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Illumina Body Map 2: averaged replicates
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Results for MEIS3_TGIF2LX
Z-value: 1.62
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Transcription factors associated with MEIS3_TGIF2LX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TGIF2LX | hg19_v2_chrX_+_89176881_89176955 | 0.15 | 4.0e-01 | Click! |
| MEIS3 | hg19_v2_chr19_-_47922373_47922572 | -0.13 | 4.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_107590383 Show fit | 5.91 |
ENST00000525934.1
ENST00000531293.1 |
sarcolipin |
|
| chr8_+_86351056 Show fit | 4.58 |
ENST00000285381.2
|
carbonic anhydrase III, muscle specific |
|
| chr19_-_45826125 Show fit | 4.37 |
ENST00000221476.3
|
creatine kinase, muscle |
|
| chr17_+_41003166 Show fit | 4.12 |
ENST00000308423.2
|
amine oxidase, copper containing 3 |
|
| chr3_+_8775466 Show fit | 3.91 |
ENST00000343849.2
ENST00000397368.2 |
caveolin 3 |
|
| chr11_+_18287721 Show fit | 3.84 |
ENST00000356524.4
|
serum amyloid A1 |
|
| chr11_+_18287801 Show fit | 3.81 |
ENST00000532858.1
ENST00000405158.2 |
serum amyloid A1 |
|
| chr12_-_54978086 Show fit | 3.63 |
ENST00000553113.1
|
protein phosphatase 1, regulatory (inhibitor) subunit 1A |
|
| chr17_-_1395954 Show fit | 3.02 |
ENST00000359786.5
|
myosin IC |
|
| chr16_+_1290694 Show fit | 2.63 |
ENST00000338844.3
|
tryptase alpha/beta 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEIS3_TGIF2LX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.7 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
| 2.0 | 5.9 | GO:1901877 | regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) |
| 0.0 | 5.2 | GO:0022617 | extracellular matrix disassembly(GO:0022617) |
| 0.1 | 4.6 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.3 | 4.4 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 1.4 | 4.1 | GO:1902283 | negative regulation of primary amine oxidase activity(GO:1902283) |
| 0.2 | 4.0 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
| 0.6 | 3.9 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.1 | 3.7 | GO:1903846 | positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846) |
| 0.5 | 3.6 | GO:0071395 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.4 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.1 | 5.9 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 5.5 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 4.2 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 4.0 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.8 | 3.0 | GO:0045160 | myosin I complex(GO:0045160) |
| 0.0 | 2.9 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 2.5 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 2.3 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 2.2 | GO:0005861 | troponin complex(GO:0005861) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 8.1 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.0 | 7.0 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 5.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.3 | 4.6 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.4 | 4.4 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 1.0 | 4.1 | GO:0052595 | tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596) |
| 0.5 | 4.0 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.3 | 3.9 | GO:0071253 | connexin binding(GO:0071253) |
| 0.2 | 3.7 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 6.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 4.5 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 4.0 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 3.9 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 3.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.6 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.0 | 1.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.1 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.7 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.7 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 6.0 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 5.3 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.3 | 4.6 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 3.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 2.5 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 2.1 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 1.8 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 1.2 | REACTOME FGFR1 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR1 ligand binding and activation |