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Illumina Body Map 2: averaged replicates
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Results for KLF1
Z-value: 3.55
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Transcription factors associated with KLF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF1 | hg19_v2_chr19_-_12997995_12998021 | 0.15 | 4.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 10.4 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 0.2 | 8.7 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.1 | 8.7 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.5 | 8.2 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.7 | 7.3 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 0.4 | 6.6 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.1 | 6.5 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 0.2 | 6.4 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 1.5 | 5.9 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.0 | 5.6 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.6 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 11.6 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 10.5 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 2.3 | 9.1 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.1 | 8.5 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.3 | 8.2 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 8.0 | GO:0005874 | microtubule(GO:0005874) |
| 0.2 | 7.7 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 7.7 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 7.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.0 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 14.5 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.1 | 11.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.5 | 9.1 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.4 | 8.3 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 8.2 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.8 | 8.0 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 7.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 6.5 | GO:0002020 | protease binding(GO:0002020) |
| 0.1 | 6.0 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 7.5 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 6.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 5.1 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 5.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 4.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.0 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 3.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 3.6 | PID S1P S1P4 PATHWAY | S1P4 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.2 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 8.2 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 6.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 6.2 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 5.9 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 5.8 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.2 | 5.7 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.2 | 5.7 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 5.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 4.9 | REACTOME KINESINS | Genes involved in Kinesins |