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Illumina Body Map 2: averaged replicates

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Results for IRX6_IRX4

Z-value: 0.77

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
ENSG00000159387.7 iroquois homeobox 6
ENSG00000113430.5 iroquois homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg19_v2_chr5_-_1882858_1883003-0.134.9e-01Click!
IRX6hg19_v2_chr16_+_55357672_55357672-0.057.7e-01Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_46716969 1.87 ENST00000435666.2
lymphocyte cytosolic protein 1 (L-plastin)
chr17_+_38673270 1.62 ENST00000578280.1
RP5-1028K7.2
chr21_-_34185989 1.22 ENST00000487113.1
ENST00000382373.4
chromosome 21 open reading frame 62
chr5_+_54320078 1.15 ENST00000231009.2
granzyme K (granzyme 3; tryptase II)
chr21_-_34185944 1.12 ENST00000479548.1
chromosome 21 open reading frame 62
chr21_-_34186006 1.11 ENST00000490358.1
chromosome 21 open reading frame 62
chr7_-_142232071 1.09 ENST00000390364.3
T cell receptor beta variable 10-1(gene/pseudogene)
chr3_-_27498235 1.00 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr16_+_777739 0.83 ENST00000563792.1
hydroxyacylglutathione hydrolase-like
chr6_+_140175987 0.75 ENST00000414038.1
ENST00000431609.1
RP5-899B16.1
chr8_-_101724989 0.71 ENST00000517403.1
poly(A) binding protein, cytoplasmic 1
chr1_+_26644441 0.70 ENST00000374213.2
CD52 molecule
chrX_+_49294472 0.70 ENST00000361446.5
G antigen 12B
chr6_-_108145499 0.69 ENST00000369020.3
ENST00000369022.2
sex comb on midleg-like 4 (Drosophila)
chr12_-_76462713 0.66 ENST00000552056.1
nucleosome assembly protein 1-like 1
chr1_-_8763278 0.63 ENST00000468247.1
arginine-glutamic acid dipeptide (RE) repeats
chr15_-_51630772 0.62 ENST00000557858.1
ENST00000558328.1
ENST00000396404.4
ENST00000561075.1
ENST00000405011.2
ENST00000559980.1
ENST00000453807.2
ENST00000396402.1
cytochrome P450, family 19, subfamily A, polypeptide 1
chr2_+_58655520 0.61 ENST00000455219.3
ENST00000449448.2
long intergenic non-protein coding RNA 1122
chr16_+_776936 0.60 ENST00000549114.1
ENST00000341413.4
ENST00000562187.1
ENST00000564537.1
hydroxyacylglutathione hydrolase-like
chr18_+_616672 0.59 ENST00000338387.7
clusterin-like 1 (retinal)
chr4_+_40195262 0.57 ENST00000503941.1
ras homolog family member H
chr4_+_40194570 0.57 ENST00000507851.1
ras homolog family member H
chr12_-_10282742 0.56 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
C-type lectin domain family 7, member A
chr16_+_777246 0.54 ENST00000561546.1
ENST00000564545.1
ENST00000389703.3
ENST00000567414.1
ENST00000568141.1
hydroxyacylglutathione hydrolase-like
chr7_+_143826151 0.53 ENST00000408899.2
olfactory receptor, family 2, subfamily A, member 14
chr14_+_22992573 0.53 ENST00000390516.1
T cell receptor alpha joining 21
chr12_-_10282681 0.51 ENST00000533022.1
C-type lectin domain family 7, member A
chr4_-_143481822 0.51 ENST00000510812.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr3_-_9994021 0.51 ENST00000411976.2
ENST00000412055.1
proline-rich transmembrane protein 3
chr12_+_32655048 0.49 ENST00000427716.2
ENST00000266482.3
FYVE, RhoGEF and PH domain containing 4
chr14_-_106845789 0.49 ENST00000390617.2
immunoglobulin heavy variable 3-35 (non-functional)
chr12_-_10282836 0.48 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
C-type lectin domain family 7, member A
chr7_-_16844611 0.48 ENST00000401412.1
ENST00000419304.2
anterior gradient 2
chr9_-_5084580 0.48 ENST00000601793.1
Uncharacterized protein
chr15_-_64665911 0.48 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
Uncharacterized protein
chr2_-_207583120 0.47 ENST00000452335.2
dystrotelin
chr14_+_22993296 0.44 ENST00000390517.1
T cell receptor alpha joining 20
chr4_+_40194609 0.44 ENST00000508513.1
ras homolog family member H
chr17_-_29641084 0.43 ENST00000544462.1
ecotropic viral integration site 2B
chrX_+_15767971 0.42 ENST00000479740.1
ENST00000454127.2
carbonic anhydrase VB, mitochondrial
chr17_-_29641104 0.42 ENST00000577894.1
ENST00000330927.4
ecotropic viral integration site 2B
chr10_+_90660832 0.42 ENST00000371924.1
STAM binding protein-like 1
chr5_+_59783540 0.41 ENST00000515734.2
prostate androgen-regulated transcript 1 (non-protein coding)
chr1_-_3566627 0.41 ENST00000419924.2
ENST00000270708.7
WD repeat containing, antisense to TP73
chr12_+_32655110 0.41 ENST00000546442.1
ENST00000583694.1
FYVE, RhoGEF and PH domain containing 4
chr14_-_21737551 0.40 ENST00000554891.1
ENST00000555883.1
ENST00000553753.1
ENST00000555914.1
ENST00000557336.1
ENST00000555215.1
ENST00000556628.1
ENST00000555137.1
ENST00000556226.1
ENST00000555309.1
ENST00000556142.1
ENST00000554969.1
ENST00000554455.1
ENST00000556513.1
ENST00000557201.1
ENST00000420743.2
ENST00000557768.1
ENST00000553300.1
ENST00000554383.1
ENST00000554539.1
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr22_-_24096562 0.39 ENST00000398465.3
pre-B lymphocyte 3
chr10_-_115904361 0.39 ENST00000428953.1
ENST00000543782.1
chromosome 10 open reading frame 118
chrX_+_47990039 0.38 ENST00000304270.5
sperm acrosome associated 5B
chrX_+_47867194 0.36 ENST00000376940.3
sperm acrosome associated 5
chr7_-_55583740 0.35 ENST00000453256.1
vesicular, overexpressed in cancer, prosurvival protein 1
chr2_+_58655461 0.35 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
long intergenic non-protein coding RNA 1122
chr4_+_158142750 0.34 ENST00000505888.1
ENST00000449365.1
glutamate receptor, ionotropic, AMPA 2
chr16_+_777118 0.33 ENST00000562141.1
hydroxyacylglutathione hydrolase-like
chr17_-_42327236 0.32 ENST00000399246.2
AC003102.1
chr1_-_3566590 0.31 ENST00000424367.1
ENST00000378322.3
WD repeat containing, antisense to TP73
chr7_-_92855762 0.31 ENST00000453812.2
ENST00000394468.2
HEPACAM family member 2
chr3_+_68053359 0.30 ENST00000478136.1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr15_+_81225699 0.30 ENST00000560027.1
KIAA1199
chr5_+_169758393 0.28 ENST00000521471.1
ENST00000518357.1
ENST00000436248.3
CTB-114C7.3
chr17_-_6524159 0.25 ENST00000589033.1
KIAA0753
chrX_-_19988382 0.25 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
chromosome X open reading frame 23
chr11_+_61891445 0.25 ENST00000394818.3
ENST00000533896.1
ENST00000278849.4
inner centromere protein antigens 135/155kDa
chr7_-_80141328 0.25 ENST00000398291.3
guanine nucleotide binding protein, alpha transducing 3
chrY_-_21738068 0.24 ENST00000599485.1
Uncharacterized protein
chr19_-_22379753 0.23 ENST00000397121.2
zinc finger protein 676
chr1_-_149859466 0.23 ENST00000331128.3
histone cluster 2, H2ab
chr5_+_175490540 0.21 ENST00000515817.1
family with sequence similarity 153, member B
chr6_+_116691001 0.21 ENST00000537543.1
dermatan sulfate epimerase
chr5_-_177207634 0.21 ENST00000513554.1
ENST00000440605.3
family with sequence similarity 153, member A
chr8_+_84824920 0.20 ENST00000523678.1
RP11-120I21.2
chr6_-_117747015 0.17 ENST00000368508.3
ENST00000368507.3
c-ros oncogene 1 , receptor tyrosine kinase
chr20_+_11008408 0.17 ENST00000378252.1
chromosome 20 open reading frame 187
chr1_+_67673297 0.17 ENST00000425614.1
ENST00000395227.1
interleukin 23 receptor
chr7_+_23210760 0.17 ENST00000366347.4
Uncharacterized protein
chr7_+_6121296 0.16 ENST00000428901.1
AC004895.4
chr18_-_28622774 0.16 ENST00000434452.1
desmocollin 3
chr17_-_47723943 0.16 ENST00000510476.1
ENST00000503676.1
speckle-type POZ protein
chr11_+_6897856 0.15 ENST00000379829.2
olfactory receptor, family 10, subfamily A, member 4
chrX_+_36254051 0.15 ENST00000378657.4
chromosome X open reading frame 30
chr20_+_10199566 0.14 ENST00000430336.1
synaptosomal-associated protein, 25kDa
chr2_+_160590469 0.14 ENST00000409591.1
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr14_+_56127989 0.14 ENST00000555573.1
kinectin 1 (kinesin receptor)
chr1_+_170904612 0.13 ENST00000367759.4
ENST00000367758.3
maestro heat-like repeat family member 9
chr20_+_44330651 0.13 ENST00000305479.2
WAP four-disulfide core domain 13
chrX_-_135962923 0.13 ENST00000565438.1
RNA binding motif protein, X-linked
chr1_-_110284384 0.12 ENST00000540225.1
glutathione S-transferase mu 3 (brain)
chr4_+_158141899 0.11 ENST00000264426.9
ENST00000506284.1
glutamate receptor, ionotropic, AMPA 2
chr18_-_56985776 0.11 ENST00000587244.1
complexin 4
chr14_+_56127960 0.11 ENST00000553624.1
kinectin 1 (kinesin receptor)
chr19_-_20048639 0.11 ENST00000595282.1
Uncharacterized protein
chr10_+_118350522 0.10 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
pancreatic lipase-related protein 1
chrX_+_47863734 0.10 ENST00000304355.5
sperm acrosome associated 5
chr10_+_118350468 0.10 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
pancreatic lipase-related protein 1
chr3_-_139199565 0.09 ENST00000511956.1
retinol binding protein 2, cellular
chr3_-_139199589 0.09 ENST00000506825.1
retinol binding protein 2, cellular
chr12_-_88423164 0.08 ENST00000298699.2
ENST00000550553.1
chromosome 12 open reading frame 50
chr4_+_130017268 0.08 ENST00000425929.1
ENST00000508673.1
ENST00000508622.1
chromosome 4 open reading frame 33
chr6_-_49834209 0.07 ENST00000507853.1
cysteine-rich secretory protein 1
chr9_-_37465396 0.07 ENST00000307750.4
zinc finger and BTB domain containing 5
chr4_-_104119488 0.07 ENST00000514974.1
centromere protein E, 312kDa
chr11_+_110225855 0.06 ENST00000526605.1
ENST00000526703.1
RP11-347E10.1
chr6_-_49834240 0.06 ENST00000335847.4
cysteine-rich secretory protein 1
chr6_-_39290744 0.06 ENST00000507712.1
potassium channel, subfamily K, member 16
chr12_-_124118151 0.06 ENST00000534960.1
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
chr4_-_104119528 0.05 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
centromere protein E, 312kDa
chr8_-_74495065 0.05 ENST00000523533.1
staufen double-stranded RNA binding protein 2
chr9_-_27573651 0.05 ENST00000379995.1
ENST00000379997.3
chromosome 9 open reading frame 72
chr3_-_168865522 0.05 ENST00000464456.1
MDS1 and EVI1 complex locus
chr10_+_86184676 0.05 ENST00000543283.1
coiled-coil serine-rich protein 2
chr3_+_186158169 0.05 ENST00000435548.1
ENST00000421006.1
RP11-78H24.1
chr4_+_144312659 0.04 ENST00000509992.1
GRB2-associated binding protein 1
chr2_-_238333919 0.04 ENST00000409162.1
Uncharacterized protein
chr3_+_111758553 0.04 ENST00000419127.1
transmembrane protease, serine 7
chr20_+_10199468 0.04 ENST00000254976.2
ENST00000304886.2
synaptosomal-associated protein, 25kDa
chr14_-_23623577 0.04 ENST00000422941.2
ENST00000453702.1
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr13_-_41768654 0.03 ENST00000379483.3
kelch repeat and BTB (POZ) domain containing 7
chr2_+_226264401 0.03 ENST00000431435.1
AC067961.1
chr8_+_67976593 0.03 ENST00000262210.5
ENST00000412460.1
centrosome and spindle pole associated protein 1
chr21_-_48024986 0.02 ENST00000291700.4
ENST00000367071.4
S100 calcium binding protein B
chrY_-_6742068 0.02 ENST00000215479.5
amelogenin, Y-linked
chr8_+_27631903 0.01 ENST00000305188.8
establishment of sister chromatid cohesion N-acetyltransferase 2
chr3_+_111630451 0.01 ENST00000495180.1
pleckstrin homology-like domain, family B, member 2
chr4_+_71458012 0.00 ENST00000449493.2
ameloblastin (enamel matrix protein)
chr15_+_66585555 0.00 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
DIS3 mitotic control homolog (S. cerevisiae)-like

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.1 0.6 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 1.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 1.6 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 0.5 GO:1903899 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.1 0.7 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.2 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.0 0.2 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.0 0.2 GO:0010966 regulation of phosphate transport(GO:0010966)
0.0 0.2 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 1.0 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.7 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.1 GO:0070458 establishment of blood-nerve barrier(GO:0008065) cellular detoxification of nitrogen compound(GO:0070458)
0.0 1.6 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.7 GO:0045730 respiratory burst(GO:0045730)
0.0 0.4 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 1.9 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.2 GO:0000801 central element(GO:0000801)
0.0 0.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 1.6 GO:0001772 immunological synapse(GO:0001772)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.0 GO:0032420 stereocilium(GO:0032420)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.1 0.5 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0 1.6 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 1.6 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.2 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 1.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.5 GO:0003796 lysozyme activity(GO:0003796)
0.0 0.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.6 GO:0070330 aromatase activity(GO:0070330)
0.0 0.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.6 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation