM2 domain containing 1
chr11_+_22688150 0.55 ENST00000454584.2
GAS2
growth arrest-specific 2

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.3 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.6 2.9 GO:0036371 protein localization to T-tubule(GO:0036371)
0.5 0.5 GO:0006533 aspartate catabolic process(GO:0006533)
0.5 4.8 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.5 1.4 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
0.4 1.7 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.4 6.2 GO:0055009 atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.4 1.1 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.3 2.4 GO:0002933 lipid hydroxylation(GO:0002933)
0.3 0.8 GO:0060733 regulation of eIF2 alpha phosphorylation by amino acid starvation(GO:0060733) regulation of translational initiation in response to starvation(GO:0071262) positive regulation of translational initiation in response to starvation(GO:0071264)
0.2 2.2 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.2 0.7 GO:0006106 fumarate metabolic process(GO:0006106)
0.2 0.8 GO:0048789 cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942)
0.2 1.0 GO:0010966 regulation of phosphate transport(GO:0010966)
0.2 0.9 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.2 0.7 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.2 3.5 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.2 2.8 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.2 2.8 GO:0061635 regulation of protein complex stability(GO:0061635)
0.2 0.6 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.2 0.6 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 3.7 GO:0001973 adenosine receptor signaling pathway(GO:0001973)
0.1 0.4 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 1.6 GO:0070779 gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1 0.5 GO:0032053 ciliary basal body organization(GO:0032053)
0.1 1.3 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 0.2 GO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.1 1.6 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.4 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 2.6 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.1 0.4 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 1.5 GO:0006662 glycerol ether metabolic process(GO:0006662)
0.1 0.4 GO:0070458 cellular detoxification of nitrogen compound(GO:0070458)
0.1 0.9 GO:0044821 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 1.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 1.0 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 1.7 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 3.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 1.6 GO:0016075 rRNA catabolic process(GO:0016075)
0.1 0.4 GO:0072560 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.1 1.1 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 2.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 3.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 1.3 GO:0006527 arginine catabolic process(GO:0006527) negative regulation of cellular response to hypoxia(GO:1900038)
0.1 1.1 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.1 0.2 GO:0035397 helper T cell enhancement of adaptive immune response(GO:0035397)
0.1 1.0 GO:0015747 urate transport(GO:0015747)
0.1 0.4 GO:0032571 response to vitamin K(GO:0032571) regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) bone regeneration(GO:1990523)
0.1 1.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.1 0.3 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.1 1.3 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.1 0.6 GO:0007000 nucleolus organization(GO:0007000)
0.1 1.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.3 GO:0016095 polyprenol catabolic process(GO:0016095)
0.1 2.5 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.0 0.4 GO:0051597 response to methylmercury(GO:0051597)
0.0 1.8 GO:0015695 organic cation transport(GO:0015695)
0.0 1.0 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.7 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.6 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 1.0 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.2 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.3 GO:0060423 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0 1.1 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.0 0.7 GO:0045792 negative regulation of cell size(GO:0045792)
0.0 0.8 GO:0060539 diaphragm development(GO:0060539)
0.0 0.8 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.3 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.7 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 1.1 GO:0031115 copper ion transport(GO:0006825) negative regulation of microtubule polymerization(GO:0031115)
0.0 0.9 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)
0.0 1.9 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.2 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.3 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.4 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 1.0 GO:0044705 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 0.4 GO:0032886 regulation of microtubule-based process(GO:0032886)
0.0 0.4 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.3 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.2 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.3 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 6.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.2 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.0 0.6 GO:0017121 phospholipid scrambling(GO:0017121)
0.0 0.6 GO:0015671 oxygen transport(GO:0015671)
0.0 0.4 GO:0070986 left/right axis specification(GO:0070986)
0.0 1.1 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 1.1 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 1.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.4 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.8 GO:0035640 exploration behavior(GO:0035640)
0.0 0.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 4.1 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.5 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0 0.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.4 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 1.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.6 GO:2000637 positive regulation of gene silencing by miRNA(GO:2000637)
0.0 0.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.5 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.5 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.3 GO:2000269 regulation of fibroblast apoptotic process(GO:2000269)
0.0 0.3 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 1.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.4 GO:0001502 cartilage condensation(GO:0001502)
0.0 0.5 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway(GO:0040036)
0.0 0.5 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 1.0 GO:0021954 central nervous system neuron development(GO:0021954)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0033150 cytoskeletal calyx(GO:0033150)
0.5 4.3 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.5 4.8 GO:0044305 calyx of Held(GO:0044305)
0.4 2.5 GO:0097513 myosin II filament(GO:0097513)
0.3 7.8 GO:0032982 myosin filament(GO:0032982)
0.3 0.8 GO:0071821 FANCM-MHF complex(GO:0071821)
0.1 1.0 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 0.9 GO:0005899 insulin receptor complex(GO:0005899)
0.1 1.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.1 2.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 0.8 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.0 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 1.0 GO:0016013 syntrophin complex(GO:0016013)
0.1 1.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 3.5 GO:0043034 costamere(GO:0043034)
0.1 0.8 GO:0030314 junctional membrane complex(GO:0030314)
0.1 1.1 GO:0045179 apical cortex(GO:0045179)
0.1 1.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.9 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.3 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 1.7 GO:0036019 endolysosome(GO:0036019)
0.0 1.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.7 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.4 GO:0000801 central element(GO:0000801)
0.0 0.4 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.8 GO:0032433 filopodium tip(GO:0032433)
0.0 0.9 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.1 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 2.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.0 GO:0030118 clathrin coat(GO:0030118)
0.0 2.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.7 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.8 GO:0005844 polysome(GO:0005844)
0.0 3.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.2 GO:0017018 myosin phosphatase activity(GO:0017018)
0.7 3.3 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.5 1.4 GO:0004370 glycerol kinase activity(GO:0004370)
0.4 3.7 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.3 1.1 GO:0032767 copper-dependent protein binding(GO:0032767)
0.2 3.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.2 0.7 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.2 2.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 0.7 GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.2 1.3 GO:0016403 dimethylargininase activity(GO:0016403)
0.2 3.6 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.2 1.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 2.8 GO:0003796 lysozyme activity(GO:0003796)
0.2 2.6 GO:0033691 sialic acid binding(GO:0033691)
0.2 1.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 1.0 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 1.3 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.1 4.8 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 1.8 GO:0019534 toxin transporter activity(GO:0019534)
0.1 0.5 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 1.3 GO:0043515 kinetochore binding(GO:0043515)
0.1 1.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 2.5 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.7 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 1.5 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 0.4 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.1 1.7 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.8 GO:0017040 ceramidase activity(GO:0017040)
0.1 4.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.1 GO:0015245 fatty acid transporter activity(GO:0015245)
0.1 1.6 GO:0000146 microfilament motor activity(GO:0000146)
0.1 1.0 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 1.0 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.3 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) cholestenone 5-alpha-reductase activity(GO:0047751)
0.1 0.7 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 0.2 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.1 1.7 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.5 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.6 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 2.2 GO:0005549 odorant binding(GO:0005549)
0.0 2.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 1.2 GO:0016918 retinal binding(GO:0016918)
0.0 2.9 GO:0030507 spectrin binding(GO:0030507)
0.0 0.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 3.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 1.0 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.3 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.9 GO:0048156 tau protein binding(GO:0048156)
0.0 1.5 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.2 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 1.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.8 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 1.8 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.4 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 1.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.4 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0 0.8 GO:0070402 NADPH binding(GO:0070402)
0.0 0.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.9 GO:0043495 protein anchor(GO:0043495)
0.0 0.6 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.7 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 1.9 GO:1901476 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 1.6 GO:0019894 kinesin binding(GO:0019894)
0.0 1.8 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 4.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.6 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 2.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.9 GO:0005158 insulin receptor binding(GO:0005158)
0.0 4.5 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.5 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.7 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 1.0 GO:0097110 scaffold protein binding(GO:0097110)
0.0 1.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 2.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 0.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.5 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 2.6 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 1.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.9 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.8 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.0 PID RHOA PATHWAY RhoA signaling pathway
0.0 1.0 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.6 PID INSULIN PATHWAY Insulin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.2 3.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 3.7 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 7.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 0.7 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 2.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.0 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.7 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 3.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.5 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 1.0 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 1.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.5 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 6.4 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 1.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.8 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 0.8 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.6 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 5.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.5 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.4 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.5 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling