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Illumina Body Map 2: averaged replicates
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Results for NRF1
Z-value: 5.89
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Transcription factors associated with NRF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NRF1 | hg19_v2_chr7_+_129251531_129251601 | -0.00 | 9.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NRF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.7 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 0.1 | 17.5 | GO:0006415 | translational termination(GO:0006415) |
| 0.1 | 16.1 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.3 | 15.2 | GO:0038202 | TORC1 signaling(GO:0038202) |
| 0.3 | 14.8 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.2 | 14.3 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 13.8 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.4 | 13.5 | GO:0070987 | error-free translesion synthesis(GO:0070987) |
| 2.2 | 12.9 | GO:1903490 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
| 0.4 | 11.4 | GO:0034063 | stress granule assembly(GO:0034063) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 124.0 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 23.0 | GO:0005730 | nucleolus(GO:0005730) |
| 1.4 | 19.5 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 18.7 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.5 | 17.8 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 15.9 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.2 | 15.2 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 15.0 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.1 | 14.6 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 14.1 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 39.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 31.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 24.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 19.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 19.5 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 16.6 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.2 | 13.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.3 | 13.4 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.2 | 13.3 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.4 | 13.1 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.4 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.3 | 12.5 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.2 | 11.2 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 10.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.3 | 9.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 8.6 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.1 | 7.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 6.9 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.2 | 5.9 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 5.7 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 41.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 27.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.4 | 23.0 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |
| 0.7 | 17.6 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.4 | 14.9 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.2 | 14.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 13.8 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.2 | 12.2 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.3 | 11.4 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.1 | 11.3 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |