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Illumina Body Map 2: averaged replicates
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Results for MAZ_ZNF281_GTF2F1
Z-value: 5.10
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Transcription factors associated with MAZ_ZNF281_GTF2F1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000103495.9 | MYC associated zinc finger protein | |
| ENSG00000162702.7 | zinc finger protein 281 | |
| ENSG00000125651.9 | general transcription factor IIF subunit 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GTF2F1 | hg19_v2_chr19_-_6393216_6393229 | 0.50 | 3.3e-03 | Click! |
| MAZ | hg19_v2_chr16_+_29819372_29819442 | 0.19 | 3.1e-01 | Click! |
| ZNF281 | hg19_v2_chr1_-_200379180_200379191 | -0.07 | 7.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAZ_ZNF281_GTF2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 97.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.9 | 70.9 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 2.7 | 61.7 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 1.0 | 46.9 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 1.9 | 44.7 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.4 | 43.7 | GO:0007269 | neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643) |
| 0.4 | 42.3 | GO:1901379 | regulation of potassium ion transmembrane transport(GO:1901379) |
| 1.1 | 41.1 | GO:0035640 | exploration behavior(GO:0035640) |
| 4.4 | 39.6 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 0.6 | 38.2 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 194.9 | GO:0043204 | perikaryon(GO:0043204) |
| 0.5 | 144.4 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.8 | 101.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 1.7 | 92.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.4 | 89.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 2.0 | 79.4 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.8 | 70.8 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 1.2 | 70.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 2.0 | 61.9 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.5 | 56.2 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 90.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.4 | 78.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.1 | 60.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 1.9 | 50.5 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 3.5 | 45.2 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.1 | 45.2 | GO:0008017 | microtubule binding(GO:0008017) |
| 2.2 | 43.5 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 1.4 | 42.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 2.8 | 42.1 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 1.1 | 41.9 | GO:0030506 | ankyrin binding(GO:0030506) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 70.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.9 | 66.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 38.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 38.5 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.5 | 36.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.5 | 34.4 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.2 | 25.8 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.5 | 24.7 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.4 | 20.4 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.8 | 20.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 78.5 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 1.3 | 68.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.9 | 62.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 1.3 | 55.7 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 1.4 | 55.2 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.8 | 52.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 1.0 | 52.7 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 1.9 | 47.8 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.7 | 42.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.5 | 38.9 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |