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Illumina Body Map 2: averaged replicates
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Results for MIXL1_GSX1_BSX_MEOX2_LHX4
Z-value: 1.70
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Transcription factors associated with MIXL1_GSX1_BSX_MEOX2_LHX4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000185155.7 | Mix paired-like homeobox | |
| ENSG00000169840.4 | GS homeobox 1 | |
| ENSG00000188909.4 | brain specific homeobox | |
| ENSG00000106511.5 | mesenchyme homeobox 2 | |
| ENSG00000121454.4 | LIM homeobox 4 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| LHX4 | hg19_v2_chr1_+_180199393_180199426 | -0.47 | 6.2e-03 | Click! |
| GSX1 | hg19_v2_chr13_+_28366780_28366780 | -0.38 | 3.0e-02 | Click! |
| BSX | hg19_v2_chr11_-_122852428_122852549 | -0.37 | 4.0e-02 | Click! |
| MEOX2 | hg19_v2_chr7_-_15726296_15726437 | -0.32 | 7.5e-02 | Click! |
| MIXL1 | hg19_v2_chr1_+_226411319_226411366 | -0.19 | 3.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_36245561 Show fit | 8.36 |
ENST00000506189.1
|
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
|
| chr6_-_32157947 Show fit | 7.76 |
ENST00000375050.4
|
pre-B-cell leukemia homeobox 2 |
|
| chr13_-_46716969 Show fit | 7.33 |
ENST00000435666.2
|
lymphocyte cytosolic protein 1 (L-plastin) |
|
| chr3_+_108541545 Show fit | 6.59 |
ENST00000295756.6
|
T cell receptor associated transmembrane adaptor 1 |
|
| chr14_+_22337014 Show fit | 6.55 |
ENST00000390436.2
|
T cell receptor alpha variable 13-1 |
|
| chrX_+_135730297 Show fit | 6.46 |
ENST00000370629.2
|
CD40 ligand |
|
| chr12_+_8666126 Show fit | 6.00 |
ENST00000299665.2
|
C-type lectin domain family 4, member D |
|
| chr3_+_108541608 Show fit | 5.50 |
ENST00000426646.1
|
T cell receptor associated transmembrane adaptor 1 |
|
| chr15_+_58430368 Show fit | 5.13 |
ENST00000558772.1
ENST00000219919.4 |
aquaporin 9 |
|
| chr2_-_158300556 Show fit | 5.05 |
ENST00000264192.3
|
cytohesin 1 interacting protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of MIXL1_GSX1_BSX_MEOX2_LHX4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.2 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 1.4 | 12.9 | GO:0001920 | negative regulation of receptor recycling(GO:0001920) |
| 1.7 | 10.0 | GO:1904823 | pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823) |
| 0.4 | 9.9 | GO:2000353 | positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.0 | 9.6 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.0 | 8.9 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 8.1 | GO:0038094 | Fc-gamma receptor signaling pathway(GO:0038094) |
| 0.3 | 8.0 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.1 | 8.0 | GO:0002292 | T cell differentiation involved in immune response(GO:0002292) |
| 0.0 | 7.9 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.3 | 17.6 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.3 | 13.5 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 12.0 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.0 | 11.0 | GO:0005769 | early endosome(GO:0005769) |
| 0.3 | 8.7 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.3 | 8.6 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.3 | 7.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 7.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 6.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.4 | 12.1 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.2 | 10.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.3 | 10.2 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 2.0 | 10.0 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.1 | 10.0 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 3.3 | 9.9 | GO:0005174 | CD40 receptor binding(GO:0005174) |
| 0.0 | 9.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.3 | 9.1 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.2 | 7.9 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.3 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 10.4 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.2 | 8.7 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 7.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 7.1 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.1 | 6.4 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 6.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 5.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 5.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 4.3 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 15.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 12.1 | REACTOME DOWNSTREAM TCR SIGNALING | Genes involved in Downstream TCR signaling |
| 0.0 | 10.3 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.7 | 9.9 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.1 | 8.9 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.3 | 8.8 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.1 | 6.9 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 6.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 6.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |