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Illumina Body Map 2: averaged replicates
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Results for NKX3-2
Z-value: 1.61
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Transcription factors associated with NKX3-2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX3-2 | hg19_v2_chr4_-_13546632_13546674 | -0.02 | 8.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_99573677 Show fit | 3.97 |
ENST00000292401.4
|
alpha-2-glycoprotein 1, zinc-binding |
|
| chr15_+_89402148 Show fit | 3.82 |
ENST00000560601.1
|
aggrecan |
|
| chr11_-_102401469 Show fit | 3.77 |
ENST00000260227.4
|
matrix metallopeptidase 7 (matrilysin, uterine) |
|
| chr17_+_68071389 Show fit | 3.40 |
ENST00000283936.1
ENST00000392671.1 |
potassium inwardly-rectifying channel, subfamily J, member 16 |
|
| chr11_-_26593649 Show fit | 3.31 |
ENST00000455601.2
|
mucin 15, cell surface associated |
|
| chr7_-_120498357 Show fit | 3.17 |
ENST00000415871.1
ENST00000222747.3 ENST00000430985.1 |
tetraspanin 12 |
|
| chr5_+_78407602 Show fit | 3.13 |
ENST00000274353.5
ENST00000524080.1 |
betaine--homocysteine S-methyltransferase |
|
| chrX_+_105937068 Show fit | 2.99 |
ENST00000324342.3
|
ring finger protein 128, E3 ubiquitin protein ligase |
|
| chr3_+_125694347 Show fit | 2.98 |
ENST00000505382.1
ENST00000511082.1 |
rhophilin associated tail protein 1B |
|
| chrX_+_105936982 Show fit | 2.66 |
ENST00000418562.1
|
ring finger protein 128, E3 ubiquitin protein ligase |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX3-2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.6 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 8.4 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 7.1 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.1 | 6.0 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.2 | 5.5 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.0 | 5.3 | GO:1901379 | regulation of potassium ion transmembrane transport(GO:1901379) |
| 0.2 | 4.7 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 0.2 | 4.6 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.3 | 3.9 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
| 0.2 | 3.8 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 12.7 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 11.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 3.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.4 | 3.4 | GO:1990393 | 3M complex(GO:1990393) |
| 0.3 | 2.9 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.0 | 2.8 | GO:0031514 | motile cilium(GO:0031514) |
| 0.2 | 2.6 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.2 | 2.5 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.1 | 2.1 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 8.1 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.3 | 7.1 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.3 | 6.7 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 5.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 5.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 5.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 5.4 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.6 | 4.9 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.0 | 4.9 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 3.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 7.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 6.9 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 6.0 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 5.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 3.8 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 2.9 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.2 | 2.1 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
| 0.0 | 2.0 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 1.9 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.9 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.2 | 8.6 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 5.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 4.2 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.2 | 3.8 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 3.6 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 3.4 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 3.2 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.1 | 2.4 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 2.2 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |