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Illumina Body Map 2: averaged replicates
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Results for MAF_NRL
Z-value: 1.83
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Transcription factors associated with MAF_NRL
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAF | hg19_v2_chr16_-_79633799_79633872 | -0.13 | 4.9e-01 | Click! |
| NRL | hg19_v2_chr14_-_24553834_24553850 | -0.08 | 6.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_57431679 Show fit | 6.95 |
ENST00000371237.4
ENST00000535057.1 ENST00000543257.1 |
complement component 8, beta polypeptide |
|
| chr11_+_116700600 Show fit | 6.02 |
ENST00000227667.3
|
apolipoprotein C-III |
|
| chr11_+_116700614 Show fit | 5.97 |
ENST00000375345.1
|
apolipoprotein C-III |
|
| chr5_-_156390230 Show fit | 4.67 |
ENST00000407087.3
ENST00000274532.2 |
T-cell immunoglobulin and mucin domain containing 4 |
|
| chr22_+_21128167 Show fit | 3.71 |
ENST00000215727.5
|
serpin peptidase inhibitor, clade D (heparin cofactor), member 1 |
|
| chr1_+_233749739 Show fit | 3.24 |
ENST00000366621.3
|
potassium channel, subfamily K, member 1 |
|
| chr9_-_116840728 Show fit | 2.87 |
ENST00000265132.3
|
alpha-1-microglobulin/bikunin precursor |
|
| chr10_+_96443378 Show fit | 2.79 |
ENST00000285979.6
|
cytochrome P450, family 2, subfamily C, polypeptide 18 |
|
| chr14_-_106237742 Show fit | 2.79 |
ENST00000390551.2
|
immunoglobulin heavy constant gamma 3 (G3m marker) |
|
| chr22_+_22712087 Show fit | 2.71 |
ENST00000390294.2
|
immunoglobulin lambda variable 1-47 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAF_NRL
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 31.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 12.7 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 4.0 | 12.0 | GO:0060621 | negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910) |
| 0.5 | 11.8 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.2 | 6.3 | GO:0019373 | epoxygenase P450 pathway(GO:0019373) |
| 1.5 | 6.0 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 1.8 | 5.5 | GO:0021919 | BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919) |
| 0.3 | 4.2 | GO:0042167 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 0.8 | 3.9 | GO:1904075 | trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 0.5 | 3.8 | GO:0048014 | Tie signaling pathway(GO:0048014) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 18.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.4 | 13.0 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.2 | 10.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.9 | 8.9 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.3 | 6.4 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 6.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 6.0 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 4.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 4.5 | GO:0005604 | basement membrane(GO:0005604) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.4 | GO:0003823 | antigen binding(GO:0003823) |
| 3.2 | 13.0 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.1 | 9.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 9.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 6.3 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.1 | 6.2 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.8 | 6.0 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.5 | 5.5 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.1 | 4.8 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 4.5 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 8.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 6.6 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 6.3 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 4.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 4.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 3.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 3.1 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 3.0 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 2.4 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 17.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 14.1 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.4 | 7.4 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.2 | 4.5 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 4.3 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.2 | 3.2 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.1 | 3.1 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 2.9 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 2.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 2.3 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |