ISMARA results: NR1H2

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Illumina Body Map 2: averaged replicates

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Results for NR1H2

Z-value: 1.61

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Transcription factors associated with NR1H2

Gene Symbol	Gene ID	Gene Info
NR1H2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000131408.9	nuclear receptor subfamily 1 group H member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR1H2	hg19_v2_chr19_+_50832895_50832928	-0.36	4.2e-02	Click!

Activity profile of NR1H2 motif

Sorted Z-values of NR1H2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_77774897 Show fit	6.40	ENST00000281030.2	THRSP Ensembl NCBI GeneCards UniProt NextProt Show fit	thyroid hormone responsive
chr7_+_80253387 Show fit	2.74	ENST00000438020.1	CD36 Ensembl NCBI GeneCards UniProt NextProt Show fit	CD36 molecule (thrombospondin receptor)
chr9_-_107690420 Show fit	2.57	ENST00000423487.2 ENST00000374733.1 ENST00000374736.3	ABCA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATP-binding cassette, sub-family A (ABC1), member 1
chr12_-_47226152 Show fit	2.30	ENST00000546940.1	SLC38A4 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 38, member 4
chr16_+_56995762 Show fit	2.28	ENST00000200676.3 ENST00000379780.2	CETP Ensembl NCBI GeneCards UniProt NextProt Show fit	cholesteryl ester transfer protein, plasma
chr11_-_118083600 Show fit	2.27	ENST00000524477.1	AMICA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	adhesion molecule, interacts with CXADR antigen 1
chr2_-_216946500 Show fit	2.25	ENST00000265322.7	PECR Ensembl NCBI GeneCards UniProt NextProt Show fit	peroxisomal trans-2-enoyl-CoA reductase
chr20_+_5987890 Show fit	2.22	ENST00000378868.4	CRLS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cardiolipin synthase 1
chr1_-_237167718 Show fit	2.20	ENST00000464121.2	MT1HL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	metallothionein 1H-like 1
chr12_+_32115400 Show fit	2.18	ENST00000381054.3	KIAA1551 Ensembl NCBI GeneCards UniProt NextProt Show fit	KIAA1551

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1H2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	6.5	GO:0055091	phospholipid homeostasis(GO:0055091)
0.3	6.4	GO:0006853	carnitine shuttle(GO:0006853)
0.0	4.6	GO:0006888	ER to Golgi vesicle-mediated transport(GO:0006888)
0.1	4.2	GO:0032094	response to food(GO:0032094)
0.0	3.5	GO:0009108	coenzyme biosynthetic process(GO:0009108)
0.0	3.3	GO:0002377	immunoglobulin production(GO:0002377)
0.8	3.0	GO:0055099	response to high density lipoprotein particle(GO:0055099)
0.2	2.7	GO:2000332	blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.2	2.7	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.0	2.7	GO:0006687	glycosphingolipid metabolic process(GO:0006687)

Showing 1 to 10 of 133 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.1	GO:0031966	mitochondrial membrane(GO:0031966)
0.1	6.5	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.1	6.4	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0	5.6	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	5.1	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.1	3.6	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	3.5	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.1	2.7	GO:0044232	organelle membrane contact site(GO:0044232)
0.0	2.7	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0	2.4	GO:0016605	PML body(GO:0016605)

Showing 1 to 10 of 57 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	3.9	GO:0017129	triglyceride binding(GO:0017129)
0.0	3.5	GO:0015297	antiporter activity(GO:0015297)
0.1	3.4	GO:0016805	dipeptidase activity(GO:0016805)
0.2	2.7	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
0.1	2.7	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.6	2.6	GO:0090556	apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.4	2.5	GO:0004882	androgen receptor activity(GO:0004882)
0.2	2.3	GO:0030369	ICAM-3 receptor activity(GO:0030369)
0.0	2.3	GO:0003735	structural constituent of ribosome(GO:0003735)
0.7	2.2	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)

Showing 1 to 10 of 105 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
3.9	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
3.1	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
2.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
2.5	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
2.2	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
2.1	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
2.0	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
2.0	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
1.9	PID CMYB PATHWAY	C-MYB transcription factor network
1.7	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	8.0	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	6.5	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	4.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	4.5	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.2	3.5	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	2.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	2.4	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.1	2.3	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.0	2.2	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	2.1	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Showing 1 to 10 of 42 entries

Results for NR1H2

Z-value: 1.61

Motif logo

Transcription factors associated with NR1H2

Activity-expression correlation:

Activity profile of NR1H2 motif

Sorted Z-values of NR1H2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1H2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: