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Illumina Body Map 2: averaged replicates

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Results for NKX2-5

Z-value: 1.55

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Transcription factors associated with NKX2-5

Gene Symbol Gene ID Gene Info
NKX2-5
ENSG00000183072.9 NK2 homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-5hg19_v2_chr5_-_172662303_172662360-0.115.5e-01Click!

Activity profile of NKX2-5 motif

Sorted Z-values of NKX2-5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_81320151 8.31 ENST00000372325.2
ENST00000372327.5
ENST00000417041.1
SFTPA2
surfactant protein A2
chr14_+_22356029 5.14 ENST00000390437.2
TRAV12-2
T cell receptor alpha variable 12-2
chr14_+_22309368 4.88 ENST00000390433.1
TRAV12-1
T cell receptor alpha variable 12-1
chr10_+_81370689 4.71 ENST00000372308.3
ENST00000398636.3
ENST00000428376.2
ENST00000372313.5
ENST00000419470.2
ENST00000429958.1
ENST00000439264.1
SFTPA1
surfactant protein A1
chr16_+_32859034 4.22 ENST00000567458.2
ENST00000560724.1
IGHV2OR16-5
immunoglobulin heavy variable 2/OR16-5 (non-functional)
chr14_-_106758101 3.78 ENST00000390611.2
IGHV2-26
immunoglobulin heavy variable 2-26
chr4_-_74853897 3.49 ENST00000296028.3
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr14_+_22788560 3.47 ENST00000390468.1
TRAV41
T cell receptor alpha variable 41
chr9_-_117692697 3.31 ENST00000223795.2
TNFSF8
tumor necrosis factor (ligand) superfamily, member 8
chr1_-_36947652 3.26 ENST00000533491.1
CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr14_-_107179265 3.24 ENST00000390634.2
IGHV2-70
immunoglobulin heavy variable 2-70
chr1_+_161676739 3.15 ENST00000236938.6
ENST00000367959.2
ENST00000546024.1
ENST00000540521.1
ENST00000367949.2
ENST00000350710.3
ENST00000540926.1
FCRLA
Fc receptor-like A
chr1_-_36947120 3.10 ENST00000361632.4
CSF3R
colony stimulating factor 3 receptor (granulocyte)
chr1_-_206306107 2.96 ENST00000436158.1
ENST00000455672.1
RP11-38J22.6
RP11-38J22.6
chr14_-_106830057 2.86 ENST00000390616.2
IGHV4-34
immunoglobulin heavy variable 4-34
chr1_-_160616804 2.70 ENST00000538290.1
SLAMF1
signaling lymphocytic activation molecule family member 1
chr1_+_161677034 2.66 ENST00000349527.4
ENST00000309691.6
ENST00000294796.4
ENST00000367953.3
ENST00000367950.1
FCRLA
Fc receptor-like A
chr5_+_147258266 2.54 ENST00000296694.4
SCGB3A2
secretoglobin, family 3A, member 2
chr19_+_10947251 2.47 ENST00000592854.1
C19orf38
chromosome 19 open reading frame 38
chr22_+_40322595 2.38 ENST00000420971.1
ENST00000544756.1
GRAP2
GRB2-related adaptor protein 2
chr22_-_50524298 2.25 ENST00000311597.5
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr22_-_50523760 2.12 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr1_+_161676983 2.12 ENST00000367957.2
FCRLA
Fc receptor-like A
chr22_-_50523807 2.08 ENST00000442311.1
ENST00000538737.1
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr17_-_29624343 2.03 ENST00000247271.4
OMG
oligodendrocyte myelin glycoprotein
chr15_-_74726283 2.03 ENST00000543145.2
SEMA7A
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr22_-_50523843 1.99 ENST00000535444.1
ENST00000431262.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr22_+_40322623 1.95 ENST00000399090.2
GRAP2
GRB2-related adaptor protein 2
chr7_+_142919130 1.91 ENST00000408947.3
TAS2R40
taste receptor, type 2, member 40
chr7_-_24957699 1.81 ENST00000441059.1
ENST00000415162.1
OSBPL3
oxysterol binding protein-like 3
chr17_-_29641104 1.77 ENST00000577894.1
ENST00000330927.4
EVI2B
ecotropic viral integration site 2B
chrX_+_71353499 1.77 ENST00000373677.1
NHSL2
NHS-like 2
chr17_-_29641084 1.77 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr3_+_45984947 1.72 ENST00000304552.4
CXCR6
chemokine (C-X-C motif) receptor 6
chr14_-_106406090 1.69 ENST00000390593.2
IGHV6-1
immunoglobulin heavy variable 6-1
chr14_-_106963409 1.67 ENST00000390621.2
IGHV1-45
immunoglobulin heavy variable 1-45
chr19_+_1026566 1.67 ENST00000348419.3
ENST00000565096.2
ENST00000562958.2
ENST00000562075.2
ENST00000607102.1
CNN2
calponin 2
chr15_+_81589254 1.61 ENST00000394652.2
IL16
interleukin 16
chr2_-_175499294 1.61 ENST00000392547.2
WIPF1
WAS/WASL interacting protein family, member 1
chr14_+_22963806 1.60 ENST00000390493.1
TRAJ44
T cell receptor alpha joining 44
chr2_-_85895295 1.59 ENST00000428225.1
ENST00000519937.2
SFTPB
surfactant protein B
chr6_-_41715128 1.58 ENST00000356667.4
ENST00000373025.3
ENST00000425343.2
PGC
progastricsin (pepsinogen C)
chr13_+_95364963 1.56 ENST00000438290.2
SOX21-AS1
SOX21 antisense RNA 1 (head to head)
chr16_+_33006369 1.45 ENST00000425181.3
IGHV3OR16-10
immunoglobulin heavy variable 3/OR16-10 (non-functional)
chr17_-_80291818 1.38 ENST00000269389.3
ENST00000581691.1
SECTM1
secreted and transmembrane 1
chr1_+_26606608 1.31 ENST00000319041.6
SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr13_-_95364389 1.28 ENST00000376945.2
SOX21
SRY (sex determining region Y)-box 21
chr5_-_171615315 1.27 ENST00000176763.5
STK10
serine/threonine kinase 10
chr4_+_81118647 1.27 ENST00000415738.2
PRDM8
PR domain containing 8
chr7_-_81399411 1.25 ENST00000423064.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr6_-_112115103 1.21 ENST00000462598.3
FYN
FYN oncogene related to SRC, FGR, YES
chr4_-_168155577 1.20 ENST00000541354.1
ENST00000509854.1
ENST00000512681.1
ENST00000421836.2
ENST00000510741.1
ENST00000510403.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chrX_-_142722897 1.18 ENST00000338017.4
SLITRK4
SLIT and NTRK-like family, member 4
chr2_+_152214098 1.14 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr7_-_142919360 1.13 ENST00000595842.1
AC073342.1
HCG2002387; Uncharacterized protein
chr12_+_113354341 1.11 ENST00000553152.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr17_-_79623597 1.10 ENST00000574024.1
ENST00000331056.5
PDE6G
phosphodiesterase 6G, cGMP-specific, rod, gamma
chr11_+_118754475 1.08 ENST00000292174.4
CXCR5
chemokine (C-X-C motif) receptor 5
chr11_-_73689037 1.05 ENST00000544615.1
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr1_+_27153173 1.00 ENST00000374142.4
ZDHHC18
zinc finger, DHHC-type containing 18
chr5_-_149792295 1.00 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr11_+_108093755 0.97 ENST00000527891.1
ENST00000532931.1
ATM
ataxia telangiectasia mutated
chr5_-_134788086 0.97 ENST00000537858.1
TIFAB
TRAF-interacting protein with forkhead-associated domain, family member B
chr7_-_81399355 0.96 ENST00000457544.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr17_+_74261277 0.96 ENST00000327490.6
UBALD2
UBA-like domain containing 2
chr4_-_168155730 0.95 ENST00000502330.1
ENST00000357154.3
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr14_+_23002427 0.95 ENST00000390527.1
TRAJ10
T cell receptor alpha joining 10
chr12_+_4918342 0.95 ENST00000280684.3
ENST00000433855.1
KCNA6
potassium voltage-gated channel, shaker-related subfamily, member 6
chr7_-_81399329 0.93 ENST00000453411.1
ENST00000444829.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr13_+_24846799 0.93 ENST00000488060.1
SPATA13
spermatogenesis associated 13
chr14_-_85705818 0.92 ENST00000556016.1
RP11-789A21.1
RP11-789A21.1
chr10_-_128359008 0.92 ENST00000488181.1
C10orf90
chromosome 10 open reading frame 90
chr2_+_113403434 0.92 ENST00000272542.3
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr17_+_74261413 0.90 ENST00000587913.1
UBALD2
UBA-like domain containing 2
chr1_+_207494853 0.89 ENST00000367064.3
ENST00000367063.2
ENST00000391921.4
ENST00000367067.4
ENST00000314754.8
ENST00000367065.5
ENST00000391920.4
ENST00000367062.4
ENST00000343420.6
CD55
CD55 molecule, decay accelerating factor for complement (Cromer blood group)
chr9_-_20382446 0.89 ENST00000380321.1
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr17_-_982198 0.88 ENST00000571945.1
ENST00000536794.2
ABR
active BCR-related
chr3_+_46283863 0.88 ENST00000545097.1
ENST00000541018.1
CCR3
chemokine (C-C motif) receptor 3
chr1_+_100817262 0.80 ENST00000455467.1
CDC14A
cell division cycle 14A
chr1_-_202858227 0.79 ENST00000367262.3
RABIF
RAB interacting factor
chr4_-_76861392 0.78 ENST00000505594.1
NAAA
N-acylethanolamine acid amidase
chr2_+_201997492 0.77 ENST00000494258.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr6_-_112115074 0.76 ENST00000368667.2
FYN
FYN oncogene related to SRC, FGR, YES
chr15_-_60683326 0.75 ENST00000559350.1
ENST00000558986.1
ENST00000560389.1
ANXA2
annexin A2
chrX_+_150565038 0.73 ENST00000370361.1
VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr11_+_108093839 0.72 ENST00000452508.2
ATM
ataxia telangiectasia mutated
chr11_-_19223523 0.72 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr18_+_61575200 0.70 ENST00000238508.3
SERPINB10
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr13_-_30951282 0.69 ENST00000420219.1
LINC00426
long intergenic non-protein coding RNA 426
chr19_+_5681153 0.68 ENST00000579559.1
ENST00000577222.1
HSD11B1L
RPL36
hydroxysteroid (11-beta) dehydrogenase 1-like
ribosomal protein L36
chr7_-_81399287 0.67 ENST00000354224.6
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr8_-_73793975 0.67 ENST00000523881.1
RP11-1145L24.1
RP11-1145L24.1
chr7_-_81399438 0.67 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chrX_-_13835147 0.66 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr1_-_248738080 0.66 ENST00000328782.2
OR2T34
olfactory receptor, family 2, subfamily T, member 34
chr5_-_88180342 0.65 ENST00000502983.1
MEF2C
myocyte enhancer factor 2C
chr2_-_201936302 0.65 ENST00000453765.1
ENST00000452799.1
ENST00000446678.1
ENST00000418596.3
FAM126B
family with sequence similarity 126, member B
chr7_-_37488834 0.64 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr3_-_111314230 0.63 ENST00000317012.4
ZBED2
zinc finger, BED-type containing 2
chr7_-_107883678 0.61 ENST00000417701.1
NRCAM
neuronal cell adhesion molecule
chr3_-_187388173 0.61 ENST00000287641.3
SST
somatostatin
chr4_+_156680518 0.60 ENST00000513437.1
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr17_+_75447326 0.60 ENST00000591088.1
SEPT9
septin 9
chr17_-_19771216 0.60 ENST00000395544.4
ULK2
unc-51 like autophagy activating kinase 2
chr2_+_48541776 0.59 ENST00000413569.1
ENST00000340553.3
FOXN2
forkhead box N2
chr17_+_45973516 0.58 ENST00000376741.4
SP2
Sp2 transcription factor
chr3_+_46283916 0.56 ENST00000395940.2
CCR3
chemokine (C-C motif) receptor 3
chr7_-_37488777 0.56 ENST00000445322.1
ENST00000448602.1
ELMO1
engulfment and cell motility 1
chr14_+_81421710 0.56 ENST00000342443.6
TSHR
thyroid stimulating hormone receptor
chr1_+_76540386 0.55 ENST00000328299.3
ST6GALNAC3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr7_+_129007964 0.55 ENST00000460109.1
ENST00000474594.1
ENST00000446212.1
AHCYL2
adenosylhomocysteinase-like 2
chr4_-_168155700 0.54 ENST00000357545.4
ENST00000512648.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr7_+_129906660 0.53 ENST00000222481.4
CPA2
carboxypeptidase A2 (pancreatic)
chr10_-_128359074 0.52 ENST00000544758.1
C10orf90
chromosome 10 open reading frame 90
chr1_+_114472222 0.49 ENST00000369558.1
ENST00000369561.4
HIPK1
homeodomain interacting protein kinase 1
chr17_+_29421987 0.47 ENST00000431387.4
NF1
neurofibromin 1
chr3_+_186692745 0.47 ENST00000438590.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr14_+_64565442 0.47 ENST00000553308.1
SYNE2
spectrin repeat containing, nuclear envelope 2
chr18_+_13382553 0.47 ENST00000586222.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr20_+_57226284 0.46 ENST00000458280.1
ENST00000355957.5
ENST00000361770.5
ENST00000312283.8
ENST00000412911.1
ENST00000359617.4
ENST00000371141.4
STX16
syntaxin 16
chr14_+_81421921 0.45 ENST00000554263.1
ENST00000554435.1
TSHR
thyroid stimulating hormone receptor
chr12_-_49259643 0.44 ENST00000309739.5
RND1
Rho family GTPase 1
chr3_-_15374659 0.44 ENST00000426925.1
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr2_-_96874553 0.43 ENST00000337288.5
ENST00000443962.1
STARD7
StAR-related lipid transfer (START) domain containing 7
chr5_+_55147205 0.43 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA
interleukin 31 receptor A
chr4_-_46126093 0.43 ENST00000295452.4
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chr4_+_2470664 0.41 ENST00000314289.8
ENST00000541204.1
ENST00000502316.1
ENST00000507247.1
ENST00000509258.1
ENST00000511859.1
RNF4
ring finger protein 4
chr17_+_58755184 0.41 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
BCAS3
breast carcinoma amplified sequence 3
chr1_-_102312600 0.40 ENST00000359814.3
OLFM3
olfactomedin 3
chr14_+_81421861 0.40 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr9_+_127020202 0.39 ENST00000373600.3
ENST00000320246.5
NEK6
NIMA-related kinase 6
chr20_+_19867150 0.39 ENST00000255006.6
RIN2
Ras and Rab interactor 2
chr11_+_60102304 0.39 ENST00000300182.4
MS4A6E
membrane-spanning 4-domains, subfamily A, member 6E
chr20_-_41818373 0.38 ENST00000373187.1
ENST00000356100.2
ENST00000373184.1
ENST00000373190.1
PTPRT
protein tyrosine phosphatase, receptor type, T
chr1_+_154300217 0.38 ENST00000368489.3
ATP8B2
ATPase, aminophospholipid transporter, class I, type 8B, member 2
chr16_-_30134266 0.38 ENST00000484663.1
ENST00000478356.1
MAPK3
mitogen-activated protein kinase 3
chr1_+_154301264 0.37 ENST00000341822.2
ATP8B2
ATPase, aminophospholipid transporter, class I, type 8B, member 2
chrX_+_115567767 0.36 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr13_-_53422640 0.36 ENST00000338862.4
ENST00000377942.3
PCDH8
protocadherin 8
chr6_-_39290316 0.35 ENST00000425054.2
ENST00000373227.4
ENST00000373229.5
ENST00000437525.2
KCNK16
potassium channel, subfamily K, member 16
chr3_+_108321623 0.35 ENST00000497905.1
ENST00000463306.1
DZIP3
DAZ interacting zinc finger protein 3
chr16_-_3149229 0.34 ENST00000572431.1
ENST00000572548.1
ZSCAN10
zinc finger and SCAN domain containing 10
chr2_+_136289030 0.34 ENST00000409478.1
ENST00000264160.4
ENST00000329971.3
ENST00000438014.1
R3HDM1
R3H domain containing 1
chr7_-_28220354 0.33 ENST00000283928.5
JAZF1
JAZF zinc finger 1
chr6_+_26273144 0.33 ENST00000377733.2
HIST1H2BI
histone cluster 1, H2bi
chr10_+_111967345 0.33 ENST00000332674.5
ENST00000453116.1
MXI1
MAX interactor 1, dimerization protein
chr16_+_57769635 0.33 ENST00000379661.3
ENST00000562592.1
ENST00000566726.1
KATNB1
katanin p80 (WD repeat containing) subunit B 1
chr10_+_133753533 0.32 ENST00000422256.2
PPP2R2D
protein phosphatase 2, regulatory subunit B, delta
chr12_+_123717967 0.32 ENST00000536130.1
ENST00000546132.1
C12orf65
chromosome 12 open reading frame 65
chr14_-_75179774 0.32 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
AREL1
AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr14_+_81421355 0.32 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr15_-_72563585 0.32 ENST00000287196.9
ENST00000260376.7
PARP6
poly (ADP-ribose) polymerase family, member 6
chr7_+_142457315 0.31 ENST00000486171.1
ENST00000311737.7
PRSS1
protease, serine, 1 (trypsin 1)
chr7_-_14942467 0.30 ENST00000407950.1
ENST00000444700.2
DGKB
diacylglycerol kinase, beta 90kDa
chr19_+_41313017 0.30 ENST00000595621.1
ENST00000595051.1
EGLN2
egl-9 family hypoxia-inducible factor 2
chr12_-_50222187 0.30 ENST00000335999.6
NCKAP5L
NCK-associated protein 5-like
chr15_-_81282133 0.29 ENST00000261758.4
MESDC2
mesoderm development candidate 2
chr10_+_73156664 0.29 ENST00000398809.4
ENST00000398842.3
ENST00000461841.3
ENST00000299366.7
CDH23
cadherin-related 23
chr14_+_78227105 0.27 ENST00000439131.2
ENST00000355883.3
ENST00000557011.1
ENST00000556047.1
C14orf178
chromosome 14 open reading frame 178
chr10_+_86184676 0.27 ENST00000543283.1
CCSER2
coiled-coil serine-rich protein 2
chr2_+_219646462 0.27 ENST00000258415.4
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr2_-_27545431 0.26 ENST00000233545.2
MPV17
MpV17 mitochondrial inner membrane protein
chr4_-_168155417 0.26 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr7_+_99775366 0.25 ENST00000394018.2
ENST00000416412.1
STAG3
stromal antigen 3
chrX_-_13835398 0.24 ENST00000475307.1
GPM6B
glycoprotein M6B
chr17_+_54230819 0.24 ENST00000318698.2
ENST00000566473.2
ANKFN1
ankyrin-repeat and fibronectin type III domain containing 1
chr1_-_102312517 0.24 ENST00000338858.5
OLFM3
olfactomedin 3
chr5_+_169780485 0.23 ENST00000377360.4
KCNIP1
Kv channel interacting protein 1
chr7_-_99774945 0.23 ENST00000292377.2
GPC2
glypican 2
chr5_+_122110691 0.22 ENST00000379516.2
ENST00000505934.1
ENST00000514949.1
SNX2
sorting nexin 2
chr3_-_56717246 0.22 ENST00000355628.5
FAM208A
family with sequence similarity 208, member A
chr20_+_57226841 0.21 ENST00000358029.4
ENST00000361830.3
STX16
syntaxin 16
chr17_-_40169659 0.21 ENST00000457167.4
DNAJC7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr3_+_130300585 0.20 ENST00000511332.1
COL6A6
collagen, type VI, alpha 6
chr3_-_107941230 0.20 ENST00000264538.3
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr15_+_42841008 0.20 ENST00000260372.3
ENST00000568876.1
ENST00000568846.2
ENST00000562398.1
HAUS2
HAUS augmin-like complex, subunit 2
chr10_-_49813090 0.20 ENST00000249601.4
ARHGAP22
Rho GTPase activating protein 22
chr11_+_94277017 0.20 ENST00000358752.2
FUT4
fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
chr10_+_79626633 0.20 ENST00000372387.1
AL391421.1
Uncharacterized protein; cDNA FLJ43696 fis, clone TBAES2007964
chr11_-_5863127 0.19 ENST00000329322.5
ENST00000379946.2
OR52E6
olfactory receptor, family 52, subfamily E, member 6
chr7_+_151791095 0.18 ENST00000422997.2
GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr1_-_26232951 0.18 ENST00000426559.2
ENST00000455785.2
STMN1
stathmin 1
chr1_-_23520755 0.17 ENST00000314113.3
HTR1D
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
chr12_-_51422017 0.17 ENST00000394904.3
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr13_+_25670268 0.17 ENST00000281589.3
PABPC3
poly(A) binding protein, cytoplasmic 3
chr8_-_95220775 0.17 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17
cadherin 17, LI cadherin (liver-intestine)
chr1_+_203765437 0.17 ENST00000550078.1
ZBED6
zinc finger, BED-type containing 6
chrX_+_14547632 0.16 ENST00000218075.4
GLRA2
glycine receptor, alpha 2
chr15_+_42697018 0.16 ENST00000397204.4
CAPN3
calpain 3, (p94)
chr16_-_30134441 0.16 ENST00000395200.1
MAPK3
mitogen-activated protein kinase 3
chr15_-_42840961 0.16 ENST00000563454.1
ENST00000397130.3
ENST00000570160.1
ENST00000323443.2
LRRC57
leucine rich repeat containing 57
chr3_-_127309521 0.16 ENST00000469111.1
TPRA1
transmembrane protein, adipocyte asscociated 1
chr3_+_42201653 0.16 ENST00000341421.3
ENST00000396175.1
TRAK1
trafficking protein, kinesin binding 1
chr12_+_14518598 0.16 ENST00000261168.4
ENST00000538511.1
ENST00000545723.1
ENST00000543189.1
ENST00000536444.1
ATF7IP
activating transcription factor 7 interacting protein
chr12_+_123717458 0.15 ENST00000253233.1
C12orf65
chromosome 12 open reading frame 65
chr17_+_27055798 0.14 ENST00000268766.6
NEK8
NIMA-related kinase 8
chr14_-_68159152 0.14 ENST00000554035.1
RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr11_+_17756279 0.14 ENST00000265969.6
KCNC1
potassium voltage-gated channel, Shaw-related subfamily, member 1
chr1_+_211433275 0.13 ENST00000367005.4
RCOR3
REST corepressor 3
chr22_-_33968239 0.13 ENST00000452586.2
ENST00000421768.1
LARGE
like-glycosyltransferase

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.4 1.7 GO:1905229 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.4 8.6 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.3 4.5 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.3 1.7 GO:1904882 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.3 1.6 GO:0002225 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.2 1.0 GO:0002901 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.2 1.0 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.2 4.7 GO:0008228 opsonization(GO:0008228)
0.2 0.7 GO:0052364 multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419)
0.2 2.0 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.2 0.9 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.2 6.5 GO:0097186 amelogenesis(GO:0097186)
0.2 0.5 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.2 12.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 0.4 GO:2000656 regulation of apolipoprotein binding(GO:2000656) negative regulation of apolipoprotein binding(GO:2000657)
0.1 3.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 2.0 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.1 3.5 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.1 2.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.6 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.1 0.5 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.9 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.1 0.3 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.1 0.7 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1 0.7 GO:0035995 detection of muscle stretch(GO:0035995)
0.1 9.9 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.1 0.9 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.6 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.1 1.0 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 0.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.6 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 0.8 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 0.6 GO:0075071 autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071)
0.1 0.4 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.5 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 0.9 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.7 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 5.3 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 1.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.8 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 1.1 GO:0048535 lymph node development(GO:0048535)
0.0 0.9 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.7 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 1.3 GO:2000401 regulation of lymphocyte migration(GO:2000401)
0.0 0.5 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.0 0.2 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 0.1 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.0 2.1 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 4.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 1.1 GO:0030728 ovulation(GO:0030728)
0.0 3.1 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.2 GO:0015692 lead ion transport(GO:0015692)
0.0 0.3 GO:0050957 equilibrioception(GO:0050957)
0.0 1.1 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 0.7 GO:0045332 phospholipid translocation(GO:0045332)
0.0 1.0 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.3 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.4 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.5 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.4 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 1.2 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.0 1.1 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.1 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.1 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 1.0 GO:0097503 sialylation(GO:0097503)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.2 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.2 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.6 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.2 GO:0014827 intestine smooth muscle contraction(GO:0014827)
0.0 1.5 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 1.3 GO:0030834 regulation of actin filament depolymerization(GO:0030834)
0.0 0.2 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.0 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.2 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.0 0.6 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.3 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 1.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.1 GO:0035330 regulation of hippo signaling(GO:0035330)
0.0 0.3 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.4 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.2 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.5 GO:0010719 negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.0 0.9 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.0 1.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 14.6 GO:0042599 lamellar body(GO:0042599)
0.2 12.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.7 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 1.0 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 2.5 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.1 1.8 GO:0032433 filopodium tip(GO:0032433)
0.1 6.3 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 8.9 GO:0005901 caveola(GO:0005901)
0.1 0.8 GO:0060091 kinocilium(GO:0060091)
0.0 0.1 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.4 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 1.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 4.5 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.8 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
0.0 0.3 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.2 GO:0070826 paraferritin complex(GO:0070826)
0.0 0.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0097134 Y chromosome(GO:0000806) cyclin A2-CDK2 complex(GO:0097124) cyclin E1-CDK2 complex(GO:0097134)
0.0 6.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.7 GO:1990391 DNA repair complex(GO:1990391)
0.0 5.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0043194 axon initial segment(GO:0043194)
0.0 0.2 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.5 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.5 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.7 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.6 GO:0031105 septin complex(GO:0031105)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.4 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.4 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.2 1.7 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.2 2.0 GO:0042610 CD8 receptor binding(GO:0042610)
0.2 3.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 12.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 1.7 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.2 2.8 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 1.0 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 0.4 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.1 2.6 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 0.9 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 0.4 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 2.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 1.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 1.9 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.5 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1 4.5 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.5 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 1.6 GO:0005522 profilin binding(GO:0005522)
0.1 0.7 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.1 3.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.8 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.2 GO:0015322 proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322)
0.1 1.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.6 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.7 GO:0031433 telethonin binding(GO:0031433)
0.0 0.5 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 1.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 8.4 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 4.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 8.3 GO:0003823 antigen binding(GO:0003823)
0.0 0.7 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.4 GO:0070097 delta-catenin binding(GO:0070097)
0.0 1.1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 6.3 GO:0005319 lipid transporter activity(GO:0005319)
0.0 0.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.2 GO:0015087 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0 0.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.2 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 1.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.8 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.6 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.3 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.6 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.6 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 6.9 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.2 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 2.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 11.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 3.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 6.2 PID ARF6 PATHWAY Arf6 signaling events
0.1 2.0 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 2.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.1 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 2.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.8 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.0 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 1.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 1.5 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.5 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 3.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.5 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.7 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.7 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 7.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.0 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 4.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 2.0 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 1.7 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 1.0 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.8 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 1.2 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 2.5 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.7 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 1.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis