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Illumina Body Map 2: averaged replicates
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Results for MAX_TFEB
Z-value: 1.38
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Transcription factors associated with MAX_TFEB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAX | hg19_v2_chr14_-_65569244_65569413 | 0.51 | 3.1e-03 | Click! |
| TFEB | hg19_v2_chr6_-_41703296_41703367 | 0.36 | 4.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAX_TFEB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.0 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 1.8 | 7.1 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.1 | 6.6 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.7 | 5.9 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.0 | 5.7 | GO:0000209 | protein polyubiquitination(GO:0000209) |
| 1.8 | 5.4 | GO:0072573 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) |
| 0.4 | 4.4 | GO:0021615 | glossopharyngeal nerve morphogenesis(GO:0021615) |
| 0.5 | 3.8 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.4 | 3.8 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.1 | 3.6 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.0 | GO:0016604 | nuclear body(GO:0016604) |
| 0.1 | 8.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 8.6 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 8.4 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.1 | 7.4 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.1 | 7.0 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 6.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.7 | 5.9 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 4.9 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.5 | 4.8 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.0 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 13.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 9.8 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 8.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 7.9 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.1 | 5.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.3 | 5.6 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 4.6 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.0 | 4.2 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 3.8 | GO:0008186 | ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.8 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 6.4 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.2 | 5.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 4.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 4.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 3.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 3.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 3.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 3.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.5 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.5 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.2 | 9.7 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 9.3 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.0 | 6.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 6.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 5.7 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 5.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 5.0 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 4.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 3.8 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |