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Illumina Body Map 2: averaged replicates
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Results for MLX_USF2_USF1_PAX2
Z-value: 1.87
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Transcription factors associated with MLX_USF2_USF1_PAX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000108788.7 | MAX dimerization protein MLX | |
| ENSG00000105698.11 | upstream transcription factor 2, c-fos interacting | |
| ENSG00000158773.10 | upstream transcription factor 1 | |
| ENSG00000075891.17 | paired box 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MLX | hg19_v2_chr17_+_40719073_40719092 | 0.39 | 2.9e-02 | Click! |
| USF1 | hg19_v2_chr1_-_161015752_161015778 | 0.35 | 4.6e-02 | Click! |
| USF2 | hg19_v2_chr19_+_35759824_35759891 | 0.20 | 2.7e-01 | Click! |
| PAX2 | hg19_v2_chr10_+_102505468_102505546 | -0.14 | 4.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_44520009 Show fit | 7.14 |
ENST00000607482.1
ENST00000372459.2 |
cathepsin A |
|
| chr20_+_44519948 Show fit | 7.09 |
ENST00000354880.5
ENST00000191018.5 |
cathepsin A |
|
| chr6_+_160390102 Show fit | 4.88 |
ENST00000356956.1
|
insulin-like growth factor 2 receptor |
|
| chr2_-_220042825 Show fit | 4.41 |
ENST00000409789.1
|
cyclin Pas1/PHO80 domain containing 1 |
|
| chrX_+_128913906 Show fit | 4.24 |
ENST00000356892.3
|
SAM and SH3 domain containing 3 |
|
| chr17_-_76124711 Show fit | 3.90 |
ENST00000306591.7
ENST00000590602.1 |
transmembrane channel-like 6 |
|
| chr20_-_44519839 Show fit | 3.81 |
ENST00000372518.4
|
neuralized E3 ubiquitin protein ligase 2 |
|
| chr19_+_1067271 Show fit | 3.81 |
ENST00000536472.1
ENST00000590214.1 |
histocompatibility (minor) HA-1 |
|
| chr12_-_58146128 Show fit | 3.78 |
ENST00000551800.1
ENST00000549606.1 ENST00000257904.6 |
cyclin-dependent kinase 4 |
|
| chr6_-_33385655 Show fit | 3.78 |
ENST00000440279.3
ENST00000607266.1 |
cutA divalent cation tolerance homolog (E. coli) |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLX_USF2_USF1_PAX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 14.3 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 0.0 | 13.7 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.3 | 11.3 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.8 | 10.1 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.0 | 9.7 | GO:0010038 | response to metal ion(GO:0010038) |
| 1.4 | 9.5 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.5 | 9.1 | GO:0060155 | platelet dense granule organization(GO:0060155) |
| 0.1 | 8.5 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.3 | 7.0 | GO:0090520 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.5 | 6.8 | GO:0033299 | secretion of lysosomal enzymes(GO:0033299) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 39.6 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 21.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 2.2 | 15.5 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 0.1 | 13.9 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.1 | 13.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 12.4 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 12.3 | GO:0016605 | PML body(GO:0016605) |
| 0.3 | 10.4 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 8.8 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.4 | 8.6 | GO:0030897 | HOPS complex(GO:0030897) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 15.8 | GO:0004308 | exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) |
| 0.0 | 14.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 11.7 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.3 | 10.2 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.2 | 9.5 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 9.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.3 | 8.2 | GO:0015929 | hexosaminidase activity(GO:0015929) |
| 0.1 | 7.3 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.5 | 7.2 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 1.2 | 7.0 | GO:0046624 | sphingolipid transporter activity(GO:0046624) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 11.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 8.9 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.2 | 8.7 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 8.0 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 7.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 6.6 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.2 | 5.8 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 5.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 5.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 31.0 | REACTOME TRANS GOLGI NETWORK VESICLE BUDDING | Genes involved in trans-Golgi Network Vesicle Budding |
| 0.4 | 26.5 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.3 | 13.2 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.0 | 9.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 7.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 6.8 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 6.7 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.3 | 6.4 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 6.3 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 5.8 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |