ISMARA results: MECOM

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Illumina Body Map 2: averaged replicates

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Results for MECOM

Z-value: 1.35

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Transcription factors associated with MECOM

Gene Symbol	Gene ID	Gene Info
MECOM Ensembl NCBI GeneCards UniProt NextProt	ENSG00000085276.13	MDS1 and EVI1 complex locus

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MECOM	hg19_v2_chr3_-_168864427_168864464	-0.10	6.0e-01	Click!

Activity profile of MECOM motif

Sorted Z-values of MECOM motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr18_-_24722995 Show fit	1.80	ENST00000581714.1	CHST9 Ensembl NCBI GeneCards UniProt NextProt Show fit	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr12_-_86650154 Show fit	1.68	ENST00000552435.2	MGAT4C Ensembl NCBI GeneCards UniProt NextProt Show fit	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr12_-_86650045 Show fit	1.68	ENST00000604798.1	MGAT4C Ensembl NCBI GeneCards UniProt NextProt Show fit	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr10_-_21186144 Show fit	1.56	ENST00000377119.1	NEBL Ensembl NCBI GeneCards UniProt NextProt Show fit	nebulette
chr7_+_35756092 Show fit	1.45	ENST00000458087.3	AC018647.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	AC018647.3
chr7_+_35756186 Show fit	1.43	ENST00000430518.1	AC018647.3 Ensembl NCBI GeneCards UniProt NextProt Show fit	AC018647.3
chr3_-_178103144 Show fit	1.39	ENST00000417383.1 ENST00000418585.1 ENST00000411727.1 ENST00000439810.1	RP11-33A14.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-33A14.1
chr1_+_74701062 Show fit	1.37	ENST00000326637.3	TNNI3K Ensembl NCBI GeneCards UniProt NextProt Show fit	TNNI3 interacting kinase
chr12_-_86650077 Show fit	1.32	ENST00000552808.2 ENST00000547225.1	MGAT4C Ensembl NCBI GeneCards UniProt NextProt Show fit	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr1_+_172422026 Show fit	1.26	ENST00000367725.4	C1orf105 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromosome 1 open reading frame 105

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MECOM

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.5	GO:0007019	microtubule depolymerization(GO:0007019)
0.2	2.4	GO:0070327	thyroid hormone transport(GO:0070327)
0.1	2.3	GO:0086069	bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.2	2.1	GO:1902748	positive regulation of lens fiber cell differentiation(GO:1902748)
0.0	1.8	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	1.6	GO:0055003	cardiac myofibril assembly(GO:0055003)
0.0	1.6	GO:0008542	visual learning(GO:0008542)
0.1	1.5	GO:0017121	phospholipid scrambling(GO:0017121)
0.1	1.4	GO:2000576	positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1	1.1	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)

Showing 1 to 10 of 76 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	1.4	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	1.4	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	1.1	GO:0043205	microfibril(GO:0001527) fibril(GO:0043205)
0.1	1.0	GO:0042589	zymogen granule membrane(GO:0042589)
0.1	0.9	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.9	GO:0005916	fascia adherens(GO:0005916)
0.0	0.7	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.0	0.7	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.6	GO:0035686	sperm fibrous sheath(GO:0035686)

Showing 1 to 10 of 27 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	4.7	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.3	2.4	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	2.1	GO:0070412	R-SMAD binding(GO:0070412)
0.3	1.8	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	1.8	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	1.6	GO:0031005	filamin binding(GO:0031005)
0.1	1.5	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.1	1.4	GO:0031013	troponin I binding(GO:0031013)
0.1	1.3	GO:0045504	dynein heavy chain binding(GO:0045504)
0.1	1.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)

Showing 1 to 10 of 52 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.0	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.8	ST GA12 PATHWAY	G alpha 12 Pathway
0.8	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.7	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.6	PID CONE PATHWAY	Visual signal transduction: Cones
0.4	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling

Showing 1 to 6 of 6 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.7	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	2.7	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	1.8	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	1.5	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	1.3	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.0	0.8	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.7	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.7	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.6	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	0.6	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism

Showing 1 to 10 of 17 entries

Results for MECOM

Z-value: 1.35

Motif logo

Transcription factors associated with MECOM

Activity-expression correlation:

Activity profile of MECOM motif

Sorted Z-values of MECOM motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MECOM

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: