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Illumina Body Map 2: averaged replicates
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Results for MYBL2
Z-value: 3.86
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Transcription factors associated with MYBL2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYBL2 | hg19_v2_chr20_+_42295745_42295797 | 0.59 | 3.6e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYBL2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 35.6 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.2 | 28.6 | GO:0007286 | spermatid development(GO:0007286) |
| 0.2 | 24.3 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.4 | 19.7 | GO:0007099 | centriole replication(GO:0007099) |
| 0.3 | 17.9 | GO:0035036 | sperm-egg recognition(GO:0035036) |
| 3.3 | 13.2 | GO:0000711 | meiotic DNA repair synthesis(GO:0000711) |
| 0.7 | 12.8 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 0.4 | 12.7 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.7 | 12.6 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 3.9 | 11.8 | GO:0051039 | histone displacement(GO:0001207) positive regulation of transcription involved in meiotic cell cycle(GO:0051039) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.3 | GO:0031514 | motile cilium(GO:0031514) |
| 0.5 | 17.4 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 0.1 | 16.3 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 16.3 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.3 | 14.4 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.3 | 13.3 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.2 | 12.6 | GO:0045171 | intercellular bridge(GO:0045171) |
| 2.8 | 11.3 | GO:0030849 | autosome(GO:0030849) |
| 0.6 | 9.4 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.3 | 9.2 | GO:0097431 | mitotic spindle pole(GO:0097431) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 18.8 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.2 | 13.6 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.7 | 13.5 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.1 | 13.2 | GO:0051087 | chaperone binding(GO:0051087) |
| 1.1 | 12.0 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.2 | 11.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 11.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.1 | 11.0 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.2 | 11.0 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.3 | 10.8 | GO:0045503 | dynein light chain binding(GO:0045503) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 14.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 6.4 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 4.9 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 4.4 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 3.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 1.2 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| 0.1 | 0.9 | PID NECTIN PATHWAY | Nectin adhesion pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 14.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 13.0 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.5 | 8.4 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.2 | 7.3 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 6.2 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.4 | 5.4 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.0 | 4.3 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.1 | 4.2 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.1 | 3.8 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |