Motif ID: NKX2-1

Z-value: 1.348


Transcription factors associated with NKX2-1:

Gene SymbolEntrez IDGene Name
NKX2-1 ENSG00000136352.13 NKX2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-1hg19_v2_chr14_-_36990061_369901540.569.4e-04Click!


Activity profile for motif NKX2-1.

activity profile for motif NKX2-1


Sorted Z-values histogram for motif NKX2-1

Sorted Z-values for motif NKX2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_101962128 5.965 ENST00000550514.1
MYBPC1
myosin binding protein C, slow type
chr3_-_42744312 3.442 ENST00000416756.1
ENST00000441594.1
HHATL

hedgehog acyltransferase-like

chr20_+_30407151 3.250 ENST00000375985.4
MYLK2
myosin light chain kinase 2
chr20_+_30407105 3.170 ENST00000375994.2
MYLK2
myosin light chain kinase 2
chr17_-_10452929 3.112 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
MYH2


myosin, heavy chain 2, skeletal muscle, adult


chr19_+_38924316 3.096 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
RYR1


ryanodine receptor 1 (skeletal)


chr9_-_97356075 2.802 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chr2_+_168043793 2.433 ENST00000409273.1
ENST00000409605.1
XIRP2

xin actin-binding repeat containing 2

chr8_+_22019168 2.379 ENST00000318561.3
ENST00000521315.1
ENST00000437090.2
ENST00000520605.1
ENST00000522109.1
ENST00000524255.1
ENST00000523296.1
ENST00000518615.1
SFTPC







surfactant protein C







chr3_-_42744270 1.853 ENST00000457462.1
HHATL
hedgehog acyltransferase-like
chr6_-_113953705 1.844 ENST00000452675.1
RP11-367G18.1
RP11-367G18.1
chr3_-_42744130 1.741 ENST00000417472.1
ENST00000442469.1
HHATL

hedgehog acyltransferase-like

chr15_-_42448788 1.738 ENST00000382396.4
ENST00000397272.3
PLA2G4F

phospholipase A2, group IVF

chr10_-_81320151 1.671 ENST00000372325.2
ENST00000372327.5
ENST00000417041.1
SFTPA2


surfactant protein A2


chr6_-_117747015 1.611 ENST00000368508.3
ENST00000368507.3
ROS1

c-ros oncogene 1 , receptor tyrosine kinase

chr17_-_1508379 1.531 ENST00000412517.3
SLC43A2
solute carrier family 43 (amino acid system L transporter), member 2
chr3_+_121311966 1.447 ENST00000338040.4
FBXO40
F-box protein 40
chr14_+_81421710 1.428 ENST00000342443.6
TSHR
thyroid stimulating hormone receptor
chr16_+_28303804 1.393 ENST00000341901.4
SBK1
SH3 domain binding kinase 1
chr14_+_81421355 1.333 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr14_+_81421921 1.276 ENST00000554263.1
ENST00000554435.1
TSHR

thyroid stimulating hormone receptor

chrX_+_22056165 1.201 ENST00000535894.1
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr14_+_81421861 1.193 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr5_-_58335281 1.113 ENST00000358923.6
PDE4D
phosphodiesterase 4D, cAMP-specific
chr5_-_58571935 1.106 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr14_+_94393605 1.082 ENST00000556222.1
ENST00000554404.1
ENST00000557000.2
FAM181A


family with sequence similarity 181, member A


chr2_+_220299547 1.061 ENST00000312358.7
SPEG
SPEG complex locus
chr2_-_85895295 1.058 ENST00000428225.1
ENST00000519937.2
SFTPB

surfactant protein B

chr17_-_42466864 0.982 ENST00000353281.4
ENST00000262407.5
ITGA2B

integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)

chr6_+_43968306 0.967 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223


chromosome 6 open reading frame 223


chr17_+_59529743 0.944 ENST00000589003.1
ENST00000393853.4
TBX4

T-box 4

chr14_+_22362613 0.920 ENST00000390438.2
TRAV8-4
T cell receptor alpha variable 8-4
chr11_+_60223225 0.905 ENST00000524807.1
ENST00000345732.4
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr7_-_24957699 0.848 ENST00000441059.1
ENST00000415162.1
OSBPL3

oxysterol binding protein-like 3

chr6_-_160679905 0.843 ENST00000366953.3
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr10_+_63808970 0.831 ENST00000309334.5
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr3_+_155755482 0.823 ENST00000472028.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr11_+_35160709 0.795 ENST00000415148.2
ENST00000433354.2
ENST00000449691.2
ENST00000437706.2
ENST00000360158.4
ENST00000428726.2
ENST00000526669.2
ENST00000433892.2
ENST00000278386.6
ENST00000434472.2
ENST00000352818.4
ENST00000442151.2
CD44











CD44 molecule (Indian blood group)











chrX_-_108976410 0.783 ENST00000504980.1
ACSL4
acyl-CoA synthetase long-chain family member 4
chr3_-_139195350 0.781 ENST00000232217.2
RBP2
retinol binding protein 2, cellular
chr13_-_41240717 0.756 ENST00000379561.5
FOXO1
forkhead box O1
chr17_-_49198216 0.752 ENST00000262013.7
ENST00000357122.4
SPAG9

sperm associated antigen 9

chr6_-_134373732 0.733 ENST00000275230.5
SLC2A12
solute carrier family 2 (facilitated glucose transporter), member 12
chrX_-_108976449 0.731 ENST00000469857.1
ACSL4
acyl-CoA synthetase long-chain family member 4
chr15_+_74911430 0.725 ENST00000562670.1
ENST00000564096.1
CLK3

CDC-like kinase 3

chr6_-_41673552 0.724 ENST00000419574.1
ENST00000445214.1
TFEB

transcription factor EB

chr1_-_17338386 0.709 ENST00000341676.5
ENST00000452699.1
ATP13A2

ATPase type 13A2

chr19_+_55014085 0.702 ENST00000351841.2
LAIR2
leukocyte-associated immunoglobulin-like receptor 2
chr19_-_10679644 0.696 ENST00000393599.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr16_+_640055 0.686 ENST00000568586.1
ENST00000538492.1
ENST00000248139.3
RAB40C


RAB40C, member RAS oncogene family


chr9_+_109685630 0.678 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr20_+_825275 0.666 ENST00000541082.1
FAM110A
family with sequence similarity 110, member A
chr12_-_54694758 0.653 ENST00000553070.1
NFE2
nuclear factor, erythroid 2
chr17_-_76778339 0.650 ENST00000591455.1
ENST00000446868.3
ENST00000361101.4
ENST00000589296.1
CYTH1



cytohesin 1



chr6_-_87804815 0.645 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr14_-_106068065 0.632 ENST00000390541.2
IGHE
immunoglobulin heavy constant epsilon
chr22_-_30968813 0.629 ENST00000443111.2
ENST00000443136.1
ENST00000426220.1
GAL3ST1


galactose-3-O-sulfotransferase 1


chr22_-_30968839 0.608 ENST00000445645.1
ENST00000416358.1
ENST00000423371.1
ENST00000411821.1
ENST00000448604.1
GAL3ST1




galactose-3-O-sulfotransferase 1




chr1_-_153538011 0.603 ENST00000368707.4
S100A2
S100 calcium binding protein A2
chr6_-_26056695 0.594 ENST00000343677.2
HIST1H1C
histone cluster 1, H1c
chr11_-_105948040 0.563 ENST00000534815.1
KBTBD3
kelch repeat and BTB (POZ) domain containing 3
chr11_+_60223312 0.559 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
MS4A1




membrane-spanning 4-domains, subfamily A, member 1




chr6_+_31674639 0.558 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
LY6G6F

MEGT1
lymphocyte antigen 6 complex, locus G6F

HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr17_+_40610862 0.555 ENST00000393829.2
ENST00000546249.1
ENST00000537728.1
ENST00000264649.6
ENST00000585525.1
ENST00000343619.4
ENST00000544137.1
ENST00000589727.1
ENST00000587824.1
ATP6V0A1








ATPase, H+ transporting, lysosomal V0 subunit a1








chr12_-_719573 0.545 ENST00000397265.3
NINJ2
ninjurin 2
chr15_-_94614049 0.537 ENST00000556447.1
ENST00000555772.1
CTD-3049M7.1

CTD-3049M7.1

chr8_-_16859690 0.537 ENST00000180166.5
FGF20
fibroblast growth factor 20
chrX_+_23928500 0.537 ENST00000435707.1
CXorf58
chromosome X open reading frame 58
chr9_+_33290491 0.532 ENST00000379540.3
ENST00000379521.4
ENST00000318524.6
NFX1


nuclear transcription factor, X-box binding 1


chr1_+_66999268 0.528 ENST00000371039.1
ENST00000424320.1
SGIP1

SH3-domain GRB2-like (endophilin) interacting protein 1

chr1_-_153538292 0.524 ENST00000497140.1
ENST00000368708.3
S100A2

S100 calcium binding protein A2

chr3_-_56950407 0.509 ENST00000496106.1
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr8_-_114389353 0.484 ENST00000343508.3
CSMD3
CUB and Sushi multiple domains 3
chr1_-_175712665 0.474 ENST00000263525.2
TNR
tenascin R
chr8_+_145203548 0.469 ENST00000534366.1
MROH1
maestro heat-like repeat family member 1
chr1_-_228604328 0.465 ENST00000355586.4
ENST00000366698.2
ENST00000520264.1
ENST00000479800.1
ENST00000295033.3
TRIM17




tripartite motif containing 17




chr3_-_11685345 0.450 ENST00000430365.2
VGLL4
vestigial like 4 (Drosophila)
chr7_-_142583506 0.444 ENST00000359396.3
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr14_-_74892805 0.442 ENST00000331628.3
ENST00000554953.1
SYNDIG1L

synapse differentiation inducing 1-like

chr21_+_45773515 0.442 ENST00000397932.2
ENST00000300481.9
TRPM2

transient receptor potential cation channel, subfamily M, member 2

chr9_+_129986734 0.441 ENST00000444677.1
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr8_-_144679602 0.431 ENST00000526710.1
EEF1D
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr19_-_39390212 0.430 ENST00000437828.1
SIRT2
sirtuin 2
chr21_-_36421401 0.428 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr19_-_51336443 0.424 ENST00000598673.1
KLK15
kallikrein-related peptidase 15
chr15_-_102463298 0.418 ENST00000326183.3
OR4F4
olfactory receptor, family 4, subfamily F, member 4
chr15_+_76030311 0.415 ENST00000543887.1
AC019294.1
AC019294.1
chr11_-_105948129 0.413 ENST00000526793.1
KBTBD3
kelch repeat and BTB (POZ) domain containing 3
chr5_+_131705438 0.400 ENST00000245407.3
SLC22A5
solute carrier family 22 (organic cation/carnitine transporter), member 5
chr10_+_111967345 0.390 ENST00000332674.5
ENST00000453116.1
MXI1

MAX interactor 1, dimerization protein

chr1_-_175712829 0.388 ENST00000367674.2
TNR
tenascin R
chr3_+_19189946 0.385 ENST00000328405.2
KCNH8
potassium voltage-gated channel, subfamily H (eag-related), member 8
chr17_+_61554829 0.378 ENST00000582627.1
ACE
angiotensin I converting enzyme
chr11_-_15643937 0.377 ENST00000533082.1
RP11-531H8.2
RP11-531H8.2
chr9_+_133986782 0.366 ENST00000372301.2
AIF1L
allograft inflammatory factor 1-like
chr6_-_71012773 0.365 ENST00000370496.3
ENST00000357250.6
COL9A1

collagen, type IX, alpha 1

chr5_-_134783038 0.360 ENST00000503143.2
C5orf20
chromosome 5 open reading frame 20
chr8_+_118147498 0.354 ENST00000519688.1
ENST00000456015.2
SLC30A8

solute carrier family 30 (zinc transporter), member 8

chr8_+_70404996 0.338 ENST00000402687.4
ENST00000419716.3
SULF1

sulfatase 1

chr14_+_67708137 0.335 ENST00000556345.1
ENST00000555925.1
ENST00000557783.1
MPP5


membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)


chr15_-_33360085 0.322 ENST00000334528.9
FMN1
formin 1
chr18_+_13382553 0.315 ENST00000586222.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr19_-_39390350 0.313 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
SIRT2


sirtuin 2


chr6_-_42858534 0.309 ENST00000408925.2
C6orf226
chromosome 6 open reading frame 226
chr20_-_35724388 0.305 ENST00000344359.3
ENST00000373664.3
RBL1

retinoblastoma-like 1 (p107)

chr16_+_640201 0.301 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr16_-_18937072 0.296 ENST00000569122.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr19_+_48972459 0.295 ENST00000427476.1
CYTH2
cytohesin 2
chr17_-_34195889 0.289 ENST00000311880.2
C17orf66
chromosome 17 open reading frame 66
chr10_-_103454876 0.285 ENST00000331272.7
FBXW4
F-box and WD repeat domain containing 4
chr2_+_220379052 0.285 ENST00000347842.3
ENST00000358078.4
ASIC4

acid-sensing (proton-gated) ion channel family member 4

chr19_+_50148087 0.276 ENST00000601038.1
ENST00000595242.1
SCAF1

SR-related CTD-associated factor 1

chr19_+_48972265 0.274 ENST00000452733.2
CYTH2
cytohesin 2
chr17_-_37123646 0.273 ENST00000378079.2
FBXO47
F-box protein 47
chr7_-_27224795 0.273 ENST00000006015.3
HOXA11
homeobox A11
chrX_+_136648297 0.266 ENST00000287538.5
ZIC3
Zic family member 3
chr7_-_142583478 0.265 ENST00000436401.1
TRPV6
transient receptor potential cation channel, subfamily V, member 6
chr10_+_82300575 0.265 ENST00000313455.4
SH2D4B
SH2 domain containing 4B
chr12_+_56401268 0.257 ENST00000262032.5
IKZF4
IKAROS family zinc finger 4 (Eos)
chr1_-_247876105 0.256 ENST00000302084.2
OR6F1
olfactory receptor, family 6, subfamily F, member 1
chr4_+_55524085 0.255 ENST00000412167.2
ENST00000288135.5
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr10_+_102222798 0.248 ENST00000343737.5
WNT8B
wingless-type MMTV integration site family, member 8B
chr16_+_2022036 0.247 ENST00000568546.1
TBL3
transducin (beta)-like 3
chr19_-_38720354 0.247 ENST00000416611.1
DPF1
D4, zinc and double PHD fingers family 1
chr1_-_156269428 0.245 ENST00000339922.3
VHLL
von Hippel-Lindau tumor suppressor-like
chr4_-_122872029 0.242 ENST00000502968.1
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr12_+_13349711 0.237 ENST00000538364.1
ENST00000396301.3
EMP1

epithelial membrane protein 1

chr6_+_42883727 0.236 ENST00000304672.1
ENST00000441198.1
ENST00000446507.1
PTCRA


pre T-cell antigen receptor alpha


chr16_-_67493110 0.235 ENST00000602876.1
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr17_-_34195862 0.234 ENST00000592980.1
ENST00000587626.1
C17orf66

chromosome 17 open reading frame 66

chr1_+_204485571 0.231 ENST00000454264.2
ENST00000367183.3
MDM4

Mdm4 p53 binding protein homolog (mouse)

chr20_-_56285595 0.230 ENST00000395816.3
ENST00000347215.4
PMEPA1

prostate transmembrane protein, androgen induced 1

chr11_+_105948216 0.229 ENST00000278618.4
AASDHPPT
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr2_-_105882585 0.227 ENST00000595531.1
AC012360.2
LOC644617 protein; Uncharacterized protein
chr3_+_184056614 0.224 ENST00000453072.1
FAM131A
family with sequence similarity 131, member A
chr12_+_25205628 0.223 ENST00000554942.1
LRMP
lymphoid-restricted membrane protein
chr7_-_27224842 0.221 ENST00000517402.1
HOXA11
homeobox A11
chr1_+_206643806 0.221 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr12_+_121837905 0.220 ENST00000392465.3
ENST00000554606.1
ENST00000392464.2
ENST00000555076.1
RNF34



ring finger protein 34, E3 ubiquitin protein ligase



chr14_+_67707826 0.219 ENST00000261681.4
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr5_-_172662303 0.218 ENST00000517440.1
ENST00000329198.4
NKX2-5

NK2 homeobox 5

chr6_-_55740352 0.218 ENST00000370830.3
BMP5
bone morphogenetic protein 5
chr3_+_4535025 0.215 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1




inositol 1,4,5-trisphosphate receptor, type 1




chr12_-_21810726 0.210 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr22_+_50986462 0.209 ENST00000395676.2
KLHDC7B
kelch domain containing 7B
chr19_+_1942453 0.209 ENST00000591752.1
CSNK1G2
casein kinase 1, gamma 2
chr17_+_59489112 0.206 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr10_-_98031155 0.206 ENST00000495266.1
BLNK
B-cell linker
chr21_+_33671264 0.205 ENST00000339944.4
MRAP
melanocortin 2 receptor accessory protein
chr9_-_5830768 0.205 ENST00000381506.3
ERMP1
endoplasmic reticulum metallopeptidase 1
chr12_-_21810765 0.203 ENST00000450584.1
ENST00000350669.1
LDHB

lactate dehydrogenase B

chr19_+_39390320 0.202 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr12_-_67197760 0.200 ENST00000539540.1
ENST00000540433.1
ENST00000541947.1
ENST00000538373.1
GRIP1



glutamate receptor interacting protein 1



chr2_+_152266604 0.199 ENST00000430328.2
RIF1
RAP1 interacting factor homolog (yeast)
chr3_+_172361483 0.198 ENST00000598405.1
AC007919.2
HCG1787166; PRO1163; Uncharacterized protein
chr5_-_146889619 0.196 ENST00000343218.5
DPYSL3
dihydropyrimidinase-like 3
chr1_-_153518270 0.196 ENST00000354332.4
ENST00000368716.4
S100A4

S100 calcium binding protein A4

chr1_+_228337553 0.194 ENST00000366714.2
GJC2
gap junction protein, gamma 2, 47kDa
chrX_+_134478706 0.192 ENST00000370761.3
ENST00000339249.4
ENST00000370760.3
ZNF449


zinc finger protein 449


chr8_-_80680078 0.190 ENST00000337919.5
ENST00000354724.3
HEY1

hes-related family bHLH transcription factor with YRPW motif 1

chr15_+_89182178 0.189 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr13_+_95364963 0.188 ENST00000438290.2
SOX21-AS1
SOX21 antisense RNA 1 (head to head)
chrX_+_153170455 0.188 ENST00000430697.1
ENST00000337474.5
ENST00000370049.1
AVPR2


arginine vasopressin receptor 2


chr11_-_88796803 0.188 ENST00000418177.2
ENST00000455756.2
GRM5

glutamate receptor, metabotropic 5

chr21_+_45432174 0.187 ENST00000380221.3
ENST00000291574.4
TRAPPC10

trafficking protein particle complex 10

chr18_+_42260861 0.186 ENST00000282030.5
SETBP1
SET binding protein 1
chr8_-_94752946 0.185 ENST00000519109.1
RBM12B
RNA binding motif protein 12B
chr11_-_65325430 0.185 ENST00000322147.4
LTBP3
latent transforming growth factor beta binding protein 3
chrX_+_114423963 0.182 ENST00000424776.3
RBMXL3
RNA binding motif protein, X-linked-like 3
chrX_+_103029314 0.175 ENST00000429977.1
PLP1
proteolipid protein 1
chr1_-_152595579 0.169 ENST00000335674.1
LCE3A
late cornified envelope 3A
chr19_-_46234119 0.168 ENST00000317683.3
FBXO46
F-box protein 46
chr9_-_7800067 0.166 ENST00000358227.4
TMEM261
transmembrane protein 261
chr2_-_230787879 0.164 ENST00000435716.1
TRIP12
thyroid hormone receptor interactor 12
chr1_-_153517473 0.161 ENST00000368715.1
S100A4
S100 calcium binding protein A4
chr1_+_202431859 0.160 ENST00000391959.3
ENST00000367270.4
PPP1R12B

protein phosphatase 1, regulatory subunit 12B

chr4_-_123377880 0.159 ENST00000226730.4
IL2
interleukin 2
chr1_-_62190793 0.158 ENST00000371177.2
ENST00000606498.1
TM2D1

TM2 domain containing 1

chr3_+_4535155 0.148 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chrX_+_136648643 0.142 ENST00000370606.3
ZIC3
Zic family member 3
chr18_+_33877654 0.141 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
FHOD3



formin homology 2 domain containing 3



chr5_+_134094461 0.139 ENST00000452510.2
ENST00000354283.4
DDX46

DEAD (Asp-Glu-Ala-Asp) box polypeptide 46

chr1_-_33786699 0.138 ENST00000442999.3
A3GALT2
alpha 1,3-galactosyltransferase 2
chr1_-_38397384 0.134 ENST00000373027.1
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr6_-_27841289 0.131 ENST00000355981.2
HIST1H4L
histone cluster 1, H4l
chr8_-_28747424 0.130 ENST00000523436.1
ENST00000397363.4
ENST00000521777.1
ENST00000520184.1
ENST00000521022.1
INTS9




integrator complex subunit 9




chr3_+_187930429 0.130 ENST00000420410.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr2_-_175870085 0.129 ENST00000409156.3
CHN1
chimerin 1
chr16_-_29757272 0.127 ENST00000329410.3
C16orf54
chromosome 16 open reading frame 54
chrY_-_25345070 0.127 ENST00000382510.4
ENST00000426000.2
ENST00000540248.1
ENST00000405239.1
DAZ1



deleted in azoospermia 1



chr19_+_751122 0.126 ENST00000215582.6
MISP
mitotic spindle positioning
chr12_+_6961279 0.119 ENST00000229268.8
ENST00000389231.5
ENST00000542087.1
USP5


ubiquitin specific peptidase 5 (isopeptidase T)


chr12_+_50479101 0.117 ENST00000551966.1
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr16_-_58663720 0.113 ENST00000564557.1
ENST00000569240.1
ENST00000441024.2
ENST00000569020.1
ENST00000317147.5
CNOT1




CCR4-NOT transcription complex, subunit 1




chr12_+_25205568 0.111 ENST00000548766.1
ENST00000556887.1
LRMP

lymphoid-restricted membrane protein

chr1_-_202679535 0.111 ENST00000367268.4
SYT2
synaptotagmin II
chr10_-_7708918 0.108 ENST00000256861.6
ENST00000397146.2
ENST00000446830.2
ENST00000397145.2
ITIH5



inter-alpha-trypsin inhibitor heavy chain family, member 5



chr11_-_65325203 0.107 ENST00000526927.1
ENST00000536982.1
LTBP3

latent transforming growth factor beta binding protein 3

chr7_+_99156145 0.107 ENST00000452314.1
ENST00000252713.4
ZNF655

zinc finger protein 655

chr1_-_25291475 0.101 ENST00000338888.3
ENST00000399916.1
RUNX3

runt-related transcription factor 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.0 GO:1903060 regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) regulation of protein lipidation(GO:1903059) negative regulation of protein lipidation(GO:1903060)
1.3 6.4 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.7 3.4 GO:1902170 cellular response to nitric oxide(GO:0071732) cellular response to reactive nitrogen species(GO:1902170)
0.5 1.6 GO:0010966 regulation of phosphate transport(GO:0010966)
0.3 1.5 GO:0070672 response to interleukin-15(GO:0070672)
0.2 0.9 GO:0035110 obsolete leg morphogenesis(GO:0035110)
0.2 0.7 GO:0048102 autophagic cell death(GO:0048102)
0.2 0.7 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.2 1.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 2.8 GO:0006000 fructose metabolic process(GO:0006000)
0.1 0.8 GO:0010761 fibroblast migration(GO:0010761)
0.1 3.1 GO:0031000 response to caffeine(GO:0031000)
0.1 0.8 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.1 0.5 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.1 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.4 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 8.5 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 0.6 GO:0046621 negative regulation of organ growth(GO:0046621)
0.1 0.3 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.1 0.2 GO:0048263 determination of dorsal identity(GO:0048263)
0.1 0.6 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.4 GO:0003416 endochondral bone growth(GO:0003416) growth plate cartilage development(GO:0003417) bone growth(GO:0098868)
0.1 0.2 GO:0045023 G0 to G1 transition(GO:0045023)
0.1 0.8 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 0.2 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.1 0.8 GO:1901797 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.1 0.5 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.5 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 0.2 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.0 0.1 GO:0003080 obsolete negative regulation of natriuresis(GO:0003080)
0.0 0.3 GO:0002005 angiotensin catabolic process in blood(GO:0002005)
0.0 0.4 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.7 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.8 GO:0015695 organic cation transport(GO:0015695)
0.0 1.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 1.7 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 1.4 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 1.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.3 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 0.2 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0 0.2 GO:0071436 sodium ion export(GO:0071436)
0.0 0.4 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0070244 negative regulation of thymocyte apoptotic process(GO:0070244)
0.0 0.2 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 5.1 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187)
0.0 0.6 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.0 0.8 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.7 GO:0017158 regulation of calcium ion-dependent exocytosis(GO:0017158)
0.0 0.5 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 1.3 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.8 GO:0033572 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.0 0.5 GO:0060113 inner ear receptor cell differentiation(GO:0060113)
0.0 0.1 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.5 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.1 GO:0033145 positive regulation of intracellular steroid hormone receptor signaling pathway(GO:0033145)
0.0 0.1 GO:0050703 interleukin-1 alpha secretion(GO:0050703)
0.0 0.3 GO:0043550 regulation of lipid kinase activity(GO:0043550)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0098827 terminal cisterna(GO:0014802) endoplasmic reticulum subcompartment(GO:0098827)
0.5 3.4 GO:0042599 lamellar body(GO:0042599)
0.4 9.1 GO:0032982 myosin filament(GO:0032982)
0.1 6.4 GO:0043195 terminal bouton(GO:0043195)
0.1 1.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 0.7 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.4 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 1.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.4 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.5 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.0 2.2 GO:0005626 obsolete insoluble fraction(GO:0005626)
0.0 0.1 GO:0001650 fibrillar center(GO:0001650)
0.0 0.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 1.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.2 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.6 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177)
0.0 1.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.2 GO:0043218 compact myelin(GO:0043218)
0.0 9.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.1 GO:0042584 chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584)
0.0 0.4 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.3 GO:0071565 nBAF complex(GO:0071565)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.4 GO:0032027 myosin light chain binding(GO:0032027)
0.7 5.2 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.7 2.8 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.5 6.0 GO:0031432 titin binding(GO:0031432)
0.4 3.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.1 3.1 GO:0000146 microfilament motor activity(GO:0000146)
0.1 0.7 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.1 1.2 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.4 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 0.2 GO:0031780 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 0.4 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 0.8 GO:0008432 JUN kinase binding(GO:0008432)
0.1 0.4 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.7 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.8 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.0 1.5 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.0 0.2 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 2.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.3 GO:0031711 peptidyl-dipeptidase activity(GO:0008241) bradykinin receptor binding(GO:0031711)
0.0 1.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.8 GO:0019841 retinol binding(GO:0019841)
0.0 1.7 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.1 GO:0008859 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) exoribonuclease II activity(GO:0008859)
0.0 0.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.0 GO:0019003 GDP binding(GO:0019003)
0.0 0.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 1.5 GO:0015179 L-amino acid transmembrane transporter activity(GO:0015179)
0.0 0.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.1 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.9 GO:0050699 WW domain binding(GO:0050699)
0.0 0.2 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 1.2 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.9 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.6 GO:0051117 ATPase binding(GO:0051117)
0.0 0.3 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 9.5 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.