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Illumina Body Map 2: averaged replicates
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Results for NFIA
Z-value: 2.69
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Transcription factors associated with NFIA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFIA | hg19_v2_chr1_+_61330931_61331017 | 0.58 | 4.5e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFIA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.9 | GO:0006936 | muscle contraction(GO:0006936) |
| 1.6 | 11.1 | GO:0032971 | regulation of muscle filament sliding(GO:0032971) |
| 2.4 | 9.7 | GO:1901846 | positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846) |
| 0.4 | 8.9 | GO:2001212 | regulation of vasculogenesis(GO:2001212) |
| 0.5 | 7.6 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.1 | 7.5 | GO:0033275 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.7 | 7.4 | GO:0070777 | gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.6 | 7.3 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.0 | 7.3 | GO:0060047 | heart contraction(GO:0060047) |
| 1.4 | 7.1 | GO:0014878 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 22.8 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 19.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.1 | 17.1 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.2 | 12.9 | GO:0031430 | M band(GO:0031430) |
| 1.2 | 12.4 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 11.3 | GO:0044297 | cell body(GO:0044297) |
| 0.0 | 8.3 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 7.8 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 1.0 | 7.6 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.0 | 6.8 | GO:0030017 | sarcomere(GO:0030017) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.1 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.1 | 14.4 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 10.0 | GO:0003774 | motor activity(GO:0003774) |
| 0.2 | 7.6 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.7 | 7.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.2 | 7.4 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.3 | 7.1 | GO:0031432 | titin binding(GO:0031432) |
| 0.0 | 6.9 | GO:0008201 | heparin binding(GO:0008201) |
| 0.7 | 6.5 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.2 | 6.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 12.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 5.1 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 4.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 4.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 4.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 3.6 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 3.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 3.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 10.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 9.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 9.2 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 7.1 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 6.6 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 4.6 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.1 | 4.4 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 4.2 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.2 | 3.3 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |