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Illumina Body Map 2: averaged replicates
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Results for MYF6
Z-value: 2.73
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Transcription factors associated with MYF6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYF6 | hg19_v2_chr12_+_81101277_81101321 | -0.24 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_108518986 Show fit | 8.17 |
ENST00000375915.2
|
family with sequence similarity 155, member A |
|
| chr2_+_79740118 Show fit | 7.15 |
ENST00000496558.1
ENST00000451966.1 |
catenin (cadherin-associated protein), alpha 2 |
|
| chr22_-_21905120 Show fit | 5.57 |
ENST00000331505.5
|
RIMS binding protein 3C |
|
| chr2_+_115199876 Show fit | 5.46 |
ENST00000436732.1
ENST00000410059.1 |
dipeptidyl-peptidase 10 (non-functional) |
|
| chr2_+_105471969 Show fit | 5.14 |
ENST00000361360.2
|
POU class 3 homeobox 3 |
|
| chr4_-_168155700 Show fit | 4.51 |
ENST00000357545.4
ENST00000512648.1 |
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 |
|
| chr4_-_168155730 Show fit | 4.36 |
ENST00000502330.1
ENST00000357154.3 |
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 |
|
| chr7_+_96635277 Show fit | 3.86 |
ENST00000007660.5
|
distal-less homeobox 6 |
|
| chrX_-_92928557 Show fit | 3.77 |
ENST00000373079.3
ENST00000475430.2 |
nucleosome assembly protein 1-like 3 |
|
| chr10_+_25463951 Show fit | 3.56 |
ENST00000376351.3
|
G protein-coupled receptor 158 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYF6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 20.2 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.3 | 15.3 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 9.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 9.0 | GO:0008038 | neuron recognition(GO:0008038) |
| 0.2 | 8.3 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.5 | 7.4 | GO:0060083 | smooth muscle contraction involved in micturition(GO:0060083) |
| 0.5 | 7.4 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
| 0.3 | 6.9 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 0.2 | 6.9 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.4 | 6.8 | GO:0098703 | calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 32.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 28.2 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 19.6 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 15.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.4 | 14.8 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 14.4 | GO:0043679 | axon terminus(GO:0043679) |
| 0.5 | 8.2 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.3 | 7.4 | GO:0016471 | vacuolar proton-transporting V-type ATPase complex(GO:0016471) |
| 0.1 | 6.6 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 6.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 20.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.8 | 12.9 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.1 | 11.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 8.9 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.1 | 8.1 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.1 | 7.0 | GO:0030507 | spectrin binding(GO:0030507) |
| 2.3 | 6.8 | GO:0015275 | stretch-activated, cation-selective, calcium channel activity(GO:0015275) |
| 1.6 | 6.5 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.1 | 6.2 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 5.8 | GO:0005525 | GTP binding(GO:0005525) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 16.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 9.7 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 6.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 6.5 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 4.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 4.3 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 3.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 3.3 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.1 | 3.2 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 11.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 9.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 8.9 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.2 | 6.7 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.3 | 6.3 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.1 | 5.6 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.2 | 5.3 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 4.7 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.1 | 4.2 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |