ISMARA results: MYOD1

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Illumina Body Map 2: averaged replicates

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Results for MYOD1

Z-value: 5.35

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Transcription factors associated with MYOD1

Gene Symbol	Gene ID	Gene Info
MYOD1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000129152.3	myogenic differentiation 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MYOD1	hg19_v2_chr11_+_17741111_17741124	0.80	4.4e-08	Click!

Activity profile of MYOD1 motif

Sorted Z-values of MYOD1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_152590946 Show fit	28.32	ENST00000172853.10	NEB Ensembl NCBI GeneCards UniProt NextProt Show fit	nebulin
chr3_+_42727011 Show fit	25.64	ENST00000287777.4	KLHL40 Ensembl NCBI GeneCards UniProt NextProt Show fit	kelch-like family member 40
chr20_+_30407151 Show fit	23.22	ENST00000375985.4	MYLK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin light chain kinase 2
chr20_+_30407105 Show fit	23.22	ENST00000375994.2	MYLK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin light chain kinase 2
chr17_+_33474826 Show fit	22.31	ENST00000268876.5 ENST00000433649.1 ENST00000378449.1	UNC45B Ensembl NCBI GeneCards UniProt NextProt Show fit	unc-45 homolog B (C. elegans)
chr17_+_33474860 Show fit	20.80	ENST00000394570.2	UNC45B Ensembl NCBI GeneCards UniProt NextProt Show fit	unc-45 homolog B (C. elegans)
chr8_-_41522779 Show fit	20.31	ENST00000522231.1 ENST00000314214.8 ENST00000348036.4 ENST00000457297.1 ENST00000522543.1	ANK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin 1, erythrocytic
chr8_-_41522719 Show fit	20.30	ENST00000335651.6	ANK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin 1, erythrocytic
chr16_+_30387141 Show fit	19.98	ENST00000566955.1	MYLPF Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle
chr19_-_45826125 Show fit	19.59	ENST00000221476.3	CKM Ensembl NCBI GeneCards UniProt NextProt Show fit	creatine kinase, muscle

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MYOD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	134.9	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
8.6	60.2	GO:0032971	regulation of muscle filament sliding(GO:0032971)
6.5	58.7	GO:0048630	skeletal muscle tissue growth(GO:0048630)
0.2	46.1	GO:0007519	skeletal muscle tissue development(GO:0007519)
8.9	44.4	GO:0007525	somatic muscle development(GO:0007525)
0.3	43.1	GO:0061077	chaperone-mediated protein folding(GO:0061077)
3.3	42.8	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)
1.6	40.8	GO:0035090	maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
2.4	35.5	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
0.2	34.6	GO:0043271	negative regulation of ion transport(GO:0043271)

Showing 1 to 10 of 252 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	158.4	GO:0030017	sarcomere(GO:0030017)
2.6	121.5	GO:0005859	muscle myosin complex(GO:0005859)
4.0	95.8	GO:0005861	troponin complex(GO:0005861)
1.0	74.7	GO:0031672	A band(GO:0031672)
2.5	70.9	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
2.1	61.8	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.4	46.1	GO:0034707	chloride channel complex(GO:0034707)
0.4	37.0	GO:0016528	sarcoplasm(GO:0016528)
0.9	24.6	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
1.4	24.3	GO:0099634	postsynaptic specialization membrane(GO:0099634)

Showing 1 to 10 of 109 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	202.6	GO:0008307	structural constituent of muscle(GO:0008307)
2.8	70.9	GO:0022848	acetylcholine-gated cation channel activity(GO:0022848)
0.1	65.7	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
3.9	54.5	GO:0031014	troponin T binding(GO:0031014)
0.3	47.2	GO:0005254	chloride channel activity(GO:0005254)
4.6	46.4	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.6	43.1	GO:0051879	Hsp90 protein binding(GO:0051879)
1.7	40.6	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
1.8	27.2	GO:0031433	telethonin binding(GO:0031433)
1.2	27.0	GO:0005344	oxygen transporter activity(GO:0005344)

Showing 1 to 10 of 186 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	49.2	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.6	46.6	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.3	32.7	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.1	14.3	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.1	9.8	PID FOXO PATHWAY	FoxO family signaling
0.1	9.1	PID NOTCH PATHWAY	Notch signaling pathway
0.1	8.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.5	7.5	PID ENDOTHELIN PATHWAY	Endothelins
0.1	7.3	PID AURORA B PATHWAY	Aurora B signaling
0.3	5.8	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	190.0	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.7	86.6	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
3.9	70.9	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1	32.4	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1	29.7	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.6	16.0	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.4	15.3	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.2	13.9	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.3	12.1	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.4	11.9	REACTOME PURINE SALVAGE	Genes involved in Purine salvage

Showing 1 to 10 of 49 entries

Results for MYOD1

Z-value: 5.35

Motif logo

Transcription factors associated with MYOD1

Activity-expression correlation:

Activity profile of MYOD1 motif

Sorted Z-values of MYOD1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MYOD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: