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Illumina Body Map 2: averaged replicates
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Results for MEIS1
Z-value: 2.72
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Transcription factors associated with MEIS1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEIS1 | hg19_v2_chr2_+_66666432_66666462 | -0.15 | 4.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_-_36013368 Show fit | 10.21 |
ENST00000442617.1
ENST00000397326.2 ENST00000397328.1 ENST00000451685.1 |
myoglobin |
|
| chr21_+_40823753 Show fit | 7.79 |
ENST00000333634.4
|
SH3 domain binding glutamic acid-rich protein |
|
| chr7_+_123295861 Show fit | 6.51 |
ENST00000458573.2
ENST00000456238.2 |
leiomodin 2 (cardiac) |
|
| chr6_-_127780510 Show fit | 6.44 |
ENST00000487331.2
ENST00000483725.3 |
KIAA0408 |
|
| chr6_+_53883708 Show fit | 5.95 |
ENST00000514921.1
ENST00000274897.5 ENST00000370877.2 |
muscular LMNA-interacting protein |
|
| chr6_+_53948221 Show fit | 5.80 |
ENST00000460844.2
|
muscular LMNA-interacting protein |
|
| chr19_-_45826125 Show fit | 5.76 |
ENST00000221476.3
|
creatine kinase, muscle |
|
| chr6_+_53948328 Show fit | 5.74 |
ENST00000370876.2
|
muscular LMNA-interacting protein |
|
| chr14_+_32963433 Show fit | 5.45 |
ENST00000554410.1
|
A kinase (PRKA) anchor protein 6 |
|
| chr1_-_144866711 Show fit | 5.25 |
ENST00000530130.1
|
phosphodiesterase 4D interacting protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEIS1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 23.7 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.4 | 20.0 | GO:0007274 | neuromuscular synaptic transmission(GO:0007274) |
| 0.0 | 15.3 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.1 | 14.5 | GO:0034605 | cellular response to heat(GO:0034605) |
| 3.5 | 13.9 | GO:1901846 | positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846) |
| 0.3 | 13.3 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 2.1 | 12.4 | GO:0036309 | protein localization to M-band(GO:0036309) |
| 0.3 | 12.2 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.5 | 11.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.3 | 10.8 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 89.2 | GO:0030016 | myofibril(GO:0030016) |
| 0.1 | 30.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.5 | 29.4 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 28.5 | GO:0097060 | synaptic membrane(GO:0097060) |
| 0.1 | 20.1 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.1 | 19.9 | GO:0016605 | PML body(GO:0016605) |
| 1.1 | 19.4 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.0 | 17.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 16.1 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.8 | 15.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.3 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.2 | 21.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 21.5 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.1 | 21.2 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.4 | 16.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.7 | 14.9 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.2 | 13.7 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.5 | 13.5 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.4 | 13.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 12.2 | GO:0017124 | SH3 domain binding(GO:0017124) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.7 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 5.5 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.0 | 5.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 4.6 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 4.6 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 4.5 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 4.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 4.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 3.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.6 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 10.4 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.3 | 8.7 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 8.6 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 7.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 7.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 7.0 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.1 | 7.0 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 6.8 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 5.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |