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Illumina Body Map 2: averaged replicates
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Results for MZF1
Z-value: 2.08
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Transcription factors associated with MZF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MZF1 | hg19_v2_chr19_-_59084647_59084721 | -0.35 | 4.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_32157947 Show fit | 4.68 |
ENST00000375050.4
|
pre-B-cell leukemia homeobox 2 |
|
| chr5_+_82767284 Show fit | 3.33 |
ENST00000265077.3
|
versican |
|
| chr9_-_35650900 Show fit | 3.31 |
ENST00000259608.3
|
signaling threshold regulating transmembrane adaptor 1 |
|
| chr11_-_46142505 Show fit | 3.12 |
ENST00000524497.1
ENST00000418153.2 |
PHD finger protein 21A |
|
| chr1_+_167599330 Show fit | 3.03 |
ENST00000367854.3
ENST00000361496.3 |
RCSD domain containing 1 |
|
| chr1_+_154975110 Show fit | 2.90 |
ENST00000535420.1
ENST00000368426.3 |
zinc finger and BTB domain containing 7B |
|
| chrX_+_64808248 Show fit | 2.84 |
ENST00000609672.1
|
moesin |
|
| chr1_+_154975258 Show fit | 2.71 |
ENST00000417934.2
|
zinc finger and BTB domain containing 7B |
|
| chr11_-_46142615 Show fit | 2.60 |
ENST00000529734.1
ENST00000323180.6 |
PHD finger protein 21A |
|
| chr17_+_4618734 Show fit | 2.58 |
ENST00000571206.1
|
arrestin, beta 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MZF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.3 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.2 | 11.0 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 0.2 | 8.6 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.0 | 7.8 | GO:0043312 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.1 | 7.5 | GO:0031295 | T cell costimulation(GO:0031295) |
| 1.3 | 6.6 | GO:0002032 | desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032) |
| 0.0 | 6.4 | GO:0016575 | histone deacetylation(GO:0016575) |
| 0.8 | 6.3 | GO:0044334 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730) |
| 0.2 | 6.3 | GO:0010867 | positive regulation of triglyceride biosynthetic process(GO:0010867) |
| 1.4 | 5.7 | GO:2000173 | regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.6 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.1 | 9.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 9.0 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 8.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 7.8 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 7.6 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.8 | 6.3 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.0 | 6.3 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 5.8 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.9 | 5.3 | GO:0071595 | Nem1-Spo7 phosphatase complex(GO:0071595) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.0 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 11.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.3 | 10.5 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.2 | 10.0 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 7.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 7.6 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 7.4 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 7.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.3 | 7.2 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.1 | 6.7 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.4 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 13.3 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.4 | 12.4 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.3 | 12.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 8.8 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 8.4 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 8.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 7.2 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.2 | 7.1 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 5.8 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.9 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 10.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 8.9 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.1 | 6.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 6.7 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 5.1 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 5.0 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 4.6 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 4.3 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 4.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |