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Illumina Body Map 2: averaged replicates
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Results for NFATC2_NFATC3
Z-value: 2.54
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Transcription factors associated with NFATC2_NFATC3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFATC2 | hg19_v2_chr20_-_50179368_50179392 | -0.45 | 9.1e-03 | Click! |
| NFATC3 | hg19_v2_chr16_+_68119247_68119293 | -0.21 | 2.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFATC2_NFATC3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 23.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.2 | 18.3 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.1 | 16.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 13.9 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.3 | 13.1 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.3 | 11.5 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 3.6 | 10.9 | GO:1902362 | melanocyte apoptotic process(GO:1902362) |
| 0.8 | 10.7 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 9.7 | GO:0008542 | visual learning(GO:0008542) |
| 1.3 | 7.8 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 31.3 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 29.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.6 | 18.1 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 11.5 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 11.1 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.6 | 10.9 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 1.0 | 10.7 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 10.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.5 | 10.4 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 8.4 | GO:0016235 | aggresome(GO:0016235) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 41.6 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 34.6 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.4 | 17.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 13.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 12.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 11.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 10.9 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.1 | 10.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.3 | 9.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 8.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 25.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.3 | 23.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 19.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 13.4 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 7.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 6.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 6.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 6.0 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 5.5 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 28.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.7 | 21.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 12.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.7 | 11.7 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.2 | 10.5 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 8.5 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.3 | 8.3 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.2 | 7.3 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 6.7 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 4.9 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |