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Illumina Body Map 2: averaged replicates
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Results for NOTO_VSX2_DLX2_DLX6_NKX6-1
Z-value: 1.67
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Transcription factors associated with NOTO_VSX2_DLX2_DLX6_NKX6-1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000214513.3 | notochord homeobox | |
| ENSG00000119614.2 | visual system homeobox 2 | |
| ENSG00000115844.6 | distal-less homeobox 2 | |
| ENSG00000006377.9 | distal-less homeobox 6 | |
| ENSG00000163623.5 | NK6 homeobox 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX6-1 | hg19_v2_chr4_-_85418103_85418103 | 0.28 | 1.3e-01 | Click! |
| VSX2 | hg19_v2_chr14_+_74706150_74706175 | 0.16 | 3.7e-01 | Click! |
| DLX6 | hg19_v2_chr7_+_96635277_96635301 | 0.14 | 4.5e-01 | Click! |
| NOTO | hg19_v2_chr2_+_73429386_73429386 | -0.08 | 6.5e-01 | Click! |
| DLX2 | hg19_v2_chr2_-_172967621_172967637 | 0.04 | 8.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NOTO_VSX2_DLX2_DLX6_NKX6-1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 2.9 | 11.4 | GO:1901846 | positive regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901846) |
| 0.8 | 11.2 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.1 | 10.9 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.8 | 10.6 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.5 | 9.2 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.5 | 8.3 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.5 | 7.3 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
| 0.1 | 7.3 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 1.2 | 5.8 | GO:0060127 | subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 22.6 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.1 | 17.1 | GO:0005796 | Golgi lumen(GO:0005796) |
| 1.3 | 14.8 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.4 | 12.2 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 8.8 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 7.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 7.0 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 6.1 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 5.6 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 5.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 29.1 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.1 | 16.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 11.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 10.4 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.5 | 9.2 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.0 | 6.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 6.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.2 | 6.0 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 5.7 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 5.6 | GO:0005179 | hormone activity(GO:0005179) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 11.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 8.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 7.7 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 6.9 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 4.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 4.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.0 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 3.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.7 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 5.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 5.0 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 3.9 | REACTOME INTEGRATION OF ENERGY METABOLISM | Genes involved in Integration of energy metabolism |
| 0.0 | 3.5 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 3.3 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 3.2 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 2.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 2.3 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 2.0 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |