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Illumina Body Map 2: averaged replicates

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Results for LHX3

Z-value: 1.57

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Transcription factors associated with LHX3

Gene Symbol Gene ID Gene Info
LHX3
ENSG00000107187.11 LIM homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX3hg19_v2_chr9_-_139094988_139095012-0.411.9e-02Click!

Activity profile of LHX3 motif

Sorted Z-values of LHX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_155484103 4.94 ENST00000302068.4
FGB
fibrinogen beta chain
chr4_+_155484155 4.68 ENST00000509493.1
FGB
fibrinogen beta chain
chr3_+_151591422 4.30 ENST00000362032.5
SUCNR1
succinate receptor 1
chr5_-_39274617 3.47 ENST00000510188.1
FYB
FYN binding protein
chr8_-_66750978 3.25 ENST00000523253.1
PDE7A
phosphodiesterase 7A
chr2_+_218994002 2.82 ENST00000428565.1
CXCR2
chemokine (C-X-C motif) receptor 2
chr12_-_10282681 2.65 ENST00000533022.1
CLEC7A
C-type lectin domain family 7, member A
chr7_-_36764062 2.61 ENST00000435386.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr19_+_14693888 2.60 ENST00000547437.1
ENST00000397439.2
ENST00000417570.1
CLEC17A
C-type lectin domain family 17, member A
chr2_+_135596180 2.60 ENST00000283054.4
ENST00000392928.1
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr12_-_10282742 2.55 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr7_-_36764142 2.53 ENST00000258749.5
ENST00000535891.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr2_-_89160117 2.51 ENST00000390238.2
IGKJ5
immunoglobulin kappa joining 5
chr19_-_51920952 2.43 ENST00000356298.5
ENST00000339313.5
ENST00000529627.1
ENST00000439889.2
ENST00000353836.5
ENST00000432469.2
SIGLEC10
sialic acid binding Ig-like lectin 10
chr12_-_10282836 2.29 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr3_+_186692745 2.22 ENST00000438590.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr20_-_7238861 2.14 ENST00000428954.1
RP11-19D2.1
RP11-19D2.1
chr2_+_135596106 2.10 ENST00000356140.5
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr11_+_59824060 2.08 ENST00000395032.2
ENST00000358152.2
MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr3_+_63953415 2.07 ENST00000484332.1
ATXN7
ataxin 7
chr1_-_92952433 1.97 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr7_-_115799942 1.97 ENST00000484212.1
TFEC
transcription factor EC
chr1_-_160549235 1.85 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
CD84
CD84 molecule
chr17_-_39093672 1.84 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr20_+_5987890 1.84 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr1_-_150944411 1.81 ENST00000368949.4
CERS2
ceramide synthase 2
chr7_-_87342564 1.79 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr11_+_59824127 1.79 ENST00000278865.3
MS4A3
membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chrX_+_107288280 1.78 ENST00000458383.1
VSIG1
V-set and immunoglobulin domain containing 1
chr5_-_88120083 1.74 ENST00000509373.1
MEF2C
myocyte enhancer factor 2C
chr6_-_159466136 1.68 ENST00000367066.3
ENST00000326965.6
TAGAP
T-cell activation RhoGTPase activating protein
chr16_-_28634874 1.67 ENST00000395609.1
ENST00000350842.4
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr6_-_66417107 1.50 ENST00000370621.3
ENST00000370618.3
ENST00000503581.1
ENST00000393380.2
EYS
eyes shut homolog (Drosophila)
chr1_+_244214577 1.47 ENST00000358704.4
ZBTB18
zinc finger and BTB domain containing 18
chr5_-_88120151 1.47 ENST00000506716.1
MEF2C
myocyte enhancer factor 2C
chr14_+_22959438 1.46 ENST00000390489.1
TRAJ48
T cell receptor alpha joining 48
chr2_-_145278475 1.45 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr4_-_36245561 1.43 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr19_+_50016411 1.32 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr5_-_173217916 1.31 ENST00000523617.1
CTB-43E15.4
CTB-43E15.4
chrX_+_9431324 1.30 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr14_+_22963806 1.28 ENST00000390493.1
TRAJ44
T cell receptor alpha joining 44
chr9_-_128246769 1.26 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr6_+_130339710 1.24 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr12_+_59989918 1.19 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr12_-_118628315 1.17 ENST00000540561.1
TAOK3
TAO kinase 3
chr17_-_27418537 1.16 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr14_-_52436247 1.15 ENST00000597846.1
AL358333.1
HCG2013195; Uncharacterized protein
chr14_+_62164340 1.15 ENST00000557538.1
ENST00000539097.1
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr8_-_57123815 1.14 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr14_+_22465771 1.13 ENST00000390445.2
TRAV17
T cell receptor alpha variable 17
chr1_-_150208320 1.12 ENST00000534220.1
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr3_+_41236325 1.12 ENST00000426215.1
ENST00000405570.1
CTNNB1
catenin (cadherin-associated protein), beta 1, 88kDa
chr17_-_64225508 1.11 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr12_-_118628350 1.11 ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr10_+_104263743 1.08 ENST00000369902.3
ENST00000369899.2
ENST00000423559.2
SUFU
suppressor of fused homolog (Drosophila)
chr3_+_141106643 1.07 ENST00000514251.1
ZBTB38
zinc finger and BTB domain containing 38
chr6_-_9933500 1.06 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr19_+_48949030 1.04 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr1_-_150208412 1.03 ENST00000532744.1
ENST00000369114.5
ENST00000369115.2
ENST00000369116.4
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_+_66820058 1.02 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr5_-_173217931 1.01 ENST00000522731.1
CTB-43E15.4
CTB-43E15.4
chr12_-_78934441 0.99 ENST00000546865.1
ENST00000547089.1
RP11-171L9.1
RP11-171L9.1
chr17_-_60142609 0.99 ENST00000397786.2
MED13
mediator complex subunit 13
chrX_+_107288197 0.99 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr5_-_88119580 0.98 ENST00000539796.1
MEF2C
myocyte enhancer factor 2C
chr1_-_150208363 0.96 ENST00000436748.2
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr4_-_41884620 0.91 ENST00000504870.1
LINC00682
long intergenic non-protein coding RNA 682
chr3_-_141747950 0.91 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr1_-_150208291 0.90 ENST00000533654.1
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr10_-_74283694 0.89 ENST00000398763.4
ENST00000418483.2
ENST00000489666.2
MICU1
mitochondrial calcium uptake 1
chr19_+_50016610 0.87 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr7_+_39017504 0.87 ENST00000403058.1
POU6F2
POU class 6 homeobox 2
chr19_+_48949087 0.86 ENST00000598711.1
GRWD1
glutamate-rich WD repeat containing 1
chrM_-_14670 0.86 ENST00000361681.2
MT-ND6
mitochondrially encoded NADH dehydrogenase 6
chr2_-_8715616 0.85 ENST00000418358.1
AC011747.3
AC011747.3
chr17_-_38956205 0.84 ENST00000306658.7
KRT28
keratin 28
chr12_-_7656357 0.84 ENST00000396620.3
ENST00000432237.2
ENST00000359156.4
CD163
CD163 molecule
chr10_-_115904361 0.83 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr11_-_67981046 0.83 ENST00000402789.1
ENST00000402185.2
ENST00000458496.1
SUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chrX_-_110655306 0.82 ENST00000371993.2
DCX
doublecortin
chr15_+_64680003 0.80 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr3_+_121902511 0.79 ENST00000490131.1
CASR
calcium-sensing receptor
chr4_+_95128748 0.79 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr3_+_68055366 0.78 ENST00000496687.1
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr2_-_99279928 0.77 ENST00000414521.2
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr12_-_42631529 0.76 ENST00000548917.1
YAF2
YY1 associated factor 2
chr5_+_67586465 0.75 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr6_+_114178512 0.74 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr7_-_105332084 0.74 ENST00000472195.1
ATXN7L1
ataxin 7-like 1
chr1_-_24126023 0.73 ENST00000429356.1
GALE
UDP-galactose-4-epimerase
chr4_-_120243545 0.73 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr6_+_26104104 0.73 ENST00000377803.2
HIST1H4C
histone cluster 1, H4c
chr7_+_107224364 0.72 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chr4_-_23891693 0.72 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr12_+_49740700 0.72 ENST00000549441.2
ENST00000395069.3
DNAJC22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr4_-_23891658 0.71 ENST00000507380.1
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chrX_+_107288239 0.69 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr4_+_113568207 0.69 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr11_-_67980744 0.69 ENST00000401547.2
ENST00000453170.1
ENST00000304363.4
SUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chrX_-_39186610 0.66 ENST00000429281.1
ENST00000448597.1
RP11-265P11.2
RP11-265P11.2
chr15_+_48483736 0.66 ENST00000417307.2
ENST00000559641.1
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr1_-_24126051 0.63 ENST00000445705.1
GALE
UDP-galactose-4-epimerase
chr9_-_215744 0.63 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr17_-_71223839 0.63 ENST00000579872.1
ENST00000580032.1
FAM104A
family with sequence similarity 104, member A
chr3_-_47517302 0.62 ENST00000441517.2
ENST00000545718.1
SCAP
SREBF chaperone
chr4_+_41937131 0.61 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
TMEM33
transmembrane protein 33
chr14_-_104408032 0.61 ENST00000455348.2
RD3L
retinal degeneration 3-like
chr19_-_43969796 0.59 ENST00000244333.3
LYPD3
LY6/PLAUR domain containing 3
chrX_+_108779004 0.58 ENST00000218004.1
NXT2
nuclear transport factor 2-like export factor 2
chr20_+_11008408 0.57 ENST00000378252.1
C20orf187
chromosome 20 open reading frame 187
chrX_-_106243294 0.56 ENST00000255495.7
MORC4
MORC family CW-type zinc finger 4
chr14_+_55494323 0.56 ENST00000339298.2
SOCS4
suppressor of cytokine signaling 4
chr13_-_81801115 0.55 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr1_+_115572415 0.54 ENST00000256592.1
TSHB
thyroid stimulating hormone, beta
chr10_-_90611566 0.52 ENST00000371930.4
ANKRD22
ankyrin repeat domain 22
chr17_+_35851570 0.52 ENST00000394386.1
DUSP14
dual specificity phosphatase 14
chr1_+_168250194 0.50 ENST00000367821.3
TBX19
T-box 19
chr5_+_179135246 0.49 ENST00000508787.1
CANX
calnexin
chr16_-_1538765 0.49 ENST00000447419.2
ENST00000440447.2
PTX4
pentraxin 4, long
chr3_+_69812877 0.49 ENST00000457080.1
ENST00000328528.6
MITF
microphthalmia-associated transcription factor
chr5_+_126984710 0.49 ENST00000379445.3
CTXN3
cortexin 3
chr19_-_11457162 0.48 ENST00000590482.1
TMEM205
transmembrane protein 205
chr11_-_559377 0.48 ENST00000486629.1
C11orf35
chromosome 11 open reading frame 35
chr3_+_138340067 0.47 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr19_+_11457175 0.46 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159
coiled-coil domain containing 159
chr18_+_72201664 0.46 ENST00000358821.3
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr10_-_27529486 0.44 ENST00000375888.1
ACBD5
acyl-CoA binding domain containing 5
chr2_+_185463093 0.44 ENST00000302277.6
ZNF804A
zinc finger protein 804A
chr14_+_55493920 0.44 ENST00000395472.2
ENST00000555846.1
SOCS4
suppressor of cytokine signaling 4
chr6_-_138833630 0.44 ENST00000533765.1
NHSL1
NHS-like 1
chr6_-_47445214 0.43 ENST00000604014.1
RP11-385F7.1
RP11-385F7.1
chr8_-_25281747 0.42 ENST00000421054.2
GNRH1
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chrX_-_106243451 0.42 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr17_-_10372875 0.40 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr8_+_119294456 0.39 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr2_+_234826016 0.38 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr14_-_107049312 0.38 ENST00000390627.2
IGHV3-53
immunoglobulin heavy variable 3-53
chr10_+_106937525 0.37 ENST00000369699.4
SORCS3
sortilin-related VPS10 domain containing receptor 3
chr14_+_39583427 0.36 ENST00000308317.6
ENST00000396249.2
ENST00000250379.8
ENST00000534684.2
ENST00000527381.1
GEMIN2
gem (nuclear organelle) associated protein 2
chr12_+_40787194 0.35 ENST00000425730.2
ENST00000454784.4
MUC19
mucin 19, oligomeric
chr5_-_78809950 0.35 ENST00000334082.6
HOMER1
homer homolog 1 (Drosophila)
chr4_+_158141899 0.34 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr3_+_138340049 0.34 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chrM_+_10464 0.33 ENST00000361335.1
MT-ND4L
mitochondrially encoded NADH dehydrogenase 4L
chr19_+_11457232 0.33 ENST00000587531.1
CCDC159
coiled-coil domain containing 159
chrX_+_84258832 0.31 ENST00000373173.2
APOOL
apolipoprotein O-like
chr18_+_28956740 0.30 ENST00000308128.4
ENST00000359747.4
DSG4
desmoglein 4
chr14_-_106668095 0.30 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chr15_-_20193370 0.29 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr15_-_75748115 0.29 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr19_+_9296279 0.28 ENST00000344248.2
OR7D2
olfactory receptor, family 7, subfamily D, member 2
chr7_-_122840015 0.28 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr16_+_28565230 0.28 ENST00000317058.3
CCDC101
coiled-coil domain containing 101
chr8_+_91233750 0.27 ENST00000523406.1
LINC00534
long intergenic non-protein coding RNA 534
chr12_+_4385230 0.27 ENST00000536537.1
CCND2
cyclin D2
chr13_+_113301358 0.27 ENST00000356049.1
C13orf35
chromosome 13 open reading frame 35
chr1_-_45988542 0.26 ENST00000424390.1
PRDX1
peroxiredoxin 1
chr7_-_15014398 0.26 ENST00000437998.1
DGKB
diacylglycerol kinase, beta 90kDa
chr16_+_15489629 0.26 ENST00000396385.3
MPV17L
MPV17 mitochondrial membrane protein-like
chr16_+_72459838 0.26 ENST00000564508.1
AC004158.3
AC004158.3
chr16_+_89334512 0.25 ENST00000602042.1
AC137932.1
AC137932.1
chr4_+_74301880 0.25 ENST00000395792.2
ENST00000226359.2
AFP
alpha-fetoprotein
chr20_-_656823 0.25 ENST00000246104.6
SCRT2
scratch family zinc finger 2
chr11_-_5799897 0.24 ENST00000317093.2
OR52N5
olfactory receptor, family 52, subfamily N, member 5
chr19_-_6279932 0.24 ENST00000252674.7
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr4_+_158142750 0.23 ENST00000505888.1
ENST00000449365.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr6_+_23337918 0.23 ENST00000431001.1
RP11-439H9.1
RP11-439H9.1
chr1_-_182640988 0.22 ENST00000367556.1
RGS8
regulator of G-protein signaling 8
chr11_-_327537 0.22 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr6_-_49712091 0.21 ENST00000371159.4
CRISP3
cysteine-rich secretory protein 3
chr18_+_72201829 0.21 ENST00000582365.1
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr12_-_53994805 0.21 ENST00000328463.7
ATF7
activating transcription factor 7
chrX_+_24167746 0.20 ENST00000428571.1
ENST00000539115.1
ZFX
zinc finger protein, X-linked
chr18_+_6774000 0.20 ENST00000532723.1
ARHGAP28
Rho GTPase activating protein 28
chr5_+_55149150 0.20 ENST00000297015.3
IL31RA
interleukin 31 receptor A
chr5_-_59783882 0.20 ENST00000505507.2
ENST00000502484.2
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_11287243 0.19 ENST00000539585.1
TAS2R30
taste receptor, type 2, member 30
chr14_-_57197224 0.15 ENST00000554597.1
ENST00000556696.1
RP11-1085N6.3
Uncharacterized protein
chr2_-_14541060 0.15 ENST00000418420.1
ENST00000417751.1
LINC00276
long intergenic non-protein coding RNA 276
chr2_-_231860596 0.15 ENST00000441063.1
ENST00000434094.1
ENST00000418330.1
ENST00000457803.1
ENST00000414876.1
ENST00000446741.1
ENST00000426904.1
AC105344.2
SPATA3 antisense RNA 1 (head to head)
chr4_+_71384257 0.13 ENST00000339336.4
AMTN
amelotin
chr5_+_59783941 0.12 ENST00000506884.1
ENST00000504876.2
PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr4_+_71384300 0.12 ENST00000504451.1
AMTN
amelotin
chr12_-_52761262 0.11 ENST00000257901.3
KRT85
keratin 85
chr1_-_182641037 0.09 ENST00000483095.2
RGS8
regulator of G-protein signaling 8
chr1_-_57285038 0.09 ENST00000343433.6
C1orf168
chromosome 1 open reading frame 168
chr4_-_68829226 0.09 ENST00000396188.2
TMPRSS11A
transmembrane protease, serine 11A
chr15_-_75748143 0.08 ENST00000568431.1
ENST00000568309.1
ENST00000568190.1
ENST00000570115.1
ENST00000564778.1
SIN3A
SIN3 transcription regulator family member A
chr15_+_86686953 0.08 ENST00000421325.2
AGBL1
ATP/GTP binding protein-like 1
chr2_+_78143006 0.07 ENST00000443419.1
AC073628.1
AC073628.1
chr16_-_52061283 0.07 ENST00000566314.1
C16orf97
chromosome 16 open reading frame 97
chr4_-_41749724 0.06 ENST00000510424.1
PHOX2B
paired-like homeobox 2b
chr4_-_103940791 0.06 ENST00000510559.1
ENST00000394789.3
ENST00000296422.7
SLC9B1
solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1
chr11_+_5009424 0.06 ENST00000300762.1
MMP26
matrix metallopeptidase 26
chr18_-_5197501 0.05 ENST00000580650.1
C18orf42
chromosome 18 open reading frame 42
chr6_-_49712147 0.05 ENST00000433368.2
ENST00000354620.4
CRISP3
cysteine-rich secretory protein 3
chr4_-_68829144 0.04 ENST00000508048.1
TMPRSS11A
transmembrane protease, serine 11A
chr15_-_99057551 0.04 ENST00000558256.1
FAM169B
family with sequence similarity 169, member B
chrM_+_14741 0.04 ENST00000361789.2
MT-CYB
mitochondrially encoded cytochrome b

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.7 9.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.7 4.7 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.7 2.0 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.6 4.2 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.5 1.4 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.5 2.8 GO:0038112 interleukin-8-mediated signaling pathway(GO:0038112)
0.5 1.8 GO:0014011 Schwann cell proliferation involved in axon regeneration(GO:0014011) negative regulation of Schwann cell migration(GO:1900148) regulation of Schwann cell proliferation involved in axon regeneration(GO:1905044) negative regulation of Schwann cell proliferation involved in axon regeneration(GO:1905045)
0.4 1.8 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.4 1.1 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.3 7.5 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.3 1.1 GO:0007403 glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
0.2 1.1 GO:0070101 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101)
0.2 1.8 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.2 0.6 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.2 1.8 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.2 2.1 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 1.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.2 0.9 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.2 1.4 GO:0021767 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 1.2 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 3.5 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.4 GO:1990637 response to prolactin(GO:1990637)
0.1 1.1 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.1 0.9 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.4 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.3 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
0.1 2.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 1.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 3.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 0.6 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 1.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 1.4 GO:0019388 galactose catabolic process(GO:0019388)
0.1 0.4 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.1 3.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.7 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 2.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 4.0 GO:0043486 histone exchange(GO:0043486)
0.1 1.9 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 1.1 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.1 1.7 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 0.4 GO:0050955 thermoception(GO:0050955)
0.0 0.2 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.0 0.4 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.0 1.5 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 1.0 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.8 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.8 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.8 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 1.0 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.0 0.4 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.5 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.1 GO:0021934 medulla oblongata development(GO:0021550) hindbrain tangential cell migration(GO:0021934) lateral line system development(GO:0048925)
0.0 0.4 GO:1900452 regulation of long term synaptic depression(GO:1900452)
0.0 0.9 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.8 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.7 GO:0051764 actin crosslink formation(GO:0051764)
0.0 3.0 GO:0070268 cornification(GO:0070268)
0.0 0.5 GO:0033189 response to vitamin A(GO:0033189)
0.0 0.3 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 0.8 GO:1901998 toxin transport(GO:1901998)
0.0 0.7 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.5 GO:0021983 pituitary gland development(GO:0021983)
0.0 0.2 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.8 GO:0006953 acute-phase response(GO:0006953)
0.0 0.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.5 GO:0000188 inactivation of MAPK activity(GO:0000188)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 9.6 GO:0005577 fibrinogen complex(GO:0005577)
0.2 0.7 GO:0042585 germinal vesicle(GO:0042585)
0.2 4.0 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.9 GO:1990246 uniplex complex(GO:1990246)
0.1 1.1 GO:0070369 Scrib-APC-beta-catenin complex(GO:0034750) beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.8 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.1 0.4 GO:0060076 postsynaptic density(GO:0014069) excitatory synapse(GO:0060076) postsynaptic specialization(GO:0099572)
0.1 2.8 GO:0042629 mast cell granule(GO:0042629)
0.1 1.1 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 1.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.4 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 1.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 0.3 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.4 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 1.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.5 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 1.1 GO:0097546 ciliary base(GO:0097546)
0.0 3.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.1 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 3.9 GO:0035579 specific granule membrane(GO:0035579)
0.0 1.5 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.0 0.8 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.4 GO:0032982 myosin filament(GO:0032982)
0.0 2.7 GO:0005882 intermediate filament(GO:0005882)
0.0 0.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 6.5 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.6 1.8 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.5 2.8 GO:0004918 interleukin-8 receptor activity(GO:0004918)
0.4 2.2 GO:0019770 IgG receptor activity(GO:0019770)
0.4 2.6 GO:0042806 fucose binding(GO:0042806)
0.3 1.4 GO:0003978 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
0.3 1.8 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.3 1.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.2 1.7 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.2 2.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.2 0.7 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.2 7.5 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.2 4.2 GO:0003680 AT DNA binding(GO:0003680)
0.2 1.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 1.8 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 4.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 1.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 4.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 9.6 GO:0051087 chaperone binding(GO:0051087)
0.1 2.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 4.0 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 0.8 GO:0043559 insulin binding(GO:0043559)
0.0 1.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 2.0 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.3 GO:0070300 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) phosphatidic acid binding(GO:0070300)
0.0 0.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.4 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.7 GO:0016805 dipeptidase activity(GO:0016805)
0.0 2.4 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.7 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.6 GO:0043236 laminin binding(GO:0043236)
0.0 2.1 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.4 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.7 GO:0005080 protein kinase C binding(GO:0005080)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 10.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 6.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.8 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 2.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.9 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 1.1 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.0 1.3 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 3.5 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 5.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 1.1 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 4.7 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 1.8 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.6 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 3.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 4.0 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.1 1.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 2.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.0 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 2.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 0.7 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.7 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 1.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 2.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.0 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 1.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.8 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.1 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 3.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.1 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events