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Illumina Body Map 2: averaged replicates
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Results for NR2E3
Z-value: 2.17
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Transcription factors associated with NR2E3
Network of associatons between targets according to the STRING database.
First level regulatory network of NR2E3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 12.9 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 0.2 | 7.9 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 1.1 | 7.7 | GO:0014718 | positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) |
| 0.5 | 6.7 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
| 0.5 | 6.4 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.3 | 6.2 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.1 | 6.0 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 1.8 | 5.5 | GO:0006147 | guanine catabolic process(GO:0006147) |
| 0.8 | 5.5 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.5 | 5.1 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.2 | 18.7 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 9.7 | GO:0031674 | I band(GO:0031674) |
| 0.0 | 8.5 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 7.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 7.7 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 6.6 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.3 | 6.3 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.5 | 5.3 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.2 | 5.1 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 13.9 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.2 | 12.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.8 | 8.9 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.3 | 8.4 | GO:0055103 | ligase regulator activity(GO:0055103) |
| 0.7 | 6.4 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.6 | 6.2 | GO:1904315 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.0 | 5.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.2 | 5.6 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 1.8 | 5.5 | GO:0008892 | guanine deaminase activity(GO:0008892) |
| 0.3 | 4.7 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.9 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 7.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 4.5 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.0 | 4.5 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 4.1 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 3.8 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 3.7 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 3.7 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 3.4 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 2.7 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 6.4 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.2 | 5.9 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 5.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 5.3 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 5.0 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 4.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 4.5 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 3.9 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 3.7 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |