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Illumina Body Map 2: averaged replicates
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Results for NR6A1
Z-value: 1.57
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Transcription factors associated with NR6A1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR6A1 | hg19_v2_chr9_-_127358087_127358170 | -0.23 | 2.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_106539557 Show fit | 3.37 |
ENST00000390599.2
|
immunoglobulin heavy variable 1-8 |
|
| chr14_-_96180435 Show fit | 3.22 |
ENST00000556450.1
ENST00000555202.1 ENST00000554012.1 ENST00000402399.1 |
T-cell leukemia/lymphoma 1A |
|
| chr19_-_7797045 Show fit | 2.98 |
ENST00000328853.5
|
C-type lectin domain family 4, member G |
|
| chr15_-_20170354 Show fit | 2.92 |
ENST00000338912.5
|
immunoglobulin heavy variable 1/OR15-9 (non-functional) |
|
| chr9_-_137809718 Show fit | 2.85 |
ENST00000371806.3
|
ficolin (collagen/fibrinogen domain containing) 1 |
|
| chr14_+_22670455 Show fit | 2.81 |
ENST00000390460.1
|
T cell receptor alpha variable 26-2 |
|
| chr14_-_106733624 Show fit | 2.78 |
ENST00000390610.2
|
immunoglobulin heavy variable 1-24 |
|
| chr15_-_22448819 Show fit | 2.76 |
ENST00000604066.1
|
immunoglobulin heavy variable 1/OR15-1 (non-functional) |
|
| chr14_-_106471723 Show fit | 2.74 |
ENST00000390595.2
|
immunoglobulin heavy variable 1-3 |
|
| chr14_-_106642049 Show fit | 2.69 |
ENST00000390605.2
|
immunoglobulin heavy variable 1-18 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR6A1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.5 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.9 | 7.5 | GO:1904799 | regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) negative regulation of branching morphogenesis of a nerve(GO:2000173) |
| 0.7 | 4.1 | GO:2001274 | negative regulation of glucose import in response to insulin stimulus(GO:2001274) |
| 0.0 | 4.0 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 0.0 | 3.5 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.2 | 3.2 | GO:0010918 | positive regulation of mitochondrial membrane potential(GO:0010918) |
| 0.9 | 2.8 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
| 0.0 | 2.8 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 0.1 | 2.7 | GO:0002710 | negative regulation of T cell mediated immunity(GO:0002710) |
| 0.2 | 2.6 | GO:0001865 | NK T cell differentiation(GO:0001865) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 19.2 | GO:0019814 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 7.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.6 | 4.0 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.1 | 3.5 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 3.1 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.3 | 2.8 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.9 | 2.7 | GO:0005940 | septin ring(GO:0005940) septin collar(GO:0032173) |
| 0.2 | 2.2 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.0 | 2.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 2.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 7.9 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 4.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.3 | 4.3 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 0.0 | 3.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.1 | 3.6 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 3.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 3.4 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.1 | 3.2 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 2.9 | GO:0005178 | integrin binding(GO:0005178) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 5.7 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 5.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 5.1 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.1 | 4.2 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 2.9 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 2.2 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 2.0 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 2.0 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.6 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.1 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 5.4 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 2.6 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 2.3 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 2.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 2.2 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.0 | 2.0 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 2.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 1.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 1.6 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |