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Illumina Body Map 2: averaged replicates
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Results for MBD2
Z-value: 1.57
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Transcription factors associated with MBD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MBD2 | hg19_v2_chr18_-_51750948_51751059 | 0.15 | 4.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_42275153 Show fit | 4.52 |
ENST00000294964.5
|
protein kinase domain containing, cytoplasmic |
|
| chr6_-_45983581 Show fit | 3.09 |
ENST00000339561.6
|
chloride intracellular channel 5 |
|
| chr6_-_45983549 Show fit | 2.96 |
ENST00000544153.1
|
chloride intracellular channel 5 |
|
| chr6_+_17281573 Show fit | 2.84 |
ENST00000379052.5
|
RNA binding motif protein 24 |
|
| chr2_+_220299547 Show fit | 2.72 |
ENST00000312358.7
|
SPEG complex locus |
|
| chr14_-_21566731 Show fit | 2.64 |
ENST00000360947.3
|
zinc finger protein 219 |
|
| chr2_+_74212073 Show fit | 2.31 |
ENST00000441217.1
|
AC073046.25 |
|
| chr20_-_590944 Show fit | 2.21 |
ENST00000246080.3
|
transcription factor 15 (basic helix-loop-helix) |
|
| chrY_+_2803322 Show fit | 2.05 |
ENST00000383052.1
ENST00000155093.3 ENST00000449237.1 ENST00000443793.1 |
zinc finger protein, Y-linked |
|
| chr7_+_128470431 Show fit | 2.02 |
ENST00000325888.8
ENST00000346177.6 |
filamin C, gamma |
Network of associatons between targets according to the STRING database.
First level regulatory network of MBD2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.1 | GO:0050667 | homocysteine metabolic process(GO:0050667) |
| 0.3 | 6.0 | GO:0060088 | auditory receptor cell stereocilium organization(GO:0060088) |
| 0.5 | 4.5 | GO:0042997 | negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
| 0.1 | 4.0 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.1 | 3.8 | GO:0033173 | calcineurin-NFAT signaling cascade(GO:0033173) |
| 0.1 | 3.7 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
| 0.1 | 3.5 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.3 | 3.0 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.0 | 2.8 | GO:0010830 | regulation of myotube differentiation(GO:0010830) |
| 0.3 | 2.7 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.3 | 7.0 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 6.0 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.1 | 4.0 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 4.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 3.7 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.3 | 3.0 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.1 | 3.0 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.1 | 2.1 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.7 | 2.0 | GO:0072563 | endothelial microparticle(GO:0072563) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 7.0 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.1 | 5.7 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 5.1 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 4.9 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 4.6 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 4.2 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.4 | 3.8 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.0 | 3.7 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 3.5 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.4 | 3.0 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.4 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 4.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 3.5 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 3.4 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 3.2 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 2.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 2.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 2.0 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 1.6 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 3.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 2.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 2.4 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.8 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 1.6 | REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY | Genes involved in Adenylate cyclase activating pathway |
| 0.0 | 1.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.4 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 1.3 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |