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Illumina Body Map 2: averaged replicates
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Results for NR4A3
Z-value: 1.94
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Transcription factors associated with NR4A3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR4A3 | hg19_v2_chr9_+_102584128_102584144 | -0.25 | 1.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR4A3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 14.4 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.2 | 13.4 | GO:0043403 | skeletal muscle tissue regeneration(GO:0043403) |
| 0.9 | 8.5 | GO:0010269 | response to selenium ion(GO:0010269) |
| 0.1 | 8.3 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 1.1 | 7.9 | GO:0033133 | positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301) |
| 0.3 | 7.1 | GO:1990845 | adaptive thermogenesis(GO:1990845) |
| 0.9 | 6.6 | GO:2001293 | malonyl-CoA metabolic process(GO:2001293) |
| 0.4 | 5.5 | GO:0086029 | Purkinje myocyte to ventricular cardiac muscle cell signaling(GO:0086029) Purkinje myocyte to ventricular cardiac muscle cell communication(GO:0086068) |
| 0.3 | 5.5 | GO:0046951 | ketone body biosynthetic process(GO:0046951) |
| 0.2 | 5.4 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 37.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 22.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 13.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 11.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.2 | 10.8 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 8.4 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 7.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 6.5 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 6.4 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 6.4 | GO:0030018 | Z disc(GO:0030018) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 10.8 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 1.3 | 10.0 | GO:0035473 | lipase binding(GO:0035473) |
| 0.1 | 9.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 9.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 8.9 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 8.3 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 1.6 | 7.9 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 1.0 | 7.1 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
| 0.2 | 6.7 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.2 | 5.7 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 11.6 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 7.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 6.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 4.8 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 4.7 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 4.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 4.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 4.2 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 3.8 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 17.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.3 | 17.7 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.4 | 10.8 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 9.5 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 7.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 7.0 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 6.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.3 | 5.8 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 5.8 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |