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Illumina Body Map 2: averaged replicates
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Results for LHX3
Z-value: 1.57
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Transcription factors associated with LHX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LHX3 | hg19_v2_chr9_-_139094988_139095012 | -0.41 | 1.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_155484103 Show fit | 4.94 |
ENST00000302068.4
|
fibrinogen beta chain |
|
| chr4_+_155484155 Show fit | 4.68 |
ENST00000509493.1
|
fibrinogen beta chain |
|
| chr3_+_151591422 Show fit | 4.30 |
ENST00000362032.5
|
succinate receptor 1 |
|
| chr5_-_39274617 Show fit | 3.47 |
ENST00000510188.1
|
FYN binding protein |
|
| chr8_-_66750978 Show fit | 3.25 |
ENST00000523253.1
|
phosphodiesterase 7A |
|
| chr2_+_218994002 Show fit | 2.82 |
ENST00000428565.1
|
chemokine (C-X-C motif) receptor 2 |
|
| chr12_-_10282681 Show fit | 2.65 |
ENST00000533022.1
|
C-type lectin domain family 7, member A |
|
| chr7_-_36764062 Show fit | 2.61 |
ENST00000435386.1
|
acyloxyacyl hydrolase (neutrophil) |
|
| chr19_+_14693888 Show fit | 2.60 |
ENST00000547437.1
ENST00000397439.2 ENST00000417570.1 |
C-type lectin domain family 17, member A |
|
| chr2_+_135596180 Show fit | 2.60 |
ENST00000283054.4
ENST00000392928.1 |
aminocarboxymuconate semialdehyde decarboxylase |
Network of associatons between targets according to the STRING database.
First level regulatory network of LHX3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 9.6 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.3 | 7.5 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
| 0.7 | 4.7 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.6 | 4.2 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.1 | 4.0 | GO:0043486 | histone exchange(GO:0043486) |
| 0.1 | 3.5 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.1 | 3.5 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.1 | 3.2 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.0 | 3.0 | GO:0070268 | cornification(GO:0070268) |
| 0.5 | 2.8 | GO:0038112 | interleukin-8-mediated signaling pathway(GO:0038112) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 9.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 6.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 4.0 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.0 | 3.9 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.0 | 3.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 2.8 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 2.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.5 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 1.5 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 1.4 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.6 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.2 | 7.5 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 1.3 | 5.1 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.1 | 4.7 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.1 | 4.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.2 | 4.2 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 4.0 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.5 | 2.8 | GO:0004918 | interleukin-8 receptor activity(GO:0004918) |
| 0.4 | 2.6 | GO:0042806 | fucose binding(GO:0042806) |
| 0.0 | 2.4 | GO:0008013 | beta-catenin binding(GO:0008013) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.4 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.1 | 6.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 5.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.5 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.1 | 2.8 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 2.3 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 2.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 2.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.9 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 1.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.6 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 4.7 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 4.0 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 3.5 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 3.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 2.8 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.7 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 2.6 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 2.1 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 2.0 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |