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Illumina Body Map 2: averaged replicates

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Results for NR1H4

Z-value: 1.06

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Transcription factors associated with NR1H4

Gene Symbol Gene ID Gene Info
ENSG00000012504.9 nuclear receptor subfamily 1 group H member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1H4hg19_v2_chr12_+_100867733_1008677500.183.2e-01Click!

Activity profile of NR1H4 motif

Sorted Z-values of NR1H4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_116663127 3.75 ENST00000433069.1
ENST00000542499.1
apolipoprotein A-V
chr9_-_137809718 3.14 ENST00000371806.3
ficolin (collagen/fibrinogen domain containing) 1
chr20_+_30639991 2.41 ENST00000534862.1
ENST00000538448.1
ENST00000375862.2
hemopoietic cell kinase
chr14_-_25103472 2.41 ENST00000216341.4
ENST00000382542.1
ENST00000382540.1
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr20_+_30640004 2.37 ENST00000520553.1
ENST00000518730.1
ENST00000375852.2
hemopoietic cell kinase
chr19_+_7741968 2.33 ENST00000597445.1
chromosome 19 open reading frame 59
chr17_+_43318434 2.20 ENST00000587489.1
formin-like 1
chr22_+_22786288 2.17 ENST00000390301.2
immunoglobulin lambda variable 1-36
chr14_-_25103388 2.09 ENST00000526004.1
ENST00000415355.3
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr20_+_62369623 2.01 ENST00000467211.1
RP4-583P15.14
chr3_+_111260856 1.88 ENST00000352690.4
CD96 molecule
chr14_+_22356029 1.85 ENST00000390437.2
T cell receptor alpha variable 12-2
chr3_+_111260954 1.85 ENST00000283285.5
CD96 molecule
chr11_-_64511575 1.76 ENST00000431822.1
ENST00000377486.3
ENST00000394432.3
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr18_-_67624160 1.75 ENST00000581982.1
ENST00000280200.4
CD226 molecule
chr14_+_22314715 1.74 ENST00000390434.3
T cell receptor alpha variable 8-2
chr5_+_133450365 1.73 ENST00000342854.5
ENST00000321603.6
ENST00000321584.4
ENST00000378564.1
ENST00000395029.1
transcription factor 7 (T-cell specific, HMG-box)
chr17_-_73840614 1.69 ENST00000586108.1
unc-13 homolog D (C. elegans)
chr12_-_7281469 1.68 ENST00000542370.1
ENST00000266560.3
retinol binding protein 5, cellular
chr3_+_111260980 1.67 ENST00000438817.2
CD96 molecule
chr19_+_1071203 1.64 ENST00000543365.1
histocompatibility (minor) HA-1
chr17_-_73840415 1.63 ENST00000592386.1
ENST00000412096.2
ENST00000586147.1
unc-13 homolog D (C. elegans)
chr12_-_68845165 1.61 ENST00000360485.3
ENST00000441255.2
RP11-81H14.2
chr10_-_95360983 1.52 ENST00000371464.3
retinol binding protein 4, plasma
chr22_+_23247030 1.48 ENST00000390324.2
immunoglobulin lambda joining 3
chr2_+_192542879 1.44 ENST00000409510.1
nucleic acid binding protein 1
chr17_-_73840774 1.43 ENST00000207549.4
unc-13 homolog D (C. elegans)
chr17_-_73839792 1.42 ENST00000590762.1
unc-13 homolog D (C. elegans)
chr7_+_2671663 1.39 ENST00000407643.1
tweety family member 3
chr16_+_23847339 1.36 ENST00000303531.7
protein kinase C, beta
chr2_+_192543153 1.26 ENST00000425611.2
nucleic acid binding protein 1
chr2_+_192543694 1.25 ENST00000435931.1
nucleic acid binding protein 1
chr19_-_42636617 1.24 ENST00000529067.1
ENST00000529952.1
ENST00000533720.1
ENST00000389341.5
ENST00000342301.4
POU class 2 homeobox 2
chr1_-_25256368 1.22 ENST00000308873.6
runt-related transcription factor 3
chr16_+_23847267 1.20 ENST00000321728.7
protein kinase C, beta
chr19_-_11689752 1.20 ENST00000592659.1
ENST00000592828.1
ENST00000218758.5
ENST00000412435.2
acid phosphatase 5, tartrate resistant
chr3_+_52828805 1.19 ENST00000416872.2
ENST00000449956.2
inter-alpha-trypsin inhibitor heavy chain 3
chr1_+_28206150 1.18 ENST00000456990.1
thymocyte selection associated family member 2
chr3_+_122296443 1.12 ENST00000464300.2
poly (ADP-ribose) polymerase family, member 15
chr18_-_67623906 1.08 ENST00000583955.1
CD226 molecule
chr12_+_6898674 1.07 ENST00000541982.1
ENST00000539492.1
CD4 molecule
chr19_+_1026566 1.05 ENST00000348419.3
ENST00000565096.2
ENST00000562958.2
ENST00000562075.2
ENST00000607102.1
calponin 2
chr22_+_45072925 1.04 ENST00000006251.7
proline rich 5 (renal)
chr2_-_182545603 1.04 ENST00000295108.3
neuronal differentiation 1
chr12_+_6898638 1.03 ENST00000011653.4
CD4 molecule
chr2_+_192542850 1.01 ENST00000410026.2
nucleic acid binding protein 1
chr12_+_109273806 1.00 ENST00000228476.3
ENST00000547768.1
D-amino-acid oxidase
chr16_+_2014941 0.99 ENST00000531523.1
small nucleolar RNA host gene 9 (non-protein coding)
chr2_-_64371546 0.99 ENST00000358912.4
pellino E3 ubiquitin protein ligase 1
chr18_-_67624412 0.97 ENST00000580335.1
CD226 molecule
chr16_+_23847355 0.97 ENST00000498058.1
protein kinase C, beta
chr2_+_233877324 0.95 ENST00000409905.1
Uncharacterized protein
chr9_+_127023704 0.93 ENST00000373596.1
ENST00000425237.1
NIMA-related kinase 6
chr8_-_131028660 0.88 ENST00000401979.2
ENST00000517654.1
ENST00000522361.1
ENST00000518167.1
family with sequence similarity 49, member B
chr14_+_21492331 0.86 ENST00000533984.1
ENST00000532213.2
AL161668.5
chr19_+_1026298 0.85 ENST00000263097.4
calponin 2
chr7_+_2671568 0.85 ENST00000258796.7
tweety family member 3
chr22_+_45072958 0.84 ENST00000403581.1
proline rich 5 (renal)
chr11_-_65624415 0.83 ENST00000524553.1
ENST00000527344.1
cofilin 1 (non-muscle)
chr11_-_65625014 0.81 ENST00000534784.1
cofilin 1 (non-muscle)
chr19_+_10197463 0.81 ENST00000590378.1
ENST00000397881.3
chromosome 19 open reading frame 66
chr1_+_156024525 0.81 ENST00000368305.4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr1_+_29241027 0.80 ENST00000373797.1
erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)
chr1_+_162351503 0.79 ENST00000458626.2
chromosome 1 open reading frame 226
chr1_-_27240455 0.77 ENST00000254227.3
nuclear receptor subfamily 0, group B, member 2
chr22_+_20105012 0.74 ENST00000331821.3
ENST00000411892.1
RAN binding protein 1
chr19_-_36304201 0.73 ENST00000301175.3
proline dehydrogenase (oxidase) 2
chr19_+_19496624 0.71 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATA zinc finger domain containing 2A
chr22_+_20104947 0.71 ENST00000402752.1
RAN binding protein 1
chr16_+_81478775 0.70 ENST00000537098.3
c-Maf inducing protein
chr1_-_149908217 0.68 ENST00000369140.3
myotubularin related protein 11
chr11_-_62380199 0.68 ENST00000419857.1
ENST00000394773.2
echinoderm microtubule associated protein like 3
chr1_+_156024552 0.68 ENST00000368304.5
ENST00000368302.3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr11_-_118305921 0.66 ENST00000532619.1
RP11-770J1.4
chr8_-_131028782 0.66 ENST00000519020.1
family with sequence similarity 49, member B
chr14_-_65769392 0.65 ENST00000555736.1
CTD-2509G16.5
chr22_+_20105259 0.65 ENST00000416427.1
ENST00000421656.1
ENST00000423859.1
ENST00000418705.2
RAN binding protein 1
chr12_+_120875887 0.65 ENST00000229379.2
cytochrome c oxidase subunit VIa polypeptide 1
chr19_-_11688951 0.63 ENST00000589792.1
acid phosphatase 5, tartrate resistant
chr17_-_4852243 0.62 ENST00000225655.5
profilin 1
chr12_-_8088871 0.61 ENST00000075120.7
solute carrier family 2 (facilitated glucose transporter), member 3
chr3_+_14989186 0.60 ENST00000435454.1
ENST00000323373.6
nuclear receptor subfamily 2, group C, member 2
chr2_-_74780176 0.60 ENST00000409549.1
lysyl oxidase-like 3
chr3_-_126236605 0.59 ENST00000290868.2
urocanate hydratase 1
chr5_+_132208014 0.58 ENST00000296877.2
liver expressed antimicrobial peptide 2
chr17_-_4852332 0.58 ENST00000572383.1
profilin 1
chr1_+_25599018 0.58 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
Rh blood group, D antigen
chr6_-_33548006 0.58 ENST00000374467.3
BCL2-antagonist/killer 1
chr19_+_11546440 0.57 ENST00000589126.1
ENST00000588269.1
ENST00000587509.1
ENST00000592741.1
ENST00000593101.1
ENST00000587327.1
protein kinase C substrate 80K-H
chr12_+_56511943 0.57 ENST00000257940.2
ENST00000552345.1
ENST00000551880.1
ENST00000546903.1
ENST00000551790.1
zinc finger CCCH-type containing 10
extended synaptotagmin-like protein 1
chr19_+_11546153 0.55 ENST00000591946.1
ENST00000252455.2
ENST00000412601.1
protein kinase C substrate 80K-H
chr22_+_50714103 0.55 ENST00000595015.1
Uncharacterized protein
chr3_-_126236588 0.55 ENST00000383579.3
urocanate hydratase 1
chr17_-_26879567 0.53 ENST00000581945.1
ENST00000444148.1
ENST00000301032.4
ENST00000335765.4
unc-119 homolog (C. elegans)
chr14_+_57671888 0.53 ENST00000391612.1
AL391152.1
chr3_-_194119083 0.53 ENST00000401815.1
glycoprotein V (platelet)
chr14_+_22957581 0.53 ENST00000390487.1
T cell receptor alpha joining 50
chr3_+_50316458 0.52 ENST00000316436.3
leucine-rich single-pass membrane protein 2
chr19_+_11546093 0.52 ENST00000591462.1
protein kinase C substrate 80K-H
chr14_-_54908043 0.51 ENST00000556113.1
ENST00000553660.1
ENST00000395573.4
ENST00000557690.1
ENST00000216416.4
cornichon family AMPA receptor auxiliary protein 1
chr12_+_120875910 0.51 ENST00000551806.1
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
chr1_-_16539094 0.51 ENST00000270747.3
Rho guanine nucleotide exchange factor (GEF) 19
chr3_-_57113314 0.50 ENST00000338458.4
ENST00000468727.1
Rho guanine nucleotide exchange factor (GEF) 3
chr19_+_10196981 0.50 ENST00000591813.1
chromosome 19 open reading frame 66
chr17_+_73975292 0.50 ENST00000397640.1
ENST00000416485.1
ENST00000588202.1
ENST00000590676.1
ENST00000586891.1
TEN1 CST complex subunit
chr8_-_110346614 0.49 ENST00000239690.4
NudC domain containing 1
chr6_-_33547975 0.49 ENST00000442998.2
ENST00000360661.5
BCL2-antagonist/killer 1
chr19_+_19496728 0.48 ENST00000537887.1
ENST00000417582.2
GATA zinc finger domain containing 2A
chr8_-_131028869 0.48 ENST00000518283.1
ENST00000519110.1
family with sequence similarity 49, member B
chr1_+_12123414 0.48 ENST00000263932.2
tumor necrosis factor receptor superfamily, member 8
chr2_+_219433281 0.47 ENST00000273064.6
ENST00000509807.2
ENST00000542068.1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr12_-_6451235 0.47 ENST00000440083.2
ENST00000162749.2
tumor necrosis factor receptor superfamily, member 1A
chr12_-_6451186 0.47 ENST00000540022.1
ENST00000536194.1
tumor necrosis factor receptor superfamily, member 1A
chr12_-_107168696 0.46 ENST00000551505.1
Uncharacterized protein
chr1_-_225616515 0.46 ENST00000338179.2
ENST00000425080.1
lamin B receptor
chr6_+_96025341 0.45 ENST00000369293.1
ENST00000358812.4
mannosidase, endo-alpha
chr8_+_110346546 0.45 ENST00000521662.1
ENST00000521688.1
ENST00000520147.1
enhancer of yellow 2 homolog (Drosophila)
chr11_-_65430554 0.44 ENST00000308639.9
ENST00000406246.3
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr16_-_69166460 0.43 ENST00000523421.1
ENST00000448552.2
ENST00000306585.6
ENST00000567763.1
ENST00000522497.1
ENST00000522091.1
ENST00000519520.1
CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)
chr2_+_207024306 0.43 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
eukaryotic translation elongation factor 1 beta 2
chr11_-_58345569 0.42 ENST00000528954.1
ENST00000528489.1
leupaxin
chr18_+_3448455 0.42 ENST00000549780.1
TGFB-induced factor homeobox 1
chr3_+_190105909 0.42 ENST00000456423.1
claudin 16
chr1_+_26872324 0.41 ENST00000531382.1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_+_151483855 0.41 ENST00000427934.2
ENST00000271636.7
cingulin
chr17_-_1083078 0.41 ENST00000574266.1
ENST00000302538.5
active BCR-related
chrX_+_106449862 0.40 ENST00000372453.3
ENST00000535523.1
PIH1 domain containing 3
chr12_+_100661156 0.40 ENST00000360820.2
SCY1-like 2 (S. cerevisiae)
chr8_-_101321584 0.39 ENST00000523167.1
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr1_+_25598989 0.39 ENST00000454452.2
Rh blood group, D antigen
chr12_-_8088773 0.38 ENST00000544291.1
solute carrier family 2 (facilitated glucose transporter), member 3
chr13_+_27844464 0.38 ENST00000241463.4
RAS-like, family 11, member A
chr2_-_214014959 0.37 ENST00000442445.1
ENST00000457361.1
ENST00000342002.2
IKAROS family zinc finger 2 (Helios)
chr1_+_1334895 0.37 ENST00000448629.2
ENST00000444362.1
HCG20425, isoform CRA_a; Uncharacterized protein; cDNA FLJ53815
chr1_+_203765437 0.37 ENST00000550078.1
zinc finger, BED-type containing 6
chr1_+_12123463 0.36 ENST00000417814.2
tumor necrosis factor receptor superfamily, member 8
chr1_-_36789755 0.36 ENST00000270824.1
eva-1 homolog B (C. elegans)
chrX_-_106449656 0.35 ENST00000372466.4
ENST00000421752.1
ENST00000372461.3
nucleoporin 62kDa C-terminal like
chr9_+_116343192 0.34 ENST00000471324.2
regulator of G-protein signaling 3
chr3_-_38071122 0.33 ENST00000334661.4
phospholipase C, delta 1
chr12_-_6451014 0.32 ENST00000366159.4
ENST00000539372.1
tumor necrosis factor receptor superfamily, member 1A
chr17_-_3595042 0.30 ENST00000552723.1
purinergic receptor P2X, ligand-gated ion channel, 5
chr22_-_20104700 0.30 ENST00000439169.2
ENST00000445045.1
ENST00000404751.3
ENST00000252136.7
ENST00000403707.3
tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr17_+_45286387 0.30 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
myosin, light chain 4, alkali; atrial, embryonic
chr11_-_4414880 0.29 ENST00000254436.7
ENST00000543625.1
tripartite motif containing 21
chr4_+_26322409 0.29 ENST00000514807.1
ENST00000348160.4
ENST00000509158.1
ENST00000355476.3
recombination signal binding protein for immunoglobulin kappa J region
chr19_+_1495362 0.28 ENST00000395479.4
receptor accessory protein 6
chr2_+_219433588 0.27 ENST00000295701.5
RCD1 required for cell differentiation1 homolog (S. pombe)
chr5_+_162930114 0.27 ENST00000280969.5
methionine adenosyltransferase II, beta
chr20_-_45981138 0.27 ENST00000446994.2
zinc finger, MYND-type containing 8
chr12_-_16430619 0.26 ENST00000344941.3
solute carrier family 15, member 5
chr7_-_22233442 0.26 ENST00000401957.2
Rap guanine nucleotide exchange factor (GEF) 5
chr7_-_71802595 0.25 ENST00000446128.1
calneuron 1
chrX_-_152989798 0.25 ENST00000441714.1
ENST00000442093.1
ENST00000429550.1
ENST00000345046.6
B-cell receptor-associated protein 31
chr16_-_73178346 0.25 ENST00000358463.2
chromosome 16 open reading frame 47
chr17_-_59940830 0.25 ENST00000259008.2
BRCA1 interacting protein C-terminal helicase 1
chr6_+_152011628 0.25 ENST00000404742.1
ENST00000440973.1
estrogen receptor 1
chr3_-_47484661 0.25 ENST00000495603.2
SREBF chaperone
chr17_-_43568062 0.25 ENST00000421073.2
ENST00000584420.1
ENST00000589780.1
ENST00000430334.3
pleckstrin homology domain containing, family M (with RUN domain) member 1
chr14_-_34931458 0.24 ENST00000298130.4
serine palmitoyltransferase, small subunit A
chr11_-_67188642 0.24 ENST00000546202.1
ENST00000542876.1
protein phosphatase 1, catalytic subunit, alpha isozyme
chr19_-_51220176 0.24 ENST00000359082.3
ENST00000293441.1
SH3 and multiple ankyrin repeat domains 1
chr15_+_101256294 0.23 ENST00000559755.1
RP11-66B24.5
chr12_-_46121554 0.22 ENST00000609803.1
long intergenic non-protein coding RNA 938
chr17_+_36858694 0.22 ENST00000563897.1
CTB-58E17.1
chr1_-_1334685 0.22 ENST00000400809.3
ENST00000408918.4
cyclin L2
chr8_-_116504448 0.22 ENST00000518018.1
trichorhinophalangeal syndrome I
chr3_-_15540055 0.21 ENST00000605797.1
ENST00000435459.2
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr3_-_69249863 0.21 ENST00000478263.1
ENST00000462512.1
FERM domain containing 4B
chr12_-_58135903 0.21 ENST00000257897.3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr10_+_64564469 0.20 ENST00000373783.1
2-aminoethanethiol (cysteamine) dioxygenase
chr12_-_56727676 0.20 ENST00000547572.1
ENST00000257931.5
ENST00000440411.3
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr19_+_40871734 0.20 ENST00000359274.5
phospholipase D family, member 3
chr2_-_214015111 0.20 ENST00000433134.1
IKAROS family zinc finger 2 (Helios)
chr11_-_65429891 0.20 ENST00000527874.1
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr12_-_56727487 0.20 ENST00000548043.1
ENST00000425394.2
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr18_+_19668021 0.20 ENST00000579830.1
Uncharacterized protein
chr2_-_47143160 0.20 ENST00000409800.1
ENST00000409218.1
multiple coagulation factor deficiency 2
chr17_-_73975444 0.20 ENST00000293217.5
ENST00000537812.1
acyl-CoA oxidase 1, palmitoyl
chr6_-_38607673 0.19 ENST00000481247.1
BTB (POZ) domain containing 9
chr14_-_69444957 0.19 ENST00000556571.1
ENST00000553659.1
ENST00000555616.1
actinin, alpha 1
chr15_+_83776137 0.19 ENST00000322019.9
transmembrane 6 superfamily member 1
chr5_+_138629628 0.19 ENST00000508689.1
ENST00000514528.1
matrin 3
chr6_-_38607628 0.18 ENST00000498633.1
BTB (POZ) domain containing 9
chr19_+_6361841 0.18 ENST00000596605.1
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr22_+_21321447 0.18 ENST00000434714.1
apoptosis-inducing factor, mitochondrion-associated, 3
chr6_+_30594619 0.18 ENST00000318999.7
ENST00000376485.4
ENST00000376478.2
ENST00000319027.5
ENST00000376483.4
ENST00000329992.8
ENST00000330083.5
alpha tubulin acetyltransferase 1
chr1_+_1334914 0.18 ENST00000576232.1
ENST00000570344.1
HCG20425, isoform CRA_a; Uncharacterized protein; cDNA FLJ53815
chr5_-_33892046 0.17 ENST00000352040.3
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr17_+_17685422 0.17 ENST00000395774.1
retinoic acid induced 1
chr17_-_73257667 0.17 ENST00000538886.1
ENST00000580799.1
ENST00000351904.7
ENST00000537686.1
golgi-associated, gamma adaptin ear containing, ARF binding protein 3
chrX_-_153141783 0.17 ENST00000458029.1
L1 cell adhesion molecule
chr17_+_7533439 0.16 ENST00000441599.2
ENST00000380450.4
ENST00000416273.3
ENST00000575903.1
ENST00000576830.1
ENST00000571153.1
ENST00000575618.1
ENST00000576152.1
sex hormone-binding globulin
chr3_+_160117062 0.16 ENST00000497311.1
structural maintenance of chromosomes 4
chr3_+_160117418 0.16 ENST00000465903.1
ENST00000485645.1
ENST00000360111.2
ENST00000472991.1
ENST00000467468.1
ENST00000469762.1
ENST00000489573.1
ENST00000462787.1
ENST00000490207.1
ENST00000485867.1
structural maintenance of chromosomes 4
chrX_-_47930980 0.16 ENST00000442455.3
ENST00000428686.1
ENST00000276054.4
zinc finger protein 630
chr19_-_14201776 0.16 ENST00000269724.5
sterile alpha motif domain containing 1
chr19_-_49250054 0.16 ENST00000602105.1
ENST00000332955.2
izumo sperm-egg fusion 1
chr3_-_147123837 0.15 ENST00000462748.2
Zic family member 4
chr17_-_27038765 0.15 ENST00000581289.1
ENST00000301039.2
protein interacting with cyclin A1

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1H4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
1.6 4.8 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
1.5 6.2 GO:0002432 granuloma formation(GO:0002432)
1.0 3.1 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.9 3.6 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.8 3.8 GO:0010902 positive regulation of very-low-density lipoprotein particle remodeling(GO:0010902)
0.6 3.8 GO:0002727 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of natural killer cell cytokine production(GO:0002729)
0.6 4.5 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.5 2.1 GO:0035397 helper T cell enhancement of adaptive immune response(GO:0035397)
0.4 1.1 GO:0048597 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.3 1.0 GO:0060730 regulation of intestinal epithelial structure maintenance(GO:0060730)
0.3 1.0 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.3 2.0 GO:0035709 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.3 1.7 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.3 0.8 GO:0045553 TRAIL biosynthetic process(GO:0045553) regulation of TRAIL biosynthetic process(GO:0045554) positive regulation of TRAIL biosynthetic process(GO:0045556)
0.3 2.1 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.3 0.8 GO:0006117 acetaldehyde metabolic process(GO:0006117)
0.3 1.5 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.2 1.6 GO:2000784 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.2 1.8 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.2 1.0 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.2 1.1 GO:0019556 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.1 0.3 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.1 1.0 GO:0008063 Toll signaling pathway(GO:0008063)
0.1 0.5 GO:2001287 negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 0.6 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 0.7 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 1.9 GO:0038203 TORC2 signaling(GO:0038203)
0.1 1.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 2.2 GO:0051014 actin filament severing(GO:0051014)
0.1 0.3 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.1 1.2 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 0.2 GO:0050894 determination of affect(GO:0050894)
0.1 1.3 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.1 0.3 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.1 0.3 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 6.2 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 0.4 GO:1900242 regulation of synaptic vesicle endocytosis(GO:1900242)
0.1 0.4 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.1 GO:2001113 negative regulation of hepatocyte growth factor receptor signaling pathway(GO:1902203) regulation of cellular response to hepatocyte growth factor stimulus(GO:2001112) negative regulation of cellular response to hepatocyte growth factor stimulus(GO:2001113)
0.0 0.2 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
0.0 0.4 GO:2000370 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.0 0.1 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.4 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 1.2 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 1.6 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.3 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.2 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.0 0.5 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.3 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0 0.1 GO:2000619 negative regulation of histone H4-K16 acetylation(GO:2000619)
0.0 0.8 GO:1904776 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 1.0 GO:0015695 organic cation transport(GO:0015695)
0.0 1.5 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.3 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.3 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.5 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 2.0 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 0.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.4 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 1.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.2 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.1 GO:2000360 egg activation(GO:0007343) negative regulation of binding of sperm to zona pellucida(GO:2000360)
0.0 0.5 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 1.6 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.9 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.0 0.0 GO:0051935 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.0 0.1 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.1 GO:0010265 SCF complex assembly(GO:0010265)
0.0 2.2 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.4 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.0 GO:0070876 SOSS complex(GO:0070876)
0.3 3.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.3 6.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 0.8 GO:0035525 NF-kappaB p50/p65 complex(GO:0035525)
0.1 3.8 GO:0042627 chylomicron(GO:0042627)
0.1 2.2 GO:0032059 bleb(GO:0032059)
0.1 1.5 GO:0071986 Ragulator complex(GO:0071986)
0.1 0.4 GO:0031251 PAN complex(GO:0031251)
0.1 0.3 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 1.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 2.1 GO:0042101 T cell receptor complex(GO:0042101)
0.1 1.2 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 1.9 GO:0031932 TORC2 complex(GO:0031932)
0.1 4.5 GO:0001772 immunological synapse(GO:0001772)
0.0 0.2 GO:0009368 endopeptidase Clp complex(GO:0009368)
0.0 0.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.3 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 1.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 1.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.8 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.5 GO:0000124 SAGA complex(GO:0000124)
0.0 0.3 GO:0000796 condensin complex(GO:0000796)
0.0 0.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.7 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 4.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.5 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 1.9 GO:0035580 specific granule lumen(GO:0035580)
0.0 2.8 GO:0005901 caveola(GO:0005901)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 1.3 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 2.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.5 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.6 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.5 3.8 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.3 2.0 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.3 2.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.2 1.0 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.2 0.7 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.2 1.3 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.2 0.5 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 2.2 GO:0033691 sialic acid binding(GO:0033691)
0.1 3.2 GO:0019841 retinol binding(GO:0019841)
0.1 2.2 GO:0005522 profilin binding(GO:0005522)
0.1 1.8 GO:0008199 ferric iron binding(GO:0008199)
0.1 1.0 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 1.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.8 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 2.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 2.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.3 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.1 4.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 1.8 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 1.4 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 1.1 GO:0051400 BH domain binding(GO:0051400)
0.0 0.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 1.0 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 1.2 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.3 GO:0000150 recombinase activity(GO:0000150)
0.0 0.9 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.3 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 4.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 2.3 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.3 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.3 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 1.0 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 6.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.5 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.1 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.2 GO:0005497 androgen binding(GO:0005497)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.3 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.2 GO:0035326 enhancer binding(GO:0035326)
0.0 1.0 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 4.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 1.5 GO:0032947 protein complex scaffold(GO:0032947)
0.0 2.2 GO:0003823 antigen binding(GO:0003823)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.4 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 4.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 2.3 PID ARF 3PATHWAY Arf1 pathway
0.1 1.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 1.6 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 2.0 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.8 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.8 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.8 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.6 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 2.3 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.2 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.8 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.0 PID E2F PATHWAY E2F transcription factor network
0.0 1.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 0.4 REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX Genes involved in Signaling by TGF-beta Receptor Complex
0.3 2.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.1 3.8 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 4.7 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.1 5.6 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 3.6 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 1.6 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 9.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 0.8 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 1.0 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.5 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.6 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 1.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 1.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.0 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.3 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 2.1 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions