ISMARA results: MEF2D

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Illumina Body Map 2: averaged replicates

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Results for MEF2D_MEF2A

Z-value: 7.99

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Transcription factors associated with MEF2D_MEF2A

Gene Symbol	Gene ID	Gene Info
MEF2D Ensembl NCBI GeneCards UniProt NextProt	ENSG00000116604.13	myocyte enhancer factor 2D
MEF2A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000068305.13	myocyte enhancer factor 2A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MEF2A	hg19_v2_chr15_+_100106244_100106292	0.42	1.6e-02	Click!
MEF2D	hg19_v2_chr1_-_156460391_156460417	0.40	2.5e-02	Click!

Activity profile of MEF2D_MEF2A motif

Sorted Z-values of MEF2D_MEF2A motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_19223523 Show fit	72.82	ENST00000265968.3	CSRP3 Ensembl NCBI GeneCards UniProt NextProt Show fit	cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr7_-_113559104 Show fit	68.71	ENST00000284601.3	PPP1R3A Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 1, regulatory subunit 3A
chr1_-_201391149 Show fit	59.71	ENST00000555948.1 ENST00000556362.1	TNNI1 Ensembl NCBI GeneCards UniProt NextProt Show fit	troponin I type 1 (skeletal, slow)
chr2_+_168043793 Show fit	59.44	ENST00000409273.1 ENST00000409605.1	XIRP2 Ensembl NCBI GeneCards UniProt NextProt Show fit	xin actin-binding repeat containing 2
chr17_+_37821593 Show fit	59.34	ENST00000578283.1	TCAP Ensembl NCBI GeneCards UniProt NextProt Show fit	titin-cap
chr6_-_123957942 Show fit	59.30	ENST00000398178.3	TRDN Ensembl NCBI GeneCards UniProt NextProt Show fit	triadin
chr6_-_123958051 Show fit	55.87	ENST00000546248.1	TRDN Ensembl NCBI GeneCards UniProt NextProt Show fit	triadin
chr2_+_88367299 Show fit	55.78	ENST00000419482.2 ENST00000444564.2	SMYD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SET and MYND domain containing 1
chr16_-_31439735 Show fit	54.77	ENST00000287490.4	COX6A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytochrome c oxidase subunit VIa polypeptide 2
chr10_-_115423792 Show fit	53.97	ENST00000369360.3 ENST00000360478.3 ENST00000359988.3 ENST00000369358.4	NRAP Ensembl NCBI GeneCards UniProt NextProt Show fit	nebulin-related anchoring protein

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2D_MEF2A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.4	472.1	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.3	211.5	GO:0043687	post-translational protein modification(GO:0043687)
48.9	195.6	GO:1901846	positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846)
17.9	143.0	GO:0035995	detection of muscle stretch(GO:0035995)
3.1	115.3	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
10.8	108.0	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.9	101.1	GO:0032233	positive regulation of actin filament bundle assembly(GO:0032233)
0.7	97.7	GO:0005977	glycogen metabolic process(GO:0005977)
1.4	60.9	GO:0045214	sarcomere organization(GO:0045214)
0.4	60.7	GO:0006941	striated muscle contraction(GO:0006941)

Showing 1 to 10 of 179 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	503.5	GO:0031674	I band(GO:0031674)
6.8	291.5	GO:0005859	muscle myosin complex(GO:0005859)
17.7	283.4	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
9.8	236.0	GO:0005861	troponin complex(GO:0005861)
3.8	162.8	GO:0031430	M band(GO:0031430)
0.3	114.9	GO:0000151	ubiquitin ligase complex(GO:0000151)
17.1	102.6	GO:0005927	muscle tendon junction(GO:0005927)
4.7	60.8	GO:0097512	cardiac myofibril(GO:0097512)
3.4	60.3	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
14.6	58.2	GO:0005863	striated muscle myosin thick filament(GO:0005863)

Showing 1 to 10 of 86 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.2	342.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.3	267.5	GO:0003779	actin binding(GO:0003779)
0.3	242.2	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.7	187.8	GO:0044325	ion channel binding(GO:0044325)
1.2	103.7	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
1.1	103.2	GO:0008307	structural constituent of muscle(GO:0008307)
5.0	94.4	GO:0032036	myosin heavy chain binding(GO:0032036)
15.5	93.0	GO:0051373	FATZ binding(GO:0051373)
4.6	91.2	GO:0031432	titin binding(GO:0031432)
6.0	84.4	GO:0031014	troponin T binding(GO:0031014)

Showing 1 to 10 of 139 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	58.6	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
2.2	51.8	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.2	26.9	PID FGF PATHWAY	FGF signaling pathway
0.3	26.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	24.6	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.4	21.2	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	20.4	PID BMP PATHWAY	BMP receptor signaling
0.1	15.4	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.2	13.9	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	13.5	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway

Showing 1 to 10 of 33 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.2	473.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.3	96.6	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.1	83.6	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
1.4	62.9	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.5	31.9	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.4	29.5	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.3	23.3	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.8	23.1	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.6	18.7	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.2	18.6	REACTOME SIGNAL TRANSDUCTION BY L1	Genes involved in Signal transduction by L1

Showing 1 to 10 of 50 entries

Results for MEF2D_MEF2A

Z-value: 7.99

Motif logo

Transcription factors associated with MEF2D_MEF2A

Activity-expression correlation:

Activity profile of MEF2D_MEF2A motif

Sorted Z-values of MEF2D_MEF2A motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2D_MEF2A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: