Project
Illumina Body Map 2: averaged replicates
Navigation
Downloads
Results for MAFK
Z-value: 2.16
Motif logo
Transcription factors associated with MAFK
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFK | hg19_v2_chr7_+_1570322_1570360 | -0.52 | 2.1e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_69962185 Show fit | 9.39 |
ENST00000305231.7
|
UDP glucuronosyltransferase 2 family, polypeptide B7 |
|
| chr4_+_69962212 Show fit | 9.24 |
ENST00000508661.1
|
UDP glucuronosyltransferase 2 family, polypeptide B7 |
|
| chr1_+_198607801 Show fit | 4.87 |
ENST00000367379.1
|
protein tyrosine phosphatase, receptor type, C |
|
| chr5_+_101569696 Show fit | 4.72 |
ENST00000597120.1
|
AC008948.1 |
|
| chr17_-_64216748 Show fit | 3.83 |
ENST00000585162.1
|
apolipoprotein H (beta-2-glycoprotein I) |
|
| chr4_+_74275057 Show fit | 3.70 |
ENST00000511370.1
|
albumin |
|
| chr4_+_69681710 Show fit | 3.50 |
ENST00000265403.7
ENST00000458688.2 |
UDP glucuronosyltransferase 2 family, polypeptide B10 |
|
| chr1_+_158801095 Show fit | 3.47 |
ENST00000368141.4
|
myeloid cell nuclear differentiation antigen |
|
| chr14_+_21423611 Show fit | 3.41 |
ENST00000304625.2
|
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) |
|
| chr21_+_39628852 Show fit | 3.37 |
ENST00000398938.2
|
potassium inwardly-rectifying channel, subfamily J, member 15 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFK
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 34.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.3 | 33.3 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.1 | 16.5 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.3 | 8.6 | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity(GO:0045954) |
| 0.1 | 8.6 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 7.8 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 1.5 | 7.4 | GO:2000473 | regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473) |
| 0.1 | 6.8 | GO:0002228 | natural killer cell mediated immunity(GO:0002228) |
| 0.3 | 6.5 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
| 0.0 | 6.5 | GO:0009062 | fatty acid catabolic process(GO:0009062) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 59.3 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.2 | 37.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 22.0 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 13.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.2 | 12.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 11.5 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 10.6 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 10.0 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 9.3 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.5 | 8.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 40.8 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.2 | 36.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 12.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.4 | 8.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.2 | 8.7 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.1 | 7.4 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.6 | 7.0 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 2.2 | 6.7 | GO:0003973 | (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854) |
| 1.6 | 6.3 | GO:0019862 | IgA binding(GO:0019862) |
| 0.0 | 6.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 8.2 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 8.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 7.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 6.5 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 6.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 6.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 5.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 5.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 5.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 37.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.2 | 27.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 11.5 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.2 | 10.9 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.1 | 10.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.3 | 9.9 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.2 | 9.9 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.4 | 8.9 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| 0.0 | 7.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.4 | 6.9 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |