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Illumina Body Map 2: averaged replicates
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Results for NKX2-6
Z-value: 1.68
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Transcription factors associated with NKX2-6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX2-6 | hg19_v2_chr8_-_23563922_23564111 | -0.46 | 8.8e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_22788560 Show fit | 6.31 |
ENST00000390468.1
|
T cell receptor alpha variable 41 |
|
| chr19_+_3178736 Show fit | 4.50 |
ENST00000246115.3
|
sphingosine-1-phosphate receptor 4 |
|
| chr22_-_37882395 Show fit | 4.42 |
ENST00000416983.3
ENST00000424765.2 ENST00000356998.3 |
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
|
| chr7_+_142498725 Show fit | 4.29 |
ENST00000466254.1
|
T cell receptor beta constant 2 |
|
| chr7_+_142028105 Show fit | 4.02 |
ENST00000390353.2
|
T cell receptor beta variable 6-1 |
|
| chr14_+_22580233 Show fit | 3.90 |
ENST00000390454.2
|
T cell receptor alpha variable 25 |
|
| chr22_+_22723969 Show fit | 3.86 |
ENST00000390295.2
|
immunoglobulin lambda variable 7-46 (gene/pseudogene) |
|
| chr6_-_159466136 Show fit | 3.82 |
ENST00000367066.3
ENST00000326965.6 |
T-cell activation RhoGTPase activating protein |
|
| chr9_-_137809718 Show fit | 3.76 |
ENST00000371806.3
|
ficolin (collagen/fibrinogen domain containing) 1 |
|
| chr6_-_159466042 Show fit | 3.48 |
ENST00000338313.5
|
T-cell activation RhoGTPase activating protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.1 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 8.4 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 7.8 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.4 | 5.2 | GO:0048003 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007) |
| 0.2 | 4.5 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.0 | 4.5 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.2 | 4.4 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.0 | 3.9 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 1.3 | 3.8 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
| 0.0 | 3.8 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 8.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 5.0 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.1 | 4.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.4 | 3.8 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.0 | 3.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 3.6 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 3.6 | GO:0005901 | caveola(GO:0005901) |
| 0.2 | 3.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 3.3 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 8.4 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 7.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.5 | 5.2 | GO:0030884 | lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884) |
| 0.3 | 4.5 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
| 0.9 | 4.4 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.2 | 3.8 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.0 | 3.8 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 3.7 | GO:1902936 | phosphatidylinositol bisphosphate binding(GO:1902936) |
| 0.3 | 3.4 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.0 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 5.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 5.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 4.5 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 3.7 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 3.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 3.2 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 2.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 4.6 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 4.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.2 | 4.4 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 4.0 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 3.7 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.1 | 3.7 | REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS | Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| 0.1 | 3.7 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.0 | 3.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 3.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |