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Illumina Body Map 2: averaged replicates
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Results for NR3C1
Z-value: 3.08
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Transcription factors associated with NR3C1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR3C1 | hg19_v2_chr5_-_142784888_142784925 | -0.56 | 9.8e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_106692191 Show fit | 13.58 |
ENST00000390607.2
|
immunoglobulin heavy variable 3-21 |
|
| chr14_-_106805716 Show fit | 12.99 |
ENST00000438142.2
|
immunoglobulin heavy variable 4-31 |
|
| chr14_-_106054659 Show fit | 12.85 |
ENST00000390539.2
|
immunoglobulin heavy constant alpha 2 (A2m marker) |
|
| chr14_-_106453155 Show fit | 11.25 |
ENST00000390594.2
|
immunoglobulin heavy variable 1-2 |
|
| chr22_+_23237555 Show fit | 9.87 |
ENST00000390321.2
|
immunoglobulin lambda constant 1 (Mcg marker) |
|
| chr14_-_106642049 Show fit | 9.61 |
ENST00000390605.2
|
immunoglobulin heavy variable 1-18 |
|
| chr15_-_22448819 Show fit | 9.30 |
ENST00000604066.1
|
immunoglobulin heavy variable 1/OR15-1 (non-functional) |
|
| chr22_+_23248512 Show fit | 8.34 |
ENST00000390325.2
|
immunoglobulin lambda constant 3 (Kern-Oz+ marker) |
|
| chr14_-_106781017 Show fit | 8.23 |
ENST00000390612.2
|
immunoglobulin heavy variable 4-28 |
|
| chr2_-_89513402 Show fit | 8.08 |
ENST00000498435.1
|
immunoglobulin kappa variable 1-27 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR3C1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 160.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.2 | 147.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.2 | 42.1 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 40.1 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.1 | 8.1 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.3 | 5.7 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 1.8 | 5.3 | GO:0050904 | diapedesis(GO:0050904) |
| 0.7 | 5.1 | GO:0045425 | positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425) |
| 0.2 | 4.8 | GO:0002710 | negative regulation of T cell mediated immunity(GO:0002710) |
| 0.1 | 4.5 | GO:0045576 | mast cell activation(GO:0045576) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 140.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.3 | 75.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 72.8 | GO:0005615 | extracellular space(GO:0005615) |
| 6.8 | 20.4 | GO:0071745 | IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751) |
| 0.1 | 12.2 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.2 | 8.8 | GO:0098636 | protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 8.6 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 6.9 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.6 | 6.5 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 0.2 | 6.5 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 193.8 | GO:0003823 | antigen binding(GO:0003823) |
| 2.5 | 162.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 9.5 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 8.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.3 | 7.7 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 7.0 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 1.1 | 6.9 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.6 | 6.5 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.1 | 6.1 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 1.0 | 6.0 | GO:0047006 | 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 15.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 14.8 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 8.9 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 7.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 5.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 5.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 5.1 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 4.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.3 | 10.4 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 6.9 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.4 | 6.1 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 5.7 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.2 | 5.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 5.2 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 5.1 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.2 | 4.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 4.2 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |