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Illumina Body Map 2: averaged replicates
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Results for MESP1
Z-value: 1.96
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Transcription factors associated with MESP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MESP1 | hg19_v2_chr15_-_90294523_90294541 | -0.08 | 6.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_106805716 Show fit | 4.24 |
ENST00000438142.2
|
immunoglobulin heavy variable 4-31 |
|
| chr14_-_106781017 Show fit | 3.46 |
ENST00000390612.2
|
immunoglobulin heavy variable 4-28 |
|
| chr14_-_107179265 Show fit | 3.28 |
ENST00000390634.2
|
immunoglobulin heavy variable 2-70 |
|
| chr7_-_150675372 Show fit | 3.24 |
ENST00000262186.5
|
potassium voltage-gated channel, subfamily H (eag-related), member 2 |
|
| chr5_-_138725594 Show fit | 3.12 |
ENST00000302125.8
|
marginal zone B and B1 cell-specific protein |
|
| chrX_-_152939252 Show fit | 3.10 |
ENST00000340888.3
|
pregnancy up-regulated nonubiquitous CaM kinase |
|
| chr5_-_138725560 Show fit | 2.99 |
ENST00000412103.2
ENST00000457570.2 |
marginal zone B and B1 cell-specific protein |
|
| chr2_-_89161064 Show fit | 2.94 |
ENST00000390241.2
|
immunoglobulin kappa joining 2 |
|
| chr14_-_106539557 Show fit | 2.93 |
ENST00000390599.2
|
immunoglobulin heavy variable 1-8 |
|
| chr14_-_106642049 Show fit | 2.88 |
ENST00000390605.2
|
immunoglobulin heavy variable 1-18 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MESP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 54.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 14.5 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.1 | 8.5 | GO:0042100 | B cell proliferation(GO:0042100) |
| 1.0 | 6.1 | GO:2001274 | negative regulation of glucose import in response to insulin stimulus(GO:2001274) |
| 0.8 | 3.9 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.8 | 3.3 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 0.4 | 3.3 | GO:2000860 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 1.1 | 3.2 | GO:1902303 | regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303) |
| 0.1 | 3.1 | GO:0034755 | iron ion transmembrane transport(GO:0034755) |
| 0.1 | 3.1 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 25.0 | GO:0019814 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 7.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 7.3 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 6.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 5.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 5.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 5.1 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.7 | 4.7 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.0 | 3.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 3.4 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 46.6 | GO:0003823 | antigen binding(GO:0003823) |
| 0.4 | 24.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.5 | 4.2 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.0 | 4.1 | GO:0005518 | collagen binding(GO:0005518) |
| 1.0 | 3.9 | GO:0004047 | aminomethyltransferase activity(GO:0004047) |
| 0.1 | 3.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.8 | 3.3 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.1 | 3.0 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 3.0 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.1 | 3.0 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 5.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 5.4 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 4.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 4.6 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 4.1 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 4.0 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 3.7 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 3.5 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 3.3 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 4.7 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.1 | 4.3 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 4.1 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 4.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 4.0 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.2 | 3.9 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 3.9 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 3.7 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 3.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |