Motif ID: NKX2-8

Z-value: 1.972


Transcription factors associated with NKX2-8:

Gene SymbolEntrez IDGene Name
NKX2-8 ENSG00000136327.6 NKX2-8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-8hg19_v2_chr14_-_37051798_370518310.327.1e-02Click!


Activity profile for motif NKX2-8.

activity profile for motif NKX2-8


Sorted Z-values histogram for motif NKX2-8

Sorted Z-values for motif NKX2-8



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_106573756 4.840 ENST00000390601.2
IGHV3-11
immunoglobulin heavy variable 3-11 (gene/pseudogene)
chr14_-_107049312 4.790 ENST00000390627.2
IGHV3-53
immunoglobulin heavy variable 3-53
chr14_-_106552755 4.454 ENST00000390600.2
IGHV3-9
immunoglobulin heavy variable 3-9
chr14_-_107199464 4.342 ENST00000433072.2
IGHV3-72
immunoglobulin heavy variable 3-72
chr14_-_106518922 4.274 ENST00000390598.2
IGHV3-7
immunoglobulin heavy variable 3-7
chr14_-_106692191 4.217 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr14_-_106586656 4.196 ENST00000390602.2
IGHV3-13
immunoglobulin heavy variable 3-13
chr14_-_107131560 4.009 ENST00000390632.2
IGHV3-66
immunoglobulin heavy variable 3-66
chr14_-_106994333 3.730 ENST00000390624.2
IGHV3-48
immunoglobulin heavy variable 3-48
chr14_-_106622419 3.466 ENST00000390604.2
IGHV3-16
immunoglobulin heavy variable 3-16 (non-functional)
chr16_+_32063311 3.173 ENST00000426099.1
AC142381.1
AC142381.1
chr14_-_106791536 3.082 ENST00000390613.2
IGHV3-30
immunoglobulin heavy variable 3-30
chr14_-_107219365 3.028 ENST00000424969.2
IGHV3-74
immunoglobulin heavy variable 3-74
chr14_-_106845789 2.849 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr17_+_37784749 2.825 ENST00000394265.1
ENST00000394267.2
PPP1R1B

protein phosphatase 1, regulatory (inhibitor) subunit 1B

chr14_-_106963409 2.823 ENST00000390621.2
IGHV1-45
immunoglobulin heavy variable 1-45
chr14_+_22356029 2.696 ENST00000390437.2
TRAV12-2
T cell receptor alpha variable 12-2
chr14_+_22362613 2.518 ENST00000390438.2
TRAV8-4
T cell receptor alpha variable 8-4
chr16_-_33647696 2.425 ENST00000558425.1
ENST00000569103.2
RP11-812E19.9

Uncharacterized protein

chr15_-_20170354 2.405 ENST00000338912.5
IGHV1OR15-9
immunoglobulin heavy variable 1/OR15-9 (non-functional)
chr3_+_111717511 2.203 ENST00000478951.1
ENST00000393917.2
TAGLN3

transgelin 3

chr16_+_89696692 2.203 ENST00000261615.4
DPEP1
dipeptidase 1 (renal)
chr5_+_156607829 2.170 ENST00000422843.3
ITK
IL2-inducible T-cell kinase
chr16_+_33020496 2.164 ENST00000565407.2
IGHV3OR16-8
immunoglobulin heavy variable 3/OR16-8 (non-functional)
chr22_-_30925150 2.056 ENST00000437871.1
SEC14L6
SEC14-like 6 (S. cerevisiae)
chr6_-_32731243 2.053 ENST00000427449.1
ENST00000411527.1
HLA-DQB2

major histocompatibility complex, class II, DQ beta 2

chr3_+_111717600 2.053 ENST00000273368.4
TAGLN3
transgelin 3
chr16_+_33006369 2.027 ENST00000425181.3
IGHV3OR16-10
immunoglobulin heavy variable 3/OR16-10 (non-functional)
chr2_-_36779411 1.984 ENST00000406220.1
AC007401.2
Uncharacterized protein
chr5_-_176056974 1.967 ENST00000510387.1
ENST00000506696.1
SNCB

synuclein, beta

chr19_-_17622269 1.962 ENST00000595116.1
CTD-3131K8.2
CTD-3131K8.2
chr6_-_32731299 1.962 ENST00000435145.2
ENST00000437316.2
HLA-DQB2

major histocompatibility complex, class II, DQ beta 2

chr3_+_137728842 1.912 ENST00000183605.5
CLDN18
claudin 18
chr16_+_32077386 1.883 ENST00000354689.6
IGHV3OR16-9
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr22_+_29834572 1.832 ENST00000354373.2
RFPL1
ret finger protein-like 1
chr3_-_116163830 1.820 ENST00000333617.4
LSAMP
limbic system-associated membrane protein
chr16_+_33629600 1.776 ENST00000562905.2
IGHV3OR16-13
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr2_+_204801471 1.764 ENST00000316386.6
ENST00000435193.1
ICOS

inducible T-cell co-stimulator

chr5_+_92919043 1.724 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr5_+_35852797 1.685 ENST00000508941.1
IL7R
interleukin 7 receptor
chr5_+_3596168 1.680 ENST00000302006.3
IRX1
iroquois homeobox 1
chr14_-_24732403 1.675 ENST00000206765.6
TGM1
transglutaminase 1
chr13_-_46964177 1.639 ENST00000389908.3
KIAA0226L
KIAA0226-like
chr20_+_58296265 1.611 ENST00000395636.2
ENST00000361300.4
PHACTR3

phosphatase and actin regulator 3

chr4_-_176708533 1.604 ENST00000507520.1
GPM6A
glycoprotein M6A
chr12_-_12837423 1.568 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr15_-_56757329 1.561 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr12_+_25205568 1.543 ENST00000548766.1
ENST00000556887.1
LRMP

lymphoid-restricted membrane protein

chr10_-_15762124 1.530 ENST00000378076.3
ITGA8
integrin, alpha 8
chr3_-_58613323 1.507 ENST00000474531.1
ENST00000465970.1
FAM107A

family with sequence similarity 107, member A

chrX_-_110039286 1.492 ENST00000434224.1
CHRDL1
chordin-like 1
chr14_+_22309368 1.479 ENST00000390433.1
TRAV12-1
T cell receptor alpha variable 12-1
chr15_+_51973680 1.472 ENST00000542355.2
SCG3
secretogranin III
chr8_+_24241789 1.447 ENST00000256412.4
ENST00000538205.1
ADAMDEC1

ADAM-like, decysin 1

chr3_+_172361483 1.431 ENST00000598405.1
AC007919.2
HCG1787166; PRO1163; Uncharacterized protein
chr2_-_133429091 1.427 ENST00000345008.6
LYPD1
LY6/PLAUR domain containing 1
chr16_+_226658 1.401 ENST00000320868.5
ENST00000397797.1
HBA1

hemoglobin, alpha 1

chr11_-_114466477 1.334 ENST00000375478.3
NXPE4
neurexophilin and PC-esterase domain family, member 4
chr15_+_40453204 1.325 ENST00000287598.6
ENST00000412359.3
BUB1B

BUB1 mitotic checkpoint serine/threonine kinase B

chrX_-_72095622 1.307 ENST00000290273.5
DMRTC1
DMRT-like family C1
chr3_-_139195350 1.302 ENST00000232217.2
RBP2
retinol binding protein 2, cellular
chr1_+_55464600 1.283 ENST00000371265.4
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr8_+_27182862 1.282 ENST00000521164.1
ENST00000346049.5
PTK2B

protein tyrosine kinase 2 beta

chr3_-_180397256 1.253 ENST00000442201.2
CCDC39
coiled-coil domain containing 39
chr12_-_10320256 1.250 ENST00000538745.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr12_+_13349650 1.246 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
EMP1



epithelial membrane protein 1



chr2_+_207024306 1.187 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
EEF1B2



eukaryotic translation elongation factor 1 beta 2



chr20_+_42143136 1.170 ENST00000373134.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chrX_+_144908928 1.168 ENST00000408967.2
TMEM257
transmembrane protein 257
chr14_-_24732368 1.155 ENST00000544573.1
TGM1
transglutaminase 1
chr7_-_92855762 1.148 ENST00000453812.2
ENST00000394468.2
HEPACAM2

HEPACAM family member 2

chr16_+_88872176 1.136 ENST00000569140.1
CDT1
chromatin licensing and DNA replication factor 1
chr6_-_160679905 1.132 ENST00000366953.3
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
chr4_-_46126093 1.094 ENST00000295452.4
GABRG1
gamma-aminobutyric acid (GABA) A receptor, gamma 1
chrX_-_70326455 1.070 ENST00000374251.5
CXorf65
chromosome X open reading frame 65
chr12_-_11548496 1.061 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
PRB2

PRB1
proline-rich protein BstNI subfamily 2

proline-rich protein BstNI subfamily 1
chr6_+_149539053 1.043 ENST00000451095.1
RP1-111D6.3
RP1-111D6.3
chr12_+_25205666 1.038 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr7_-_92848878 1.008 ENST00000341723.4
HEPACAM2
HEPACAM family member 2
chr4_-_123377880 1.006 ENST00000226730.4
IL2
interleukin 2
chr7_-_92848858 1.005 ENST00000440868.1
HEPACAM2
HEPACAM family member 2
chr7_-_766879 0.999 ENST00000537384.1
ENST00000417852.1
PRKAR1B

protein kinase, cAMP-dependent, regulatory, type I, beta

chr17_+_76210267 0.976 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
BIRC5



baculoviral IAP repeat containing 5



chr12_+_13349711 0.971 ENST00000538364.1
ENST00000396301.3
EMP1

epithelial membrane protein 1

chr17_-_46703826 0.968 ENST00000550387.1
ENST00000311177.5
HOXB9

homeobox B9

chr6_+_34433844 0.963 ENST00000244458.2
ENST00000374043.2
PACSIN1

protein kinase C and casein kinase substrate in neurons 1

chr3_+_239652 0.960 ENST00000435603.1
CHL1
cell adhesion molecule L1-like
chrX_-_72095808 0.960 ENST00000373529.5
DMRTC1
DMRT-like family C1
chr1_+_16083098 0.946 ENST00000496928.2
ENST00000508310.1
FBLIM1

filamin binding LIM protein 1

chr4_+_37245799 0.928 ENST00000309447.5
KIAA1239
KIAA1239
chr6_-_132272504 0.928 ENST00000367976.3
CTGF
connective tissue growth factor
chr17_+_76210367 0.917 ENST00000592734.1
ENST00000587746.1
BIRC5

baculoviral IAP repeat containing 5

chr6_+_84222220 0.917 ENST00000369700.3
PRSS35
protease, serine, 35
chr11_-_114466471 0.893 ENST00000424261.2
NXPE4
neurexophilin and PC-esterase domain family, member 4
chr3_-_87039662 0.859 ENST00000494229.1
VGLL3
vestigial like 3 (Drosophila)
chr3_-_121740969 0.856 ENST00000393631.1
ENST00000273691.3
ENST00000344209.5
ILDR1


immunoglobulin-like domain containing receptor 1


chr22_-_50523807 0.850 ENST00000442311.1
ENST00000538737.1
MLC1

megalencephalic leukoencephalopathy with subcortical cysts 1

chr6_-_131299929 0.831 ENST00000531356.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr16_+_23194033 0.810 ENST00000300061.2
SCNN1G
sodium channel, non-voltage-gated 1, gamma subunit
chr7_+_30185496 0.804 ENST00000455738.1
C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr14_-_24042184 0.788 ENST00000544177.1
JPH4
junctophilin 4
chr14_+_22670455 0.784 ENST00000390460.1
TRAV26-2
T cell receptor alpha variable 26-2
chr7_-_99716914 0.779 ENST00000431404.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_-_95007193 0.768 ENST00000370207.4
ENST00000334047.7
F3

coagulation factor III (thromboplastin, tissue factor)

chr22_-_50523760 0.760 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr4_-_119274121 0.754 ENST00000296498.3
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr17_+_61086917 0.747 ENST00000424789.2
ENST00000389520.4
TANC2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chr17_+_42015654 0.703 ENST00000565120.1
RP11-527L4.2
Uncharacterized protein
chr12_-_21810726 0.698 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr14_+_24540154 0.695 ENST00000559778.1
ENST00000560761.1
ENST00000557889.1
CPNE6


copine VI (neuronal)


chr3_+_47021168 0.695 ENST00000450053.3
ENST00000292309.5
ENST00000383740.2
NBEAL2


neurobeachin-like 2


chr15_+_51973708 0.689 ENST00000558709.1
SCG3
secretogranin III
chr6_+_52051171 0.689 ENST00000340057.1
IL17A
interleukin 17A
chr6_+_116782527 0.684 ENST00000368606.3
ENST00000368605.1
FAM26F

family with sequence similarity 26, member F

chr19_-_44259053 0.683 ENST00000601170.1
SMG9
SMG9 nonsense mediated mRNA decay factor
chr11_-_10715117 0.676 ENST00000527509.2
MRVI1
murine retrovirus integration site 1 homolog
chr20_-_17539456 0.672 ENST00000544874.1
ENST00000377868.2
BFSP1

beaded filament structural protein 1, filensin

chr1_+_16083123 0.670 ENST00000510393.1
ENST00000430076.1
FBLIM1

filamin binding LIM protein 1

chrX_-_48776292 0.659 ENST00000376509.4
PIM2
pim-2 oncogene
chr17_+_73642486 0.656 ENST00000579469.1
SMIM6
small integral membrane protein 6
chrX_+_115567767 0.654 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr14_+_24540046 0.644 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
CPNE6



copine VI (neuronal)



chr12_-_10320190 0.642 ENST00000543993.1
ENST00000339968.6
OLR1

oxidized low density lipoprotein (lectin-like) receptor 1

chr20_-_44485835 0.638 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
ACOT8


acyl-CoA thioesterase 8


chr19_-_44259136 0.638 ENST00000270066.6
SMG9
SMG9 nonsense mediated mRNA decay factor
chr17_+_76227391 0.636 ENST00000586400.1
ENST00000421688.1
ENST00000374946.3
TMEM235


transmembrane protein 235


chr12_+_25205155 0.634 ENST00000550945.1
LRMP
lymphoid-restricted membrane protein
chr19_-_51893827 0.629 ENST00000574814.1
CTD-2616J11.4
chromosome 19 open reading frame 84
chr12_-_21810765 0.627 ENST00000450584.1
ENST00000350669.1
LDHB

lactate dehydrogenase B

chr3_-_8811288 0.626 ENST00000316793.3
ENST00000431493.1
OXTR

oxytocin receptor

chr3_+_126423045 0.625 ENST00000290913.3
ENST00000508789.1
CHCHD6

coiled-coil-helix-coiled-coil-helix domain containing 6

chr3_+_4535025 0.615 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1




inositol 1,4,5-trisphosphate receptor, type 1




chr1_+_228337553 0.613 ENST00000366714.2
GJC2
gap junction protein, gamma 2, 47kDa
chr17_+_73642315 0.612 ENST00000556126.2
SMIM6
small integral membrane protein 6
chr15_+_51973550 0.602 ENST00000220478.3
SCG3
secretogranin III
chr4_-_819901 0.597 ENST00000304062.6
CPLX1
complexin 1
chr8_+_67405794 0.592 ENST00000522977.1
ENST00000480005.1
C8orf46

chromosome 8 open reading frame 46

chr8_+_67405755 0.587 ENST00000521495.1
C8orf46
chromosome 8 open reading frame 46
chr12_-_75603482 0.577 ENST00000341669.3
ENST00000298972.1
ENST00000350228.2
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr16_-_66952742 0.577 ENST00000565235.2
ENST00000568632.1
ENST00000565796.1
CDH16


cadherin 16, KSP-cadherin


chr10_-_14596140 0.576 ENST00000496330.1
FAM107B
family with sequence similarity 107, member B
chr12_+_25205446 0.574 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP


lymphoid-restricted membrane protein


chr2_+_79252822 0.570 ENST00000272324.5
REG3G
regenerating islet-derived 3 gamma
chr2_+_79252834 0.569 ENST00000409471.1
REG3G
regenerating islet-derived 3 gamma
chr19_-_38720354 0.567 ENST00000416611.1
DPF1
D4, zinc and double PHD fingers family 1
chr6_+_84222194 0.566 ENST00000536636.1
PRSS35
protease, serine, 35
chr2_+_79252804 0.559 ENST00000393897.2
REG3G
regenerating islet-derived 3 gamma
chr22_-_50523843 0.558 ENST00000535444.1
ENST00000431262.2
MLC1

megalencephalic leukoencephalopathy with subcortical cysts 1

chr5_+_140474181 0.551 ENST00000194155.4
PCDHB2
protocadherin beta 2
chr13_+_108921977 0.543 ENST00000430559.1
ENST00000375887.4
TNFSF13B

tumor necrosis factor (ligand) superfamily, member 13b

chr11_-_67141640 0.539 ENST00000533438.1
CLCF1
cardiotrophin-like cytokine factor 1
chr1_-_67266939 0.536 ENST00000304526.2
INSL5
insulin-like 5
chr6_+_69942298 0.525 ENST00000238918.8
BAI3
brain-specific angiogenesis inhibitor 3
chr12_-_75603202 0.518 ENST00000393288.2
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr15_+_45422178 0.515 ENST00000389037.3
ENST00000558322.1
DUOX1

dual oxidase 1

chr7_+_99816859 0.515 ENST00000317271.2
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr12_-_102591604 0.513 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr16_+_22501658 0.499 ENST00000415833.2
NPIPB5
nuclear pore complex interacting protein family, member B5
chr1_-_160924589 0.499 ENST00000368029.3
ITLN2
intelectin 2
chr11_-_132812987 0.490 ENST00000541867.1
OPCML
opioid binding protein/cell adhesion molecule-like
chr1_+_16348525 0.481 ENST00000331433.4
CLCNKA
chloride channel, voltage-sensitive Ka
chrX_-_110655306 0.479 ENST00000371993.2
DCX
doublecortin
chr11_+_35211429 0.478 ENST00000525688.1
ENST00000278385.6
ENST00000533222.1
CD44


CD44 molecule (Indian blood group)


chr12_-_75603643 0.471 ENST00000549446.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr19_-_9003586 0.466 ENST00000380951.5
MUC16
mucin 16, cell surface associated
chr17_-_8198636 0.462 ENST00000577745.1
ENST00000579192.1
ENST00000396278.1
SLC25A35


solute carrier family 25, member 35


chr14_-_106068065 0.459 ENST00000390541.2
IGHE
immunoglobulin heavy constant epsilon
chr8_-_86162077 0.458 ENST00000551479.1
RP11-219B4.6
Uncharacterized protein
chr1_+_120839412 0.455 ENST00000355228.4
FAM72B
family with sequence similarity 72, member B
chr3_+_67048721 0.454 ENST00000295568.4
ENST00000484414.1
ENST00000460576.1
ENST00000417314.2
KBTBD8



kelch repeat and BTB (POZ) domain containing 8



chr8_+_104310661 0.453 ENST00000522566.1
FZD6
frizzled family receptor 6
chr2_-_159313214 0.451 ENST00000409889.1
ENST00000283233.5
ENST00000536771.1
CCDC148


coiled-coil domain containing 148


chr3_-_150966902 0.448 ENST00000424796.2
P2RY14
purinergic receptor P2Y, G-protein coupled, 14
chr15_-_70387120 0.445 ENST00000539550.1
TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr5_+_149737202 0.445 ENST00000451292.1
ENST00000377797.3
ENST00000445265.2
ENST00000323668.7
ENST00000439160.2
ENST00000394269.3
ENST00000427724.2
ENST00000504761.2
ENST00000513346.1
ENST00000515516.1
TCOF1









Treacher Collins-Franceschetti syndrome 1









chr11_+_12108410 0.444 ENST00000527997.1
RP13-631K18.5
RP13-631K18.5
chr2_-_68547019 0.421 ENST00000409862.1
CNRIP1
cannabinoid receptor interacting protein 1
chr1_+_158223923 0.415 ENST00000289429.5
CD1A
CD1a molecule
chr2_-_68547061 0.413 ENST00000263655.3
CNRIP1
cannabinoid receptor interacting protein 1
chr11_-_133826852 0.411 ENST00000533871.2
ENST00000321016.8
IGSF9B

immunoglobulin superfamily, member 9B

chr4_+_15341442 0.403 ENST00000397700.2
ENST00000295297.4
C1QTNF7

C1q and tumor necrosis factor related protein 7

chr3_+_10183447 0.403 ENST00000345392.2
VHL
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
chr14_+_63671577 0.402 ENST00000555125.1
RHOJ
ras homolog family member J
chr15_-_35047166 0.401 ENST00000290374.4
GJD2
gap junction protein, delta 2, 36kDa
chr7_-_38295997 0.401 ENST00000390334.1
TRGJP2
T cell receptor gamma joining P2
chr6_+_149539106 0.400 ENST00000443992.1
RP1-111D6.3
RP1-111D6.3
chr6_+_43968306 0.399 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223


chromosome 6 open reading frame 223


chr3_-_53290016 0.395 ENST00000423525.2
ENST00000423516.1
ENST00000296289.6
ENST00000462138.1
TKT



transketolase



chr4_-_164253738 0.380 ENST00000509586.1
ENST00000504391.1
ENST00000512819.1
NPY1R


neuropeptide Y receptor Y1


chr8_+_128426535 0.380 ENST00000465342.2
POU5F1B
POU class 5 homeobox 1B
chrX_+_591524 0.379 ENST00000554971.1
ENST00000381575.1
SHOX

short stature homeobox

chr16_-_55478666 0.374 ENST00000565307.1
RP11-212I21.2
RP11-212I21.2
chr12_+_25205628 0.369 ENST00000554942.1
LRMP
lymphoid-restricted membrane protein
chr15_-_77363441 0.360 ENST00000346495.2
ENST00000424443.3
ENST00000561277.1
TSPAN3


tetraspanin 3


chr17_-_62502399 0.352 ENST00000450599.2
ENST00000585060.1
DDX5

DEAD (Asp-Glu-Ala-Asp) box helicase 5

chr12_-_49504449 0.342 ENST00000547675.1
LMBR1L
limb development membrane protein 1-like
chr17_-_28661065 0.339 ENST00000328886.4
ENST00000538566.2
TMIGD1

transmembrane and immunoglobulin domain containing 1

chr13_-_46756351 0.334 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr7_-_36764142 0.331 ENST00000258749.5
ENST00000535891.1
AOAH

acyloxyacyl hydrolase (neutrophil)

chr18_+_44497455 0.326 ENST00000592005.1
KATNAL2
katanin p60 subunit A-like 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0072081 proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081)
0.5 2.8 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.4 0.4 GO:0042069 regulation of catecholamine metabolic process(GO:0042069)
0.3 1.7 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.3 1.0 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.3 0.8 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.2 1.9 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.2 0.9 GO:0045023 G0 to G1 transition(GO:0045023)
0.2 1.3 GO:0006089 lactate metabolic process(GO:0006089)
0.2 1.3 GO:0034501 protein localization to kinetochore(GO:0034501)
0.2 1.3 GO:0003351 epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.2 0.6 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.2 0.5 GO:0046005 positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.2 0.5 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.1 4.1 GO:0006906 vesicle fusion(GO:0006906)
0.1 0.7 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.1 4.0 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.1 0.7 GO:0010508 positive regulation of autophagy(GO:0010508)
0.1 0.4 GO:0005997 xylulose metabolic process(GO:0005997)
0.1 0.5 GO:0042335 cuticle development(GO:0042335)
0.1 1.7 GO:0006953 acute-phase response(GO:0006953)
0.1 1.1 GO:0007090 obsolete regulation of S phase of mitotic cell cycle(GO:0007090)
0.1 0.4 GO:0019614 phenol-containing compound catabolic process(GO:0019336) catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.1 1.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 0.8 GO:0035313 wound healing, spreading of epidermal cells(GO:0035313) wound healing, spreading of cells(GO:0044319) epiboly(GO:0090504) epiboly involved in wound healing(GO:0090505)
0.1 0.3 GO:0006667 sphinganine metabolic process(GO:0006667)
0.1 0.3 GO:0035584 calcium-mediated signaling using intracellular calcium source(GO:0035584)
0.1 0.2 GO:0001692 histamine metabolic process(GO:0001692)
0.1 0.3 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 1.2 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532)
0.1 0.2 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601) regulation of glutamate receptor signaling pathway(GO:1900449) regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 1.3 GO:0014009 glial cell proliferation(GO:0014009)
0.1 1.3 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1 0.8 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.0 1.1 GO:0015695 organic cation transport(GO:0015695)
0.0 1.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.4 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0 2.0 GO:0042417 dopamine metabolic process(GO:0042417)
0.0 0.1 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428) antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.0 0.1 GO:0006848 pyruvate transport(GO:0006848)
0.0 1.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.1 GO:0018874 benzoate metabolic process(GO:0018874)
0.0 0.6 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.4 GO:0010923 negative regulation of phosphatase activity(GO:0010923) negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.3 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.0 1.0 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 1.0 GO:0045806 negative regulation of endocytosis(GO:0045806)
0.0 0.1 GO:0032203 telomere formation via telomerase(GO:0032203)
0.0 0.3 GO:1901797 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797)
0.0 1.0 GO:0001709 cell fate determination(GO:0001709)
0.0 1.3 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 1.7 GO:0001764 neuron migration(GO:0001764)
0.0 0.8 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.3 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.3 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 1.7 GO:0006968 cellular defense response(GO:0006968)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 2.4 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.6 GO:0014047 glutamate secretion(GO:0014047)
0.0 2.0 GO:0008360 regulation of cell shape(GO:0008360)
0.0 2.3 GO:0050796 regulation of insulin secretion(GO:0050796)
0.0 0.1 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.0 2.4 GO:0007399 nervous system development(GO:0007399)
0.0 0.0 GO:1903306 negative regulation of regulated secretory pathway(GO:1903306)
0.0 0.1 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 1.0 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.0 0.0 GO:0030578 nuclear body organization(GO:0030575) PML body organization(GO:0030578)
0.0 0.2 GO:0030321 transepithelial chloride transport(GO:0030321)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0032133 chromosome passenger complex(GO:0032133)
0.2 0.8 GO:0043083 synaptic cleft(GO:0043083)
0.2 4.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 1.3 GO:0051233 spindle midzone(GO:0051233)
0.1 0.8 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 1.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 2.2 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.4 GO:0030891 VCB complex(GO:0030891)
0.1 1.3 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 2.2 GO:0000299 obsolete integral to membrane of membrane fraction(GO:0000299)
0.0 0.8 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 1.7 GO:0001533 cornified envelope(GO:0001533)
0.0 1.0 GO:0005801 cis-Golgi network(GO:0005801)
0.0 2.0 GO:0043195 terminal bouton(GO:0043195)
0.0 1.0 GO:0005922 connexon complex(GO:0005922)
0.0 0.3 GO:0002178 palmitoyltransferase complex(GO:0002178) serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.8 GO:0008091 spectrin(GO:0008091)
0.0 1.0 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.8 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.8 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0001940 male pronucleus(GO:0001940)
0.0 1.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.5 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.6 GO:0071565 nBAF complex(GO:0071565)
0.0 0.6 GO:0005902 microvillus(GO:0005902)
0.0 0.3 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.3 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.5 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 3.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.4 GO:0042611 MHC protein complex(GO:0042611)
0.0 0.7 GO:0031526 brush border membrane(GO:0031526)
0.0 2.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0042824 MHC class I peptide loading complex(GO:0042824) TAP complex(GO:0042825)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 2.6 GO:0005938 cell cortex(GO:0005938)
0.0 2.1 GO:0005882 intermediate filament(GO:0005882)
0.0 1.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.4 1.2 GO:0031493 nucleosomal histone binding(GO:0031493) SAM domain binding(GO:0032093)
0.3 4.0 GO:0032395 MHC class II receptor activity(GO:0032395)
0.3 1.0 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.2 2.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 1.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 1.9 GO:0050897 cobalt ion binding(GO:0050897)
0.1 0.6 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 0.4 GO:0001602 pancreatic polypeptide receptor activity(GO:0001602)
0.1 0.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 1.7 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.1 1.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.1 0.4 GO:0004802 transketolase activity(GO:0004802)
0.1 1.0 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.8 GO:0042731 PH domain binding(GO:0042731)
0.1 0.6 GO:0005000 vasopressin receptor activity(GO:0005000)
0.1 0.3 GO:0072544 L-DOPA receptor activity(GO:0035643) L-DOPA binding(GO:0072544) tyrosine binding(GO:0072545)
0.1 4.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 2.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 2.0 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.1 0.2 GO:0045030 UTP-activated nucleotide receptor activity(GO:0045030)
0.1 1.0 GO:0005243 gap junction channel activity(GO:0005243)
0.1 0.8 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 1.9 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 1.3 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.5 GO:0004985 opioid receptor activity(GO:0004985)
0.1 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 1.7 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.0 0.3 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 0.9 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.4 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.1 GO:0004960 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.0 1.0 GO:0019841 retinol binding(GO:0019841)
0.0 0.4 GO:0045029 uridine nucleotide receptor activity(GO:0015065) UDP-activated nucleotide receptor activity(GO:0045029) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0 0.3 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.2 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.4 GO:0008160 protein tyrosine phosphatase activator activity(GO:0008160) protein phosphatase activator activity(GO:0072542)
0.0 1.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.1 GO:0050833 pyruvate secondary active transmembrane transporter activity(GO:0005477) pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.8 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.1 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.0 1.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.0 GO:0030552 cAMP binding(GO:0030552)
0.0 0.1 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.0 0.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 2.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.8 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.3 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 1.6 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.6 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.3 GO:0030553 cyclic nucleotide binding(GO:0030551) cGMP binding(GO:0030553)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.3 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.2 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction